Lipid absorption triggers drug supersaturation at the intestinal unstirred water layer and promotes drug absorption from mixed micelles

Pharmaceutical Research

Volumn 30, Issue 12, 2013, Pages 3045-3058

  Yeap, Yan Yan ^a   Trevaskis, Natalie L ^a   Porter, Christopher J H ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

absorption; food effect; lipid based formulations; poorly water soluble drug; supersaturation; unstirred water layer

Indexed keywords

AMILORIDE; BRIJ 97; CINNARIZINE; FATTY ACID; LIPID; OLEIC ACID; SURFACTANT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIGESTIVE TRACT PARAMETERS; DRUG ABSORPTION; DRUG FORMULATION; DRUG SOLUBILITY; DRUG SUPERSATURATION; FOOD DRUG INTERACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTESTINAL UNSTIRRED WATER LAYER; INTESTINE PERFUSION; JEJUNUM; LIPID ABSORPTION; LIPID COMPOSITION; MICELLE; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PRIORITY JOURNAL; RAT; STOMACH PH; THERMODYNAMICS;

ACID SENSING ION CHANNEL BLOCKERS; AMILORIDE; ANIMALS; CALCIUM CHANNEL BLOCKERS; CINNARIZINE; COLLOIDS; INTESTINAL ABSORPTION; JEJUNUM; MALE; MICELLES; OLEIC ACID; PHARMACEUTICAL VEHICLES; RATS; RATS, SPRAGUE-DAWLEY; WATER;

EID: 84890559312     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-013-1104-6     Document Type: Article

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