PLGA microspheres for the ocular delivery of a peptide drug, vancomycin using emulsification/spray-drying as the preparation method: In vitro/in vivo studies

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 57, Issue 2, 2004, Pages 207-212

  Gavini, Elisabetta ^a   Chetoni, Patrizia ^b   Cossu, Massimo ^a   Alvarez, Maria Gemma ^c   Saettone, Marco Fabrizio ^b   Giunchedi, Paolo ^a  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Aqueous humor; Emulsification spray drying; In vivo studies; Microspheres; Ocular delivery; Peptide drug; Poly(lactide co glycolide); Vancomycin

Indexed keywords

HYDROXYPROPYLCELLULOSE; MICROSPHERE; PEPTIDE DERIVATIVE; POLYGLACTIN; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS HUMOR; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG RELEASE; MALE; MICROEMULSION; MICROENCAPSULATION; NONHUMAN; PARTICLE SIZE; RABBIT; SPRAY DRYING; VISCOELASTICITY;

EID: 1442359755     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2003.10.018     Document Type: Article

References (16)

1. Brod D., Flynn H.W. Infectious endophthalmitis. Curr. Opin. Infect. Dis. 10:1997;153-162.
2. Ptlughelder S.C., Flynn H.W. Infectious endophthalmitis. Infect. Dis. Clin. North Am. 6:1992;859-873.
3. Souli M., Kopsinis G., Kavouklis E., Gabriel L., Giamarellou H. Vancomycin levels in human aqueous humour after intravenous and subconjunctival administration. Int. J. Antimicrob. Agents. 18:2001;239-243.
4. Reynolds J.E.F. Martindale The Extra Pharmacopoeia. 31st ed. 1996;Pharmaceutical Press, London, UK. pp. 295-297.
5. Cheung R.P.F., Dipiro J.T. Vancomycin; an update. Pharmacotherapy. 6:1986;153-169.
6. Giunchedi P., Conte U., Chetoni P., Saettone M.F. Pectin microspheres as ophthalmic carriers for Piroxicam: evaluation in vitro and in vivo in albino rabbits. Eur. J. Pharm. Sci. 9:1999;1-7.
7. Giunchedi P., Chetoni P., Conte U., Saettone M.F. Albumin microspheres for ocular delivery of Piroxicam. Pharm. Pharmacol. Commun. 6:2000;149-153.
8. Yeh M.K., Tung S.M., Lu D.W., Chen J.L., Chiang C.H. Formulation factors for preparing ocular biodegradable delivery system of 5-fluorouracil microparticles. J. Microencapsul. 18:2001;507-519.
9. Ignatius A.A., Claes L.E. In vitro biocompatibility of bioerosorbable polymers: poly(D,L-lactide) (PLA) and poly(D,L-lactide-co-glicolide) (PLGA). Biomaterials. 17:1996;831-839.
10. Mordenti J., Thomsen K., Licko V., Berleau L., Kahn J.W., Cuthbertson R.A., Duenas E.T., Ryan A.M., Schofield C., Berger T.W., Meng Y.G., Cleland J. Intraocular pharmacokinetics and safety of a humanized monoclonal antibody in rabbits after intravitreal administration of a solution or a PLGA microsphere formulation. Toxicol. Sci. 52:1999;101-106.
11. Pinstner H., Gutwald R., Ordung R., Reuther J., Muhling J. Poly(L-lactide): a long term degradation study in vivo. Biomaterials. 14:1993;671-677.
12. Özalp Y., Özdemir N., Kocagöz S., Hasirci V. Controlled release of Vancomycin from biodegradable microcapsules. J. Microencapsul. 18:2001;89-110.
13. Edmunson C. Bean H.S., Carless J.E., Beckett A.H. Advances in Pharmaceutical Sciences. 1967;Academic Press, New York.
14. Gupta P.K., Johnson H., Allexon C. In vitro and in vivo evaluation of clarithromycin/poly(lactic acid) microspheres for intramuscular drug delivery. J. Controlled Release. 26:1993;229-234.
15. Olejnik O. Conventional systems in ophthalmic drug delivery. Mitra A.K. Ophthalmic Drug Delivery Systems. 1993;177-198 Marcel Dekker, New York.
16. Saettone M.F., Giannaccini B., Barattini F., Tellini N. The validity of rabbits for investigations on ophthalmic vehicles: a comparison of four different vehicles containing tropicamide in humans and rabbits. Pharm. Acta Helv. 57:1982;47-55.