Effect of chitosan and of N-carboxymethylchitosan on intraocular penetration of topically applied ofloxacin

International Journal of Pharmaceutics

Volumn 273, Issue 1-2, 2004, Pages 37-44

  Di Colo, G ^a   Zambito, Y ^a   Burgalassi, S ^a   Nardini, I ^a   Saettone, M F ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Absorption enhancer; Chitosan; N carboxymethylchitosan; Ocular drug delivery; Ofloxacin; Pharmacokinetics

Indexed keywords

ANTIBIOTIC AGENT; CHITOSAN DERIVATIVE; EYE DROPS; METHYL GROUP; N CARBOXYMETHYLCHITOSAN; OFLOXACIN; POLYMER; POLYVINYL ALCOHOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AQUEOUS HUMOR; AQUEOUS SOLUTION; ARTICLE; COMMERCIAL PHENOMENA; CONTROLLED STUDY; CORNEA PERMEABILITY; DEACETYLATION; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG FORMULATION; DRUG INSTILLATION; DRUG PENETRATION; DRUG RETENTION; DRUG SOLUTION; EYE IRRITATION; FLOW KINETICS; LACRIMAL FLUID; MALE; METHYLATION; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RABBIT; STATISTICAL SIGNIFICANCE; VISCOSITY;

ANIMALS; ANTI-INFECTIVE AGENTS; AQUEOUS HUMOR; BIOLOGICAL AVAILABILITY; CHITIN; CHITOSAN; EYE; INSTILLATION, DRUG; MALE; OFLOXACIN; OPHTHALMIC SOLUTIONS; PERMEABILITY; RABBITS; TEARS;

EID: 1542328829     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2003.12.018     Document Type: Article

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