-
1
-
-
33846379526
-
Therapeutic resistance in lung cancer
-
A. Nadkar, C. Pungaliya, K. Drake, E. Zajac, S.S Singhal and S. Awasthi, Therapeutic resistance in lung cancer, Expert Opin. Drug Metab. Toxicol. 2 (2006), 753-777.
-
(2006)
Expert Opin. Drug Metab. Toxicol
, vol.2
, pp. 753-777
-
-
Nadkar, A.1
Pungaliya, C.2
Drake, K.3
Zajac, E.4
Singhal, S.S.5
Awasthi, S.6
-
2
-
-
54249087596
-
RNAi mediated silencing of Nrf2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy
-
A. Singh, S. Boldin-Adamsky, R.K. Thimmulappa, S.K. Rath, H. Ashush, J. Coulter et al., RNAi mediated silencing of Nrf2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy, Cancer Res. 68 (2008), 7975-7984.
-
(2008)
Cancer Res
, vol.68
, pp. 7975-7984
-
-
Singh, A.1
Boldin-Adamsky, S.2
Thimmulappa, R.K.3
Rath, S.K.4
Ashush, H.5
Coulter, J.6
-
3
-
-
0035575767
-
Expression of gammaglutamyl cysteine synthetase in nonsmall cell lung carcinoma
-
Y. Soini, U. Napankangas, K. Jarvinen, R. Kaarteenaho-Wiik, P. Paakko and V.L. Kinnula, Expression of gammaglutamyl cysteine synthetase in nonsmall cell lung carcinoma, Cancer 92 (2001), 2911-2919.
-
(2001)
Cancer
, vol.92
, pp. 2911-2919
-
-
Soini, Y.1
Napankangas, U.2
Jarvinen, K.3
Kaarteenaho-Wiik, R.4
Paakko, P.5
Kinnula, V.L.6
-
4
-
-
0028106016
-
Glutathione-associated enzymes in anticancer drug resistance
-
K.D. Tew, Glutathione-associated enzymes in anticancer drug resistance, Cancer Res. 54 (1994), 4313-4320.
-
(1994)
Cancer Res
, vol.54
, pp. 4313-4320
-
-
Tew, K.D.1
-
5
-
-
33645804599
-
Role of the glutathione metabolic pathway in lung cancer treatment and prognosis: A review
-
P. Yang, J.O. Ebbert, Z. Sun and R.M. Weinshilboum, Role of the glutathione metabolic pathway in lung cancer treatment and prognosis: A review, J. Clin. Oncol. 24 (2006), 1761-1769.
-
(2006)
J. Clin. Oncol
, vol.24
, pp. 1761-1769
-
-
Yang, P.1
Ebbert, J.O.2
Sun, Z.3
Weinshilboum, R.M.4
-
6
-
-
33748146888
-
Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate
-
D. Trachootham, Y. Zhou, H. Zhang, Y. Demizu, Z. Chen, H. Pelicano et al., Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate, Cancer Cell 10 (2006), 241-252.
-
(2006)
Cancer Cell
, vol.10
, pp. 241-252
-
-
Trachootham, D.1
Zhou, Y.2
Zhang, H.3
Demizu, Y.4
Chen, Z.5
Pelicano, H.6
-
7
-
-
3543008924
-
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
-
A. Kobayashi, M.I. Kang, H. Okawa, M. Ohtsuji, Y. Zenke, T. Chiba et al., Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2, Mol. Cell Biol. 24 (2004), 7130-7139.
-
(2004)
Mol. Cell Biol
, vol.24
, pp. 7130-7139
-
-
Kobayashi, A.1
Kang, M.I.2
Okawa, H.3
Ohtsuji, M.4
Zenke, Y.5
Chiba, T.6
-
8
-
-
10044228504
-
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
-
D.D. Zhang, S.C. Lo, J.V. Cross, D.J. Templeton and M. Hannink, Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex, Mol. Cell Biol. 24 (2004), 10941-10953.
-
(2004)
Mol. Cell Biol
, vol.24
, pp. 10941-10953
-
-
Zhang, D.D.1
Lo, S.C.2
Cross, J.V.3
Templeton, D.J.4
Hannink, M.5
-
9
-
-
33847050801
-
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
-
T.W. Kensler, N. Wakabayashi and S. Biswal, Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway, Annu. Rev. Pharmacol. Toxicol. 47 (2007), 89-116.
-
(2007)
Annu. Rev. Pharmacol. Toxicol
, vol.47
, pp. 89-116
-
-
Kensler, T.W.1
Wakabayashi, N.2
Biswal, S.3
-
10
-
-
0141534255
-
Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts
-
A.Hayashi, H. Suzuki, K. Itoh, M. Yamamoto and Y. Sugiyama, Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts, Biochem. Biophys. Res. Commun. 310 (2003), 824-829.
-
(2003)
Biochem. Biophys. Res. Commun
, vol.310
, pp. 824-829
-
-
Hayashi, A.1
Suzuki, H.2
Itoh, K.3
Yamamoto, M.4
Sugiyama, Y.5
-
11
-
-
0037763721
-
Regulatory mechanisms controlling gene expression mediated by the antioxidant response element
-
T. Nguyen, P.J. Sherratt and C.B. Pickett, Regulatory mechanisms controlling gene expression mediated by the antioxidant response element, Annu. Rev. Pharmacol. Toxicol. 43 (2003), 233-260.
-
(2003)
Annu. Rev. Pharmacol. Toxicol
, vol.43
, pp. 233-260
-
-
Nguyen, T.1
Sherratt, P.J.2
Pickett, C.B.3
-
12
-
-
33646267005
-
Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene
-
V. Vollrath, A.M. Wielandt, M. Iruretagoyena and J. Chianale, Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene, Biochem. J. 395 (2006), 599-609.
-
(2006)
Biochem. J
, vol.395
, pp. 599-609
-
-
Vollrath, V.1
Wielandt, A.M.2
Iruretagoyena, M.3
Chianale, J.4
-
13
-
-
33846703755
-
Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: Implication to tumor biology
-
Y.J. Kim, J.Y. Ahn, P. Liang, C. Ip, Y. Zhang and Y.M. Park, Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology, Cancer Res. 67 (2007), 546-554.
-
(2007)
Cancer Res
, vol.67
, pp. 546-554
-
-
Kim, Y.J.1
Ahn, J.Y.2
Liang, P.3
Ip, C.4
Zhang, Y.5
Park, Y.M.6
-
14
-
-
25144440916
-
Cloning and characterization of the human glutathione synthetase 5'-flanking region
-
T.D. Lee, H. Yang, J. Whang and S.C. Lu, Cloning and characterization of the human glutathione synthetase 5'-flanking region, Biochem. J. 390 (2005), 521-528.
-
(2005)
Biochem. J
, vol.390
, pp. 521-528
-
-
Lee, T.D.1
Yang, H.2
Whang, J.3
Lu, S.C.4
-
15
-
-
15244356847
-
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice
-
T. Rangasamy, C.Y. Cho, R.K. Thimmulappa, L. Zhen, S.S. Srisuma, T.W. Kensler, M. Yamamoto et al., Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice, J. Clin. Invest. 114 (2004), 1248-1259.
-
(2004)
J. Clin. Invest
, vol.114
, pp. 1248-1259
-
-
Rangasamy, T.1
Cho, C.Y.2
Thimmulappa, R.K.3
Zhen, L.4
Srisuma, S.S.5
Kensler, T.W.6
Yamamoto, M.7
-
16
-
-
22344438250
-
Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice
-
T. Rangasamy, J. Guo, W.A. Mitzner, J. Roman, A. Singh, A.D. Fryer et al., Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice, J. Exp. Med. 202 (2005), 47-59.
-
(2005)
J. Exp. Med
, vol.202
, pp. 47-59
-
-
Rangasamy, T.1
Guo, J.2
Mitzner, W.A.3
Roman, J.4
Singh, A.5
Fryer, A.D.6
-
17
-
-
33750826092
-
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide
-
R.K. Thimmulappa, C. Scollick, K. Traore, M. Yates, M.A. Trush, K.T. Liby et al., Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide, Biochem. Biophys. Res. Commun. 351 (2006), 883-889.
-
(2006)
Biochem. Biophys. Res. Commun
, vol.351
, pp. 883-889
-
-
Thimmulappa, R.K.1
Scollick, C.2
Traore, K.3
Yates, M.4
Trush, M.A.5
Liby, K.T.6
-
18
-
-
0037434737
-
Nrf2 is an inhibitor of the Fas pathway as identified by Achilles' Heel Method a New function-based approach to gene identification in human cells
-
K.U. Kotlo, F. Yehiely, E. Efimova, H. Harasty, B. Hesabi, K. Shchors et al., Nrf2 is an inhibitor of the Fas pathway as identified by Achilles' Heel Method, a New function-based approach to gene identification in human cells, Oncogene 22 (2003), 797-806.
-
(2003)
Oncogene
, vol.22
, pp. 797-806
-
-
Kotlo, K.U.1
Yehiely, F.2
Efimova, E.3
Harasty, H.4
Hesabi, B.5
Shchors, K.6
-
19
-
-
1642540092
-
Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels
-
N. Morito, K. Yoh, K. Itoh, A. Hirayama, A. Koyama, M. Yamamoto et al., Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels, Oncogene 22 (2003), 9275-9281.
-
(2003)
Oncogene
, vol.22
, pp. 9275-9281
-
-
Morito, N.1
Yoh, K.2
Itoh, K.3
Hirayama, A.4
Koyama, A.5
Yamamoto, M.6
-
20
-
-
84881399163
-
The Keap1/Nrf2 protein axis plays a role in osteoclast differentiation by regulating intracellular reactive oxygen species signaling
-
H. Kanzaki, F. Shinohara, M. Kajiya and T. Kodama, The Keap1/Nrf2 protein axis plays a role in osteoclast differentiation by regulating intracellular reactive oxygen species signaling, J. Biol. Chem. 288 (2013), 23009-23020.
-
(2013)
J. Biol. Chem
, vol.288
, pp. 23009-23020
-
-
Kanzaki, H.1
Shinohara, F.2
Kajiya, M.3
Kodama, T.4
-
21
-
-
0000075317
-
-
D.M Glover, ed., ORL Press, Oxford, Washington DC
-
D. Hanahan, DNA cloning, D.M. Glover, ed., ORL Press, Oxford, Washington DC, 1985, vol. 1, pp. 109-135.
-
(1985)
DNA Cloning
, vol.1
, pp. 109-135
-
-
Hanahan, D.1
-
22
-
-
77952890450
-
Opposing actions of endocannabinoids on cholangiocarcinoma growth is via the differential activation of Notch signaling
-
G. Frampton, M. Coufal, H. Li, J. Ramirez and S. DeMorrow, Opposing actions of endocannabinoids on cholangiocarcinoma growth is via the differential activation of Notch signaling, Exp. Cell Res. 316 (2010), 1465-1478.
-
(2010)
Exp. Cell Res
, vol.316
, pp. 1465-1478
-
-
Frampton, G.1
Coufal, M.2
Li, H.3
Ramirez, J.4
Demorrow, S.5
-
23
-
-
79959724636
-
Anandamide exerts its antiproliferative actions on cholangiocarcinoma by activation of the GPR55 receptor
-
L. Huang, J.C. Ramirez, G.A. Frampton, L.E. Golden, M.A. Quinn, H.Y. Pae et al., Anandamide exerts its antiproliferative actions on cholangiocarcinoma by activation of the GPR55 receptor, Lab Invest. 91 (2010), 1007-1017.
-
(2010)
Lab Invest
, vol.91
, pp. 1007-1017
-
-
Huang, L.1
Ramirez, J.C.2
Frampton, G.A.3
Golden, L.E.4
Quinn, M.A.5
Pae, H.Y.6
-
24
-
-
57349185750
-
The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway
-
S. DeMorrow, H. Francis, E. Gaudio, J. Venter, A. Franchitto, S. Kopriva et al., The endocannabinoid anandamide inhibits cholangiocarcinoma growth via activation of the noncanonical Wnt signaling pathway, Am. J. Physiol. Gastrointest. Liver Physiol. 295 (2008), 1150-1158.
-
(2008)
Am. J. Physiol. Gastrointest. Liver Physiol
, vol.295
, pp. 1150-1158
-
-
Demorrow, S.1
Francis, H.2
Gaudio, E.3
Venter, J.4
Franchitto, A.5
Kopriva, S.6
-
25
-
-
56149102360
-
Realgar-induced differentiation is associated with MAPK pathways in HL-60 cells
-
N. Wang, L.W. Wang, B.D. Gou, T.L. Zhang and K. Wang, Realgar-induced differentiation is associated with MAPK pathways in HL-60 cells, Cell Biol. Int. 32 (2008), 1497-1505.
-
(2008)
Cell Biol. Int
, vol.32
, pp. 1497-1505
-
-
Wang, N.1
Wang, L.W.2
Gou, B.D.3
Zhang, T.L.4
Wang, K.5
-
26
-
-
24644486031
-
Differentiation response of acute promyelocytic leukemia cells and PML/RAR? Leukemogenic activity studies by real-time RT-PCR
-
S. Caprodossi, M. Pedinotti, C. Amantini, G. Santoni, S. Minucci, P.G. Pelicci et al., Differentiation response of acute promyelocytic leukemia cells and PML/RAR? leukemogenic activity studies by real-time RT-PCR, Mol. Biotechnol. 30 (2005), 231-238.
-
(2005)
Mol. Biotechnol
, vol.30
, pp. 231-238
-
-
Caprodossi, S.1
Pedinotti, M.2
Amantini, C.3
Santoni, G.4
Minucci, S.5
Pelicci, P.G.6
-
27
-
-
33749327295
-
Oncostatic effects of the indole melatonin and expression of its cytosolic and nuclear receptors in cultured human melanoma cell lines
-
T.W. Fischer, M.A. Zmijewski, B. Zbytek, T.W. Sweatman, R.M. Slominski, J. Wortsman et al., Oncostatic effects of the indole melatonin and expression of its cytosolic and nuclear receptors in cultured human melanoma cell lines, Int. J. Oncol. 29 (2006), 665-672.
-
(2006)
Int. J. Oncol
, vol.29
, pp. 665-672
-
-
Fischer, T.W.1
Zmijewski, M.A.2
Zbytek, B.3
Sweatman, T.W.4
Slominski, R.M.5
Wortsman, J.6
-
28
-
-
54949139208
-
Adaptive response to GSH depletion and resistance to L-buthionine-(SR)-sulfoximine: Involvement of Nrf2 activation
-
H.R. Lee, J.M. Cho, D.H. Shin, C.S. Yong, H.G. Choi, N. Wakabayashi et al., Adaptive response to GSH depletion and resistance to L-buthionine-(S,R)-sulfoximine: involvement of Nrf2 activation, Mol. Cell Biochem. 318 (2008), 23-31.
-
(2008)
Mol. Cell Biochem
, vol.318
, pp. 23-31
-
-
Lee, H.R.1
Cho, J.M.2
Shin, D.H.3
Yong, C.S.4
Choi, H.G.5
Wakabayashi, N.6
-
29
-
-
49149093703
-
Apoptosis/necrosis switch in two different cancer cell lines: Influence of benzoquinone and hydrogen peroxide-induced oxidative stress intensity, and glutathione, Toxicol
-
M.G. Baigi, L. Brault, A. Nuesque, M. Beley, R.E. Hilali, F. Ga.e et al., Apoptosis/necrosis switch in two different cancer cell lines: Influence of benzoquinone and hydrogen peroxide-induced oxidative stress intensity, and glutathione, Toxicol. in Vitro. 22 (2008), 1547-1554.
-
(2008)
Vitro
, vol.22
, pp. 1547-1554
-
-
Baigi, M.G.1
Brault, L.2
Nuesque, A.3
Beley, M.4
Hilali, R.E.5
Ga, F.6
-
30
-
-
84907273020
-
Novel function of transcription factor Nrf2 as an inhibitor of RON tyrosine kinase receptor mediated cancer cell invasion
-
T. Amalraj, R. Jessica, K.K. Naveen, W.F. James and A. Sudhakar, Novel function of transcription factor Nrf2 as an inhibitor of RON tyrosine kinase receptor mediated cancer cell invasion, J. Biol. Chem. 28 (2011), 31-35.
-
(2011)
J. Biol. Chem
, vol.28
, pp. 31-35
-
-
Amalraj, T.1
Jessica, R.2
Naveen, K.K.3
James, W.F.4
Sudhakar, A.5
-
31
-
-
0036637164
-
Direct reaction between shikonin and thiols induces apoptosis in HL60 cells
-
D. Gao, M. Hiromura, H. Yasui and H. Sakurai, Direct reaction between shikonin and thiols induces apoptosis in HL60 cells, Biol. Pharm. Bull. 25 (2002), 827-832.
-
(2002)
Biol. Pharm. Bull
, vol.25
, pp. 827-832
-
-
Gao, D.1
Hiromura, M.2
Yasui, H.3
Sakurai, H.4
-
32
-
-
84876829174
-
Shikonin attenuates lung cancer cell adhesion to extracellular matrix and metastasis by inhibiting integrin 1 expression and the ERK1/2 signaling pathway
-
H. Wang, C. Wu, S. Wan, H. Zhang, S. Zhou and G. Liu, Shikonin attenuates lung cancer cell adhesion to extracellular matrix and metastasis by inhibiting integrin 1 expression and the ERK1/2 signaling pathway, Toxicology 308 (2013), 104-112.
-
(2013)
Toxicology
, vol.308
, pp. 104-112
-
-
Wang, H.1
Wu, C.2
Wan, S.3
Zhang, H.4
Zhou, S.5
Liu, G.6
-
33
-
-
33344456501
-
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
-
B. Padmanabhan, K.I. Tong, T. Ohta, Y. Nakamura, M. Scharlock, M. Ohtsuji et al., Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer, Mol. Cell 21 (2006), 689-700.
-
(2006)
Mol. Cell
, vol.21
, pp. 689-700
-
-
Padmanabhan, B.1
Tong, K.I.2
Ohta, T.3
Nakamura, Y.4
Scharlock, M.5
Ohtsuji, M.6
-
34
-
-
33749993417
-
The consensus coding sequences of human breast and colorectal cancers
-
T. Sjoblom, S. Jones, L.D. Wood, D.W. Parsons, J. Lin, T.D. Barber et al., The consensus coding sequences of human breast and colorectal cancers, Science 314 (2006), 268-274.
-
(2006)
Science
, vol.314
, pp. 268-274
-
-
Sjoblom, T.1
Jones, S.2
Wood, L.D.3
Parsons, D.W.4
Lin, J.5
Barber, T.D.6
-
35
-
-
0043170892
-
BCL6 overexpression prevents increase in reactive oxygen species and inhibits apoptosis induced by chemotherapeutic reagents in B-cell lymphoma cells
-
T. Kurosu, T. Fukuda, T. Miki and O. Miura, BCL6 overexpression prevents increase in reactive oxygen species and inhibits apoptosis induced by chemotherapeutic reagents in B-cell lymphoma cells, Oncogene 22 (2003), 4459-4468.
-
(2003)
Oncogene
, vol.22
, pp. 4459-4468
-
-
Kurosu, T.1
Fukuda, T.2
Miki, T.3
Miura, O.4
-
36
-
-
84869003640
-
The critical role of redox homeostasis in Shikonin-induced HL-60 cell differentiation via unique modulation of the Nrf2/ARE Pathway
-
B. Zhang, N. Chen, H. Chen, Z. Wang and Q. Zheng, The critical role of redox homeostasis in Shikonin-induced HL-60 cell differentiation via unique modulation of the Nrf2/ARE Pathway, Oxid. Med. Cell Longev. 2012 (2012), 781516.
-
(2012)
Oxid. Med. Cell Longev
, vol.2012
, pp. 781516
-
-
Zhang, B.1
Chen, N.2
Chen, H.3
Wang, Z.4
Zheng, Q.5
-
37
-
-
67349269527
-
Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis
-
W. Han, J. Xie, L. Li, Z. Liu and X. Hu, Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis, Apoptosis 14 (2009), 674-686.
-
(2009)
Apoptosis
, vol.14
, pp. 674-686
-
-
Han, W.1
Xie, J.2
Li, L.3
Liu, Z.4
Hu, X.5
-
38
-
-
84862490700
-
Nec-1 Enhances shikonin-induced apoptosis in leukemia cells by inhibition of RIP-1 and ERK1/2
-
W. Han, J. Xie, Y. Fang, Z. Wang and H. Pan, Nec-1 Enhances shikonin-induced apoptosis in leukemia cells by inhibition of RIP-1 and ERK1/2, Int. J. Mol. Sci. 13 (2012), 7212-7225.
-
(2012)
Int. J. Mol. Sci
, vol.13
, pp. 7212-7225
-
-
Han, W.1
Xie, J.2
Fang, Y.3
Wang, Z.4
Pan, H.5
-
39
-
-
77953434349
-
Transient glutathione depletion determines terminal differentiation in HL-60 cells
-
S.M. Krance, P.C. Keng, J.P. Palis and N. Ballatori, Transient glutathione depletion determines terminal differentiation in HL-60 cells, Oxid. Med. Cell Longev. 3 (2010), 53-60.
-
(2010)
Oxid. Med. Cell Longev
, vol.3
, pp. 53-60
-
-
Krance, S.M.1
Keng, P.C.2
Palis, J.P.3
Ballatori, N.4
-
40
-
-
79951527854
-
The Nrf2 transcription factor is a positive regulator of myeloid differentiation of acute myeloid leukemia cells
-
I. Bobilev, V. Novik, I. Levi, O. Shpilberg, J. Levy, Y. Sharoni et al., The Nrf2 transcription factor is a positive regulator of myeloid differentiation of acute myeloid leukemia cells, Cancer Biol. Ther. 11 (2011), 317-329.
-
(2011)
Cancer Biol. Ther
, vol.11
, pp. 317-329
-
-
Bobilev, I.1
Novik, V.2
Levi, I.3
Shpilberg, O.4
Levy, J.5
Sharoni, Y.6
-
41
-
-
0035371184
-
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
-
F.Q. Schafer and G.R. Buettner, Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple, Free Radic. Biol. Med. 30 (2001), 1191-1212.
-
(2001)
Free Radic. Biol. Med
, vol.30
, pp. 1191-1212
-
-
Schafer, F.Q.1
Buettner, G.R.2
-
42
-
-
77956171147
-
NAD (P) H: Quinone acceptor oxidoreductase 1 (NQO1 a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector
-
A.T. Dinkova-Kostova and P. Talalay, NAD (P) H: quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector, Arch. Biochem. Biophys. 501 (2010), 116-123.
-
(2010)
Arch. Biochem. Biophys
, vol.501
, pp. 116-123
-
-
Dinkova-Kostova, A.T.1
Talalay, P.2
-
43
-
-
40449107193
-
Loss of keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
-
T. Ohta, K. Iijima, M. Miyamoto, I. Nakahara, H. Tanaka, M. Ohtsuji et al., Loss of keap1 function activates Nrf2 and provides advantages for lung cancer cell growth, Cancer Res. 68 (2008), 1303-1309.
-
(2008)
Cancer Res
, vol.68
, pp. 1303-1309
-
-
Ohta, T.1
Iijima, K.2
Miyamoto, M.3
Nakahara, I.4
Tanaka, H.5
Ohtsuji, M.6
-
44
-
-
23944447422
-
Protection against cisplatin-induced toxicities by Nacetylcysteine and sodium thiosulfate as assessed at the molecular, cellular, and in vivo levels
-
D.T. Dickey, Y.J. Wu, L.L. Muldoon and E.A. Neuwelt, Protection against cisplatin-induced toxicities by Nacetylcysteine and sodium thiosulfate as assessed at the molecular, cellular, and in vivo levels, J. Pharmacol. Exp. Ther. 314 (2005), 1052-1058.
-
(2005)
J. Pharmacol. Exp. Ther
, vol.314
, pp. 1052-1058
-
-
Dickey, D.T.1
Wu, Y.J.2
Muldoon, L.L.3
Neuwelt, E.A.4
-
45
-
-
0036086248
-
Novel concepts in the development of platinum antitumor drugs
-
M.A. Fuertes, J. Castilla, C. Alonso and J.M. Perez, Novel concepts in the development of platinum antitumor drugs, Curr. Med. Chem. Anticancer Agents 2 (2002), 539-551.
-
(2002)
Curr. Med. Chem. Anticancer Agents
, vol.2
, pp. 539-551
-
-
Fuertes, M.A.1
Castilla, J.2
Alonso, C.3
Perez, J.M.4
-
46
-
-
0035503798
-
Therapeutic efficacy of aortic administration of N-acetylcysteine as a chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat Model
-
E.A. Neuwelt, M.A. Pagel, B.P. Hasler, T.G. Deloughery and L.L. Muldoon, Therapeutic efficacy of aortic administration of N-acetylcysteine as a chemoprotectant against bone marrow toxicity after intracarotid administration of alkylators, with or without glutathione depletion in a rat Model, Cancer Res. 61 (2001), 7868-7874.
-
(2001)
Cancer Res
, vol.61
, pp. 7868-7874
-
-
Neuwelt, E.A.1
Pagel, M.A.2
Hasler, B.P.3
Deloughery, T.G.4
Muldoon, L.L.5
-
47
-
-
0027965261
-
Cisplatin generates superoxide anion by interaction with DNA in a cell-free system
-
H. Masuda, T. Tanaka and U. Takahama, Cisplatin generates superoxide anion by interaction with DNA in a cell-free system, Biochem. Biophys. Res. Commun. 203 (1994), 1175-1180.
-
(1994)
Biochem. Biophys. Res. Commun
, vol.203
, pp. 1175-1180
-
-
Masuda, H.1
Tanaka, T.2
Takahama, U.3
-
48
-
-
33748146888
-
Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate
-
D. Trachootham, Y. Zhou, H. Zhang, Y. Demizu, Z. Chen, H. Pelicano et al., Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate, Cancer Cell 10 (2006), 241-252.
-
(2006)
Cancer Cell
, vol.10
, pp. 241-252
-
-
Trachootham, D.1
Zhou, Y.2
Zhang, H.3
Demizu, Y.4
Chen, Z.5
Pelicano, H.6
-
49
-
-
66149168685
-
Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer
-
S. Homma, Y. Ishii, Y. Morishima, T. Yamadori, Y. Matsuno, N. Haraguchi et al., Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer, Clin. Cancer Res. 15 (2009), 3423-3432.
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 3423-3432
-
-
Homma, S.1
Ishii, Y.2
Morishima, Y.3
Yamadori, T.4
Matsuno, Y.5
Haraguchi, N.6
-
50
-
-
77954351631
-
High levels of Nrf2 determine chemoresistance in type II endometrial cancer
-
T. Jiang, N. Chen, F. Zhao, X.J. Wang, B. Kong, W. Zheng et al., High levels of Nrf2 determine chemoresistance in type II endometrial cancer, Cancer Res. 70 (2010), 5486-5496.
-
(2010)
Cancer Res
, vol.70
, pp. 5486-5496
-
-
Jiang, T.1
Chen, N.2
Zhao, F.3
Wang, X.J.4
Kong, B.5
Zheng, W.6
-
51
-
-
70350620150
-
Acquisition of doxorubicin resistance in ovarian carcinoma cells accompanies activation of the NRF2 pathway
-
G.S. Shim, S. Manandhar, D.H. Shin, T.H. Kim and M.K. Kwak, Acquisition of doxorubicin resistance in ovarian carcinoma cells accompanies activation of the NRF2 pathway, Free Radic. Biol. 47 (2010), 1619-1631.
-
(2010)
Free Radic. Biol
, vol.47
, pp. 1619-1631
-
-
Shim, G.S.1
Manandhar, S.2
Shin, D.H.3
Kim, T.H.4
Kwak, M.K.5
-
52
-
-
0033128698
-
GSH-related enzymes and GS-X pump in relation to sensitivity of human tumor cell lines to chlorambucil and adriamycin
-
K. Zhang, E.B. Yang, K.P. Wong and P. Mack, GSH-related enzymes and GS-X pump in relation to sensitivity of human tumor cell lines to chlorambucil and adriamycin, Int. J. Oncol. 14 (1999), 861-867.
-
(1999)
Int. J. Oncol
, vol.14
, pp. 861-867
-
-
Zhang, K.1
Yang, E.B.2
Wong, K.P.3
Mack, P.4
-
53
-
-
33645804599
-
Role of the glutathione metabolic pathway in lung cancer treatment and prognosis: A review
-
P. Yang, J.O. Ebbert, Z. Sun and R.M. Weinshilboum, Role of the glutathione metabolic pathway in lung cancer treatment and prognosis: a review, J. Clin. Oncol. 24 (2006), 1761-1769.
-
(2006)
J. Clin. Oncol
, vol.24
, pp. 1761-1769
-
-
Yang, P.1
Ebbert, J.O.2
Sun, Z.3
Weinshilboum, R.M.4
-
54
-
-
0033084064
-
The chemistry and biology of alkannin, shikonin, and related naphthazarin natural products
-
V.P. Papageorgiou, A.N. Assimopoulou, E.A. Couladouros, D. Hepworth and K.C. Nicolaou, The chemistry and biology of alkannin, shikonin, and related naphthazarin natural products, Angew. Chem. Int. Ed. 38 (1999), 270-301.
-
(1999)
Angew. Chem. Int. Ed
, vol.38
, pp. 270-301
-
-
Papageorgiou, V.P.1
Assimopoulou, A.N.2
Couladouros, E.A.3
Hepworth, D.4
Nicolaou, K.C.5
-
55
-
-
49149088537
-
Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells
-
X. Mao, C.R. Yu, W.H. Li and W.X. Li, Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells, Cell Res. 18 (2008), 879-888.
-
(2008)
Cell Res
, vol.18
, pp. 879-888
-
-
Mao, X.1
Yu, C.R.2
Li, W.H.3
Li, W.X.4
-
56
-
-
84891121225
-
Human gastric cancer cell line SGC-7901 apoptosis induced by SFPS-B2 via a mitochondrial-mediated pathway
-
Y.B. Ji, C.F. Ji and L. Yue, Human gastric cancer cell line SGC-7901 apoptosis induced by SFPS-B2 via a mitochondrial-mediated pathway, Biomed. Mater. Eng. 24 (2014), 130914.
-
(2014)
Biomed. Mater. Eng
, vol.24
, pp. 130914
-
-
Ji, Y.B.1
Ji, C.F.2
Yue, L.3
|