Hyaluronan nanoparticles bearing γ-secretase inhibitor: In vivo therapeutic effects on rheumatoid arthritis

Journal of Controlled Release

Volumn 192, Issue , 2014, Pages 295-300

  Heo, Roun ^a   Park, Jong Sung ^a   Jang, Hye Jin ^a   Kim, Seol Hee ^a   Shin, Jung Min ^a   Suh, Yung Doug ^a,b   Jeong, Ji Hoon ^a   Jo, Dong Gyu ^a   Park, Jae Hyung ^a,b  

^a Sungkyunkwan University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Gamma secretase; Hyaluronan; Nanoparticle; Rheumatoid arthritis

Indexed keywords

GAMMA-SECRETASE; HYALURONAN; IN-VIVO; RHEUMATOID ARTHRITIS; THERAPEUTIC EFFECTS;

NANOPARTICLES;

DRUG DISTRIBUTIO; GAMMA INTERFERON; GAMMA SECRETASE INHIBITOR; HYALURONIC ACID; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; NANOPARTICLE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYTOKINE; DIPEPTIDE; DRUG CARRIER; N-(N-(3,5-DIFLUOROPHENACETYL)ALANYL)PHENYLGLYCINE TERT-BUTYL ESTER; SECRETASE;

ANIMAL TISSUE; ARTICLE; CYTOKINE PRODUCTION; DISEASE SEVERITY; DRUG DISTRIBUTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; IN VIVO STUDY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN BLOOD LEVEL; RHEUMATOID ARTHRITIS; THERAPY EFFECT; ANIMAL; ANTAGONISTS AND INHIBITORS; ARTHRITIS, RHEUMATOID; CHEMISTRY; DRUG EFFECTS; IMMUNOLOGY; KNEE; MALE; MOUSE; PATHOLOGY;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ARTHRITIS, RHEUMATOID; CYTOKINES; DIPEPTIDES; DRUG CARRIERS; HYALURONIC ACID; KNEE JOINT; MALE; MICE; NANOPARTICLES;

EID: 84907229817     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.07.057     Document Type: Article

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