Lgr4 Protein deficiency induces ataxia-like phenotype in mice and impairs long term depression at cerebellar Parallel fiber-purkinje cell synapses

Journal of Biological Chemistry

Volumn 289, Issue 38, 2014, Pages 26492-26504

  Guan, Xin ^a   Duan, Yanhong ^a   Zeng, Qingwen ^a   Pan, Hongjie ^a   Qian, Yu ^a,c   Li, Dali ^a,b   Cao, Xiaohua ^a   Liu, Mingyao ^a,b  

^a EAST CHINA NORMAL UNIVERSITY   (China)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^c FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

LONG TERM DEPRESSION;

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; LEUCINE RICH G PROTEIN COUPLED RECEPTOR 4; UNCLASSIFIED DRUG; CREB1 PROTEIN, MOUSE; LGR4 PROTEIN, MOUSE;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATAXIA; BRAIN SLICE; CEREBELLUM; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LONG TERM DEPRESSION; MOTOR COORDINATION; MOUSE; MOUSE MUTANT; NONHUMAN; PHENOTYPE; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PURKINJE CELL; SIGNAL TRANSDUCTION; SYNAPSE; 129 MOUSE; ANIMAL; C57BL MOUSE; CELL PROLIFERATION; CEREBELLAR ATAXIA; CEREBELLUM CORTEX; DEFICIENCY; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATCH CLAMP TECHNIQUE; PATHOPHYSIOLOGY; PATTERN RECOGNITION; PHYSIOLOGY; PSYCHOMOTOR PERFORMANCE; ROTAROD TEST; SYNAPTIC TRANSMISSION;

ANIMALS; CELL PROLIFERATION; CEREBELLAR ATAXIA; CEREBELLAR CORTEX; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; LONG-TERM SYNAPTIC DEPRESSION; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; PATCH-CLAMP TECHNIQUES; PATTERN RECOGNITION, VISUAL; PHENOTYPE; PSYCHOMOTOR PERFORMANCE; PURKINJE CELLS; RECEPTORS, G-PROTEIN-COUPLED; ROTAROD PERFORMANCE TEST; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 84907222540     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.564138     Document Type: Article

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