Lgr4/Gpr48 negatively regulates TLR2/4-associated pattern recognition and innate immunity by targeting CD14 expression

Journal of Biological Chemistry

Volumn 288, Issue 21, 2013, Pages 15131-15141

  Du, Bing ^a   Luo, Weijia ^b   Li, Ruimei ^a   Tan, Binghe ^a   Han, Honghui ^a   Lu, Xiaoling ^c   Li, Dali ^a   Qian, Min ^a   Zhang, Dekai ^b   Zhao, Yongxiang ^c   Liu, Mingyao ^a,b  

^a EAST CHINA NORMAL UNIVERSITY   (China)

^b TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^c GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE IMMUNE RESPONSE; CAMP-RESPONSE ELEMENT-BINDING PROTEINS; CYTOKINE PRODUCTION; G PROTEIN COUPLED RECEPTORS; GLYCOPROTEIN HORMONE RECEPTORS; PATHOGEN-ASSOCIATED MOLECULAR PATTERNS; TOLL-LIKE RECEPTORS; TRANSCRIPTIONAL LEVELS;

ACTIVATION ANALYSIS; MACROPHAGES; PATTERN RECOGNITION; TRANSCRIPTION;

IMMUNE SYSTEM;

CD14 ANTIGEN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 48; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GEL MOBILITY SHIFT ASSAY; IMMUNE RESPONSE; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPTIC SHOCK; SIGNAL TRANSDUCTION; UPREGULATION;

CD14; CREB; G-PROTEIN-COUPLED RECEPTORS (GPCRS); LGR4; PATHOGEN-ASSOCIATED MOLECULAR PATTERN (PAMP); SEPSIS; TOLL-LIKE RECEPTORS (TLR);

ANIMALS; ANTIGENS, CD14; AUTOIMMUNE DISEASES; CELL LINE; HUMANS; IMMUNITY, INNATE; MACROPHAGES; MICE; MICE, KNOCKOUT; RECEPTORS, G-PROTEIN-COUPLED; SHOCK, SEPTIC; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; UP-REGULATION;

EID: 84878233672     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.455535     Document Type: Article

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