SRC-1 null mice exhibit moderate motor dysfunction and delayed development of cerebellar Purkinje cells

Journal of Neuroscience

Volumn 23, Issue 1, 2003, Pages 213-222

  Nishihara, Eijun ^a   Yoshida Komiya, Hiromi ^a   Chan, Chi Shing ^a   Liao, Lan ^a   Davis, Ronald L ^a   O'Malley, Bert W ^a   Xu, Jianming ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Animal model; Coactivator; Gene expression; Motor function; Nuclear receptor; Purkinje cell

Indexed keywords

NUCLEAR RECEPTOR COACTIVATOR 2; PROTEIN; STEROID RECEPTOR COACTIVATOR 1; STEROID RECEPTOR COACTIVATOR 3; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BRAIN DEVELOPMENT; BRAIN FUNCTION; BRAIN STEM; CELL MATURATION; CEREBELLUM; CONTROLLED STUDY; CORRELATION ANALYSIS; EMBRYO DEVELOPMENT; HIPPOCAMPUS; HYPOTHALAMUS; KNOCKOUT MOUSE; MOTOR DYSFUNCTION; MOUSE; NERVE CELL DIFFERENTIATION; NEWBORN PERIOD; NONHUMAN; NUCLEOTIDE SEQUENCE; OLFACTORY BULB; PERINATAL PERIOD; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN STRUCTURE; PURKINJE CELL; PYRIFORM CORTEX; STEM CELL; TIME; WILD TYPE;

EID: 0037220616     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-01-00213.2003     Document Type: Article

References (57)

1. Anderson GW, Larson RJ, Oas DR, Sandhofer CR, Schwartz HL, Mariash CN, Oppenheimer JH (1998) Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) modulates expression of the Purkinje cell protein-2 gene. A potential role for COUP-TF in repressing premature thyroid hormone action in the developing brain. J Biol Chem 273:16391-16399.
2. Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS (1997) AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science 277:965-968.
3. Atkins GB, Hu X, Guenther MG, Rachez C, Freedman LP, Lazar MA (1999) Coactivators for the orphan nuclear receptor RO Ralpha. Mol Endocrinol 13:1550-1557.
4. Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM (1997) Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90:569-580.
5. Chomez P, Neveu I, Mansen A, Kiesler E, Larsson L, Vennstrom B, Arenas E (2000) Increased cell death and delayed development in the cerebellum of mice lacking the rev-erbA(alpha) orphan receptor. Development 127:1489-1498.
6. Dussault I, Fawcett D, Matthyssen A, Bader JA, Giguere V (1998) Orphan nuclear receptor ROR alpha-deficient mice display the cerebellar defects of staggerer. Mech Dev 70:147-153.
7. Furuya S, Makino A, Hirabayashi Y (1998) An improved method for culturing cerebellar Purkinje cells with differentiated dendrites under a mixed monolayer setting. Brain Res Brain Res Protoc 3:192-198.
8. Glass CK, Rosenfeld MG (2000) The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev 14:121-141.
9. Hamilton BA, Frankel WN, Kerrebrock AW, Hawkins TL, FitzHugh W, Kusumi K, Russell LB, Mueller KL, van Berkel V, Birren BW, Kruglyak L, Lander ES (1996) Disruption of the nuclear hormone receptor RORa1-pha in staggerer mice. Nature 379:736-739.
10. Hatten ME, Heintz N (1995) Mechanisms of neural patterning and specification in the developing cerebellum. Annu Rev Neurosci 18:385-408.
11. Hayashi Y, Koike M, Matsutani M, Hoshino T (1988) Effects of fixation time and enzymatic digestion on immunohistochemical demonstration of bromodeoxyuridine in formalin-fixed, paraffin-embedded tissue. J Histochem Cytochem 36:511-514.
12. Hong H, Kohli K, Trivedi A, Johnson DL, Stallcup MR (1996) GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc Natl Acad Sci USA 93:4948-4952.
13. Koh SS, Chen D, Lee YH, Stallcup MR (2001) Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities. J Biol Chem 276:1089-1098.
14. Koibuchi N, Chin WW (1998) ROR alpha gene expression in the perinatal rat cerebellum: Ontogeny and thyroid hormone regulation. Endocrinology 139:2335-2341.
15. Koibuchi N, Chin WW (2000) Thyroid hormone action and brain development. Trends Endocrinol Metab 11:123-128.
16. Lanz RB, McKenna NJ, Onate SA, Albrecht U, Wong J, Tsai SY, Tsai MJ, O'Malley BW (1999) A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. Cell 97:17-27.
17. Leclerc N, Beesley PW, Brown I, Colonnier M, Gurd JW, Paladino T, Hawkes R (1989) Synaptophysin expression during synaptogenesis in the rat cerebellar cortex. J Comp Neurol 280:197-212.
18. Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW (1999) A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo. J Biol Chem 274:34283-34293.
19. Li H, Gomes PJ, Chen JD (1997) RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2. Proc Natl Acad Sci USA 94:8479-8484.
20. Li J, O'Malley BW, Wong J (2000) p300 requires its histone acetyl-transferase activity and SRC-1 interaction domain to facilitate thyroid hormone receptor activation in chromatin. Mol Cell Biol 20:2031-2042.
21. Linden DJ (1994) Long-term synaptic depression in the mammalian brain. Neuron 12:457-472.
22. Lopes da Silva S, Burbach JP (1995) The nuclear hormone-receptor family in the brain: Classics and orphans. Trends Neurosci 18:542-548.
23. Maeda N, Niinobe M, Inoue Y, Mikoshiba K (1989) Developmental expression and intracellular location of P400 protein characteristic of Purkinje cells in the mouse cerebellum. Dev Biol 133:67-76.
24. Mani SK, Blaustein JD, O'Malley BW (1997) Progesterone receptor function from a behavioral perspective. Horm Behav 31:244-255.
25. McEwen BS (1994) Steroid hormone actions on the brain: When is the genome involved? Horm Behav 28:396-405.
26. McEwen BS (2001) Invited review: Estrogens effects on the brain: Multiple sites and molecular mechanisms. J Appl Physiol 91:2785-2801.
27. McKenna NJ, O'Malley BW (2002) Combinatorial control of gene expression by nuclear receptors and coregulators. Cell 108:465-474.
28. Meijer OC, Steenbergen PJ, De Kloet ER (2000) Differential expression and regional distribution of steroid receptor coactivators SRC-1 and SRC-2 in brain and pituitary. Endocrinology 141:2192-2199.
29. Messer A (1988) Thyroxine injections do not cause premature induction of thymidine kinase in sg/sg mice. J Neurochem 51:888-891.
30. Misiti S, Koibuchi N, Bei M, Farsetti A, Chin WW (1999) Expression of steroid receptor coactivator-1 mRNA in the developing mouse embryo: A possible role in olfactory epithelium development. Endocrinology 140:1957-1960.
31. Morimoto M, Morita N, Ozawa H, Yokoyama K, Kawata M (1996) Distribution of glucocorticoid receptor immunoreactivity and mRNA in the rat brain: An immunohistochemical and in situ hybridization study. Neurosci Res 26:235-269.
32. Morris RG, Garrud P, Rawlins JN, O'Keefe J (1982) Place navigation impaired in rats with hippocampal lesions. Nature 297:681-683.
33. Nakanishi S, Maeda N, Mikoshiba K (1991) Immunohistochemical localization of an inositol 1,4,5-trisphosphate receptor, P400, in neural tissue: Studies in developing and adult mouse brain. J Neurosci 11:2075-2086.
34. Nishihara E, Furuyama T, Yamashita S, Mori N (1998) Expression of copper trafficking genes in the mouse brain. Neuro Report 9:3259-3263.
35. Nishihara E, Nagayama Y, Inoue S, Hiroi H, Muramatsu M, Yamashita S, Koji T (2000) Ontogenetic changes in the expression of estrogen receptor alpha and beta in rat pituitary gland detected by immunohistochemistry. Endocrinology 141:615-620.
36. Onate SA, Tsai SY, Tsai MJ, O'Malley BW (1995) Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270:1354-1357.
37. Raymond JL, Lisberger SG, Mauk MD (1996) The cerebellum: A neuronal learning machine? Science 272:1126-1131.
38. Reichardt HM, Tronche F, Bauer A, Schutz G (2000) Molecular genetic analysis of glucocorticoid signaling using the Cre/loxP system. Biol Chem 381:961-964.
39. Rissman EF, Early AH, Taylor JA, Korach KS, Lubahn DB (1997) Estrogen receptors are essential for female sexual receptivity. Endocrinology 138:507-510.
40. Shughrue PJ, Lane MV, Merchenthaler I (1997) Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system. J Comp Neurol 388:507-525.
41. Steinmayr M, Andre E, Conquet F, Rondi-Reig L, Delhaye-Bouchaud N, Auclair N, Daniel H, Crepel F, Mariani J, Sotelo C, Becker-Andre M (1998) Staggerer phenotype in retinoid-related orphan receptor alphadeficient mice. Proc Natl Acad Sci USA 95:3960-3965.
42. Suen CS, Berrodin TJ, Mastroeni R, Cheskis BJ, Lyttle CR, Frail DE (1998) A transcriptional coactivator, steroid receptor coactivator-3, selectively augments steroid receptor transcriptional activity. J Biol Chem 273:27645-27653.
43. Takeshita A, Yen PM, Misiti S, Cardona GR, Liu Y, Chin WW (1996) Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator. Endocrinology 137:3594-3597.
44. Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW (1997) TRAM-1, a novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1. J Biol Chem 272:27629-27634.
45. Tetel MJ (2000) Nuclear receptor coactivators in neuroendocrine function. J Neuroendocrinol 12:927-932.
46. Torchia J, Rose DW, Inostroza J, Kamei Y, Westin S, Glass CK, Rosenfeld MG (1997) The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. Nature 387:677-684.
47. Tsai MJ, O'Malley BW (1994) Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu Rev Biochem 63:451-486.
48. Voegel JJ, Heine MJ, Zechel C, Chambon P, Gronemeyer H (1996) TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. EMBO J 15:3667-3675.
49. Vogel MW, Sinclair M, Qiu D, Fan H (2000) Purkinje cell fate in staggerer mutants: Agenesis versus cell death. J Neurobiol 42:323-337.
50. Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S (2001) A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA. EMBO J 20:1341-1352.
51. Weiss RE, Xu J, Ning G, Pohlenz J, O'Malley BW, Refetoff S (1999) Mice deficient in the steroid receptor co-activator S (SRC-1) are resistant to thyroid hormone. EMBO J 18:1900-1904.
52. Xu J, O'Malley BW (2002) Molecular mechanisms and cellular biology of the steroid receptor coactivator (SRC) family in steroid receptor function. Rev Endocr Metab Disord 3:183-190.
53. Xu J, Qiu Y, DeMayo FJ, Tsai SY, Tsai MJ, O'Malley BW (1998) Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene. Science 279:1922-1925.
54. Xu J, Liao L, Ning G, Yoshida-Komiya H, Deng C, O'Malley BW (2000) The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development. Proc Natl Acad Sci USA 97:6379-6384.
55. Zanjani HS, Mariani J, Delhaye-Bouchaud N, Herrup K (1992) Neuronal cell loss in heterozygous staggerer mutant mice: A model for genetic contributions to the aging process. Brain Res Dev Brain Res 67:153-160.
56. Zetterstrom RH, Solomin L, Jansson L, Hoffer BJ, Olson L, Perlmann T (1997) Dopamine neuron agenesis in Nurrl-deficient mice. Science 276:248-250.
57. Zhou C, Qiu Y, Pereira FA, Crair MC, Tsai SY, Tsai MJ (1999) The nuclear orphan receptor COUP-TFI is required for differentiation of subplate neurons and guidance of thalamocortical axons. Neuron 24:847-859.