Endogenous Wnt signaling maintains neural progenitor cell potency

Stem Cells

Volumn 27, Issue 5, 2009, Pages 1130-1141

  Wexler, Eric M ^a,b   Paucer, Andres ^a   Kornblum, Harley I ^a   Plamer, Theodore D ^c   Geschwind, Daniel H ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Autocrine; Clonal analysis; Human; Neural stem cell; Neurogenesis; Wnt

Indexed keywords

AXIN; BETA CATENIN; CADHERIN; CELL PROTEIN; GREEN FLUORESCENT PROTEIN; LUCIFERASE; WNT PROTEIN;

ADULT; ANIMAL CELL; ARTICLE; CANONICAL ANALYSIS; CELL DIFFERENTIATION; CELL FATE; CELL POPULATION; CELL PROLIFERATION; CELL SPECIFICITY; CONTROLLED STUDY; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; GENE EXPRESSION PROFILING; HIPPOCAMPUS; HUMAN; HUMAN CELL; MOLECULAR CLONING; MULTIPOTENT STEM CELL; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PROMOTER REGION; PROTEIN DEPLETION; SIGNAL TRANSDUCTION;

ANIMALS; AUTOCRINE COMMUNICATION; BETA CATENIN; CELL DIFFERENTIATION; CELL LINE; EMBRYONIC STEM CELLS; HIPPOCAMPUS; HUMANS; MULTIPOTENT STEM CELLS; NEURONS; RATS; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; STEM CELLS; WNT PROTEINS;

EID: 66149171487     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.36     Document Type: Article

References (73)

1. Monje ML, Toda H, Palmer TD. Inflammatory blockade restores adult hippocampal neurogenesis. Science 2003;302:1760-1765. (Pubitemid 37505739)
2. Iosif RE, Ekdahl CT, Ahlenius H et al. Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis. J Neurosci 2006;26:9703-9712. (Pubitemid 44427709)
3. Schmidt HD, Duman RS. The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior. Behav Pharmacol 2007;18:391-418. (Pubitemid 47356367)
4. Kuhn HG, Dickinson-Anson H, Gage FH. Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation. J Neurosci 1996;16:2027. (Pubitemid 26144015)
5. van Praag H, Shubert T, Zhao C et al. Exercise enhances learning and hippocampal neurogenesis in aged mice. J Neurosci 2005;25:8680-8685. (Pubitemid 41362045)
6. van Praag H, Kempermann G, Gage FH. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci 1999;2:266. (Pubitemid 30491298)
7. Chen G, Rajkowska G, Du F et al. Enhancement of hippocampal neurogenesis by lithium. J Neurochem 2000;75:1729.
8. Sahay A, Hen R. Adult hippocampal neurogenesis in depression. Nat Neurosci 2007;10:1110-1115. (Pubitemid 47339960)
9. Wexler EM, Geschwind DH, Palmer TD. Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation. Mol Psychiatry 2008;13:285-292.
10. Filippov V, Kronenberg G, Pivneva T et al. Subpopulation of nestin-expressing progenitor cells in the adult murine hippocampus shows electrophysiological and morphological characteristics of astrocytes. Mol Cell Neurosci 2003;23:373. (Pubitemid 36802008)
11. Alvarez-Buylla A, Garcia-Verdugo JM, Tramontin AD. A unified hypothesis on the lineage of neural stem cells. Nature Rev Neurosci 2001;2:287. (Pubitemid 33673069)
12. Acheson A, Conover JC, Fandl JP et al. A BDNF autocrine loop in adult sensory neurons prevents cell death. Nature 1995;374:450-453.
13. Cheng JG, Patterson PH. LIF is an autocrine factor for sympathetic neurons. Mol Cell Neurosci 1997;9:372-380. (Pubitemid 27467489)
14. Erlandsson A, Enarsson M, Forsberg-Nilsson K. Immature neurons from CNS stem cells proliferate in response to platelet-derived growth factor. J Neurosci 2001;21:3483. (Pubitemid 32422812)
15. Wurmser AE, Palmer TD, Gage FH. Neuroscience. Cellular interactions in the stem cell niche. Science 2004;304:1253-1255.
16. Doetsch F. A niche for adult neural stem cells. Curr Opin Genet Dev 2003;13:543. (Pubitemid 37204933)
17. Palmer TD. Adult neurogenesis and the vascular Nietzsche. Neuron 2002;34:856.
18. Lie DC, Colamarino SA, Song HJ et al. Wnt signalling regulates adult hippocampal neurogenesis. Nature 2005;437:1370.
19. Adachi K, Mirzadeh Z, Sakaguchi M et al. β-Catenin signaling promotes proliferation of progenitor cells in the adult mouse subventricular zone. Stem Cells 2007;25:2827-2836. (Pubitemid 350127867)
20. Bafico A, Liu G, Goldin L et al. An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells. Cancer Cell 2004;6:497. (Pubitemid 39469985)
21. Benhaj K, Akcali KC, Ozturk M. Redundant expression of canonical Wnt ligands in human breast cancer cell lines. Oncol Rep 2006;15:701-707.
22. Hall CL, Kang S, MacDougald OA et al. Role of Wnts in prostate cancer bone metastases. J Cell Biochem 2006;97:661.
23. Chim CS, Pang R, Fung TK et al. Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma. Leukemia 2007;21:2527-2536. (Pubitemid 350148897)
24. DeAlmeida VI, Miao L, Ernst JA et al. The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo. Cancer Res 2007;67:5371-5379. (Pubitemid 46997277)
25. Fodde R, Brabletz T. Wnt/β-catenin signaling in cancer stemness and malignant behavior. Curr Opin Cell Biol 2007;19:150-158. (Pubitemid 46386404)
26. Schlange T, Matsuda Y, Lienhard S et al. Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. Breast Cancer Res 2007;9:R63.
27. Reya T, Duncan AW, Ailles L et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 2003;423:409. (Pubitemid 36626987)
28. Willert K, Brown JD, Danenberg E et al. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 2003;423:448. (Pubitemid 36626997)
29. Coudreuse D, Korswagen HC. The making of Wnt: New insights into Wnt maturation, sorting and secretion. Development 2007;134:3-12. (Pubitemid 46152702)
30. Etheridge SL, Spencer GJ, Heath DJ et al. Expression profiling and functional analysis of wnt signaling mechanisms in mesenchymal stem cells. Stem Cells 2004;22:849.
31. Aubert J, Dunstan H, Chambers I et al. Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation. Natbiotechnol 2002;20:1240. (Pubitemid 35462489)
32. Otero JJ, Fu W, Kan L et al. β-Catenin signaling is required for neural differentiation of embryonic stem cells. Development 2004;131:3545. (Pubitemid 39199366)
33. Verani R, Cappuccio I, Spinsanti P et al. Expression of the Wnt inhibitor Dickkopf-1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid. J Neurochem 2007;100:242-250. (Pubitemid 46085852)
34. Davidson KC, Jamshidi P, Daly R et al. Wnt3a regulates survival, expansion, and maintenance of neural progenitors derived from human embryonic stem cells. Mol Cell Neurosci 2007;36:408-415. (Pubitemid 47633203)
35. Yu JM, Kim JH, Song GS et al. Increase in proliferation and differentiation of neural progenitor cells isolated from postnatal and adult mice brain by Wnt-3a and Wnt-5a. Mol Cell Biochem 2006;288:17-28. (Pubitemid 44314437)
36. Hirsch C, Campano LM, Wohrle S et al. Canonical Wnt signaling transiently stimulates proliferation and enhances neurogenesis in neonatal neural progenitor cultures. Exp Cell Res 2007;313:572-587. (Pubitemid 46186307)
37. Yin ZS, Zhang H, Wang W et al. Wnt-3a protein promote neuronal differentiation of neural stem cells derived from adult mouse spinal cord. Neurol Res 2007;29:847-854. (Pubitemid 350255160)
38. Parkin NT, Kitajewski J, Varmus HE. Activity of Wnt-1 as a transmembrane protein. Genes Dev 1993;7:2181. (Pubitemid 23336144)
39. Fleming HE, Janzen V, Lo Celso C et al. Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell Stem Cell 2008;2:274-283.
40. Suda T, Arai F. Wnt signaling in the niche. Cell 2008;132:729-730.
41. Gilbertson RJ, Rich JN. Making a tumour's bed: Glioblastoma stem cells and the vascular niche. Nat Rev Cancer 2007;7:733-736. (Pubitemid 47463683)
42. Colombo E, Giannelli SG, Galli R et al. Embryonic stem-derived versus somatic neural stem cells: A comparative analysis of their developmental potential and molecular phenotype. Stem Cells 2006;24:825. (Pubitemid 44464715)
43. Palmer TD, Markakis EA, Willhoite AR et al. Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. J Neurosci 1999;19:8487.
44. Svendsen CN, ter Borg MG, Armstrong RJ et al. A new method for the rapid and long term growth of human neural precursor cells. J Neurosci Methods 1998;85:141.
45. Palmer TD, Schwartz PH, Taupin P et al. Cell culture. Progenitor cells from human brain after death. Nature 2001;411:42.
46. Yu X, Malenka RC. β-Catenin is critical for dendritic morphogenesis. Natneurosci 2003;6:1169. (Pubitemid 37346037)
47. Barraud P, Thompson L, Kirik D et al. Isolation and characterization of neural precursor cells from the Sox1-GFP reporter mouse. Eur J Neurosci 2005;22:1555-1569. (Pubitemid 41482944)
48. Barraud P, Stott S, Mollgard K et al. In vitro characterization of a human neural progenitor cell coexpressing SSEA4 and CD133. J Neurosci Res 2007;85:250-259.
49. van de Wetering M, Cavallo R, Dooijes D et al. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell 1997;88:789. (Pubitemid 27164267)
50. Day RN, Kawecki M, Berry D. Dual-function reporter protein for analysis of gene expression in living cells. Biotechniques 1998;25:848. (Pubitemid 28516509)
51. Corish P, Tyler-Smith C. Attenuation of green fluorescent protein half-life in mammalian cells. Protein Eng 1999;12:1035. (Pubitemid 30011478)
52. Castelo-Branco G, Wagner J, Rodriguez FJ et al. Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, And Wnt-5a. Proc Natl Acad Sci USA 2003;100:12747. (Pubitemid 37339970)
53. Chen G, Birnbaum RS, Yablonka-Reuveni Z et al. Separation of mouse crushed muscle extract into distinct mitogenic activities by heparin affinity chromatography. J Cell Physiol 1994;160:563-572. (Pubitemid 24288915)
54. Shibamoto S, Higano K, Takada R et al. Cytoskeletal reorganization by soluble Wnt-3a protein signalling. Genes Cells 1998;3:659. (Pubitemid 28557207)
55. Shimogori T, VanSant J, Paik E et al. Members of the Wnt, Fz, and Frp gene families expressed in postnatal mouse cerebral cortex. J Comp Neurol 2004;473:496. (Pubitemid 38580446)
56. Lein ES, Hawrylycz MJ, Ao N et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature 2007;445:168-176. (Pubitemid 46095716)
57. Hsieh JC, Kodjabachian L, Rebbert ML et al. A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature 1999;398:431. (Pubitemid 29180376)
58. Noles SR, Chenn A. Cadherin inhibition of β-catenin signaling regulates the proliferation and differentiation of neural precursor cells. Mol Cell Neurosci 2007;35:549-558. (Pubitemid 47176899)
59. Nieman MT, Kim JB, Johnson KR et al. Mechanism of extracellular domain-deleted dominant negative cadherins. J Cell Sci 1999;112(Part 10):1621.
60. Sanai N, Tramontin AD, Quinones-Hinojosa A et al. Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. Nature 2004;427:740. (Pubitemid 38294593)
61. Garcia AD, Doan NB, Imura T et al. GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain. Natneurosci 2004;7:1233. (Pubitemid 39426243)
62. Kelly GM, Greenstein P, Erezyilmaz DF et al. Zebrafish wnt8 and wnt8b share a common activity but are involved in distinct developmental pathways. Development 1995;121:1787.
63. Shimizu H, Julius MA, Giarre M et al. Transformation by Wnt family proteins correlates with regulation of β-catenin. Cell Growth Differ 1997;8:1349. (Pubitemid 28008731)
64. Sumanas S, Strege P, Heasman J et al. The putative wnt receptor Xenopus frizzled-7 functions upstream of β-catenin in vertebrate dorsoventral mesoderm patterning. Development 2000;127:1981. (Pubitemid 30311801)
65. Aulehla A, Wehrle C, Brand-Saberi B et al. Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev Cell 2003;4:395. (Pubitemid 36342364)
66. Galceran J, Miyashita-Lin EM, Devaney E et al. Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. Development 2000;127:469. (Pubitemid 30093395)
67. Lee SM, Tole S, Grove E et al. A local Wnt-3a signal is required for development of the mammalian hippocampus. Development 2000;127:457. (Pubitemid 30093394)
68. Kan L, Israsena N, Zhang Z et al. Sox1 acts through multiple independent pathways to promote neurogenesis. Dev Biol 2004;269:580. (Pubitemid 38521119)
69. Zorn AM, Barish GD, Williams BO et al. Regulation of Wnt signaling by Sox proteins: XSox17 α/β and XSox3 physically interact with β-catenin. Mol Cell 1999;4:487.
70. Graham V, Khudyakov J, Ellis P et al. SOX2 functions to maintain neural progenitor identity. Neuron 2003;39:749. (Pubitemid 37088088)
71. Mikels AJ, Nusse R. Purified Wnt5a protein activates or inhibits β-catenin-TCF signaling depending on receptor context. Plos Biol 2006;4:e115.
72. Megason SG, McMahon AP. A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development 2002;129:2087.
73. Falk S, Wurdak H, Ittner LM et al. Brain area-specific effect of TGF-β signaling on Wnt-dependent neural stem cell expansion. Cell Stem Cell 2008;2:472-483.