The molecular organization of cerebellar long-term depression

Nature Reviews Neuroscience

Volumn 3, Issue 11, 2002, Pages 896-902

  Ito, Masao ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; NEUROTRANSMITTER RECEPTOR;

ANIMAL; CEREBELLUM; CYTOLOGY; HUMAN; LONG TERM DEPRESSION; METABOLISM; NERVE TRACT; PHYSIOLOGY; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; SYNAPTOSOME;

ANIMALS; CEREBELLUM; HUMANS; LONG-TERM DEPRESSION (PHYSIOLOGY); NEURAL PATHWAYS; NEUROTRANSMITTER AGENTS; PRESYNAPTIC TERMINALS; RECEPTORS, NEUROTRANSMITTER; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

EID: 0036831284     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/nrn962     Document Type: Article

References (82)

1. Ito, M. Long-term depression. Annu. Rev. Neurosci. 12, 85–102 (1989).
2. Daniel, H., Levenes, C. & Crepel, F. Cellular mechanisms of cerebellar LTD. Trends Neurosci. 21, 401–407 (1998).
3. Ito, M. Cerebellar long-term depression: characterization, signal transduction, and functional roles. Physiol. Rev. 81, 1143–1195 (2001).
4. Napper, R. M. & Harvey, R. J. Number of parallel fiber synapses on an individual Purkinje cell in the cerebellum of the rat. J. Comp. Neurol. 274, 168–177 (1988).
5. Nieto-Bona, M. P., Garcia-Segura L. M. & Torres-Aleman, I. Transynaptic modulation by insulin-like growth factor I of dendritic spines in Purkinje cells. Int. J. Dev. Neurosci. 15, 749–754 (1997).
6. Hartell, N. A. Strong activation of parallel fibers produces localized calcium transients and a form of LTD that spreads to distant synapses. Neuron 16, 601–610 (1996).
7. Linden, D. J., Dickinson, M. H., Smeyne, M. & Connor, J. A. A long-term depression of AMPA currents in cultured cerebellar Purkinje neurons. Neuron 7, 81–89 (1991).
8. Sanes, J. R. & Lichtman, J. W. Can molecules explain longterm potentiation? Nature Neurosci. 2, 597–604 (1999).
9. Berridge, M. J. in Coincidence Detection in the Nervous System (eds Konnerth, A., Tsien, R. Y., Mikoshiba, K. & Altman, J.) 9–13 (Human Frontier Science Program, Strasbourg, France, 1996).
10. Bhalla, U. S. & Iyengar, R. Emergent properties of networks of biological signalling pathways. Science 283, 381-387 (1999).
11. Kuroda, S., Schweighofer, N. & Kawato, M. Exploration of signal transduction pathways in cerebellar long-term depression by kinetic simulation. J. Neurosci. 21, 5693-5702 (2001).
12. Ekerot, C.-F. & Kano, M. Stimulation parameters including climbing fibre induced long-term depression of parallel fiber synapses. Neurosci. Res. 6, 264-268 (1989).
13. Chen, C. & Thompson, R. F. Temporal specificity of long- term depression in parallel fiber-Purkinje synapses in rat cerebellar slice. Learn. Mem. 2, 185-198 (1995).
14. Karachot, L., Kado, R. T & Ito, M. Stimulus parameters for induction of long-term depression in in vitro rat Purkinje cells. Neurosci. Res. 21, 161-168 (1994).
15. Schreurs, B. G., Oh, M. M. & Alkon, D. L. Pairing-specific long-term depression of Purkinje cell excitatory postsynaptic potentials results from a classical conditioning procedure in the rabbit cerebellar slice. J. Neurophysiol. 75, 1051-1060 (1996).
16. Wang, S. S. H., Khroug, L. & Agustine, G. J. Quantification of spread of cerebellar long-term depression with chemical two-photon uncaging of glutamate. Proc. Natl Acad. Sci. USA 97, 8635-8640 (2000).
17. Wang, S. S.-H., Denk, W. & Hausser, M. Coincidence detection in single dendritic spines mediated by calcium release. Nature Neurosci. 3, 1266-1273 (2000).
18. Kobayashi, Y. et al. Temporal firing patterns of Purkinje cells in the cerebellar ventral paraflocculus during ocular following responses in monkeys. II. Complex spikes. J. Neurophysiol. 80, 832-848 (1998).
19. Ekerot, C.-F. & Oscarsson, O. Prolonged depolarization elicited in Purkinje cell dendrites by climbing fibre impulses in the cat. J. Physiol. (Lond.) 318, 207-221 (1981).
20. Bi, G.-Q. & Poo, M.-M. Distributed synaptic modification in neural networks induced by patterned stimulation. Nature 401, 792-796 (1999).
21. Casado, M., Isope, P & Ascher, P. Involvement of presynaptic n-methyl-D-aspartate receptors in cerebellar long-term depression. Neuron 33, 123-130 (2002).
22. Takahashi, K. A. & Linden, D. J. Cannabinoid receptor modulation of synapses received by cerebellar Purkinje cells. J. Neurophysiol. 83, 1167-1180 (2000).
23. Shibuki, K. & Kimura, S. Dynamic properties of nitric oxide release from parallel fibres in rat cerebellar slices. J. Physiol. (Lond.) 498, 443-452 (1997).
24. 2+ signalling in fine dendrites and spines of cerebellar Purkinje neurons. Nature 373, 155-158 (1995).
25. Hayashi, T, Umemori, H., Mishina, M. & Yamamoto, T The AMPA receptor interacts with and signals through the protein tyrosine kinase. Nature 397, 72-76 (1999).
26. Boxall, A. R., Lancaster, B. & Garthwaite, J. Tyrosine kinase is required for long-term depression in the cerebellum. Neuron 16, 805-813 (1996).
27. Hironaka, K., Umemori, H., Tezuka, T, Mishina, M. & Yamamoto, T. The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor 82 and s subunits. J. Biol. Chem. 275, 16167-16173 (2000).
28. Knopfel, T., Anchisi, D., Alojado, M. E., Tempia, F. & Strata, P. Elevation of intradendritic sodium concentration mediated by synaptic activation of metabotropic glutamate receptors in cerebellar Purkinje cells. Eur. J. Neurosci. 12, 2199-2204 (2000).
29. 11 are localized at postsynaptic extra-junctional membrane of cerebellar Purkinje cells and hippocampal pyramidal cells. Eur. J. Neurosci. 12, 781-792 (2000).
30. Sugiyama, T. et al. Localization of phospholipase Cβ isozymes in the cerebellum. Biochem. Biophys. Res. Commun. 19, 473-478 (1999).
31. Jiang, H., Wu, D. & Simon, M. I. Activation of phospholipase Cβ4 by heterotrimeric GTP-binding proteins. J. Biol. Chem. 269, 7593-7596 (1994).
32. Narasimhan, K., Pessah, I. N. & Linden, D. J. Inositol-1,4,5- trisphosphate receptor-mediated Ca mobilization is not required for cerebellar long-term depression in reduced preparations. J. Neurophysiol. 80, 2963-2974 (1998).
33. Detre, J. A., Nairn, A. C., Aswad, D. W. & Greengard, P. Localization in mammalian brain of G-substrate, a specific substrate for guanosine 3',5'-cyclic monophosphate- dependent protein kinase. J. Neurosci. 4, 2843-2849 (1984).
34. Endo, S. et al. Molecular identification of human G-substrate, a possible downstream component of the cGMP- dependent protein kinase cascade in cerebellar Purkinje cells. Proc. Natl Acad. Sci. USA 96, 2467-2472 (1999).
35. Rosen, L. B., Ginty, D. D., Weber, M. I. & Greenberg, M. E. Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of ras. Neuron 12, 1207-1221 (1994).
36. Lev-Ram, V., Miyakawa, H., Lasser-Ross, N. & Ross, W. N. Calcium transients in cerebellar Purkinje neurons evoked by intracellular stimulation. J. Neurophysiol. 68, 1167-1177 (1992).
37. 2+ influx in Purkinje cells. Neuron 32, 113-122 (2001).
38. Parkovits, M., Leranth, C., Gorcs, T. & Young, W. S. Corticotropin-releasing factor in the olivocerebellar tract of rats: demonstration by light- and electronmicroscopic immunohistochemistry and in situ hybridization. Proc. Natl Acad. Sci. USA 84, 3911-3915 (1987).
39. Werther, G. A. et al. Localization of insulin-like growth factor-1 mRNA in rat brain by in situ hydridization-relationship to IGF-1 receptors. Mol. Endocrinol. 4, 773-778 (1990).
40. Miyata, M., Okada, D., Hashimoto, K., Kano, M. & Ito, M. Corticotropin-releasing factor plays a permissive role in cerebellar long-term depression. Neuron 22, 763-775 (1999).
41. Kojima, I., Kitaoka, M. & Ogata, E. Insulin-like growth factor-I stimulates diacylglycerol production via multiple pathways in Balb/c 3T3 cells. J. Biol. Chem. 265, 16846-16850 (1990).
42. Wang, Y. T. & Linden, D. Expression of cerebellar long-term depression requires postsynaptic clathrin-mediated endocytosis. Neuron 25, 635-647 (2000).
43. Hemart, N., Daniel, H., Jaillard, D. & Crepel, F. Receptors and second messengers involved in long-term depression in rat cerebellar slices in vitro: a reappraisal. Eur. J. Neurosci. 7, 45-53 (1995).
44. Kashiwabuchi, N. et al. Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR δ2 mutant mice. Cell 81, 245-252 (1995).
45. Hartell, N. A. Induction of cerebellar long-term depression requires activation of glutamate metabotropic receptors. Neuroreport 5, 913-916 (1994).
46. Aiba, A. et al. Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice. Cell 79, 377-388 (1994).
47. Conquet, F. et al. Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1. Nature 372, 237-243 (1994).
48. Shibuki, K. & Okada, D. Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum. Nature 349, 326-328 (1991).
49. Boxall, A. R. & Garthwaite, J. Long-term depression in rat cerebellum requires both NO synthase and NO-sensitive guanylyl cyclase. Eur. J. Neurosci. 8, 2209-2212 (1996).
50. Linden, D. J. & Connor, J. A. Long-term depression of glutamate currents in cultured cerebellar Purkinje neurons does not require nitric oxide signaling. Eur. J. Neurosci. 4, 10-15 (1991).
51. Reynolds, T. & Hartell, N. A. Roles for nitric oxide and arachidonic acid in the induction of heterosynaptic cerebellar LTD. Neuroreport 12, 133-136 (2001).
52. Wang, S. S., Khiroug, L. & Augustine, G. J. Quantification of spread of cerebellar long-term depression with chemical two-photon uncaging of glutamate. Proc. Natl Acad. Sci. USA 97, 8635-8640 (2000).
53. Crepel, F. & Jaillard, D. Pairing of pre- and postsynaptic activities in cerebellar Purkinje cells induces long-term changes in synaptic efficacy in vitro. J. Physiol. (Lond.) 432, 123-141 (1991).
54. Reynolds, T. & Hartell, N. A. An evaluation of the synapse specificity of long-term depression induced in rat cerebellar slices. J. Physiol. (Lond.) 527, 563-577 (2000).
55. Ajima, A. & Ito, M. A unique role of protein phosphatases in cerebellar long-term depression. Neuroreport 6, 297-300 (1995).
56. 2+ in the induction of cerebellar long-term depression. Neuron 18, 1025-1038 (1997).
57. Sun, Y. et al. Mechanism of glutamate receptor desensitization. Nature 417, 245-253 (2002).
58. Linden, D. J., Smeyne, M. & Connor, J. A. Induction of cerebellar long-term depression in culture requires postsynaptic action of sodium ions. Neuron 11, 1093-1100 (1993).
59. Berridge, M. J. Neuronal calcium signaling. Neuron 21, 13-26 (1998).
60. 2+ release in heart. Science 260, 807-809 (1993).
61. Miyata, M. et al. Local calcium release in dendritic spines required for long-term synaptic depression. Neuron 28, 233-244 (2000).
62. Denk, W., Sugimori, M. & Llinas, R. Two types of calcium response limited to single spines in cerebellar Purkinje cells. Proc. Natl Acad. Sci. USA 92, 8279-8282 (1995).
63. Konnerth, A., Dressen, J. & Augustine, G. J. Brief dendritic calcium signals initiate long-lasting synaptic depression in cerebellar Purkinje cells. Proc. Natl Acad. Sci. USA 89, 7051-7055 (1992).
64. Takechi, H., Eilers, J. & Konnerth, A. A new class of synaptic response involving calcium release in dendritic spines. Nature 396, 757-760 (1998).
65. Finch, E. A. & Augustine, G. J. Local calcium signalling by inositol-1,4,5-trisphosphate in Purkinje cell dendrites. Nature 396, 753-756 (1998).
66. Hashikawa, T., Nakazawa, K., Mikawa, S., Shima, H. & Nagao, M. Immunohistochemical localization of protein phosphatase isoforms in the rat cerebellum. Neurosci. Res. 22, 133-136 (1995).
67. Strack, S., Chang, D., Zaucha, J. A., Colbran, R. J. & Wadzinski, B. E. Cloning and characterization of Bδ, a novel regulatory subunit of protein phosphatase 2A. FEBS Lett. 460, 462-466 (1999).
68. Abe, H. et al. Localization of mRNA for protein phosphatase 2A in the brain of adult rats. Brain Res. Mol. Brain Res. 22, 139-143 (1994).
69. Abe, H., Tamura, S. & Kondo, H. Localization of mRNA for protein phosphatase 2C in the brain of adult rats. Brain Res. Mol. Brain Res. 13, 283-288 (1992).
70. Usuda, N. et al. Differential subcellular localization of neural isoforms of the catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin) in central nervous system neurons: immunohistochemistry on formalin-fixed paraffin sections employing antigen retrieval by microwave irradiation. J. Histochem. Cytochem. 44, 13-18 (1996).
71. Bahl, R. et al. Localization of protein Ser/Thr phosphatase 5 in rat brain. Brain Res. Mol. Brain Res. 90, 101-109 (2001).
72. Cai, M. et al. Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase. Mol. Cell. Biol. 17, 732-741 (1997).
73. Millward, T. A., Zolnierowicz, S. & Hemmings, B. A. Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem. Sci. 24, 186-191 (1999).
74. Lisman, J. E. & Fallon, J. R. What maintains memories? Science 283, 339-340 (1999).
75. Bonventre, J. V. Phospholipase A2 and signal transduction. J. Am. Soc. Nephrol. 3, 128-150 (1992).
76. Nishizuka, Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258, 607-614 (1992).
77. Linden, D. J. Phospholipase A2 controls the induction of short-term versus long-term depression in the cerebellar Purkinje neuron in culture. Neuron 15, 1393-1401 (1995).
78. Karachot, L., Shirai, Y., Vigot, R., Yamamori, T. & Ito, M. Induction of long-term depression in cerebellar Purkinje cells requires a quickly turned over protein. J. Neurophysiol. 86, 280-289 (2002).
79. Matsuda, S., Launey, T., Mikawa, S. & Hirai, H. Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons. EMBO J. 19, 2765-2774 (2000).
80. Xia, J., Chung, H. J., Wihlker, C., Huganir, R. L. & Linden, D. J. Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins. Neuron 28, 499-510 (2000).
81. Wang, Y. T. & Linden, D. Expression of cerebellar long-term depression requires postsynaptic clathrin-mediated endocytosis. Neuron 25, 635-647 (2000).
82. Malinow, R. & Malenka, R. C. AMPA receptor trafficking and synaptic plasticity. Annu. Rev. Neurosci. 25, 103-126 (2002).