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Volumn 9, Issue 9, 2014, Pages

HBx inhibits CYP2E1 gene expression via downregulating HNF4α in human hepatoma cells

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2E1; HEPATITIS B VIRUS X PROTEIN; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HEPATOCYTE NUCLEAR FACTOR 4;

EID: 84907220654     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107913     Document Type: Article
Times cited : (24)

References (48)
  • 1
    • 67650938576 scopus 로고    scopus 로고
    • Hepatocellular carcinoma epidemiological trends and risk factors
    • Schutte K, Bornschein J, Malfertheiner P (2009) Hepatocellular carcinoma epidemiological trends and risk factors. Dig Dis 27: 80-92
    • (2009) Dig Dis , vol.27 , pp. 80-92
    • Schutte, K.1    Bornschein, J.2    Malfertheiner, P.3
  • 2
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
    • El-Serag HB, Rudolph KL (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132: 2557-2576
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 3
    • 79955829415 scopus 로고    scopus 로고
    • Design and rationale of the HCC BRIDGE study in China: A longitudinal, multicenter cohort trial in hepatocellular carcinoma
    • Chen M, Therneau T, Orsini LS, Qiao YL (2011) Design and rationale of the HCC BRIDGE study in China: a longitudinal, multicenter cohort trial in hepatocellular carcinoma. BMC Gastroenterol 11: 53-60
    • (2011) BMC Gastroenterol , vol.11 , pp. 53-60
    • Chen, M.1    Therneau, T.2    Orsini, L.S.3    Qiao, Y.L.4
  • 4
    • 77955415514 scopus 로고    scopus 로고
    • Epidemiology of chronic hepatitis B virus infection, hepatocellular carcinoma, and hepatitis B virus-induced hepatocellular carcinoma
    • Kew MC (2010) Epidemiology of chronic hepatitis B virus infection, hepatocellular carcinoma, and hepatitis B virus-induced hepatocellular carcinoma. Pathol Biol (Paris) 58: 273-277
    • (2010) Pathol Biol (Paris) , vol.58 , pp. 273-277
    • Kew, M.C.1
  • 5
    • 77955429498 scopus 로고    scopus 로고
    • Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC): Molecular mechanisms and novel paradigms
    • Brechot C, Kremsdorf D, Soussan P, Pineau P, Dejean A, et al. (2010) Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC): molecular mechanisms and novel paradigms. Pathol Biol (Paris) 58: 278-287
    • (2010) Pathol Biol (Paris) , vol.58 , pp. 278-287
    • Brechot, C.1    Kremsdorf, D.2    Soussan, P.3    Pineau, P.4    Dejean, A.5
  • 6
    • 80052411388 scopus 로고    scopus 로고
    • Hepatitis B virus X gene and hepatocarcinogenesis
    • Ng SA, Lee C (2011) Hepatitis B virus X gene and hepatocarcinogenesis. J Gastroenterol 46: 974-990
    • (2011) J Gastroenterol , vol.46 , pp. 974-990
    • Ng, S.A.1    Lee, C.2
  • 7
    • 79955576105 scopus 로고    scopus 로고
    • Role of CYP2E1 in ethanol-induced oxidant stress, fatty liver and hepatotoxicity
    • Cederbaum AI (2010) Role of CYP2E1 in ethanol-induced oxidant stress, fatty liver and hepatotoxicity. Dig Dis 28: 802-811
    • (2010) Dig Dis , vol.28 , pp. 802-811
    • Cederbaum, A.I.1
  • 8
    • 77953307949 scopus 로고    scopus 로고
    • Molecular modeling of cytochrome P450 and drug metabolism
    • Wang JF, Chou KC (2010) Molecular modeling of cytochrome P450 and drug metabolism. Curr Drug Metab 11: 342-346
    • (2010) Curr Drug Metab , vol.11 , pp. 342-346
    • Wang, J.F.1    Chou, K.C.2
  • 9
    • 34547899883 scopus 로고    scopus 로고
    • Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1 CYP2 and CYP3 families in 22 different human tissues
    • Bie'che I, Narjoz C, Asselah T, Vacher S, Marcellin P, et al. (2007) Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues. Pharmacogenet Genomics 17: 731-742
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 731-742
    • Bie'che, I.1    Narjoz, C.2    Asselah, T.3    Vacher, S.4    Marcellin, P.5
  • 10
    • 84867921274 scopus 로고    scopus 로고
    • Alcohol metabolism
    • Cederbaum AI (2012) Alcohol metabolism. Clin Liver Dis 16: 667-685
    • (2012) Clin Liver Dis , vol.16 , pp. 667-685
    • Cederbaum, A.I.1
  • 11
    • 0037241174 scopus 로고    scopus 로고
    • Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans
    • Wang Z, Hall SD, Maya JF, Li L, Asghar A, et al. (2003) Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans. Br J Clin Pharmacol 55: 77-85
    • (2003) Br J Clin Pharmacol , vol.55 , pp. 77-85
    • Wang, Z.1    Hall, S.D.2    Maya, J.F.3    Li, L.4    Asghar, A.5
  • 12
    • 0034251950 scopus 로고    scopus 로고
    • The alcohol-inducible form of cytochrome P450 (CYP2E1): Role in toxicology and regulation of expression
    • Novak RF, Woodcroft KJ (2000) The alcohol-inducible form of cytochrome P450 (CYP2E1): role in toxicology and regulation of expression. Arch Pharm Res 23: 267-282
    • (2000) Arch Pharm Res , vol.23 , pp. 267-282
    • Novak, R.F.1    Woodcroft, K.J.2
  • 13
    • 0026062622 scopus 로고
    • Genetic polymorphisms in the 59- flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene
    • Hayashi S, Watanabe J, Kawajiri K (1991) Genetic polymorphisms in the 59- flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene. J Biochem 110: 559-565
    • (1991) J Biochem , vol.110 , pp. 559-565
    • Hayashi, S.1    Watanabe, J.2    Kawajiri, K.3
  • 14
    • 84872410210 scopus 로고    scopus 로고
    • Roles of cytochrome P4502E1 gene polymorphisms and the risks of alcoholic liver disease: A meta-analysis
    • Zeng T, Guo FF, Zhang CL, Song FY, Zhao XL, et al. (2013) Roles of cytochrome P4502E1 gene polymorphisms and the risks of alcoholic liver disease: a meta-analysis. PLoS One 8: e54188
    • (2013) PLoS One , vol.8 , pp. e54188
    • Zeng, T.1    Guo, F.F.2    Zhang, C.L.3    Song, F.Y.4    Zhao, X.L.5
  • 15
    • 0036321444 scopus 로고    scopus 로고
    • Underexpression of mRNA in human hepatocellular carcinoma focusing on eight loci
    • Kinoshita M, Miyata M (2002) Underexpression of mRNA in human hepatocellular carcinoma focusing on eight loci. Hepatology 36: 433-438
    • (2002) Hepatology , vol.36 , pp. 433-438
    • Kinoshita, M.1    Miyata, M.2
  • 16
    • 2942715301 scopus 로고    scopus 로고
    • Expression of cytochrome P4502E1 gene in hepatocellular carcinoma
    • Man XB, Tang L, Qiu XH, Yang LQ, Cao HF, et al. (2004) Expression of cytochrome P4502E1 gene in hepatocellular carcinoma. World J Gastroenterol 10: 1565-1568
    • (2004) World J Gastroenterol , vol.10 , pp. 1565-1568
    • Man, X.B.1    Tang, L.2    Qiu, X.H.3    Yang, L.Q.4    Cao, H.F.5
  • 17
    • 3843077740 scopus 로고    scopus 로고
    • Decreased expression of cytochrome P450 2E1 is associated with poor prognosis of hepatocellular carcinoma
    • Ho JC, Cheung ST, Leung KL, Ng IO, Fan ST (2004) Decreased expression of cytochrome P450 2E1 is associated with poor prognosis of hepatocellular carcinoma. Int J Cancer 111: 494-500
    • (2004) Int J Cancer , vol.111 , pp. 494-500
    • Ho, J.C.1    Cheung, S.T.2    Leung, K.L.3    Ng, I.O.4    Fan, S.T.5
  • 18
    • 0036200587 scopus 로고    scopus 로고
    • Liver-enriched transcription factors in liver function and development Part I: The hepatocyte nuclear factor network and liver-specific gene expression
    • Schrem H, Klempnauer J, Borlak J (2002) Liver-enriched transcription factors in liver function and development. Part I: the hepatocyte nuclear factor network and liver-specific gene expression. Pharmacol Rev 54: 129-158
    • (2002) Pharmacol Rev , vol.54 , pp. 129-158
    • Schrem, H.1    Klempnauer, J.2    Borlak, J.3
  • 19
    • 0038757830 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4a controls the development of a hepatic epithelium and liver morphogenesis
    • Parviz F, Matullo C, Garrison WD, Savatski L, Adamson JW, et al. (2003) Hepatocyte nuclear factor 4a controls the development of a hepatic epithelium and liver morphogenesis. Nat Genet 34: 292-296
    • (2003) Nat Genet , vol.34 , pp. 292-296
    • Parviz, F.1    Matullo, C.2    Garrison, W.D.3    Savatski, L.4    Adamson, J.W.5
  • 20
    • 33744795211 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4a orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver
    • Battle MA, Konopka G, Parviz F, Gaggl AL, Yang C, et al. (2006) Hepatocyte nuclear factor 4a orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver. Proc Natl Acad Sci U S A 103: 8419-8424
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 8419-8424
    • Battle, M.A.1    Konopka, G.2    Parviz, F.3    Gaggl, A.L.4    Yang, C.5
  • 21
    • 1842480044 scopus 로고    scopus 로고
    • Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors
    • Lazarevich NL, Cheremnova OA, Varga EV, Ovchinnikov DA, Kudrjavtseva EI, et al. (2004) Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors. Hepatology 39: 1038-1047
    • (2004) Hepatology , vol.39 , pp. 1038-1047
    • Lazarevich, N.L.1    Cheremnova, O.A.2    Varga, E.V.3    Ovchinnikov, D.A.4    Kudrjavtseva, E.I.5
  • 22
    • 77957724345 scopus 로고    scopus 로고
    • Deregulation of hepatocyte nuclear factor 4 (HNF4) as a marker of epithelial tumors progression
    • Lazarevich NL, Shavochkina DA, Fleishman DI, Kustova IF, Morozova OV, et al. (2010) Deregulation of hepatocyte nuclear factor 4 (HNF4) as a marker of epithelial tumors progression. Exp Oncol 32: 167-171
    • (2010) Exp Oncol , vol.32 , pp. 167-171
    • Lazarevich, N.L.1    Shavochkina, D.A.2    Fleishman, D.I.3    Kustova, I.F.4    Morozova, O.V.5
  • 23
    • 77957344834 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4 alpha suppresses the development of hepatocellular carcinoma
    • Ning BF, Ding J, Yin C, Zhong W, Wu K, et al. (2010) Hepatocyte nuclear factor 4 alpha suppresses the development of hepatocellular carcinoma. Cancer Res 70: 7640-7651
    • (2010) Cancer Res , vol.70 , pp. 7640-7651
    • Ning, B.F.1    Ding, J.2    Yin, C.3    Zhong, W.4    Wu, K.5
  • 24
    • 56149088742 scopus 로고    scopus 로고
    • Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4alpha gene
    • Yin C, Lin Y, Zhang X, Chen YX, Zeng X, et al. (2008) Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4alpha gene. Hepatology 48: 1528-1539
    • (2008) Hepatology , vol.48 , pp. 1528-1539
    • Yin, C.1    Lin, Y.2    Zhang, X.3    Chen, Y.X.4    Zeng, X.5
  • 25
    • 68749088816 scopus 로고    scopus 로고
    • The correlation of hepatocyte nuclear factor 4 alpha and 3 beta with hepatitis B virus replication in the liver of chronic hepatitis B patients
    • Long Y, Chen E, Liu C, Huang F, Zhou T, et al. (2009) The correlation of hepatocyte nuclear factor 4 alpha and 3 beta with hepatitis B virus replication in the liver of chronic hepatitis B patients. J Viral Hepat 16: 537-546
    • (2009) J Viral Hepat , vol.16 , pp. 537-546
    • Long, Y.1    Chen, E.2    Liu, C.3    Huang, F.4    Zhou, T.5
  • 26
    • 84855864378 scopus 로고    scopus 로고
    • Study of the expression levels of Hepatocyte nuclear factor 4 alpha and 3 beta in patients with different outcome of HBV infection
    • Chen EQ, Sun H, Feng P, Gong DY, Liu C, et al. (2012) Study of the expression levels of Hepatocyte nuclear factor 4 alpha and 3 beta in patients with different outcome of HBV infection. Virol J 9: 23-28
    • (2012) Virol J , vol.9 , pp. 23-28
    • Chen, E.Q.1    Sun, H.2    Feng, P.3    Gong, D.Y.4    Liu, C.5
  • 27
    • 73149094329 scopus 로고    scopus 로고
    • Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection
    • Hosel M, Quasdorff M, Wiegmann K, Webb D, Zedler U, et al. (2009) Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection. Hepatology 50: 1773-1782
    • (2009) Hepatology , vol.50 , pp. 1773-1782
    • Hosel, M.1    Quasdorff, M.2    Wiegmann, K.3    Webb, D.4    Zedler, U.5
  • 28
    • 65549138510 scopus 로고    scopus 로고
    • Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha
    • Li L, Oropeza CE, Sainz B Jr, Uprichard SL, Gonzalez FJ, et al. (2009) Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha. PLoS One 4: e5489
    • (2009) PLoS One , vol.4 , pp. e5489
    • Li, L.1    Oropeza, C.E.2    Sainz, B.3    Uprichard, S.L.4    Gonzalez, F.J.5
  • 29
    • 70450157394 scopus 로고    scopus 로고
    • The transcriptional regulation of the human CYP2C genes
    • Chen Y, Goldstein JA (2009) The transcriptional regulation of the human CYP2C genes. Curr Drug Metab 10: 567-578
    • (2009) Curr Drug Metab , vol.10 , pp. 567-578
    • Chen, Y.1    Goldstein, J.A.2
  • 30
    • 84878815670 scopus 로고    scopus 로고
    • The expression of cytokeratin 19 in lymph nodes was a poor prognostic factor for hepatocellular carcinoma after hepatic resection
    • Lee CW, Kuo WL, Yu MC, Chen TC, Tsai CN, et al. (2013) The expression of cytokeratin 19 in lymph nodes was a poor prognostic factor for hepatocellular carcinoma after hepatic resection. World J Surg Oncol 11: 136-147
    • (2013) World J Surg Oncol , vol.11 , pp. 136-147
    • Lee, C.W.1    Kuo, W.L.2    Yu, M.C.3    Chen, T.C.4    Tsai, C.N.5
  • 31
    • 84880764350 scopus 로고    scopus 로고
    • P16 Stimulates CDC42-dependent migration of hepatocellular carcinoma cells
    • Chen YW, Chu HC, Lin ZS, Shiah WJ, Chou CP, et al. (2013) P16 Stimulates CDC42-dependent migration of hepatocellular carcinoma cells. PLoS One 8: e69389
    • (2013) PLoS One , vol.8 , pp. e69389
    • Chen, Y.W.1    Chu, H.C.2    Lin, Z.S.3    Shiah, W.J.4    Chou, C.P.5
  • 32
    • 67651158824 scopus 로고    scopus 로고
    • Role of oxidative stress in alcohol-induced liver injury
    • Cederbaum AI, Lu Y, Wu D (2009) Role of oxidative stress in alcohol-induced liver injury. Arch Toxicol 83: 519-548
    • (2009) Arch Toxicol , vol.83 , pp. 519-548
    • Cederbaum, A.I.1    Lu, Y.2    Wu, D.3
  • 33
    • 77957123293 scopus 로고    scopus 로고
    • Chronic alcoholinduced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice
    • Lu Y, Wu D, Wang X, Ward SC, Cederbaum AI (2010) Chronic alcoholinduced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice. Free Radic Biol Med 49: 1406-1416
    • (2010) Free Radic Biol Med , vol.49 , pp. 1406-1416
    • Lu, Y.1    Wu, D.2    Wang, X.3    Ward, S.C.4    Cederbaum, A.I.5
  • 34
    • 0030965155 scopus 로고    scopus 로고
    • Cytotoxicity and apoptosis produced by arachidonic acid in Hep G2 cells overexpressing human cytochrome P4502E1
    • Chen Q, Galleano M, Cederbaum AI (1997) Cytotoxicity and apoptosis produced by arachidonic acid in Hep G2 cells overexpressing human cytochrome P4502E1. J Biol Chem 272: 14532-14541
    • (1997) J Biol Chem , vol.272 , pp. 14532-14541
    • Chen, Q.1    Galleano, M.2    Cederbaum, A.I.3
  • 35
    • 0032904051 scopus 로고    scopus 로고
    • Ethanol-induced apoptosis to stable HepG2 cell lines expressing human cytochrome P-4502E1
    • Wu D, Cederbaum AI (1999) Ethanol-induced apoptosis to stable HepG2 cell lines expressing human cytochrome P-4502E1. Alcohol Clin Exp Res 23: 67-76
    • (1999) Alcohol Clin Exp Res , vol.23 , pp. 67-76
    • Wu, D.1    Cederbaum, A.I.2
  • 36
    • 84888035697 scopus 로고    scopus 로고
    • Inhibition of autophagy promotes CYP2E1- dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK
    • Wu D, Cederbaum AI (2013) Inhibition of autophagy promotes CYP2E1- dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK. Redox Biol 1: 552-565
    • (2013) Redox Biol , vol.1 , pp. 552-565
    • Wu, D.1    Cederbaum, A.I.2
  • 37
    • 0028898120 scopus 로고
    • Role of the liver-enriched transcription factor HNF- 1 alpha in expression of the CYP2E1 gene
    • Liu SY, Gonzalez FJ (1995) Role of the liver-enriched transcription factor HNF- 1 alpha in expression of the CYP2E1 gene. DNA Cell Biol 14: 285-293
    • (1995) DNA Cell Biol , vol.14 , pp. 285-293
    • Liu, S.Y.1    Gonzalez, F.J.2
  • 38
    • 0034307196 scopus 로고    scopus 로고
    • Promoter function and the role of cytokines in the transcriptional regulation of rabbit CYP2E1 and CYP2E2
    • Peng HM, Coon MJ (2000) Promoter function and the role of cytokines in the transcriptional regulation of rabbit CYP2E1 and CYP2E2. Arch Biochem Biophys 382: 129-137
    • (2000) Arch Biochem Biophys , vol.382 , pp. 129-137
    • Peng, H.M.1    Coon, M.J.2
  • 39
    • 0025525299 scopus 로고
    • Transcriptional and posttranscriptional regulation of CYP2E1, an N-nitrosodimethylamine demethylase
    • Gonzalez FJ, Gelboin HV (1990) Transcriptional and posttranscriptional regulation of CYP2E1, an N-nitrosodimethylamine demethylase. Princess Takamatsu Symp 21: 157-164
    • (1990) Princess Takamatsu Symp , vol.21 , pp. 157-164
    • Gonzalez, F.J.1    Gelboin, H.V.2
  • 40
    • 77957017125 scopus 로고    scopus 로고
    • IL-4- mediated transcriptional regulation of human CYP2E1 by two independent signaling pathways
    • Wang J, Hu Y, Nekvindova J, Ingelman-Sundberg M, Neve EP (2010) IL-4- mediated transcriptional regulation of human CYP2E1 by two independent signaling pathways. Biochem Pharmacol 80: 1592-1600
    • (2010) Biochem Pharmacol , vol.80 , pp. 1592-1600
    • Wang, J.1    Hu, Y.2    Nekvindova, J.3    Ingelman-Sundberg, M.4    Neve, E.P.5
  • 41
    • 0037450505 scopus 로고    scopus 로고
    • Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors
    • Akiyama TE, Gonzalez FJ (2003) Regulation of P450 genes by liver-enriched transcription factors and nuclear receptors. Biochim Biophys Acta 1619: 223-234
    • (2003) Biochim Biophys Acta , vol.1619 , pp. 223-234
    • Akiyama, T.E.1    Gonzalez, F.J.2
  • 42
    • 0027443904 scopus 로고
    • Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture
    • Abdel-Razzak Z, Loyer P, Fautrel A, Gautier JC, Corcos L, et al. (1993) Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Mol Pharmacol 44: 707-715
    • (1993) Mol Pharmacol , vol.44 , pp. 707-715
    • Abdel-Razzak, Z.1    Loyer, P.2    Fautrel, A.3    Gautier, J.C.4    Corcos, L.5
  • 43
    • 0037371329 scopus 로고    scopus 로고
    • Mechanisms of down-regulation of CYP2E1 expression by inflammatory cytokines in rat hepatoma cells
    • Hakkola J, Hu Y, Ingelman-Sundberg M (2003) Mechanisms of down-regulation of CYP2E1 expression by inflammatory cytokines in rat hepatoma cells. J Pharmacol Exp Ther 304: 1048-1054
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 1048-1054
    • Hakkola, J.1    Hu, Y.2    Ingelman-Sundberg, M.3
  • 44
    • 84887208273 scopus 로고    scopus 로고
    • Zinc-dependent interaction between JAB1 and pre-S2 mutant large surface antigen of hepatitis B virus and its implications for viral hepatocarcinogenesis
    • Hsu JL, Chuang WJ, Su IJ, Gui WJ, Chang YY, et al. (2013) Zinc-dependent interaction between JAB1 and pre-S2 mutant large surface antigen of hepatitis B virus and its implications for viral hepatocarcinogenesis. J Virol 87: 12675-12684
    • (2013) J Virol , vol.87 , pp. 12675-12684
    • Hsu, J.L.1    Chuang, W.J.2    Su, I.J.3    Gui, W.J.4    Chang, Y.Y.5
  • 45
    • 3142765079 scopus 로고    scopus 로고
    • Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4alpha-deficient mice
    • Wiwi CA, Gupte M, Waxman DJ (2004) Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4alpha-deficient mice. Mol Endocrinol 18: 1975-1987
    • (2004) Mol Endocrinol , vol.18 , pp. 1975-1987
    • Wiwi, C.A.1    Gupte, M.2    Waxman, D.J.3
  • 46
    • 84984535216 scopus 로고    scopus 로고
    • Identification of androgen response elements in the enhancer i of hepatitis B virus: A mechanism for sex disparity in chronic hepatitis B
    • Wang SH, Yeh SH, Lin WH, Wang HY, Chen DS, et al. (2009) Identification of androgen response elements in the enhancer I of hepatitis B virus: a mechanism for sex disparity in chronic hepatitis B. Hepatology 50: 1392-1402
    • (2009) Hepatology , vol.50 , pp. 1392-1402
    • Wang, S.H.1    Yeh, S.H.2    Lin, W.H.3    Wang, H.Y.4    Chen, D.S.5
  • 47
    • 77952990855 scopus 로고    scopus 로고
    • Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription
    • Wu MH, Ma WL, Hsu CL, Chen YL, Ou JH, et al. (2010) Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription. Sci Transl Med 2: 32ra35
    • (2010) Sci Transl Med , vol.2 , pp. 32ra35
    • Wu, M.H.1    Ma, W.L.2    Hsu, C.L.3    Chen, Y.L.4    Ou, J.H.5
  • 48
    • 84863115453 scopus 로고    scopus 로고
    • Enhancement of hepatitis B virus replication by androgen and its receptor in mice
    • Tian Y, Kuo CF, Chen WL, Ou JH (2012) Enhancement of hepatitis B virus replication by androgen and its receptor in mice. J Virol 86: 1904-1910
    • (2012) J Virol , vol.86 , pp. 1904-1910
    • Tian, Y.1    Kuo, C.F.2    Chen, W.L.3    Ou, J.H.4


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