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Volumn 8, Issue 7, 2013, Pages

p16 Stimulates CDC42-Dependent Migration of Hepatocellular Carcinoma Cells

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; PROTEIN CDC42; PROTEIN P16; RAC1 PROTEIN;

EID: 84880764350     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0069389     Document Type: Article
Times cited : (22)

References (44)
  • 2
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: from genes to environment
    • 10.1038/nrc1934
    • Farazi PA, DePinho RA, (2006) Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 6: 674-687. doi:10.1038/nrc1934. PubMed: 16929323.
    • (2006) Nat Rev Cancer , vol.6 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 3
    • 0028306247 scopus 로고
    • Molecular events in the pathogenesis of hepadnavirus-associated hepatocellular carcinoma
    • 10.1146/annurev.med.45.1.297
    • Robinson WS, (1994) Molecular events in the pathogenesis of hepadnavirus-associated hepatocellular carcinoma. Annu Rev Med 45: 297-323. doi:10.1146/annurev.med.45.1.297. PubMed: 8198385.
    • (1994) Annu Rev Med , vol.45 , pp. 297-323
    • Robinson, W.S.1
  • 4
    • 0033867475 scopus 로고    scopus 로고
    • Genetics of hepatocellular carcinoma
    • 10.1006/scbi.2000.0319
    • Buendia MA, (2000) Genetics of hepatocellular carcinoma. Semin Cancer Biol 10: 185-200. doi:10.1006/scbi.2000.0319. PubMed: 10936068.
    • (2000) Semin Cancer Biol , vol.10 , pp. 185-200
    • Buendia, M.A.1
  • 5
    • 0033590404 scopus 로고    scopus 로고
    • High frequency of p16INK4A gene alterations in hepatocellular carcinoma
    • 10.1038/sj.onc.1202359
    • Liew CT, Li HM, Lo KW, Leow CK, Chan JY, et al. (1999) High frequency of p16INK4A gene alterations in hepatocellular carcinoma. Oncogene 18: 789-795. doi:10.1038/sj.onc.1202359. PubMed: 9989830.
    • (1999) Oncogene , vol.18 , pp. 789-795
    • Liew, C.T.1    Li, H.M.2    Lo, K.W.3    Leow, C.K.4    Chan, J.Y.5
  • 6
    • 0032924622 scopus 로고    scopus 로고
    • p16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma
    • 10.1016/S0016-5085(99)70137-X
    • Matsuda Y, Ichida T, Matsuzawa J, Sugimura K, Asakura H, (1999) p16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma. Gastroenterology 116: 394-400. doi:10.1016/S0016-5085(99)70137-X. PubMed: 9922321.
    • (1999) Gastroenterology , vol.116 , pp. 394-400
    • Matsuda, Y.1    Ichida, T.2    Matsuzawa, J.3    Sugimura, K.4    Asakura, H.5
  • 7
    • 13444278808 scopus 로고    scopus 로고
    • The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma
    • 10.1128/MCB.25.4.1228-1237.2005
    • Lewis BC, Klimstra DS, Socci ND, Xu S, Koutcher JA, et al. (2005) The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma. Mol Cell Biol 25: 1228-1237. doi:10.1128/MCB.25.4.1228-1237.2005. PubMed: 15684377.
    • (2005) Mol Cell Biol , vol.25 , pp. 1228-1237
    • Lewis, B.C.1    Klimstra, D.S.2    Socci, N.D.3    Xu, S.4    Koutcher, J.A.5
  • 8
    • 34548044683 scopus 로고    scopus 로고
    • Loss of p53 and Ink4a/Arf Cooperate in a Cell Autonomous Fashion to Induce Metastasis of Hepatocellular Carcinoma Cells
    • 10.1158/0008-5472.CAN-07-0381
    • Chen YW, Klimstra DS, Mongeau ME, Tatem JL, Boyartchuk V, et al. (2007) Loss of p53 and Ink4a/Arf Cooperate in a Cell Autonomous Fashion to Induce Metastasis of Hepatocellular Carcinoma Cells. Cancer Res 67: 7589-7596. doi:10.1158/0008-5472.CAN-07-0381. PubMed: 17699762.
    • (2007) Cancer Res , vol.67 , pp. 7589-7596
    • Chen, Y.W.1    Klimstra, D.S.2    Mongeau, M.E.3    Tatem, J.L.4    Boyartchuk, V.5
  • 9
    • 0029587551 scopus 로고
    • Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
    • 10.1016/0092-8674(95)90214-7
    • Quelle DE, Zindy F, Ashmun RA, Sherr CJ, (1995) Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 83: 993-1000. doi:10.1016/0092-8674(95)90214-7. PubMed: 8521522.
    • (1995) Cell , vol.83 , pp. 993-1000
    • Quelle, D.E.1    Zindy, F.2    Ashmun, R.A.3    Sherr, C.J.4
  • 10
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • 10.1038/366704a0
    • Serrano M, Hannon GJ, Beach D, (1993) A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 366: 704-707. doi:10.1038/366704a0. PubMed: 8259215.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 11
    • 0032549704 scopus 로고    scopus 로고
    • The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
    • 10.1016/S0092-8674(00)81400-2
    • Pomerantz J, Schreiber-Agus N, Liégeois NJ, Silverman A, Alland L, et al. (1998) The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 92: 713-723. doi:10.1016/S0092-8674(00)81400-2. PubMed: 9529248.
    • (1998) Cell , vol.92 , pp. 713-723
    • Pomerantz, J.1    Schreiber-Agus, N.2    Liégeois, N.J.3    Silverman, A.4    Alland, L.5
  • 12
    • 22144489899 scopus 로고    scopus 로고
    • INK4a/ARF: a multifunctional tumor suppressor locus
    • 10.1016/j.mrfmmm.2004.08.021
    • Sharpless NE, (2005) INK4a/ARF: a multifunctional tumor suppressor locus. Mutat Res 576: 22-38. doi:10.1016/j.mrfmmm.2004.08.021. PubMed: 15878778.
    • (2005) Mutat Res , vol.576 , pp. 22-38
    • Sharpless, N.E.1
  • 13
    • 39049124311 scopus 로고    scopus 로고
    • p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein
    • 10.1158/0008-5472.CAN-07-1960
    • Chen YW, Paliwal S, Draheim K, Grossman SR, Lewis BC, (2008) p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein. Cancer Res 68: 476-482. doi:10.1158/0008-5472.CAN-07-1960. PubMed: 18199542.
    • (2008) Cancer Res , vol.68 , pp. 476-482
    • Chen, Y.W.1    Paliwal, S.2    Draheim, K.3    Grossman, S.R.4    Lewis, B.C.5
  • 14
    • 0029665280 scopus 로고    scopus 로고
    • Inactivation of p16INK4 in hepatocellular carcinoma
    • 10.1002/hep.510240319
    • Hui AM, Sakamoto M, Kanai Y, Ino Y, Gotoh M, et al. (1996) Inactivation of p16INK4 in hepatocellular carcinoma. Hepatology 24: 575-579. doi:10.1002/hep.510240319. PubMed: 8781327.
    • (1996) Hepatology , vol.24 , pp. 575-579
    • Hui, A.M.1    Sakamoto, M.2    Kanai, Y.3    Ino, Y.4    Gotoh, M.5
  • 15
    • 0031771435 scopus 로고    scopus 로고
    • Aberrant cytoplasmic expression of the p16 protein in breast cancer is associated with accelerated tumour proliferation
    • 10.1038/bjc.1998.739
    • Emig R, Magener A, Ehemann V, Meyer A, Stilgenbauer F, et al. (1998) Aberrant cytoplasmic expression of the p16 protein in breast cancer is associated with accelerated tumour proliferation. Br J Cancer 78: 1661-1668. doi:10.1038/bjc.1998.739. PubMed: 9862580.
    • (1998) Br J Cancer , vol.78 , pp. 1661-1668
    • Emig, R.1    Magener, A.2    Ehemann, V.3    Meyer, A.4    Stilgenbauer, F.5
  • 16
    • 0034895071 scopus 로고    scopus 로고
    • Overexpression of the p16 cell cycle inhibitor in breast cancer is associated with a more malignant phenotype
    • 10.1023/A:1010623308275
    • Milde-Langosch K, Bamberger AM, Rieck G, Kelp B, Löning T, (2001) Overexpression of the p16 cell cycle inhibitor in breast cancer is associated with a more malignant phenotype. Breast Cancer Res Treat 67: 61-70. doi:10.1023/A:1010623308275. PubMed: 11518467.
    • (2001) Breast Cancer Res Treat , vol.67 , pp. 61-70
    • Milde-Langosch, K.1    Bamberger, A.M.2    Rieck, G.3    Kelp, B.4    Löning, T.5
  • 17
    • 0032948380 scopus 로고    scopus 로고
    • Overexpression of the cyclin-dependent kinase inhibitor p16 is associated with tumor recurrence in human prostate cancer
    • 10353729
    • Lee CT, Capodieci P, Osman I, Fazzari M, Ferrara J, et al. (1999) Overexpression of the cyclin-dependent kinase inhibitor p16 is associated with tumor recurrence in human prostate cancer. Clin Cancer Res 5: 977-983. PubMed: 10353729.
    • (1999) Clin Cancer Res , vol.5 , pp. 977-983
    • Lee, C.T.1    Capodieci, P.2    Osman, I.3    Fazzari, M.4    Ferrara, J.5
  • 18
    • 0034895022 scopus 로고    scopus 로고
    • Overexpression of the cell cycle inhibitor p16INK4A in high-grade prostatic intraepithelial neoplasia predicts early relapse in prostate cancer patients
    • 11297246
    • Henshall SM, Quinn DI, Lee CS, Head DR, Golovsky D, et al. (2001) Overexpression of the cell cycle inhibitor p16INK4A in high-grade prostatic intraepithelial neoplasia predicts early relapse in prostate cancer patients. Clin Cancer Res 7: 544-550. PubMed: 11297246.
    • (2001) Clin Cancer Res , vol.7 , pp. 544-550
    • Henshall, S.M.1    Quinn, D.I.2    Lee, C.S.3    Head, D.R.4    Golovsky, D.5
  • 19
    • 0031740497 scopus 로고    scopus 로고
    • Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions
    • 10.1016/S0002-9440(10)65689-1
    • Sano T, Oyama T, Kashiwabara K, Fukuda T, Nakajima T, (1998) Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am J Pathol 153: 1741-1748. doi:10.1016/S0002-9440(10)65689-1. PubMed: 9846965.
    • (1998) Am J Pathol , vol.153 , pp. 1741-1748
    • Sano, T.1    Oyama, T.2    Kashiwabara, K.3    Fukuda, T.4    Nakajima, T.5
  • 20
    • 0033531955 scopus 로고    scopus 로고
    • Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases
    • 10.1074/jbc.274.19.13198
    • Benard V, Bohl BP, Bokoch GM, (1999) Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases. J Biol Chem 274: 13198-13204. doi:10.1074/jbc.274.19.13198. PubMed: 10224076.
    • (1999) J Biol Chem , vol.274 , pp. 13198-13204
    • Benard, V.1    Bohl, B.P.2    Bokoch, G.M.3
  • 21
    • 0034799994 scopus 로고    scopus 로고
    • Assay of Cdc42, Rac, and Rho GTPase activation by affinity methods
    • 10.1016/S0076-6879(02)45028-8
    • Benard V, Bokoch GM, (2002) Assay of Cdc42, Rac, and Rho GTPase activation by affinity methods. Methods Enzymol 345: 349-359. doi:10.1016/S0076-6879(02)45028-8. PubMed: 11665618.
    • (2002) Methods Enzymol , vol.345 , pp. 349-359
    • Benard, V.1    Bokoch, G.M.2
  • 22
    • 0030794277 scopus 로고    scopus 로고
    • Identification of putative c-Myc-responsive genes: characterization of rcl, a novel growth-related gene
    • 9271375
    • Lewis BC, Shim H, Li Q, Wu CS, Lee LA, et al. (1997) Identification of putative c-Myc-responsive genes: characterization of rcl, a novel growth-related gene. Mol Cell Biol 17: 4967-4978. PubMed: 9271375.
    • (1997) Mol Cell Biol , vol.17 , pp. 4967-4978
    • Lewis, B.C.1    Shim, H.2    Li, Q.3    Wu, C.S.4    Lee, L.A.5
  • 23
    • 77956295659 scopus 로고    scopus 로고
    • Fibrolamellar carcinoma of the liver exhibits immunohistochemical evidence of both hepatocyte and bile duct differentiation
    • 10.1038/modpathol.2010.105
    • Ward SC, Huang J, Tickoo SK, Thung SN, Ladanyi M, et al. (2010) Fibrolamellar carcinoma of the liver exhibits immunohistochemical evidence of both hepatocyte and bile duct differentiation. Mod Pathol 23: 1180-1190. doi:10.1038/modpathol.2010.105. PubMed: 20495535.
    • (2010) Mod Pathol , vol.23 , pp. 1180-1190
    • Ward, S.C.1    Huang, J.2    Tickoo, S.K.3    Thung, S.N.4    Ladanyi, M.5
  • 24
    • 33947204625 scopus 로고    scopus 로고
    • Gene expression profiling reveals potential biomarkers of human hepatocellular carcinoma
    • 10.1158/1078-0432.CCR-06-1025
    • Jia HL, Ye QH, Qin LX, Budhu A, Forgues M, et al. (2007) Gene expression profiling reveals potential biomarkers of human hepatocellular carcinoma. Clin Cancer Res 13: 1133-1139. doi:10.1158/1078-0432.CCR-06-1025. PubMed: 17317821.
    • (2007) Clin Cancer Res , vol.13 , pp. 1133-1139
    • Jia, H.L.1    Ye, Q.H.2    Qin, L.X.3    Budhu, A.4    Forgues, M.5
  • 25
    • 0037443891 scopus 로고    scopus 로고
    • Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection
    • 10.1016/S0140-6736(03)12775-4
    • Iizuka N, Oka M, Yamada-Okabe H, Nishida M, Maeda Y, et al. (2003) Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection. Lancet 361: 923-929. doi:10.1016/S0140-6736(03)12775-4. PubMed: 12648972.
    • (2003) Lancet , vol.361 , pp. 923-929
    • Iizuka, N.1    Oka, M.2    Yamada-Okabe, H.3    Nishida, M.4    Maeda, Y.5
  • 26
    • 53049086329 scopus 로고    scopus 로고
    • Focal gains of VEGFA and molecular classification of hepatocellular carcinoma
    • 10.1158/0008-5472.CAN-08-0742
    • Chiang DY, Villanueva A, Hoshida Y, Peix J, Newell P, et al. (2008) Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. Cancer Res 68: 6779-6788. doi:10.1158/0008-5472.CAN-08-0742. PubMed: 18701503.
    • (2008) Cancer Res , vol.68 , pp. 6779-6788
    • Chiang, D.Y.1    Villanueva, A.2    Hoshida, Y.3    Peix, J.4    Newell, P.5
  • 27
    • 1642377561 scopus 로고    scopus 로고
    • ONCOMINE: a cancer microarray database and integrated data-mining platform
    • 15068665
    • Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, et al. (2004) ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia 6: 1-6. PubMed: 15068665.
    • (2004) Neoplasia , vol.6 , pp. 1-6
    • Rhodes, D.R.1    Yu, J.2    Shanker, K.3    Deshpande, N.4    Varambally, R.5
  • 28
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • 10.1038/nature01148
    • Etienne-Manneville S, Hall A, (2002) Rho GTPases in cell biology. Nature 420: 629-635. doi:10.1038/nature01148. PubMed: 12478284.
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 29
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • 10.1038/nrc822
    • Thiery JP, (2002) Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454. doi:10.1038/nrc822. PubMed: 12189386.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 30
    • 84865294024 scopus 로고    scopus 로고
    • Krüppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression
    • 10.1371/journal.pone.0043593
    • Lin ZS, Chu HC, Yen YC, Lewis BC, Chen YW, (2012) Krüppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression. PLOS ONE 7: e43593. doi:10.1371/journal.pone.0043593. PubMed: 22937066.
    • (2012) PLOS ONE , vol.7
    • Lin, Z.S.1    Chu, H.C.2    Yen, Y.C.3    Lewis, B.C.4    Chen, Y.W.5
  • 31
    • 0028121279 scopus 로고
    • A cell cycle regulator potentially involved in genesis of many tumor types
    • 10.1126/science.8153634
    • Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, et al. (1994) A cell cycle regulator potentially involved in genesis of many tumor types. Science 264: 436-440. doi:10.1126/science.8153634. PubMed: 8153634.
    • (1994) Science , vol.264 , pp. 436-440
    • Kamb, A.1    Gruis, N.A.2    Weaver-Feldhaus, J.3    Liu, Q.4    Harshman, K.5
  • 32
    • 0035487104 scopus 로고    scopus 로고
    • The INK4a/ARF network in tumour suppression
    • 10.1038/35088605
    • Sherr CJ, (2001) The INK4a/ARF network in tumour suppression. Nat Rev Mol Cell Biol 2: 731-737. doi:10.1038/35088605. PubMed: 11584300.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , pp. 731-737
    • Sherr, C.J.1
  • 33
    • 0028059330 scopus 로고
    • Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
    • 10.1038/ng0994-27
    • Caldas C, Hahn SA, da Costa LT, Redston MS, Schutte M, et al. (1994) Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet 8: 27-32. doi:10.1038/ng0994-27. PubMed: 7726912.
    • (1994) Nat Genet , vol.8 , pp. 27-32
    • Caldas, C.1    Hahn, S.A.2    da Costa, L.T.3    Redston, M.S.4    Schutte, M.5
  • 34
    • 33748419398 scopus 로고    scopus 로고
    • Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas
    • 10.1007/s11060-005-9037-5
    • Arifin MT, Hama S, Kajiwara Y, Sugiyama K, Saito T, et al. (2006) Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas. J Neuro Oncol 77: 273-277. doi:10.1007/s11060-005-9037-5.
    • (2006) J Neuro Oncol , vol.77 , pp. 273-277
    • Arifin, M.T.1    Hama, S.2    Kajiwara, Y.3    Sugiyama, K.4    Saito, T.5
  • 35
    • 38549148417 scopus 로고    scopus 로고
    • Notch and cancer: a double-edged sword
    • 10.1007/s00018-007-7164-1
    • Koch U, Radtke F, (2007) Notch and cancer: a double-edged sword. Cell Mol Life Sci 64: 2746-2762. doi:10.1007/s00018-007-7164-1. PubMed: 17687513.
    • (2007) Cell Mol Life Sci , vol.64 , pp. 2746-2762
    • Koch, U.1    Radtke, F.2
  • 36
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in Cancer
    • 10.1016/j.cell.2008.07.001
    • Massagué J, (2008) TGFbeta in Cancer. Cell 134: 215-230. doi:10.1016/j.cell.2008.07.001. PubMed: 18662538.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massagué, J.1
  • 37
    • 0030726538 scopus 로고    scopus 로고
    • Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro
    • 10.1038/sj.onc.1201382
    • Chintala SK, Fueyo J, Gomez-Manzano C, Venkaiah B, Bjerkvig R, et al. (1997) Adenovirus-mediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro. Oncogene 15: 2049-2057. doi:10.1038/sj.onc.1201382. PubMed: 9366522.
    • (1997) Oncogene , vol.15 , pp. 2049-2057
    • Chintala, S.K.1    Fueyo, J.2    Gomez-Manzano, C.3    Venkaiah, B.4    Bjerkvig, R.5
  • 38
    • 0033561310 scopus 로고    scopus 로고
    • The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts
    • 10.1093/emboj/18.8.2106
    • Fåhraeus R, Lane DP, (1999) The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts. EMBO J 18: 2106-2118. doi:10.1093/emboj/18.8.2106. PubMed: 10205165.
    • (1999) EMBO J , vol.18 , pp. 2106-2118
    • Fåhraeus, R.1    Lane, D.P.2
  • 39
    • 79955608106 scopus 로고    scopus 로고
    • Inhibition of Hypoxia-Induced Cell Motility by p16 in MDA-MB-231 Breast Cancer Cells
    • 20922054
    • Li L, Lu Y, (2010) Inhibition of Hypoxia-Induced Cell Motility by p16 in MDA-MB-231 Breast Cancer Cells. J Cancer 1: 126-135. PubMed: 20922054.
    • (2010) J Cancer , vol.1 , pp. 126-135
    • Li, L.1    Lu, Y.2
  • 41
    • 1942466518 scopus 로고    scopus 로고
    • p27Kip1 modulates cell migration through the regulation of RhoA activation
    • 10.1101/gad.1185504
    • Besson A, Gurian-West M, Schmidt A, Hall A, Roberts JM, (2004) p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev 18: 862-876. doi:10.1101/gad.1185504. PubMed: 15078817.
    • (2004) Genes Dev , vol.18 , pp. 862-876
    • Besson, A.1    Gurian-West, M.2    Schmidt, A.3    Hall, A.4    Roberts, J.M.5
  • 42
    • 33744816196 scopus 로고    scopus 로고
    • p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex
    • 10.1101/gad.377106
    • Nguyen L, Besson A, Heng JI, Schuurmans C, Teboul L, et al. (2006) p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex. Genes Dev 20: 1511-1524. doi:10.1101/gad.377106. PubMed: 16705040.
    • (2006) Genes Dev , vol.20 , pp. 1511-1524
    • Nguyen, L.1    Besson, A.2    Heng, J.I.3    Schuurmans, C.4    Teboul, L.5
  • 43
    • 0031759170 scopus 로고    scopus 로고
    • Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration
    • 10.1038/4042
    • Nagahara H, Vocero-Akbani AM, Snyder EL, Ho A, Latham DG, et al. (1998) Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration. Nat Med 4: 1449-1452. doi:10.1038/4042. PubMed: 9846587.
    • (1998) Nat Med , vol.4 , pp. 1449-1452
    • Nagahara, H.1    Vocero-Akbani, A.M.2    Snyder, E.L.3    Ho, A.4    Latham, D.G.5
  • 44
    • 0037216528 scopus 로고    scopus 로고
    • Novel: 27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions
    • McAllister SS, Becker-Hapak M, Pintucci G, Pagano M, Dowdy SF, (2003). Novel: 27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions. Mol Cell Biol 23: 216-228.
    • (2003) Mol Cell Biol , vol.23 , pp. 216-228
    • McAllister, S.S.1    Becker-Hapak, M.2    Pintucci, G.3    Pagano, M.4    Dowdy, S.F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.