IL-4-mediated transcriptional regulation of human CYP2E1 by two independent signaling pathways

Biochemical Pharmacology

Volumn 80, Issue 10, 2010, Pages 1592-1600

  Wang, Jue ^a   Hu, Yin ^b   Nekvindova, Jana ^a   Ingelman Sundberg, Magnus ^a   Neve, Etienne P A ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

B16A2 cell line; Cytochrome P450 2E1; Interleukin 4; Transcription factors; Transcriptional activation

Indexed keywords

CYTOCHROME P450 2E1; INTERLEUKIN 4; JANUS KINASE; STAT6 PROTEIN; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC1; UNCLASSIFIED DRUG; CYP2F1 PROTEIN, HUMAN; CYTOCHROME P450; FIREFLY LUCIFERASE; INSULIN RECEPTOR SUBSTRATE; JAK1 PROTEIN, HUMAN; JANUS KINASE 1; NFATC1 PROTEIN, HUMAN; RECOMBINANT PROTEIN; SMALL INTERFERING RNA; STAT6 PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; BIOSYNTHESIS; DNA RESPONSIVE ELEMENT; DRUG EFFECTS; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; METABOLISM; NORTHERN BLOTTING; PHYSIOLOGY; PLASMID; PROMOTER REGION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

BLOTTING, NORTHERN; CELL LINE, TUMOR; CYTOCHROME P-450 ENZYME SYSTEM; GENES, REPORTER; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; INTERLEUKIN-4; JANUS KINASE 1; LUCIFERASES, FIREFLY; NFATC TRANSCRIPTION FACTORS; PLASMIDS; PROMOTER REGIONS, GENETIC; RECOMBINANT PROTEINS; RESPONSE ELEMENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STAT6 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 77957017125     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.08.005     Document Type: Article

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