Granulocyte-Macrophage Colony-Stimulating Factor and IFN-γ Restore the Systemic TNF-γ Response to Endotoxin in Lipopolysaccharide-Desensitized Mice

Journal of Immunology

Volumn 158, Issue 6, 1997, Pages 2862-2871

  Bundschuh, Daniela S ^a   Barsig, Johannes ^a   Hartung, Thomas ^a   Randow, Felix ^b   Döcke, Wolf Dietrich ^b   Volk, Hans Dieter ^b   Wendel, Albrecht ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; BLOOD; CELL CULTURE; DESENSITIZATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; FEMALE; IMMUNOLOGICAL TOLERANCE; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MACROPHAGE; MALE; METABOLISM; MONOCYTE; MOUSE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CELLS, CULTURED; DESENSITIZATION, IMMUNOLOGIC; DRUG SYNERGISM; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; IMMUNE TOLERANCE; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENOUS; INTERFERON TYPE II; INTERLEUKIN-10; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; MONOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031569190     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. Glauser, M. P., G. Zanetti, J.-D. Baumgartner, and J. Cohen. 1991. Septic shock: pathogenesis. Lancet 338:732.
2. Parrillo, J. E. 1993 Pathogenic mechanisms of septic shock. N. Engl. J. Med. 328:1471.
3. Bone, R. C., R. A. Balk, F. B. Cerra, R. P. Dellinger, A. M. Fein, W. A. Knaus, R. M. H. Schein, and W. J. Sibbald. 1992. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Chest 101:1644.
4. Michie, H. R., K. R. Manogue, D. R. Spriggs, A. Revhaug, S. O'Dwyer, C. A. Dinarello, A. Cerami, S. M. Wolff, and D. W. Wilmore. 1988. Detection of circulating tumor necrosis factor after endotoxin administration. N. Engl. J. Med. 318:1481.
5. Beutler, B., I. W. Milsark, and A. C. Cerami. 1985. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science 229:869.
6. Tracey, K. J., B. Beutler, S. F. Lowry, J. Merryweather, S. Wolpe, I. W. Milsark, R. J. Hariri, T. J. Fahey III, A. Zentella, J. D. Albert, G. T. Shires, and A. Cerami. 1986. Shock and tissue injury induced by recombinant human cachectin. Science 234:470.
7. Tracey, K. J., and A. Cerami. 1993. Tumor necrosis factor: an updated review of its biology. Crit. Care Med. 21:S415.
8. Damas, P., A. Reuter, P. Gysen, J. Demonty, M. Lamy, and P. Franchimont. 1989. Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans. Crit. Care Med. 17:975.
9. Debets, J. M. H., R. Kampmeijer, M. P. M. H. Van der Linden, C. J. Buurman, and W. A. Van der Linden. 1989. Plasma tumor necrosis factor and mortality in critically ill septic patients. Crit. Care Med. 17:489.
10. De Waal Malefyt, R., J. Abrams, B. Bennett, C. G. Figdor, and J. E. de Vries. 1991. Interleukin-10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174:1209.
11. Fiorentino, D. F., A. Zlotnik, T. R. Mosmann, M. Howard, and A. O'Garra. 1991. IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 147:3815.
12. Marchant, A., C. Bruyns, P. Vandenabeele, M. Ducarme, C. Gérard, A. Delvaux, D. De Groote, D. Abramowicz, T. Velu, and M. Goldman. 1994. Interleukin-10 controls interferon-γ and tumor necrosis factor production during experimental endotoxemia. Eur. J. Immunol. 24:1167.
13. Gérard, C., C. Bruyns, A. Marchant, D. Abramowicz, P. Vandenabeele, A. Delvaux, W. Fiers, M. Goldman, and T. Velu. 1993. Interleukin-10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J. Exp. Med. 177:547.
14. Tiegs, G., J. Barsig, B. Matiba, S. Uhlig, and A. Wendel. 1994. Potentiation by granulocyte-macrophage colony-stimulating factor of lipopolysaccharide toxicity in mice. J. Clin. Invest. 93:2616.
15. Young, H. A., and K. I. Hardy. 1995. Role of interferon-γ in immune cell regulation. J. Leukocyte Biol. 58:373.
16. Matic, M., and S. R. Simon. 1992. Effects of interferon-γ on release of tumor necrosis factor alpha from lipopolysaccharide-tolerant human monocyte-derived macrophages. Infect. Immun. 60:3756.
17. Burchett, S. K., W. M. Weaver, J. A. Westall, A. Larsen, S. Kronheim, and C. B. Wilson. 1988. Regulation of tumor necrosis factor/cachectin and IL-1 secretion in human mononuclear phagocytes. J. Immunol. 140:3473.
18. Koerner, T. J., D. O. Adams, and T. A. Hamilton. 1987. Regulation of tumor necrosis factor (TNF) expression: Interferon-γ enhances the accumulation of mRNA for TNF induced by lipopolysaccharide in murine peritoneal macrophages. Cell. Immunol. 109:437.
19. Bone, R. C. 1991. The pathogenesis of sepsis. Ann. Intern. Med. 115:457.
20. Munoz, C., J. Carlet, C. Fitting, B. Misset, J. P. Blériot, and J.-M. Cavaillon. 1991. Dysregulation of in vitro cytokine production by monocytes during sepsis. J. Clin. Invest. 88:1747.
21. Volk, H. D., M. Thieme, U. Ruppe, S. Heym, W.-D. Döcke, D. Manger. S. Zuckermann, A. Golosubow, B. Nieter, H. Klug, and R. von Baehr. 1993. Alterations in function and phenotype of monocytes from patients with septic disease: predictive value and new therapeutic strategies. In Host Defense Dysfunction in Trauma, Shock, and Sepsis, E. Faist and J. L. Meakins, eds. Springer Verlag, Berlin, p. 246-271.
22. Docke, W. D., U. Syrbe, A. Meinecke, C. Platzer, A. Makki, K. Asadullah, C. Klug, H. Zuckermann, P. Reinke, H. Brunner, R. von Baehr, and H. D. Volk. 1994. Improvement of monocytic function: a new therapeutic approach?. In Update in Intensive Care and Emergency Medicine: Sepsis - Current Perspectives in Pathophysiology and Therapy. Vol. 18. K. Reinhart, K. Eyrich, and C. Sprung, eds. Springer Verlag, Berlin, p. 437-500.
23. Randow, F., U. Syrbe, C. Meisel, D. Krausch, H. Zuckermann, C. Platzer, and H. D. Volk. 1995. Mechanism of endotoxin desensitization: involvement of interleukin-10 and transforming growth factor-β. J. Exp. Med. 181:1887.
24. Ertel, W., J.-P. Kremer, J. Kenney, U. Steckholzer, D. Jarrar, O. Trentz, and F. W. Schildberg. 1995. Downregulation of proinflammatory cytokine release in whole blood from septic patients. Blood 85:1341.
25. Beeson, P. B. 1947. Tolerance to bacterial pyrogens. I. Factors influencing its development. J. Exp. Med. 86:29.
26. Mengozzi, M., and P. Ghezzi. 1993. Cytokine down-regulation in endotoxin tolerance. Eur. Cytokine Netw. 4:89.
27. Ayala, A., J. M. Kisala, J. A. Felt, M. M. Perrin, and I. H. Chaudry. 1992. Does endotoxin tolerance prevent the release of inflammatory monokines (interleukin-1, interleukin-6, or tumor necrosis factor) during sepsis? Arch. Surg. 127:191.
28. Cannisira, S. A., A. Rambaldi, D. R. Spriggs, F. Herrmann, D. Kufe, and J. D. Griffin. 1987. Human granulocyte-macrophage colony-stimulating factor induces expression of the tumor necrosis factor gene by the U937 cell line and by normal human monocytes. J. Clin. Invest. 79:1720.
29. Wing, E. J., D. M. Magee, T. L. Kaplan, S. S. Whiteside, and R. K. Shadduck. 1989. Recombinant human granulocyte-macrophage colony-stimulating factor enhances monocyte cytotoxicity and secretion of tumor necrosis factor-α and interferon in cancer patients. Blood 73:643.
30. Cannistra, S. A., E. Vellenga, P. Groshek, A. Rambaldi, and J. D. Griffin. 1988. Human granulocyte-macrophage colony-stimulating factor and interleukin-3 stimulate monocyte cytotoxicity through a tumor necrosis factor-dependent mechanism. Blood 71:672.
31. Hayes, M. P., and K. Zoon. 1993. Priming of human monocytes for enhanced lipopolysaccharide responses: expression of alpha interferon, interferon regulatory factors, and tumor necrosis factor. Infect. Immun. 61:3222.
32. Suk, K., S. D. Somers, and K. L. Erickson. 1993. Regulation of murine macrophage function by IL-4: IL-4 and IFN-γ differentially regulate macrophage tumoricidal activation. Immunology 80:617.
33. Debs, R. J., H J. Fuchs, R. Philip, A. B. Montgomery, E. N. Brunette, D. Liggitt, J. S. Patton, and J. E. Shellito. 1988. Lung-specific delivery of cytokines induces sustained pulmonary and systemic immunomodulation in rats. J. Immunol. 140:3482.
34. Nedwin, G. E., L. P. Svedersky, T. S. Bringman, M. A. Palladino, and D. V. Goeddel. 1985. Effect of interleukin-2. interferon-γ, and mitogens on the production of tumor necrosis factor-α and β. J. Immunol. 135:2492.
35. De Wit, H., W. H. A. Dokter, M. T. Esselink, M. R. Halle, and E. Vellenga. 1993. Interferon-γ enhances the LPS-induced G-CSF gene expression in human adherent monocytes, which is regulated at transcriptional and posttranscriptional levels. Exp. Hematol. 21:785.
36. Haas, J. G., N. Meyer, G. Riethmuller, and H. W. L. Ziegler-Heilbrock. 1990. Inhibition of lipopolysaccharide-induced in vitro desensitization by interferon-γ. Eur. J. Immunol. 20:1181.
37. Mengozzi, M., M. Sironi, M. Gadina, and P. Ghezzi. 1991. Reversal of defective IL-6 production in lipopolysaccharide-tolerant mice by phorbol myristate acetate. J. Immunol. 147:899.
38. Ralph, P., J. Prichard, and M. Cohn. 1975. Reticulum cell sarcoma: an effector cell in antibody-dependent cell-mediated immunity. J. Immunol. 114:898.
39. Ralph, P., and I., Nakoinz. 1975. Phagocytosis and cytolysis by a macrophage tumour and its cloned cell line. Nature 257:393.
40. Gantner, F., M. Leist, A. W. Lohse, P. G. Germann, and G. Tiegs. 1995. Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology 21:190.
41. Leist, M., F. Gantner, S. Jilg, and A. Wendel. 1995. Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release. J. Immunol. 154:1307.
42. Shaffer, J. P. 1986. Modified sequentially rejective multiple test procedures J. Am. Statist. Assoc. 81:826.
43. Berg, D. J., R. Kühn, K. Rajewski, W. Müller, S. Menon, N. Davidson, G. Grünig, and D. Rennick. 1995. Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not the endotoxin tolerance. J. Clin. Invest. 96:2339.
44. Tracey, K. J., Y. Fong, D. G. Hesse, K. R. Manogue, A. T. Lee, G. C. Kuo, S. F. Lowry, and A. Cerami. 1987. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 330:662.
45. Zuckerman, S. H., G. F. Evans, and L. D. Butler. 1991. Endotoxin tolerance: independent regulation of interleukin-1 and tumor necrosis factor expression. Infect. Immun. 59:2774.
46. Zuckerman, S. H., and G. F. Evans. 1992. Endotoxin tolerance: in vivo regulation of tumor necrosis factor and interleukin-1 synthesis is at the transcriptional level. Cell. Immunol. 140:513.
47. Granowitz, E. V., R. Porat, J. W. Mier, S. F. Orencole, G. Kaplanski, E. A. Lynch, K. Ye, E. Vannier, S. M. Wolff, and C. A. Dinarello. 1993. Intravenous endotoxin suppresses the cytokjne response of peripheral blood mononuclear cells of healthy humans. J. Immunol. 151:1634.
48. Rodrick, M. L., N. M. Moss, J. T. Grbic, A. Revhaug, S. T. O'Dwyer, H. R. Michie, D. B. Gough, D. Dubravec, J. McK. Manson, I. B. Saporoschetz, K. H. Collins, A. L. Jordan, D. W. Wilmore, and J. A. Mannick. 1992. Effects of in vivo endotoxin infusions on in vitro cellular immune responses in humans. J. Clin. Immunol. 12:440.
49. Zuckerman, S. H., G. F. Evans, Y. M. Snyder, and W. D. Roeder. 1989. Endotoxin-macrophage interaction: post-translational regulation of tumor necrosis factor expression. J. Immunol. 143:1223.
50. Haslberger, A., T. Sayers, H. Reiter, J. Chung, and E. Schütze. 1988. Reduced release of TNF and PCA from macrophages of tolerant mice. Circ. Shock 26:185.
51. Virca, G. D., S. Y. Kim, K. B. Glaser, and R. J. Ulevitch. 1989. Lipopolysaccharide induces hyporesponsiveness to its own action in RAW 164.7 cells. J. Biol. Chem. 264:21951.
52. Heinzel, F. P. 1990. The role of IFN-γ in the pathology of experimental endotoxemia. J. Immunol. 145:2920.
53. Doherty, G. M., J. R. Lange, H. N. Langstein, H. R. Alexander, C. M. Buresh, and J. A. Norton. 1992. Evidence for IFN-γ as a mediator of the lethality of endotoxin and tumor necrosis factor-a. J. Immunol. 149:1666.
54. Kamijo, R., J. Le, D. Shapiro, E. A. Havell, S. Huang, M. Aguet, M. Bosland, and S. Vilcek. 1993. Mice that lack the interferon-γ receptor have profoundly altered responses to infection with bacillus Calmette-Guérin and subsequent challenge with lipopolysaccharide. J. Exp. Med. 178:1435.
55. Car, B. D., V. M. Eng, B. Schnyder, L. Ozmen, S. Huang, P. Gallay, D. Heumann, M. Aguet, and B. Ryffel. 1994. Interferon-γ receptor deficient mice are resistant to endotoxic shock. J. Exp. Med. 179:1437.
56. Donnelly, R. P., S. L. Freeman, and M. P. Hayes. 1995. Inhibition of IL-10 expression by IFN-γ up-regulates transcription of TNF-α in human monocytes. J. Immunol. 155:1420.
57. Chomarat, P., M.-C. Rissoan, J. Banchereau, and P. Miossec. 1993. Interferon-γ inhibits interleukin-10 production by monocytes. J. Exp. Med. 177:523.
58. Collart, M. A., D. Belin, J.-D. Vassalli, S. de Cossodo, and P. Vassalli. 1986. γ-Interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukjn-1, and urokinase genes, which are controlled by short-lived processors. J. Exp. Med. 164:2113.
59. Devereux, S., D. C. Linch, D. Campos Costa, M. F. Spittle, and A. M. Jelliffe. 1987. Transient leucopenia induced by granulocyte-macrophage colony-stimulating factor. Lancet 2:1523.
60. Lieschke, G. J., and A. W. Burgess. 1992. Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor. N. Engl. J. Med. 327:28.
61. Lieschke, G. J., D. Maher, M. O'Connor, M. Green, W. Sheridan, M. Railings, E. Bonnem, A. W. Burgess, K. McGrath, R. M. Fox, and G. Morstyn. 1990. Phase I study of intravenously administered bacterially synthesized granulocyte-macrophage colony-stimulating factor and comparison with subcutaneous administration. Cancer Res. 50:606.
62. Lieschke, G. J., D. Maher, J. Cebon, M. O'Connor, M. Green, W. Sheridan, A. Boyd, M. Railings, E. Bonnem, D. Metcalf, A. W. Burgess, K. McGrath, R. M. Fox, and G. Morstyn. 1989. Effects of bacterially synthesized recombinant human granulocyte-macrophage colony-stimulating factor in patients with advanced malignancy. Ann. Intern. Med. 110:357.
63. Severen, A., D. Xu, J. Doyle, L. M. C. Leal, C. A. O'Donnell, S. J. Brett, D. W. Moss, and F. Y. Liew. 1993. Pre-exposure of murine macrophages to lipopolysaccharide inhibits the induction of nitric oxide synthase and reduces leishmanicidal activity. Eur. J. Immunol. 23:1711.
64. Thornhill, M. H., and D. O. Haskard. 1990. IL-4 regulates endothelial cell activation by IL-1. tumor necrosis factor, or IFN-γ. J. Immunol. 145:865.
65. Xu, H., J. A. Gonzalo, Y. St. Pierre, I. R. Williams, T. S. Kupper, R. S. Cotran, T. A. Springer, and J.-C. Gutierrez-Ramos. 1994. Leukocytosis and resistance to septic shock in intercellular adhesion molecule-1-deficient mice. J. Exp. Med. 180:95.