Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production

European Journal of Immunology

Volumn 32, Issue 4, 2002, Pages 994-1002

  Demangel, Caroline ^a,b   Bertolino, Patrick ^a   Britton, Warwick J ^a,c  

^a CENTENARY INSTITUTE   (Australia)

^b INSTITUT PASTEUR   (France)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Cell trafficking; Dendritic cell; IL 10; IL 12; Mycobacteria

Indexed keywords

CD4 ANTIGEN; CD40 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; MYCOBACTERIUM ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOCRINE EFFECT; CELL POLARITY; CELL TRANSPORT; CONTROLLED STUDY; DENDRITIC CELL; DOSE RESPONSE; DOWN REGULATION; IMMUNE RESPONSE; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; LYMPHATIC DRAINAGE; MOUSE; MYCOBACTERIOSIS; MYCOBACTERIUM BOVIS; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL; WILD TYPE;

ANIMALS; ANTIGENS, CD40; AUTOCRINE COMMUNICATION; DENDRITIC CELLS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYCOBACTERIUM BOVIS; T-LYMPHOCYTE SUBSETS; TUBERCULOSIS;

EID: 0036235268     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200204)32:4<994::AID-IMMU994>3.0.CO;2-6     Document Type: Article

References (49)

1. Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties
2. Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-γ-dependent and -independent pathways
3. An essential role for IFN-γ in resistance to Mycobacterium tuberculosis infection
4. Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines
5. The role of IL-10 in promoting disease progression in leishmaniasis
6. Increased antimycobacterial immunity in IL-10-deficient mice
7. IL-12: A cytokine at the interface of inflammation and immunity
8. Endogenous inhibition of antimycobacterial immunity by IL-10 varies between mycobacterial species
9. IL-10 gene knockout mice show enhanced Th1-like protective immunity and absent granuloma formation following Chlamydia trachomatis lung infection
10. IL-10 and the IL-10 receptor
11. Suppression of endogenous IL-10 gene expression in dendritic cells enhances antigen presentation for specific Th1 induction: Potential for cellular vaccine development
12. Human dendritic cell (DC)-based anti-infective therapy: Engineering DCs to secrete functional IFN-γ and IL-12
13. Dendritic cell (DC)-based anti-infective strategies: DCs engineered to secrete IL-12 are a potent vaccine in a murine model of an intracellular infection
14. The role of dendritic cells in the induction and regulation of immunity to microbial infection
15. Stimulation of dendritic cells via CD40 enhances immune responses to Mycobacterium tuberculosis infection
16. Mycobacterium tuberculosis-activated dendritic cells induce protective immunity in mice
17. In vivo microbial stimulation induces rapid CD40 ligand-independent production of IL-12 by dendritic cells and their redistribution to T cell areas
18. Paralysis of dendritic cell IL-12 production by microbial products prevents infection-induced immunopathology
19. IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages
20. Human dendritic cell responses to lipopolysaccharide and CD40 ligation are differentially regulated by IL-10
21. Effect of IL-10 on dendritic cell maturation and function
22. Regulatory activity of autocrine IL-10 on dendritic cell functions
23. Activation of human dendritic cells following infection with Mycobacterium tuberculosis
24. Protection against aerosol Mycobacterium tuberculosis infection using Mycobacterium bovis Bacillus Calmette Guerin-infected dendritic cells
25. Interaction of dendritic cells with mycobacteria: Where the action starts
26. Antigen-pulsed CD8α+ dendritic cells generate an immune response after subcutaneous injection without homing to the draining lymph node
27. Infection of human macrophages and dendritic cells with Mycobacterium tuberculosis induces a differential cytokine gene expression that modulates T cell response
28. Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10
29. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
30. Immunology of tuberculosis
31. Toll signaling pathways in the innate immune response
32. Dendritic cells discriminate between yeasts and hyphae of the fungus Candida albicans Implications for initiation of T helper cell immunity in vitro and in vivo J
33. Modulating the immune response with dendritic cells and their growth factors
34. Death, destruction, danger and dendritic cells
35. Dendritic cell activation by danger and antigen-specific T cell signaling
36. +T cells
37. Migration of dendritic cells into the draining lymph nodes of the lung after intratracheal instillation
38. Induction of rapid T cell activation division, and recirculation by intratracheal injection of dendritic cells in a TCR transgenic model
39. T cell priming in situ by intratracheally instilled antigen-pulsed dendritic cells
40. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites
41. Uncoupling of inflammatory chemokine receptors by IL-10: Generation of functional decoys
42. Enhanced epidermal Langerhans cell migration in IL-10 knockout mice
43. IL-10-deficient mice develop chronic enterocolitis
44. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
45. Monoclonal antibodies to murine CD40 define two distinct functional epitopes
46. Dendritic cell subtypes in mouse lymphoid organs: Cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes
47. IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: Evidence for Stat3-dependent and -independent pathways
48. Anti-IL-10 receptor monoclonal antibody is an adjuvant for T helper cell type 1 responses to soluble antigen only in the presence of lipopolysaccharide
49. Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay