The contribution of astrocytes to Alzheimer's disease

Biochemical Society Transactions

Volumn 42, Issue 5, 2014, Pages 1316-1320

  Birch, Amy M ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Alzheimer's disease; Amyloid; Astrocyte; Inflammation; Plasticity.

Indexed keywords

AMYLOID BETA PROTEIN; NERVE PROTEIN;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ASTROCYTE; ASTROCYTOSIS; BLOOD BRAIN BARRIER; CELL DIFFERENTIATION; DISEASE COURSE; GLIA CELL; NERVE CELL PLASTICITY; NERVE DEGENERATION; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PROTEIN DEGRADATION; REVIEW; ANIMAL; GLIOSIS; HUMAN; IMMUNOLOGY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ASTROCYTES; BLOOD-BRAIN BARRIER; GLIOSIS; HUMANS; NERVE TISSUE PROTEINS; NEURONAL PLASTICITY; PROTEOLYSIS;

EID: 84907212784     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20140171     Document Type: Review

References (59)

1. World Health Organization and Alzheimer's Disease International (2012) Dementia: a Public Health Priority, WHO, Geneva
2. Sastre, M., Klockgether, T. and Heneka, M.T. (2006) Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms. Int. J. Dev. Neurosci. 24, 167-176 CrossRef PubMed
3. Blasko, I., Stampfer-Kountchev, M., Robatscher, P., Veerhuis, R., Eikelenboom, P. and Grubeck-Loebenstein, B. (2004) How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes. Aging Cell 3, 169-176 CrossRef PubMed
4. Sastre, M. and Gentleman, S.M. (2010) NSAIDs: how they work and their prospects as therapeutics in Alzheimer's disease. Front. Aging Neurosci. 2, 20 PubMed
5. Lucas, S.M., Rothwell, N.J. and Gibson, R.M. (2006) The role of inflammation in CNS injury and disease. Br. J. Pharmacol. 147, S232-S240 CrossRef PubMed
6. Ogata, K. and Kosaka, T. (2002) Structural and quantitative analysis of astrocytes in the mouse hippocampus. Neuroscience 113, 221-233 CrossRef PubMed
7. Parpura, V., Heneka, M.T., Montana, V., Oliet, S.H., Schousboe, A., Haydon, P.G., Stout, Jr, R.F., Spray, D.C., Reichenbach, A., Pannicke, T. et al. (2012) Glial cells in (patho)physiology. J. Neurochem. 121, 4-27 CrossRef PubMed
8. Sofroniew, M.V. (2009) Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci. 32, 638-647 CrossRef PubMed
9. Wisniewski, H.M. and Wegiel, J. (1991) Spatial relationships between astrocytes and classical plaque components. Neurobiol. Aging 12, 593-600 CrossRef PubMed
10. Akiyama, H., Barger, S., Barnum, S., Bradt, B., Bauer, J., Cole, G.M., Cooper, N.R., Eikelenboom, P., Emmerling, M., Fiebich, B.L. et al. (2000) Inflammation and Alzheimer's disease. Neurobiol. Aging 21, 383-421 CrossRef PubMed
11. SW transgenic mice. Neurobiol. Aging 20, 581-589 CrossRef PubMed
12. Bornemann, K.D., Wiederhold, K.H., Pauli, C., Ermini, F., Stalder, M., Schnell, L., Sommer, B., Jucker, M. and Staufenbiel, M. (2001) Aβ-induced inflammatory processes in microglia cells of APP23 transgenic mice. Am. J. Pathol. 158, 63-73 CrossRef PubMed
13. Parachikova, A.I. (2007) Altered Neuroinflammation Contributes to Cognitive Decline in Alzheimer Disease Patients and a Transgenic Mouse Model of the Disease: Possible Therapeutic Avenues, Ph.D. Thesis, University of California, Irvine, Irvine, CA, U.S.A
14. DeWitt, D.A., Perry, G., Cohen, M., Doller, C. and Silver, J. (1998) Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease. Exp. Neurol. 149, 329-340 CrossRef PubMed
15. Funato, H., Yoshimura, M., Yamazaki, T., Saido, T.C., Ito, Y., Yokofujita, R., Okeda, R. and Ihara, Y. (1998) Astrocytes containing amyloid β-protein (Aβ)-positive granules are associated with Aβ-40-positive diffuse plaques in the aged human brain. Am. J. Pathol. 152, 983-992 PubMed
16. Bsibsi, M., Ravid, R., Gveric, D. and van Noort, J.M. (2002) Broad expression of Toll-like receptors in the human central nervous system. J. Neuropathol. Exp. Neurol. 61, 1013-1021 PubMed
17. Gasque, P., Dean, Y., McGreal, E., Van Beek, J. and Morgan, B. (2000) Complement components of the innate immune system in health and disease in the CNS. Immunopharmacology 49, 171-186 CrossRef PubMed
18. Husemann, J., Loike, J.D., Anankov, R., Febbraio, M. and Silverstein, S.C. (2002) Scavenger receptors in neurobiology and neuropathology: their role on microglia and other cells of the nervous system. Glia 40, 195-205 CrossRef PubMed
19. Ambrosini, E. and Aloisi, F. (2004) Chemokines and glial cells: a complex network in the central nervous system. Neurochem. Res. 29, 1017-1038 CrossRef PubMed
20. Webster, B., Hansen, L., Adame, A., Crews, L., Torrance, M., Thal, L. and Masliah, E. (2006) Astroglial activation of extracellular-regulated kinase in early stages of Alzheimer disease. J. Neuropathol. Exp. Neurol. 65, 142-151 CrossRef PubMed
21. Maragakis, N.J. and Rothstein, J.D. (2006) Mechanisms of disease: astrocytes in neurodegenerative disease. Nat. Clin. Pract. Neurol. 2, 679-689 CrossRef PubMed
22. Furman, J., Sama, D., Gant, J., Beckett, T., Murphy, M., Bachstetter, A., Van Eldik, L. and Norris, C. (2012) Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease. J. Neurosci. 32, 16129-16140 CrossRef PubMed
23. Abdul, H.M., Sama, M.A., Furman, J.L., Mathis, D.M., Beckett, T.L., Weidner, A.M., Patel, E.S., Baig, I., Murphy, M.P. and LeVine, III, H. (2009) Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling. J. Neurosci. 29, 12957-12969 CrossRef PubMed
24. 1-antichymotrypsin enhances Alzheimer-like pathology in amyloid protein precursor transgenic mice. Am. J. Pathol. 157, 2003-2010 CrossRef PubMed
25. 1-Antichymotrypsin promotes β-sheet amyloid plaque deposition in a transgenic mouse model of Alzheimer's disease. J. Neurosci. 21, 1444-1451 PubMed
26. 1-Antichymotrypsin, an inflammatory protein overexpressed in Alzheimer's disease brain, induces tau phosphorylation in neurons. Brain 129, 3020-3034 CrossRef PubMed
27. Zhao, J., O'Connor, T. and Vassar, R. (2011) The contribution of activated astrocytes to Aβ production: implications for Alzheimer's disease pathogenesis. J. Neuroinflamm. 8, 150 CrossRef
28. Kraft, A.W., Hu, X., Yoon, H., Yan, P., Xiao, Q., Wang, Y., Gil, S.C., Brown, J., Wilhelmsson, U., Restivo, J.L. et al. (2013) Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice. FASEB J. 27, 187-198 CrossRef PubMed
29. Dorfman, V.B., Pasquini, L., Riudavets, M., López-Costa, J.J., Villegas, A., Troncoso, J.C., Lopera, F., Castaño, E.M. and Morelli, L. (2010) Differential cerebral deposition of IDE and NEP in sporadic and familial Alzheimer's disease. Neurobiol. Aging 31, 1743-1757 CrossRef PubMed
30. Koistinaho, M., Lin, S., Wu, X., Esterman, M., Koger, D., Hanson, J., Higgs, R., Liu, F., Malkani, S., Bales, K.R. and Paul, S.M. (2004) Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides. Nat. Med. 10, 719-726 CrossRef PubMed
31. Pihlaja, R., Koistinaho, J., Kauppinen, R., Sandholm, J., Tanila, H. and Koistinaho, M. (2011) Multiple cellular and molecular mechanisms are involved in human Aβ clearance by transplanted adult astrocytes. Glia 59, 1643-1657 CrossRef PubMed
32. Yin, K.J., Cirrito, J.R., Yan, P., Hu, X., Xiao, Q., Pan, X., Bateman, R., Song, H., Hsu, F.F., Turk, J. et al. (2006) Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-β peptide catabolism. J. Neurosci. 26, 10939-10948 CrossRef PubMed
33. Carson, J.A. and Turner, A.J. (2002) β-Amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases? J. Neurochem. 81, 1-8 CrossRef
34. Leal, M.C., Dorfman, V.B., Gamba, A.F., Frangione, B., Wisniewski, T., Castaño, E.M., Sigurdsson, E.M. and Morelli, L. (2006) Plaque-associated overexpression of insulin-degrading enzyme in the cerebral cortex of aged transgenic Tg2576 mice with Alzheimer pathology. J. Neuropathol. Exp. Neurol. 65, 976-987 CrossRef PubMed
35. 1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition. Nat. Med. 6, 143-150 CrossRef PubMed
36. Leissring, M.A., Farris, W., Chang, A.Y., Walsh, D.M., Wu, X., Sun, X., Frosch, M.P. and Selkoe, D.J. (2003) Enhanced proteolysis of β-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron 40, 1087-1093 CrossRef PubMed
37. Marr, R.A., Rockenstein, E., Mukherjee, A., Kindy, M.S., Hersh, L.B., Gage, F.H., Verma, I.M. and Masliah, E. (2003) Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. J. Neurosci. 23, 1992-1996 PubMed
38. Bu, G. (2009) Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy. Nat. Rev. Neurosci. 10, 333-344 CrossRef PubMed
39. Bertram, L. and Tanzi, R.E. (2008) Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses. Nat. Rev. Neurosci. 9, 768-778 CrossRef PubMed
40. Ye, S., Huang, Y., Müllendorff, K., Dong, L., Giedt, G., Meng, E.C., Cohen, F.E., Kuntz, I.D., Weisgraber, K.H. and Mahley, R.W. (2005) Apolipoprotein (apo) E4 enhances amyloid β peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target. Proc. Natl. Acad. Sci. U.S.A. 102, 18700-18705 CrossRef PubMed
41. Holtzman, D.M., Bales, K.R., Tenkova, T., Fagan, A.M., Parsadanian, M., Sartorius, L.J., Mackey, B., Olney, J., McKeel, D., Wozniak, D. and Paul, S.M. (2000) Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 97, 2892-2897 CrossRef PubMed
42. 42 and improves memory in the Tg2576 mouse model of Alzheimer's disease. Mol. Cell. Neurosci. 34, 621-628 CrossRef PubMed
43. Basak, J.M., Verghese, P.B., Yoon, H., Kim, J. and Holtzman, D.M. (2012) Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes. J. Biol. Chem. 287, 13959-13971 CrossRef PubMed
44. Narayan, P., Holmström, K. M., Kim, D.-H., Whitcomb, D. J., Wilson, M. R., St. George-Hyslop, P., Wood, N. W., Dobson, C. M., Cho, K., Abramov, A. Y. and Klenerman, D. (2014) Rare individual amyloid-β oligomers act on astrocytes to initiate neuronal damage. Biochemistry 53, 2442-2453 PubMed
45. Schwartz, M., Kipnis, J., Rivest, S. and Prat, A. (2013) How do immune cells support and shape the brain in health, disease, and aging? J. Neurosci. 33, 17587-17596 CrossRef
46. Zlokovic, B.V. (2004) Clearing amyloid through the blood-brain barrier. J. Neurochem. 89, 807-811 CrossRef PubMed
47. Zlokovic, B.V. (2005) Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci. 28, 202-208 CrossRef PubMed
48. Yang, G.Y., Gong, C., Qin, Z., Liu, X.-H. and Lorris Betz, A. (1999) Tumor necrosis factor α expression produces increased blood-brain barrier permeability following temporary focal cerebral ischemia in mice. Brain Res. Mol. Brain Res. 69, 135-143 CrossRef PubMed
49. Yan, S.D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J. et al. (1996) RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease. Nature 382, 685-691 CrossRef PubMed
50. Deane, R., Du Yan, S., Submamaryan, R.K., LaRue, B., Jovanovic, S., Hogg, E., Welch, D., Manness, L., Lin, C., Yu, J. et al. (2003) RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat. Med. 9, 907-913 CrossRef PubMed
51. Deane, R., Singh, I., Sagare, A.P., Bell, R.D., Ross, N.T., LaRue, B., Love, R., Perry, S., Paquette, N., Deane, R.J. et al. (2012) A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J. Clin. Invest. 122, 1377-1392 CrossRef PubMed
52. Allaman, I., Bélanger, M. and Magistretti, P.J. (2011) Astrocyte-neuron metabolic relationships: for better and for worse. Trends Neurosci. 34, 76-87 CrossRef PubMed
53. Chung, W.S., Clarke, L.E., Wang, G.X., Stafford, B.K., Sher, A., Chakraborty, C., Joung, J., Foo, L.C., Thompson, A., Chen, C. et al. (2013) Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways. Nature 504, 394-400 CrossRef PubMed
54. Bramham, C.R. and Messaoudi, E. (2005) BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog. Neurobiol. 76, 99-125 CrossRef PubMed
55. Conner, J.M., Franks, K.M., Titterness, A.K., Russell, K., Merrill, D.A., Christie, B.R., Sejnowski, T.J. and Tuszynski, M.H. (2009) NGF is essential for hippocampal plasticity and learning. J. Neurosci. 29, 10883-10889 CrossRef PubMed
56. Han, X., Chen, M., Wang, F., Windrem, M., Wang, S., Shanz, S., Xu, Q., Oberheim, N.A., Bekar, L., Betstadt, S. et al. (2013) Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice. Cell Stem Cell 12, 342-353 CrossRef PubMed
57. Mattson, M.P. and Chan, S.L. (2001) Dysregulation of cellular calcium homeostasis in Alzheimer's disease: bad genes and bad habits. J. Mol. Neurosci. 17, 205-224 CrossRef PubMed
58. Haughey, N.J. and Mattson, M.P. (2003) Alzheimer's amyloid β-peptide enhances ATP/gap junction-mediated calcium-wave propagation in astrocytes. Neuromol. Med. 3, 173-180 CrossRef
59. Gilat-Frenkel, M., Boehm-Cagan, A., Liraz, O., Xian, X., Herz, J. and Michaelson, D. M. (2014) Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo. Curr. Alzheimer Res. 11, 549-557 PubMed