-
1
-
-
7944231119
-
Gene expression profiling of advanced ovarian cancer: Characterization of a molecular signature involving fibroblast growth factor 2
-
DOI 10.1038/sj.onc.1207979
-
De Cecco L, Marchionni L, Gariboldi M, Reid JF, Lagonigro MS, Caramuta S, Ferrario C, Bussani E, Mezzanzanica D, Turatti F, Delia D, Daidone MG, Oggionni M, Bertuletti N, Ditto A, Raspagliesi F, Pilotti S, Pierotti MA, Canevari S and Schneider C: Gene expression profiling of advanced ovarian cancer: characterization of a molecular signature involving fibroblast growth factor 2. Oncogene 23: 8171-8183, 2004. (Pubitemid 39531858)
-
(2004)
Oncogene
, vol.23
, Issue.49
, pp. 8171-8183
-
-
De Cecco, L.1
Marchionni, L.2
Gariboldi, M.3
Reid, J.F.4
Lagonigro, M.S.5
Caramuta, S.6
Ferrario, C.7
Bussani, E.8
Mezzanzanica, D.9
Turatti, F.10
Delia, D.11
Daidone, M.G.12
Oggionni, M.13
Bertuletti, N.14
Ditto, A.15
Raspagliesi, F.16
Pilotti, S.17
Pierotti, M.A.18
Canevari, S.19
Schneider, C.20
more..
-
2
-
-
33750089285
-
Phosphorylated 4E binding protein 1: A hallmark of cell signaling that correlates with survival in ovarian cancer
-
Castellvi J, Garcia A, Rojo F, Ruiz-Marcellan C, Gil A, Baselga J and Ramon y Cajal S: Phosphorylated 4E binding protein 1 : a hallmark of cell signaling that correlates with survival in ovarian cancer. Cancer 107: 1801-1811, 2006.
-
(2006)
Cancer
, vol.107
, pp. 1801-1811
-
-
Castellvi, J.1
Garcia, A.2
Rojo, F.3
Ruiz-Marcellan, C.4
Gil, A.5
Baselga, J.6
Ramon Y Cajal, S.7
-
3
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay N and Sonenberg N: Upstream and downstream of mTOR. Genes Dev 18: 1926-1945, 2004.
-
(2004)
Genes Dev
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
4
-
-
60749137451
-
Beyond chemotherapy: Targeted therapies in ovarian cancer
-
Yap TA, Carden CP and Kaye SB: Beyond chemotherapy: targeted therapies in ovarian cancer. Nature Rev Cancer 9: 167-181, 2009.
-
(2009)
Nature Rev Cancer
, vol.9
, pp. 167-181
-
-
Yap, T.A.1
Carden, C.P.2
Kaye, S.B.3
-
5
-
-
0043240182
-
Ovarian cancer: Strategies for overcoming resistance to chemotherapy
-
Agarwal R and Kaye SB: Ovarian cancer: strategies for overcoming resistance to chemotherapy. Nature Rev Cancer 5: 502-516, 2003. (Pubitemid 37328838)
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.7
, pp. 502-516
-
-
Agarwal, R.1
Kaye, S.B.2
-
7
-
-
0032883001
-
Molecular effects of paclitaxel: Myths and reality (a critical review)
-
Blagosklonny MV and Fojo T: Molecular effects of paclitaxel: myths and reality (a critical review). Int J Cancer 83: 151-156, 1999.
-
(1999)
Int J Cancer
, vol.83
, pp. 151-156
-
-
Blagosklonny, M.V.1
Fojo, T.2
-
8
-
-
0033052777
-
Mechanisms of action of and resistance to antitubulin agents: Microtubule dynamics, drug transport, and cell death
-
Dumontet C and Sikic BI: Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport, and cell death. J Clin Oncol 17: 1061-1070, 1999.
-
(1999)
J Clin Oncol
, vol.17
, pp. 1061-1070
-
-
Dumontet, C.1
Sikic, B.I.2
-
9
-
-
0036727801
-
Microtubule alterations and resistance to tubulin-binding agents
-
Drukman S and Kavallaris M: Microtubule alterations and resistance to tubulin-binding agents. Int J Oncol 21: 621-628, 2002.
-
(2002)
Int J Oncol
, vol.21
, pp. 621-628
-
-
Drukman, S.1
Kavallaris, M.2
-
10
-
-
43949138899
-
Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer
-
Coley HM: Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer. Cancer Treat Rev 34: 378-390, 2008.
-
(2008)
Cancer Treat Rev
, vol.34
, pp. 378-390
-
-
Coley, H.M.1
-
11
-
-
34047253075
-
RAD001 (Everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer
-
Mabuchi S, Altomare DA, Connolly DC, Klein-Szanto A, Litwin S, Hoelzle MK, Hensley HH, Hamilton TC and Testa JR: RAD001 (Everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer. Cancer Res 67: 2408-2413, 2007.
-
(2007)
Cancer Res
, vol.67
, pp. 2408-2413
-
-
Mabuchi, S.1
Altomare, D.A.2
Connolly, D.C.3
Klein-Szanto, A.4
Litwin, S.5
Hoelzle, M.K.6
Hensley, H.H.7
Hamilton, T.C.8
Testa, J.R.9
-
12
-
-
33646197484
-
Inhibition of the mammalian target of rapamycin (mTOR) by rapamycin increases chemosensitivity of CaSki cells to paclitaxel
-
Faried LS, Faried A, Kanuma T, Nakazato T, Tamura T, Kuwano H and Minegishi T: Inhibition of the mammalian target of rapamycin (mTOR) by rapamycin increases chemosensitivity of CaSki cells to paclitaxel. Eur J Cancer 42: 934-947, 2006.
-
(2006)
Eur J Cancer
, vol.42
, pp. 934-947
-
-
Faried, L.S.1
Faried, A.2
Kanuma, T.3
Nakazato, T.4
Tamura, T.5
Kuwano, H.6
Minegishi, T.7
-
13
-
-
34247880280
-
Akt involvement in paclitaxel chemoresistance of human ovarian cancer cells
-
DOI 10.1196/annals.1397.012, Signal Transduction Pathways, Part C: Cell Signaling in Health and Disease
-
Kim SH, Juhnn YS and Song YS: Akt involvement in paclitaxel chemoresistance of human ovarian cancer cells. Ann NY Acad Sci 1095: 82-89, 2007. (Pubitemid 47092440)
-
(2007)
Annals of the New York Academy of Sciences
, vol.1095
, pp. 82-89
-
-
Kim, S.-H.1
Juhnn, Y.-S.2
Song, Y.-S.3
-
14
-
-
2342559981
-
The TOR pathway: A target for cancer therapy
-
Bjornsti MA and Houghton PJ: The TOR pathway: a target for cancer therapy. Nat Rev Cancer 4: 335-348, 2004.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 335-348
-
-
Bjornsti, M.A.1
Houghton, P.J.2
-
15
-
-
4644239244
-
Mammalian target of rapamycin inhibition
-
Dutcher JP: Mammalian target of rapamycin inhibition. Clin Cancer Res 10: 6382-7S, 2004.
-
(2004)
Clin Cancer Res
, vol.10
-
-
Dutcher, J.P.1
-
16
-
-
16344387594
-
AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth
-
Altomare DA, Wang HQ, Skele KL, De Rienzo A, Klein-Szanto AJ, Godwin AK and Testa JR: AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth. Oncogene 5: 853-857, 2004.
-
(2004)
Oncogene
, vol.5
, pp. 853-857
-
-
Altomare, D.A.1
Wang, H.Q.2
Skele, K.L.3
De Rienzo, A.4
Klein-Szanto, A.J.5
Godwin, A.K.6
Testa, J.R.7
-
17
-
-
33750285711
-
Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway
-
DOI 10.1016/j.cellsig.2006.05.019, PII S0898656806001124
-
Meng Q, Xia C, Fang J, Rojanasakul Y and Jiang BH: Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway. Cell Signal 18: 2262-2271, 2006. (Pubitemid 44636166)
-
(2006)
Cellular Signalling
, vol.18
, Issue.12
, pp. 2262-2271
-
-
Meng, Q.1
Xia, C.2
Fang, J.3
Rojanasakul, Y.4
Jiang, B.-H.5
-
18
-
-
0036225178
-
Inhibitors of mammalian target of rapamycin as novel antitumor agents: From bench to clinic
-
Huang S and Houghton PJ: Inhibitors of mammalian target of rapamycin as novel antitumor agents: from bench to clinic. Curr Opin Investig Drugs 3: 295-304, 2002.
-
(2002)
Curr Opin Investig Drugs
, vol.3
, pp. 295-304
-
-
Huang, S.1
Houghton, P.J.2
-
19
-
-
43749116022
-
Antiproliferative effects of rapamycin as a single agent and in combination with carboplatin and paclitaxel in head and neck cancer cell lines
-
Aissat N, Le Tourneau C, Ghoul A, Serova M, Bieche I, Lokiec F, Raymond E and Faivre S: Antiproliferative effects of rapamycin as a single agent and in combination with carboplatin and paclitaxel in head and neck cancer cell lines. Cancer Chemother Pharmacol 62: 305-313, 2008.
-
(2008)
Cancer Chemother Pharmacol
, vol.62
, pp. 305-313
-
-
Aissat, N.1
Le Tourneau, C.2
Ghoul, A.3
Serova, M.4
Bieche, I.5
Lokiec, F.6
Raymond, E.7
Faivre, S.8
-
20
-
-
67249108485
-
Induction effect of rapamycin combined paclitaxel on apoptosis of ovarian cancer cell lines A2780 and SKOV3 and the molecular mechanism
-
Ma XY, Wang SX, Liu Y, Liu RH, Lu YP and Ma D: Induction effect of rapamycin combined paclitaxel on apoptosis of ovarian cancer cell lines A2780 and SKOV3 and the molecular mechanism. Ai Zheng 26: 367-370, 2007.
-
(2007)
Ai Zheng
, vol.26
, pp. 367-370
-
-
Ma, X.Y.1
Wang, S.X.2
Liu, Y.3
Liu, R.H.4
Lu, Y.P.5
Ma, D.6
-
21
-
-
33750211376
-
Predicted mechanisms of resistance to mTOR inhibitors
-
Kurmasheva RT, Huang S and Houghton PJ: Predicted mechanisms of resistance to mTOR inhibitors Br J Cancer 95: 955-960, 2006.
-
(2006)
Br J Cancer
, vol.95
, pp. 955-960
-
-
Kurmasheva, R.T.1
Huang, S.2
Houghton, P.J.3
-
22
-
-
33745903146
-
Effects of a combined treatment with mTOR inhibitor RAD001 and tamoxifen in vitro on growth and apoptosis of human cancer cells
-
Treeck O, Wackwitz B, Haus U and Ortmann O: Effects of a combined treatment with mTOR inhibitor RAD001 and tamoxifen in vitro on growth and apoptosis of human cancer cells. Gynecol Oncol 102: 292-299, 2006.
-
(2006)
Gynecol Oncol
, vol.102
, pp. 292-299
-
-
Treeck, O.1
Wackwitz, B.2
Haus, U.3
Ortmann, O.4
-
23
-
-
67349241955
-
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
-
Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, Gray NS and Sabatini DM: DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 137: 873-886, 2009.
-
(2009)
Cell
, vol.137
, pp. 873-886
-
-
Peterson, T.R.1
Laplante, M.2
Thoreen, C.C.3
Sancak, Y.4
Kang, S.A.5
Kuehl, W.M.6
Gray, N.S.7
Sabatini, D.M.8
-
24
-
-
33846318172
-
Expression and activity of mTOR and its substrates in different cell cycle phases and in oral squamous cell carcinomas of different malignant grade
-
DOI 10.1002/cbf.1332
-
Liu Y, Hidayat S, Su WH, Deng X, Yu DH and Yu BZ: Expression and activity of mTOR and its substrates in different cell cycle phases and in oral squamous cell carcinomas of different malignant grade. Cell Biochem Funct 25: 45-53, 2007. (Pubitemid 46121783)
-
(2007)
Cell Biochemistry and Function
, vol.25
, Issue.1
, pp. 45-53
-
-
Liu, Y.1
Hidayat, S.2
Su, W.-H.3
Deng, X.4
Yu, D.-H.5
Yu, B.-Z.6
-
25
-
-
62449320537
-
Kinetics of the in vivo expression of glucocorticoid receptor splice variants during prednisone treatment in childhood acute lymphoblastic leukaemia
-
Lauten M, Fernandez-Munoz I, Gerdes K, von Neuhoff N, Weite K, Schlegelberger B, Schrappe M and Beger C: Kinetics of the in vivo expression of glucocorticoid receptor splice variants during prednisone treatment in childhood acute lymphoblastic leukaemia. Pediatr Blood Cancer 2: 459-463, 2009.
-
(2009)
Pediatr Blood Cancer
, vol.2
, pp. 459-463
-
-
Lauten, M.1
Fernandez-Munoz, I.2
Gerdes, K.3
Von Neuhoff, N.4
Weite, K.5
Schlegelberger, B.6
Schrappe, M.7
Beger, C.8
-
26
-
-
0034458448
-
Signal transduction characteristics of the corticotropin-releasing hormone receptors in the feto-placental unit
-
Karteris E, Grammatopoulos D, Randeva H and Hillhouse EW: Signal transduction characteristics of the corticotropin-releasing hormone receptors in the feto-placental unit. J Clin Endocrinol Metab 85: 1989-1996, 2000.
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 1989-1996
-
-
Karteris, E.1
Grammatopoulos, D.2
Randeva, H.3
Hillhouse, E.W.4
-
27
-
-
33748589186
-
Receptor tyrosine kinase (RTK) inhibition is effective in chemosensitising EGFR-expressing drug resistant human ovarian cancer cell lines when used in combination with cytotoxic agents
-
Coley HM, Shotton CF, Ajose-Adeogun A, Modjtahedi H, Thomas H: Receptor tyrosine kinase (RTK) inhibition is effective in chemosensitising EGFR-expressing drug resistant human ovarian cancer cell lines when used in combination with cytotoxic agents. Biochem Pharmacol 72: 941-948, 2006.
-
(2006)
Biochem Pharmacol
, vol.72
, pp. 941-948
-
-
Coley, H.M.1
Shotton, C.F.2
Ajose-Adeogun, A.3
Modjtahedi, H.4
Thomas, H.5
-
28
-
-
34347211057
-
Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth
-
Roos S, Jansson N, Palmberg I, Säljö K, Powell TL and Jansson T: Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth. J Physiol 582: 449-459, 2007.
-
(2007)
J Physiol
, vol.582
, pp. 449-459
-
-
Roos, S.1
Jansson, N.2
Palmberg, I.3
Säljö, K.4
Powell, T.L.5
Jansson, T.6
-
29
-
-
33646341231
-
A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1
-
Bachmann RA, Kim JH, Wu AL, Park IH and Chen J: A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1. J Biol Chem 281: 7357-7363, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 7357-7363
-
-
Bachmann, R.A.1
Kim, J.H.2
Wu, A.L.3
Park, I.H.4
Chen, J.5
-
30
-
-
0037205409
-
Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site
-
Saitoh M, Pullen N, Brenman P, Centrell D and Dennis PB: Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site. J Biol Chem 277: 20104-20202, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 20104-20202
-
-
Saitoh, M.1
Pullen, N.2
Brenman, P.3
Centrell, D.4
Dennis, P.B.5
|