Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells

Autophagy

Volumn 10, Issue 9, 2014, Pages 1495-1508

  Xie, Chuan Ming ^a   Liu, Xiao Yu ^a   Sham, Kathy W Y ^a   Lai, Josie M Y ^a   Cheng, Christopher H K ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

AMPK; ATG; Autophagy; Cancer growth; Cell survival; Colon cancer; Elongation factor 2 kinase; MTOR; ROS; ULK1

Indexed keywords

8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; BECLIN 1; ELONGATION FACTOR 2 KINASE; EUKARYOTIC ELONGATION FACTOR 2 KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; OXALIPLATIN; PROTEIN KINASE; SMALL INTERFERING RNA; UNC 51 LIKE AUTOPHAGY ACTIVATING KINASE 1; UNCLASSIFIED DRUG; FUSED HETEROCYCLIC RINGS; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; ULK1 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL; CELL PROLIFERATION; CELL SIZE; CELL SURVIVAL; CELL VIABILITY; CLONOGENESIS; COLON CANCER; CONTROLLED STUDY; HCT116 CELL LINE; HT 29 CELL LINE; HUMAN; HUMAN CELL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; UPREGULATION; COLONIC NEOPLASMS; DRUG EFFECTS; GENE SILENCING; GENETICS; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

EUKARYOTA;

AMP-ACTIVATED PROTEIN KINASES; AUTOPHAGY; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COLONIC NEOPLASMS; ELONGATION FACTOR 2 KINASE; GENE SILENCING; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION;

EID: 84907184381     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.29164     Document Type: Article

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