-
1
-
-
0037564210
-
Myocardial Na, K-ATPase and digoxin therapy in human heart failure
-
Kjeldsen, K. et al. (2003) Myocardial Na, K-ATPase and digoxin therapy in human heart failure. Ann. N. Y. Acad. Sci., 986, 702-707.
-
(2003)
Ann. N. Y. Acad. Sci.
, vol.986
, pp. 702-707
-
-
Kjeldsen, K.1
-
2
-
-
0036106788
-
Endogenous cardiac glycosides, a new class of steroid hormones
-
Schoner, W. (2002) Endogenous cardiac glycosides, a new class of steroid hormones. Eur. J. Biochem., 269, 2440-2448.
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 2440-2448
-
-
Schoner, W.1
-
3
-
-
84859627519
-
Systemic hypertension: the roles of salt, vascular Na+/K+ ATPase and the endogenous glycosides, ouabain and marinobufagenin
-
Hauck, C., et al. (2012) Systemic hypertension: the roles of salt, vascular Na+/K+ ATPase and the endogenous glycosides, ouabain and marinobufagenin. Cardiol. Rev., 20, 130-138.
-
(2012)
Cardiol. Rev.
, vol.20
, pp. 130-138
-
-
Hauck, C.1
-
4
-
-
79954416133
-
Cardiotonic steroids attenuate ERK phosphorylation and generate cell cycle arrest to block human hepatoma cell growth
-
Xu, Z.W., et al. (2011) Cardiotonic steroids attenuate ERK phosphorylation and generate cell cycle arrest to block human hepatoma cell growth. J. Steroid Biochem. Mol. Biol., 125, 181-191.
-
(2011)
J. Steroid Biochem. Mol. Biol.
, vol.125
, pp. 181-191
-
-
Xu, Z.W.1
-
5
-
-
68849107545
-
Oleandrin-mediated inhibition of human tumor cell proliferation: importance of Na, K-ATPase alpha subunits as drug targets
-
Yang, P., et al. (2009) Oleandrin-mediated inhibition of human tumor cell proliferation: importance of Na, K-ATPase alpha subunits as drug targets. Mol. Cancer Ther., 8, 2319-2328.
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 2319-2328
-
-
Yang, P.1
-
6
-
-
0034660878
-
Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells
-
McConkey, D.J., et al. (2000) Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells. Cancer Res., 60, 3807-3812.
-
(2000)
Cancer Res.
, vol.60
, pp. 3807-3812
-
-
McConkey, D.J.1
-
7
-
-
80052267544
-
Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation
-
Xie, C.M., et al. (2011) Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation. Free Radic. Biol. Med., 51, 1365-1375.
-
(2011)
Free Radic. Biol. Med.
, vol.51
, pp. 1365-1375
-
-
Xie, C.M.1
-
8
-
-
43049151493
-
Polo on the rise-from mitotic entry to cytokinesis with Plk1
-
Petronczki, M., et al. (2008) Polo on the rise-from mitotic entry to cytokinesis with Plk1. Dev. Cell, 14, 646-659.
-
(2008)
Dev. Cell
, vol.14
, pp. 646-659
-
-
Petronczki, M.1
-
9
-
-
2942615282
-
Polo-like kinases and the orchestration of cell division
-
Barr, F.A., et al. (2004) Polo-like kinases and the orchestration of cell division. Nat. Rev. Mol. Cell Biol., 5, 429-440.
-
(2004)
Nat. Rev. Mol. Cell Biol.
, vol.5
, pp. 429-440
-
-
Barr, F.A.1
-
10
-
-
33745176774
-
Polo-like kinases, a team in control of the division
-
Van de Weerdt, B.C., et al. (2006) Polo-like kinases, a team in control of the division. Cell Cycle, 5, 853-864.
-
(2006)
Cell Cycle
, vol.5
, pp. 853-864
-
-
Van de Weerdt, B.C.1
-
11
-
-
4644266184
-
Roles of polo-like kinase 1 in the assembly of functional mitotic spindles
-
Sumara, I., et al. (2004) Roles of polo-like kinase 1 in the assembly of functional mitotic spindles. Curr. Biol., 14, 1712-1722.
-
(2004)
Curr. Biol.
, vol.14
, pp. 1712-1722
-
-
Sumara, I.1
-
12
-
-
0035858876
-
Metaphase arrest with centromere separation in polo mutants of Drosophila
-
Donaldson, M.M., et al. (2001) Metaphase arrest with centromere separation in polo mutants of Drosophila. J. Cell Biol., 153, 663-676.
-
(2001)
J. Cell Biol.
, vol.153
, pp. 663-676
-
-
Donaldson, M.M.1
-
13
-
-
51549085203
-
Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora
-
Chan, E.H., et al. (2008) Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora. Chromosoma, 117, 457-469.
-
(2008)
Chromosoma
, vol.117
, pp. 457-469
-
-
Chan, E.H.1
-
14
-
-
0035072802
-
Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes
-
do Carmo Avides, M., et al. (2001) Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes. Nat. Cell Biol., 3, 421-424.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 421-424
-
-
do Carmo Avides, M.1
-
15
-
-
78951494833
-
Aurora B kinase activation requires survivin priming phosphorylation by PLK1
-
Chu, Y., et al. (2011) Aurora B kinase activation requires survivin priming phosphorylation by PLK1. J. Mol. Cell Biol., 3, 260-267.
-
(2011)
J. Mol. Cell Biol.
, vol.3
, pp. 260-267
-
-
Chu, Y.1
-
16
-
-
0029008281
-
The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells
-
Ohkura, H., et al. (1995) The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells. Genes Dev., 9, 1059-1073.
-
(1995)
Genes Dev.
, vol.9
, pp. 1059-1073
-
-
Ohkura, H.1
-
17
-
-
2442455744
-
Increased nuclear factor-kB activation in human colorectal carcinoma and its correlation with tumor progression
-
Kojima, M., et al. (2004) Increased nuclear factor-kB activation in human colorectal carcinoma and its correlation with tumor progression. Anticancer Res., 24, 675-681.
-
(2004)
Anticancer Res.
, vol.24
, pp. 675-681
-
-
Kojima, M.1
-
18
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
Zhong, H., et al. (1999) Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res., 59, 5830-5835.
-
(1999)
Cancer Res.
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
-
19
-
-
84865536482
-
HIF-1a-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism
-
Fu, L., et al. (2012) HIF-1a-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism. Carcinogenesis, 33, 1664-1673.
-
(2012)
Carcinogenesis
, vol.33
, pp. 1664-1673
-
-
Fu, L.1
-
20
-
-
79960311482
-
PLK1 Is transcriptionally activated by NF-κB during cell detachment and enhances anoikis resistance through inhibiting β-catenin degradation in esophageal squamous cell carcinoma
-
Lin, D.C., et al. (2011) PLK1 Is transcriptionally activated by NF-κB during cell detachment and enhances anoikis resistance through inhibiting β-catenin degradation in esophageal squamous cell carcinoma. Clin. Cancer Res., 17, 4285-4295.
-
(2011)
Clin. Cancer Res.
, vol.17
, pp. 4285-4295
-
-
Lin, D.C.1
-
21
-
-
34249825771
-
The alpha1 subunit of the sodium pump could represent a novel target to combat non-small cell lung cancers
-
Mijatovic, T., et al. (2007) The alpha1 subunit of the sodium pump could represent a novel target to combat non-small cell lung cancers. J. Pathol., 212, 170-179.
-
(2007)
J. Pathol.
, vol.212
, pp. 170-179
-
-
Mijatovic, T.1
-
22
-
-
33748754439
-
Pro-inflammatory cytokine tumor necrosis factoralpha induces bone morphogenetic protein-2 in chondrocytes via mRNA stabilization and transcriptional up-regulation
-
Fukui, N., et al. (2006) Pro-inflammatory cytokine tumor necrosis factoralpha induces bone morphogenetic protein-2 in chondrocytes via mRNA stabilization and transcriptional up-regulation. J. Biol. Chem., 281, 27229-27241.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 27229-27241
-
-
Fukui, N.1
-
23
-
-
78149316509
-
Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection
-
Newton, I.P., et al. (2010) Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection. Mol. Biol. Cell, 21, 3630-3638.
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 3630-3638
-
-
Newton, I.P.1
-
24
-
-
13244258316
-
Regulation of cell cycle checkpoints by polo-like kinases
-
Xie, S., et al. (2005) Regulation of cell cycle checkpoints by polo-like kinases. Oncogene, 24, 277-286.
-
(2005)
Oncogene
, vol.24
, pp. 277-286
-
-
Xie, S.1
-
25
-
-
0036725627
-
Cardiac glycosides induce resistance to tubulindependent anticancer drugs in androgen-independent human prostate cancer
-
Huang, D.M., et al. (2002) Cardiac glycosides induce resistance to tubulindependent anticancer drugs in androgen-independent human prostate cancer. J. Biomed. Sci., 9, 443-452.
-
(2002)
J. Biomed. Sci.
, vol.9
, pp. 443-452
-
-
Huang, D.M.1
-
26
-
-
84855431152
-
Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells
-
Elbaz, H.A., et al. (2012) Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells. Toxicol. Appl. Pharmacol., 258, 51-60.
-
(2012)
Toxicol. Appl. Pharmacol.
, vol.258
, pp. 51-60
-
-
Elbaz, H.A.1
-
27
-
-
0027933414
-
Cell cycle arrest and protein kinase modulating effect of bufalin on human leukemia ML1 cells
-
Jing, Y., et al. (1994) Cell cycle arrest and protein kinase modulating effect of bufalin on human leukemia ML1 cells. Anticancer Res., 14, 1193-1198.
-
(1994)
Anticancer Res.
, vol.14
, pp. 1193-1198
-
-
Jing, Y.1
-
28
-
-
84855288196
-
Bufalin induces apoptosis through activation of both the intrinsic and extrinsic pathways in human bladder cancer cells
-
Hong, S.H., et al. (2012) Bufalin induces apoptosis through activation of both the intrinsic and extrinsic pathways in human bladder cancer cells. Oncol. Rep., 27, 114-120.
-
(2012)
Oncol. Rep.
, vol.27
, pp. 114-120
-
-
Hong, S.H.1
-
29
-
-
34247629598
-
Bufalin induces apoptosis in human osteosarcoma U-2OS and U-2OS methotrexate300-resistant cell lines
-
Yin, J.Q., et al. (2007) Bufalin induces apoptosis in human osteosarcoma U-2OS and U-2OS methotrexate300-resistant cell lines. Acta Pharmacol. Sin., 28, 712-720.
-
(2007)
Acta Pharmacol. Sin.
, vol.28
, pp. 712-720
-
-
Yin, J.Q.1
-
30
-
-
1642326716
-
Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation
-
Nowak, S.J., et al. (2004) Phosphorylation of histone H3: a balancing act between chromosome condensation and transcriptional activation. Trends Genet., 20, 214-220.
-
(2004)
Trends Genet.
, vol.20
, pp. 214-220
-
-
Nowak, S.J.1
-
31
-
-
1842737653
-
Up-regulation of Na(+),K(+)-ATPase alpha 3-isoform and down-regulation of the alpha1-isoform in human colorectal cancer
-
Sakai, H., et al. (2004) Up-regulation of Na(+),K(+)-ATPase alpha 3-isoform and down-regulation of the alpha1-isoform in human colorectal cancer. FEBS Lett., 563, 151-154.
-
(2004)
FEBS Lett.
, vol.563
, pp. 151-154
-
-
Sakai, H.1
-
32
-
-
48049096384
-
Fast degradation of the auxiliary subunit of Na+/K+-ATPase in the plasma membrane of HeLa cells
-
Yoshimura, S.H., et al. (2008) Fast degradation of the auxiliary subunit of Na+/K+-ATPase in the plasma membrane of HeLa cells. J. Cell Sci., 121, 2159-2168.
-
(2008)
J. Cell Sci.
, vol.121
, pp. 2159-2168
-
-
Yoshimura, S.H.1
-
33
-
-
56249086846
-
Na+/K+-ATPase alpha subunits as new targets in anticancer therapy
-
Mijatovic, T., et al. (2008) Na+/K+-ATPase alpha subunits as new targets in anticancer therapy. Expert Opin. Ther. Targets, 12, 1403-1417.
-
(2008)
Expert Opin. Ther. Targets
, vol.12
, pp. 1403-1417
-
-
Mijatovic, T.1
-
34
-
-
58149374576
-
Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth
-
Zhang, H., et al. (2008) Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Proc. Natl Acad. Sci. USA, 105, 19579-19586.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 19579-19586
-
-
Zhang, H.1
-
35
-
-
78549284246
-
UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells
-
Juncker, T., et al. (2011) UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells. Biochem. Pharmacol., 81, 13-23.
-
(2011)
Biochem. Pharmacol.
, vol.81
, pp. 13-23
-
-
Juncker, T.1
-
36
-
-
0742289407
-
Arsenite induces HIF-1alpha and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells
-
Gao, N., et al. (2004) Arsenite induces HIF-1alpha and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells. Mol. Cell. Biochem., 255, 33-45.
-
(2004)
Mol. Cell. Biochem.
, vol.255
, pp. 33-45
-
-
Gao, N.1
-
37
-
-
36148964068
-
Id-1 activation of PI3K/Akt/NFkappaB signaling pathway and its significance in promoting survival of esophageal cancer cells
-
Li, B., et al. (2007) Id-1 activation of PI3K/Akt/NFkappaB signaling pathway and its significance in promoting survival of esophageal cancer cells. Carcinogenesis, 28, 2313-2320.
-
(2007)
Carcinogenesis
, vol.28
, pp. 2313-2320
-
-
Li, B.1
-
38
-
-
77954895877
-
Persistent p21 expression after Nutlin-3a removal is associated with senescence-like arrest in 4N cells
-
Shen, H., et al. (2010) Persistent p21 expression after Nutlin-3a removal is associated with senescence-like arrest in 4N cells. J. Biol. Chem., 285, 23105-23114.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 23105-23114
-
-
Shen, H.1
-
39
-
-
33645823588
-
Aurora A, mitotic entry, and spindle bipolarity
-
Liu, Q., et al. (2006) Aurora A, mitotic entry, and spindle bipolarity. Proc. Natl Acad. Sci. USA, 103, 5811-5816.
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 5811-5816
-
-
Liu, Q.1
-
40
-
-
0038746733
-
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint
-
Hauf, S., et al. (2003) The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint. J. Cell Biol., 161, 281-294.
-
(2003)
J. Cell Biol.
, vol.161
, pp. 281-294
-
-
Hauf, S.1
-
41
-
-
33846931644
-
The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1
-
Lénárt, P., et al. (2007) The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1. Curr. Biol., 17, 304-315.
-
(2007)
Curr. Biol.
, vol.17
, pp. 304-315
-
-
Lénárt, P.1
-
42
-
-
45349097483
-
Regulation of hypoxia-inducible factor-1alpha by NF-κB
-
van Uden, P., et al. (2008) Regulation of hypoxia-inducible factor-1alpha by NF-κB. Biochem. J., 412, 477-484.
-
(2008)
Biochem. J.
, vol.412
, pp. 477-484
-
-
van Uden, P.1
-
43
-
-
39749196227
-
LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner
-
Nishi, K., et al. (2008) LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner. Antioxid. Redox Signal., 10, 983-995.
-
(2008)
Antioxid. Redox Signal.
, vol.10
, pp. 983-995
-
-
Nishi, K.1
-
44
-
-
0024348871
-
Expression of multiple Na+,K+-adenosine triphosphatase isoform genes in human hematopoietic cells. Behavior of the novel A3 isoform during induced maturation of HL60 cells
-
Gilmore-Hebert, M., et al. (1989) Expression of multiple Na+,K+-adenosine triphosphatase isoform genes in human hematopoietic cells. Behavior of the novel A3 isoform during induced maturation of HL60 cells. J. Clin. Invest., 84, 347-351.
-
(1989)
J. Clin. Invest.
, vol.84
, pp. 347-351
-
-
Gilmore-Hebert, M.1
-
45
-
-
78650167267
-
Human tumor cell sensitivity to oleandrin is dependent on relative expression of Na+, K+ -ATPase subunitst
-
Lin, Y., et al. (2010) Human tumor cell sensitivity to oleandrin is dependent on relative expression of Na+, K+ -ATPase subunitst. J. Exp. Ther. Oncol., 8, 271-286.
-
(2010)
J. Exp. Ther. Oncol.
, vol.8
, pp. 271-286
-
-
Lin, Y.1
-
46
-
-
33745913613
-
Oleandrin-mediated expression of Fas potentiates apoptosis in tumor cells
-
Sreenivasan, Y., et al. (2006) Oleandrin-mediated expression of Fas potentiates apoptosis in tumor cells. J. Clin. Immunol., 26, 308-322.
-
(2006)
J. Clin. Immunol.
, vol.26
, pp. 308-322
-
-
Sreenivasan, Y.1
-
47
-
-
0034791330
-
All human Na(+)-K(+)-ATPase alpha-subunit isoforms have a similar affinity for cardiac glycosides
-
Wang, J., et al. (2001) All human Na(+)-K(+)-ATPase alpha-subunit isoforms have a similar affinity for cardiac glycosides. Am. J. Physiol. Cell Physiol., 281, C1336-C1343.
-
(2001)
Am. J. Physiol. Cell Physiol.
, vol.281
-
-
Wang, J.1
|