The two faces of capsaicin

Cancer Research

Volumn 71, Issue 8, 2011, Pages 2809-2814

  Bode, Ann M ^a   Dong, Zigang ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALRGX 4975; CAPSAICIN; CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR; NG 4010; PLACEBO; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ACUTE HEART INFARCTION; APOPTOSIS; CANCER INHIBITION; CANCER PREVENTION; CANCER RISK; CARCINOGENICITY; CELL CYCLE ARREST; CORONARY ARTERY SPASM; DIABETIC NEUROPATHY; DRUG EFFICACY; DRUG SAFETY; DRUG STRUCTURE; GALLBLADDER CANCER; HUMAN; INFLAMMATION; LOW BACK PAIN; MALIGNANT TRANSFORMATION; MUCOSA INFLAMMATION; MUSCULOSKELETAL PAIN; NEURALGIA; NEUROPATHIC PAIN; NONHUMAN; OSTEOARTHRITIS; PEPPER; PERIPHERAL NEUROPATHY; POSTOPERATIVE PAIN; PRIORITY JOURNAL; PRURITUS; REVIEW; RHEUMATOID ARTHRITIS; SKIN CANCER; SKIN PAIN; STOMACH CANCER; TUMOR;

ANIMALS; ANTICARCINOGENIC AGENTS; CAPSAICIN; CARCINOGENS; HUMANS; NEOPLASMS;

EID: 79954569214     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-3756     Document Type: Review

References (50)

1. Perry L, Dickau R, Zarrillo S, Holst I, Pearsall DM, Piperno DR, et al. Starch fossils and the domestication and dispersal of chili peppers (Capsicum spp. L.) in the Americas. Science 2007;315: 986-8. (Pubitemid 46281185)
2. Pereira J. Capsicum annuum. In: Carson J, editor. The elements of materia medica and therapeutics. 3rd ed. Philadelphia: Blanchard and Lea; 1854. p. 505-7.
3. Thresh JC. Isolation of capsaicin. The Pharmaceutical Journal and Transactions 1876;6:941-7.
4. Buchheim R. Fructus Capsici. Proceedings of the American Pharmaceutical Association. 1873;22:106.
5. Nelson EK. The constitution of capsaicin, the pungent principle of capsicum. J Am Chem Soc 1919;41:1115-21.
6. Späth S, Darling SF. Synthese des capsaicins. Chem Ber 1930;63B: 737-43.
7. Kosuge S, Inagaki Y, Okumura H. Studies on the pungent principles of red pepper. Part VIII. On the chemical constitutions of the pungent principles. Nippon Nogeikagaku Kaishi 1961;35:923-7 [J Agric Chem Soc].
8. Oyagbemi AA, Saba AB, Azeez OI. Capsaicin: A novel chemopreventive molecule and its underlying molecular mechanisms of action. Indian J Cancer 2010;47:53-8.
9. Nagabhushan M, Bhide SV. Mutagenicity of chili extract and capsaicin in short-term tests. Environ Mutagen 1985;7:881-8. (Pubitemid 16180582)
10. Malagarie-Cazenave S, Olea-Herrero N, Vara D, Díaz-Laviada I. Capsaicin, a component of red peppers, induces expression of androgen receptor via PI3K and MAPK pathways in prostate LNCaP cells. FEBS Lett 2009;583:141-7.
11. Hoch-Ligeti C. Production of liver tumours by dietary means; effect of feeding chilies [Capsicum frutescens and annuum (Linn.)] to rats. Acta Unio Int Contra Cancrum 1951;7:606-11.
12. Toth B, Gannett P. Carcinogenicity of lifelong administration of capsaicin of hot pepper in mice. In Vivo 1992;6:59-63.
13. Jang JJ, Cho KJ, Lee YS, Bae JH. Different modifying responses of capsaicin in a wide-spectrum initiation model of F344 rat. J Korean Med Sci 1991;6:31-6.
14. Agrawal RC, Wiessler M, Hecker E, Bhide SV. Tumour-promoting effect of chilli extract in BALB/c mice. Int J Cancer 1986;38:689-95. (Pubitemid 17189128)
15. Kim JP, Park JG, Lee MD, Han MD, Park ST, Lee BH, et al. Cocarcinogenic effects of several Korean foods on gastric cancer induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats. Jpn J Surg 1985;15:427-37.
16. Erin N, Boyer PJ, Bonneau RH, Clawson GA, Welch DR. Capsaicinmediated denervation of sensory neurons promotes mammary tumor metastasis to lung and heart. Anticancer Res 2004;24[2B]: 1003-9. (Pubitemid 38625051)
17. Akagi A, Sano N, Uehara H, Minami T, Otsuka H, Izumi K. Noncarcinogenicity of capsaicinoids in B6C3F1 mice. Food Chem Toxicol 1998;36:1065-71.
18. Ito K, Nakazato T, Yamato K, Miyakawa Y, Yamada T, Hozumi N, et al. Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: Implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species. Cancer Res 2004;64:1071-8. (Pubitemid 38176912)
19. Muralidhara NK, Narasimhamurthy K. Non-mutagenicity of capsaicin in albino mice. Food Chem Toxicol 1988;26:955-8. (Pubitemid 19027027)
20. Chanda S, Erexson G, Frost D, Babbar S, Burlew JA, Bley K. 26-Week dermal oncogenicity study evaluating pure trans-capsaicin in Tg.AC hemizygous mice (FBV/N). Int J Toxicol 2007;26:123-33. (Pubitemid 46514924)
21. Park KK, Surh YJ. Effects of capsaicin on chemically-induced twostage mouse skin carcinogenesis. Cancer Lett 1997;114:183-4.
22. Teel RW, Huynh HT. Lack of the inhibitory effect of intragastrically administered capsaicin on NNK-induced lung tumor formation in the A.J mouse. In Vivo 1999;13:231-4. (Pubitemid 29380989)
23. Serra I, Yamamoto M, Calvo A, Cavada G, Báez S, Endoh K, et al. Association of chili pepper consumption, low socioeconomic status and longstanding gallstones with gallbladder cancer in a Chilean population. Int J Cancer 2002;102:407-11. (Pubitemid 35265881)
24. López-Carrillo L, Hernández Avila M, Dubrow R. Chili pepper consumption and gastric cancer in Mexico: A case-control study. Am J Epidemiol 1994;139:263-71. (Pubitemid 24062763)
25. Notani PN, Jayant K. Role of diet in upper aerodigestive tract cancers. Nutr Cancer 1987;10:103-13. (Pubitemid 17092529)
26. Archer VE, Jones DW. Capsaicin pepper, cancer and ethnicity. Med Hypotheses 2002;59:450-7.
27. Lee BM, Park KK. Beneficial and adverse effects of chemopreventive agents. Mutat Res 2003;523-524:265-78. (Pubitemid 36293253)
28. Buiatti E, Palli D, Decarli A, Amadori D, Avellini C, Bianchi S, et al. A case-control study of gastric cancer and diet in Italy. Int J Cancer 1989;44:611-6. (Pubitemid 19258732)
29. Dasgupta P, Chandiramani V, Parkinson MC, Beckett A, Fowler CJ. Treating the human bladder with capsaicin: Is it safe? Eur Urol 1998;33:28-31. (Pubitemid 28033414)
30. Graham DY, Smith JL, Opekun AR. Spicy food and the stomach. Evaluation by videoendoscopy. JAMA 1988;260:3473-5. (Pubitemid 19003129)
31. Myers BM, Smith JL, Graham DY. Effect of red pepper and black pepper on the stomach. Am J Gastroenterol 1987;82:211-4. (Pubitemid 17047004)
32. Szallasi A, Cortright DN, Blum CA, Eid SR. The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Discov 2007;6:357-72. (Pubitemid 46705200)
33. Hautkappe M, Roizen MF, Toledano A, Roth S, Jeffries JA, Ostermeier AM. Review of the effectiveness of capsaicin for painful cutaneous disorders and neural dysfunction. Clin J Pain 1998;14:97-106. (Pubitemid 28270206)
34. Remadevi R, Szallisi A. Adlea (ALGRX-4975), an injectable capsaicin (TRPV1 receptor agonist) formulation for longlasting pain relief. IDrugs 2008;11:120-32. (Pubitemid 351196171)
35. Nolano M, Simone DA, Wendelschafer-Crabb G, Johnson T, Hazen E, Kennedy WR. Topical capsaicin in humans: Parallel loss of epidermal nerve fibers and pain sensation. Pain 1999;81:135-45. (Pubitemid 29199909)
36. Babbar S, Marier JF, Mouksassi MS, Beliveau M, Vanhove GF, Chanda S, et al. Pharmacokinetic analysis of capsaicin after topical administration of a high-concentration capsaicin patch to patients with peripheral neuropathic pain. Ther Drug Monit 2009;31:502-10.
37. Derry S, Lloyd R, Moore RA, McQuay HJ. Topical capsaicin for chronic neuropathic pain in adults. Cochrane Database Syst Rev 2009;4: CD007393.
38. Kim-Katz SY, Anderson IB, Kearney TE, MacDougall C, Hudmon KS, Blanc PD. Topical antacid therapy for capsaicin-induced dermal pain: A poison center telephone-directed study. Am J Emerg Med 2010;28:596-602.
39. Williams SR, Clark RF, Dunford JV. Contact dermatitis associated with capsaicin: Hunan hand syndrome. Ann Emerg Med 1995;25:713-5.
40. Boudreau SA, Wang K, Svensson P, Sessle BJ, Arendt-Nielsen L. Vascular and psychophysical effects of topical capsaicin application to orofacial tissues. J Orofac Pain 2009;23:253-64.
41. Makhlough A. Topical capsaicin therapy for uremic pruritus in patients on hemodialysis. Iran J Kidney Dis 2010;4:137-40.
42. Weisshaar E, Ziethen B, Gollnick H. Lack of efficacy of topical capsaicin in serotonin-induced itch. Skin Pharmacol Appl Skin Physiol 2000;13:1-8. (Pubitemid 30093563)
43. Ellison N, Loprinzi CL, Kugler J, Hatfield AK, Miser A, Sloan JA, et al. Phase III placebo-controlled trial of capsaicin cream in the management of surgical neuropathic pain in cancer patients. J Clin Oncol 1997;15:2974-80. (Pubitemid 27330026)
44. Berger A, Henderson M, Nadoolman W, Duffy V, Cooper D, Saberski L, et al. Oral capsaicin provides temporary relief for oral mucositis pain secondary to chemotherapy/radiation therapy. J Pain Symptom Manage 1995;10:243-8.
45. Paice JA, Ferrans CE, Lashley FR, Shott S, Vizgirda V, Pitrak D. Topical capsaicin in the management of HIV-associated peripheral neuropathy. J Pain Symptom Manage 2000;19:45-52. (Pubitemid 30067623)
46. Mason L, Moore RA, Derry S, Edwards JE, McQuay HJ. Systematic review of topical capsaicin for the treatment of chronic pain. BMJ 2004;328:991.
47. Akçay AB, Ozcan T, Seyis S, Acele A. Coronary vasospasm and acute myocardial infarction induced by a topical capsaicin patch. Turk Kardiyol Dern Ars 2009;37:497-500.
48. Bode AM, Cho YY, Zheng D, Zhu F, Ericson ME, Ma WY, et al. Transient receptor potential type vanilloid 1 suppresses skin carcinogenesis. Cancer Res 2009;69:905-13.
49. Hwang MK, Bode AM, Byun S, Song NR, Lee HJ, Lee KW, et al. Cocarcinogenic effect of capsaicin involves activation of EGFR signaling but not TRPV1. Cancer Res 2010;70:6859-69.
50. Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin. Int J Toxicol 2007;26(Suppl 1):3-106.