Evaluation of 3,3′,4′-trihydroxyflavone and 3,6,4′-trihydroxyflavone (4′- O -Glucuronidation) as the in vitro functional markers for hepatic UGT1A1

Molecular Pharmaceutics

Volumn 8, Issue 6, 2011, Pages 2379-2389

  Wu, Baojian ^a   Zhang, Shuxing ^b   Hu, Ming ^a  

^a UNIVERSITY OF HOUSTON   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

flavonoids; probe substrate; regioselectivity; SN 38; UGTs

Indexed keywords

3,3'4' TRIHYDROXYFLAVONE; 3,6,4' TRIHYDROXYFLAVONE; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; BIOLOGICAL MARKER; ESTRADIOL; FLAVONOID; GLUCURONIDE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A7; GLUCURONOSYLTRANSFERASE 1A9; UNCLASSIFIED DRUG;

ARTICLE; DRUG GLUCURONIDATION; ENZYME ACTIVITY; GLUCURONIDATION; HUMAN; LIVER MICROSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; REACTION ANALYSIS;

BIOLOGICAL MARKERS; FLAVONES; FLAVONOIDS; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; KINETICS; LIVER; MOLECULAR STRUCTURE; PROTEIN ISOFORMS; RECOMBINANT PROTEINS;

EID: 82955169627     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200300w     Document Type: Article

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