Give progesterone a chance

Neural Regeneration Research

Volumn 9, Issue 15, 2014, Pages 1422-1424

  Labombarda, Florencia ^a,b   Garcia Ovejero, Daniel ^c  

^a INST DE BIOL Y MED EXPERIMENTAL   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^c HOSPITAL NACIONAL DE PARAPLÉJICOS   (Spain)

Author keywords

Myelin; Neuroprotection; Progesterone; Spinal cord injury; Trauma

Indexed keywords

METHYLPREDNISOLONE; MYELIN BASIC PROTEIN; PROGESTERONE;

ARTICLE; DRUG SAFETY; GAIT; HUMAN; NEUROPROTECTION; NONHUMAN; PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); REMYELINIZATION; SPINAL CORD INJURY; TRAUMATIC BRAIN INJURY; WHITE MATTER;

EID: 84907154009     PISSN: 16735374     EISSN: 18767958     Source Type: Journal    
DOI: 10.4103/1673-5374.139456     Document Type: Article

References (47)

1. Baptiste DC, Fehlings MG (2006) Pharmacological approaches to repair the injured spinal cord. J Neurotrauma 23:318-334.
2. Barriere G, Leblond H, Provencher J, Rossignol S (2008) Prominent role of the spinal central pattern generator in the recovery of locomotion after partial spinal cord injuries. J Neurosci 28:3976-3987.
3. Basso DM (2004) Behavioral testing after spinal cord injury: congruities, complexities, and controversies. J Neurotrauma 21:395-404.
4. Basso DM, Beattie MS, Bresnahan JC (1995) A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12:1-21.
5. Basso DM, Beattie MS, Bresnahan JC (1996) Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp Neurol 139:244-256.
6. Beauchamp K, Mutlak H, Smith WR, Shohami E, Stahel PF (2008) Pharmacology of traumatic brain injury: where is the “golden bullet”? Mol Med 14:731-740.
7. Bracken MB (2012) Steroids for acute spinal cord injury. Cochrane Database Syst Rev 1:CD001046.
8. Clarac F (2008) Some historical reflections on the neural control of locomotion. Brain Res Rev 57:13-21.
9. Cutler SM, Cekic M, Miller DM, Wali B, VanLandingham JW, Stein DG (2007) Progesterone improves acute recovery after traumatic brain injury in the aged rat. J Neurotrauma 24:1475-1486.
10. De Nicola AF, Labombarda F, Deniselle MC, Gonzalez SL, Garay L, Meyer M, Gargiulo G, Guennoun R, Schumacher M (2009) Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration. Front Neuroendocrinol 30:173-187.
11. Deumens R, Jaken RJ, Marcus MA, Joosten EA (2007) The CatWalk gait analysis in assessment of both dynamic and static gait changes after adult rat sciatic nerve resection. J Neurosci Methods 164:120-130.
12. Dolan S, Nolan AM (2007) Blockade of metabotropic glutamate receptor 5 activation inhibits mechanical hypersensitivity following abdominal surgery. Eur J Pain 11:644-651.
13. Fee DB, Swartz KR, Joy KM, Roberts KN, Scheff NN, Scheff SW (2007) Effects of progesterone on experimental spinal cord injury. Brain Res 1137:146-152.
14. Garcia-Ovejero D, Gonzalez S, Paniagua-Torija B, Lima A, Molina-Holgado E, De Nicola AF, Labombarda F (2014) Progesterone reduces secondary damage, preserves white matter, and improves locomotor outcome after spinal cord contusion. J Neurotrauma 31:857-871.
15. Gonzalez SL, Labombarda F, Gonzalez Deniselle MC, Guennoun R, Schumacher M, De Nicola AF (2004) Progesterone up-regulates neuronal brain-derived neurotrophic factor expression in the injured spinal cord. Neuroscience 125:605-614.
16. Guertin PA (2009) The mammalian central pattern generator for locomotion. Brain Res Rev 62:45-56.
17. Guo Q, Sayeed I, Baronne LM, Hoffman SW, Guennoun R, Stein DG (2006) Progesterone administration modulates AQP4 expression and edema after traumatic brain injury in male rats. Exp Neurol 198:469-478.
18. Hamers FP, Koopmans GC, Joosten EA (2006) CatWalk-assisted gait analysis in the assessment of spinal cord injury. J Neurotrauma 23:537-548.
19. Hamers FP, Lankhorst AJ, van Laar TJ, Veldhuis WB, Gispen WH (2001) Automated quantitative gait analysis during overground locomotion in the rat: its application to spinal cord contusion and transection injuries. J Neurotrauma 18:187-201.
20. Hargreaves K, Dubner R, Brown F, Flores C, Joris J (1988) A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32:77-88.
21. Hendriks WT, Eggers R, Ruitenberg MJ, Blits B, Hamers FP, Verhaagen J, Boer GJ (2006) Profound differences in spontaneous long-term functional recovery after defined spinal tract lesions in the rat. J Neurotrauma 23:18-35.
22. Hurlbert RJ (2001) The role of steroids in acute spinal cord injury: an evidence-based analysis. Spine 26:S39-S46.
23. Joosten EA, Veldhuis WB, Hamers FP (2004) Collagen containing neonatal astrocytes stimulates regrowth of injured fibers and promotes modest locomotor recovery after spinal cord injury. J Neurosci Res 77:127-142.
24. Kloos AD, Fisher LC, Detloff MR, Hassenzahl DL, Basso DM (2005) Stepwise motor and all-or-none sensory recovery is associated with nonlinear sparing after incremental spinal cord injury in rats. Exp Neurol 191:251-265.
25. Koopmans GC, Deumens R, Honig WM, Hamers FP, Steinbusch HW, Joosten EA (2005) The assessment of locomotor function in spinal cord injured rats: the importance of objective analysis of coordination. J Neurotrauma 22:214-225.
26. Kwon BK, Okon E, Hillyer J, Mann C, Baptiste D, Weaver LC, Fehlings MG, Tetzlaff W (2011) A systematic review of non-invasive pharmacologic neuroprotective treatments for acute spinal cord injury. J Neurotrauma 28:1545-1588.
27. Labombarda F, Gonzalez Deniselle MC, De Nicola AF, Gonzalez SL (2010) Progesterone and the spinal cord: good friends in bad times. Neuroimmunomodulation 17:146-149.
28. Labombarda F, Gonzalez SL, Gonzalez DM, Guennoun R, Schumacher M, de Nicola AF (2002) Cellular basis for progesterone neuroprotection in the injured spinal cord. J Neurotrauma 19:343-355.
29. Labombarda F, Gonzalez SL, Lima A, Roig P, Guennoun R, Schumacher M, de Nicola AF (2009) Effects of progesterone on oligodendrocyte progenitors, oligodendrocyte transcription factors, and myelin proteins following spinal cord injury. Glia 57:884-897.
30. Labombarda F, Gonzalez S, Lima A, Roig P, Guennoun R, Schumacher M, De Nicola AF (2011) Progesterone attenuates astro-and microgliosis and enhances oligodendrocyte differentiation following spinal cord injury. Exp Neurol 231:135-146.
31. Lammertse DP (2013) Clinical trials in spinal cord injury: lessons learned on the path to translation. The 2011 International Spinal Cord Society Sir Ludwig Guttmann Lecture. Spinal Cord 51:2-9.
32. Margulies S, Hicks R, Combination Therapies for Traumatic Brain Injury Workshop L (2009) Combination therapies for traumatic brain injury: prospective considerations. J Neurotrauma 26:925-939.
33. McConeghy KW, Hatton J, Hughes L, Cook AM (2012) A review of neuroprotection pharmacology and therapies in patients with acute traumatic brain injury. CNS drugs 26:613-636.
34. Pearson KG, Rossignol S (1991) Fictive motor patterns in chronic spinal cats. J Neurophysiol 66:1874-1887.
35. Pettus EH, Wright DW, Stein DG, Hoffman SW (2005) Progesterone treatment inhibits the inflammatory agents that accompany traumatic brain injury. Brain Res 1049:112-119.
36. Rabchevsky AG, Patel SP, Springer JE (2011) Pharmacological interventions for spinal cord injury: where do we stand? How might we step forward? Pharmacol Ther 132:15-29.
37. Scheff SW, Rabchevsky AG, Fugaccia I, Main JA, Lumpp JE, Jr. (2003) Experimental modeling of spinal cord injury: characterization of a force-defined injury device. J Neurotrauma 20:179-193.
38. Schroeder GD, Kwon BK, Eck JC, Savage JW, Hsu WK, Patel AA (2014) Survey of cervical spine research society members on the use of high-dose steroids for acute spinal cord injuries. Spine 39:971-977.
39. Schucht P, Raineteau O, Schwab ME, Fouad K (2002) Anatomical correlates of locomotor recovery following dorsal and ventral lesions of the rat spinal cord. Exp Neurol 176:143-153.
40. Schumacher M, Hussain R, Gago N, Oudinet JP, Mattern C, Ghoumari AM (2012) Progesterone synthesis in the nervous system: implications for myelination and myelin repair. Front Neurosci 6:10.
41. Silva NA, Sousa N, Reis RL, Salgado AJ (2014) From basics to clinical: a comprehensive review on spinal cord injury. Prog Neurobiol 114:25-57.
42. Stein DG (2008) Progesterone exerts neuroprotective effects after brain injury. Brain Res Rev 57:386-397.
43. Stein DG (2011) Progesterone in the treatment of acute traumatic brain injury: a clinical perspective and update. Neuroscience 191:101-106.
44. Thomas AJ, Nockels RP, Pan HQ, Shaffrey CI, Chopp M (1999) Progesterone is neuroprotective after acute experimental spinal cord trauma in rats. Spine 24:2134-2138.
45. Vrinten DH, Hamers FF (2003) ‘CatWalk’ automated quantitative gait analysis as a novel method to assess mechanical allodynia in the rat; a comparison with von Frey testing. Pain 102:203-209.
46. Wright DW, Kellermann AL, Hertzberg VS, Clark PL, Frankel M, Goldstein FC, Salomone JP, Dent LL, Harris OA, Ander DS, Lowery DW, Patel MM, Denson DD, Gordon AB, Wald MM, Gupta S, Hoffman SW, Stein DG (2007) ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury. Ann Emerg Med 49:391-402, 402 e391-392.
47. Xiao G, Wei J, Yan W, Wang W, Lu Z (2008) Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial. Crit Care 12:R61.