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Volumn 14, Issue 11-12, 2008, Pages 731-740

Pharmacology of traumatic brain injury: Where is the "golden bullet"?

Author keywords

[No Author keywords available]

Indexed keywords

4 PHOSPHONOMETHYLPIPECOLIC ACID; ANANDAMIDE; ANATIBANT; BRADYKININ; CALCIUM CHANNEL BLOCKING AGENT; CANNABINOID; CORTICOSTEROID; CYCLOSPORIN; D CCP ENE; DELBITANT; DELTIBANT; DEXANABINOL; EAA 494; GCS 19755; GLUTAMIC ACID; KALLIKREIN; KININ; LF 16 0687MA; MAGNESIUM SULFATE; METABOTROPIC RECEPTOR; METHYLPHENIDATE; METHYLPREDNISOLONE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; NIMODIPINE; NOLADIN ETHER; PLACEBO; PROGESTERONE; TIRILAZAD; TRAXOPRODIL; UNCLASSIFIED DRUG;

EID: 55749111251     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/2008-00050.Beauchamp     Document Type: Review
Times cited : (148)

References (129)
  • 1
    • 42049100961 scopus 로고    scopus 로고
    • Epidemiology and 12-month outcomes from traumatic brain injury in Australia and New Zealand
    • Myburgh et al. (2008) Epidemiology and 12-month outcomes from traumatic brain injury in Australia and New Zealand. J. Trauma 64:854-62.
    • (2008) J. Trauma , vol.64 , pp. 854-862
    • Myburgh1
  • 2
    • 39749122617 scopus 로고    scopus 로고
    • Traumatic brain injury in Finland 1991-2005: A nationwide register study of hospitalized and fatal TBI
    • Koskinen S, Alaranta H. (2008) Traumatic brain injury in Finland 1991-2005: A nationwide register study of hospitalized and fatal TBI. Brain Inj. 22:205-14.
    • (2008) Brain Inj , vol.22 , pp. 205-214
    • Koskinen, S.1    Alaranta, H.2
  • 3
    • 33644879195 scopus 로고    scopus 로고
    • The use of state workers' compensation administrative data to identify injury scenarios and quantify costs of work-related traumatic brain injuries
    • Wrona RM. (2006) The use of state workers' compensation administrative data to identify injury scenarios and quantify costs of work-related traumatic brain injuries. J. Safety Res. 37:75-81.
    • (2006) J. Safety Res , vol.37 , pp. 75-81
    • Wrona, R.M.1
  • 4
    • 34147104338 scopus 로고    scopus 로고
    • The direct economic burden of blunt and penetrating trauma in a managed care population
    • Davis KL, Joshi AV, Tortella BJ, Candrilli SD. (2007) The direct economic burden of blunt and penetrating trauma in a managed care population. J. Trauma 62:622-629.
    • (2007) J. Trauma , vol.62 , pp. 622-629
    • Davis, K.L.1    Joshi, A.V.2    Tortella, B.J.3    Candrilli, S.D.4
  • 5
    • 34249844823 scopus 로고    scopus 로고
    • American Community Survey: Earnings and employment for persons with traumatic brain injury
    • Gamboa AMJ, Holland GH, Tierney JP, Gibson DS. (2006) American Community Survey: earnings and employment for persons with traumatic brain injury. NeuroRehabilitation 21:327-33.
    • (2006) NeuroRehabilitation , vol.21 , pp. 327-333
    • Gamboa, A.M.J.1    Holland, G.H.2    Tierney, J.P.3    Gibson, D.S.4
  • 6
    • 34547583260 scopus 로고    scopus 로고
    • Double catastrophe: Injury-related bankruptcies
    • Woolhandler S, Himmelstein DU. (2006) Double catastrophe: injury-related bankruptcies. Med. Care 45:699-701.
    • (2006) Med. Care , vol.45 , pp. 699-701
    • Woolhandler, S.1    Himmelstein, D.U.2
  • 7
    • 43049084426 scopus 로고    scopus 로고
    • Hypoxia and hypotension, the "lethal duo" in traumatic brain injury: Implications for prehospital care
    • Stahel PF, Smith WR, Moore EE. (2008) Hypoxia and hypotension, the "lethal duo" in traumatic brain injury: implications for prehospital care. Intensive Care Med. 34:402-4.
    • (2008) Intensive Care Med , vol.34 , pp. 402-404
    • Stahel, P.F.1    Smith, W.R.2    Moore, E.E.3
  • 8
    • 34547759327 scopus 로고    scopus 로고
    • Guidelines for the management of severe traumatic brain injury
    • The Brain Trauma Foundation
    • The Brain Trauma Foundation. (2007) Guidelines for the management of severe traumatic brain injury. J. Neurotrauma 24: S1-6.
    • (2007) J. Neurotrauma , vol.24
  • 9
    • 0001643813 scopus 로고
    • The use of dexamethasone in the treatment of cerebral edema resulting from brain tumors and brain surgery
    • Ghallich JH FL. (1961) The use of dexamethasone in the treatment of cerebral edema resulting from brain tumors and brain surgery. Am. Pract. Dig. Treat. 12:169-74.
    • (1961) Am. Pract. Dig. Treat , vol.12 , pp. 169-174
    • Ghallich, J.F.1
  • 10
    • 0019988360 scopus 로고
    • Osmotherapy and steroid therapy in acute brain edema
    • in German
    • Gobiet W. (1982) Osmotherapy and steroid therapy in acute brain edema [in German]. Schweiz Med. Wochenschr. 112:966-967.
    • (1982) Schweiz Med. Wochenschr , vol.112 , pp. 966-967
    • Gobiet, W.1
  • 11
    • 5044223264 scopus 로고    scopus 로고
    • Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): Randomised placebo-controlled trial
    • Roberts I et al. (2004) Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial. Lancet 364:1321-8.
    • (2004) Lancet , vol.364 , pp. 1321-1328
    • Roberts, I.1
  • 12
    • 5044219667 scopus 로고    scopus 로고
    • A CRASH landing in severe head injury
    • Sauerland S, Maegele M. (2004) A CRASH landing in severe head injury. Lancet 364:1291-2.
    • (2004) Lancet , vol.364 , pp. 1291-1292
    • Sauerland, S.1    Maegele, M.2
  • 13
    • 34249902812 scopus 로고    scopus 로고
    • Guidelines for the management of severe traumatic brain injury; XV: Steroids
    • The Brain Trauma Foundation
    • The Brain Trauma Foundation. (2007) Guidelines for the management of severe traumatic brain injury; XV: steroids. J. Neurotrauma 24:S91-5.
    • (2007) J. Neurotrauma , vol.24
  • 14
    • 0023836392 scopus 로고
    • Effects of the 21-aminosteroid U74006F on experimental head injury in mice
    • Hall ED, Yonkers PA, McCall JM, Braughler JM. (1988) Effects of the 21-aminosteroid U74006F on experimental head injury in mice. J. Neurosurg. 68:456-61.
    • (1988) J. Neurosurg , vol.68 , pp. 456-461
    • Hall, E.D.1    Yonkers, P.A.2    McCall, J.M.3    Braughler, J.M.4
  • 15
    • 0024417710 scopus 로고
    • The 21-aminosteroid inhibitors of lipid peroxidation: Reactions with lipid peroxyl and phenoxy radicals
    • Braughler JM, Pregenzer JF. (1989) The 21-aminosteroid inhibitors of lipid peroxidation: reactions with lipid peroxyl and phenoxy radicals. Free Radic. Biol. Med. 7:125-30.
    • (1989) Free Radic. Biol. Med , vol.7 , pp. 125-130
    • Braughler, J.M.1    Pregenzer, J.F.2
  • 16
    • 0028805686 scopus 로고
    • Lazaroids: CNS pharmacology and current research
    • Clark WM, Hazel JS, Coull BM. (1995) Lazaroids: CNS pharmacology and current research. Drugs 50:971-83.
    • (1995) Drugs , vol.50 , pp. 971-983
    • Clark, W.M.1    Hazel, J.S.2    Coull, B.M.3
  • 17
    • 0024589421 scopus 로고
    • Central nervous system trauma and stroke; II: Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation
    • Hall ED, Braughler JM. (1989) Central nervous system trauma and stroke; II: physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation. Free Radic. Biol. Med. 6:303-13.
    • (1989) Free Radic. Biol. Med , vol.6 , pp. 303-313
    • Hall, E.D.1    Braughler, J.M.2
  • 19
    • 0028187682 scopus 로고
    • Therapeutic potential of the lazaroids (21-aminosteroids) in acute central nervous system trauma, ischemia and subarachnoid hemorrhage
    • Hall ED, McCall JM, Means ED. (1994) Therapeutic potential of the lazaroids (21-aminosteroids) in acute central nervous system trauma, ischemia and subarachnoid hemorrhage. Adv. Pharmacol. 28:221-68.
    • (1994) Adv. Pharmacol , vol.28 , pp. 221-268
    • Hall, E.D.1    McCall, J.M.2    Means, E.D.3
  • 21
    • 0027793559 scopus 로고
    • Use of a biophysical-kinetic model to understand the roles of protein binding and membrane partitioning on passive diffusion of highly lipophilic molecules across cellular barriers
    • Raub TJ, Barsuhn CL, Williams LR, Decker DE, Sawada GA, Ho NF. (1993) Use of a biophysical-kinetic model to understand the roles of protein binding and membrane partitioning on passive diffusion of highly lipophilic molecules across cellular barriers. J. Drug Target. 1:269-86.
    • (1993) J. Drug Target , vol.1 , pp. 269-286
    • Raub, T.J.1    Barsuhn, C.L.2    Williams, L.R.3    Decker, D.E.4    Sawada, G.A.5    Ho, N.F.6
  • 22
    • 0031657984 scopus 로고    scopus 로고
    • A multicenter trial on the efficacy of using tirilazad mesylate in cases of head injury
    • Marshall LF et al. (1998) A multicenter trial on the efficacy of using tirilazad mesylate in cases of head injury. J. Neurosurg. 89:519-25.
    • (1998) J. Neurosurg , vol.89 , pp. 519-525
    • Marshall, L.F.1
  • 23
    • 0034564633 scopus 로고    scopus 로고
    • Aminosteroids for acute traumatic brain injury
    • CD001527
    • Roberts I. (2000) Aminosteroids for acute traumatic brain injury. Cochrane Database Syst. Rev: CD001527.
    • (2000) Cochrane Database Syst. Rev
    • Roberts, I.1
  • 24
    • 0036593191 scopus 로고    scopus 로고
    • Oestrogen as a neuroprotective hormone
    • Behl C. (2002) Oestrogen as a neuroprotective hormone. Nat. Rev. Neurosci. 3:433-42.
    • (2002) Nat. Rev. Neurosci , vol.3 , pp. 433-442
    • Behl, C.1
  • 25
    • 0030855406 scopus 로고    scopus 로고
    • Progesterone protects against lipid peroxidation following traumatic brain injury in rats
    • Roof RL, Hoffman SW, Stein DG. (1997) Progesterone protects against lipid peroxidation following traumatic brain injury in rats. Mol. Chem. Neuropathol. 31:1-11.
    • (1997) Mol. Chem. Neuropathol , vol.31 , pp. 1-11
    • Roof, R.L.1    Hoffman, S.W.2    Stein, D.G.3
  • 26
    • 0032401798 scopus 로고    scopus 로고
    • Progesterone facilitates the acquisition of avoidance learning and protects against subcortical neuronal death following prefrontal cortex ablation in the rat
    • Asbury ET, Fritts ME, Horton JE, Isaac WL. (1998) Progesterone facilitates the acquisition of avoidance learning and protects against subcortical neuronal death following prefrontal cortex ablation in the rat. Behav. Brain Res. 97:99-106.
    • (1998) Behav. Brain Res , vol.97 , pp. 99-106
    • Asbury, E.T.1    Fritts, M.E.2    Horton, J.E.3    Isaac, W.L.4
  • 27
    • 20444477493 scopus 로고    scopus 로고
    • Progesterone treatment inhibits the inflammatory agents that accompany traumatic brain injury
    • Pettus EH, Wright DW, Stein DG, Hoffman SW. (2005) Progesterone treatment inhibits the inflammatory agents that accompany traumatic brain injury. Brain Res. 1049:112-9.
    • (2005) Brain Res , vol.1049 , pp. 112-119
    • Pettus, E.H.1    Wright, D.W.2    Stein, D.G.3    Hoffman, S.W.4
  • 28
    • 0028072396 scopus 로고
    • Progesterone facilitates cognitive recovery and reduces secondary neuronal loss caused by cortical contusion injury in male rats
    • Roof RL, Duvdevani R, Braswell L, Stein DG. (1994) Progesterone facilitates cognitive recovery and reduces secondary neuronal loss caused by cortical contusion injury in male rats. Exp. Neurol. 129:64-9.
    • (1994) Exp. Neurol , vol.129 , pp. 64-69
    • Roof, R.L.1    Duvdevani, R.2    Braswell, L.3    Stein, D.G.4
  • 29
    • 0029878565 scopus 로고    scopus 로고
    • Progesterone rapidly decreases brain edema: Treatment delayed up to 24 hours is still effective
    • Roof RL, Duvdevani R, Heyburn JW, Stein DG. (1996) Progesterone rapidly decreases brain edema: treatment delayed up to 24 hours is still effective. Exp. Neurol. 138:246-51.
    • (1996) Exp. Neurol , vol.138 , pp. 246-251
    • Roof, R.L.1    Duvdevani, R.2    Heyburn, J.W.3    Stein, D.G.4
  • 30
    • 0036444181 scopus 로고    scopus 로고
    • Progesterone protects against necrotic damage and behavioral abnormalities caused by traumatic brain injury
    • Shear DA, Galani R, Hoffman SW, Stein DG. (2002) Progesterone protects against necrotic damage and behavioral abnormalities caused by traumatic brain injury. Exp. Neurol. 178:59-67.
    • (2002) Exp. Neurol , vol.178 , pp. 59-67
    • Shear, D.A.1    Galani, R.2    Hoffman, S.W.3    Stein, D.G.4
  • 31
    • 0033570133 scopus 로고    scopus 로고
    • Progesterone is neuroprotective after acute experimental spinal cord trauma in rats
    • Thomas AJ, Nockels RP, Pan HQ, Shaffrey CI, Chopp M. (1999) Progesterone is neuroprotective after acute experimental spinal cord trauma in rats. Spine 24:2134-8.
    • (1999) Spine , vol.24 , pp. 2134-2138
    • Thomas, A.J.1    Nockels, R.P.2    Pan, H.Q.3    Shaffrey, C.I.4    Chopp, M.5
  • 32
    • 0034850817 scopus 로고    scopus 로고
    • Serum progesterone levels correlate with decreased cerebral edema after traumatic brain injury in male rats
    • Wright DW, Bauer ME, Hoffman SW, Stein DG. (2001) Serum progesterone levels correlate with decreased cerebral edema after traumatic brain injury in male rats. J. Neurotrauma 18:901-9.
    • (2001) J. Neurotrauma , vol.18 , pp. 901-909
    • Wright, D.W.1    Bauer, M.E.2    Hoffman, S.W.3    Stein, D.G.4
  • 33
    • 18844369078 scopus 로고    scopus 로고
    • Steady-state serum concentrations of progesterone following continuous intravenous infusion in patients with acute moderate to severe traumatic brain injury
    • Wright DW, Ritchie JC, Mullins RE, Kellermann AL, Denson DD. (2005) Steady-state serum concentrations of progesterone following continuous intravenous infusion in patients with acute moderate to severe traumatic brain injury. J. Clin. Pharmacol. 45:640-8.
    • (2005) J. Clin. Pharmacol , vol.45 , pp. 640-648
    • Wright, D.W.1    Ritchie, J.C.2    Mullins, R.E.3    Kellermann, A.L.4    Denson, D.D.5
  • 34
    • 33947165175 scopus 로고    scopus 로고
    • Wright DW et al. (2007) ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury. Ann. Emerg. Med. 49:391-402, 402 e391-2.
    • Wright DW et al. (2007) ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury. Ann. Emerg. Med. 49:391-402, 402 e391-2.
  • 35
    • 43249131666 scopus 로고    scopus 로고
    • Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: A randomized controlled trial
    • Xiao G, Wei J, Yan W, Wang W, Lu Z. (2008) Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial. Crit. Care 12:R61.
    • (2008) Crit. Care , vol.12
    • Xiao, G.1    Wei, J.2    Yan, W.3    Wang, W.4    Lu, Z.5
  • 36
    • 0034065936 scopus 로고    scopus 로고
    • Glutamate as a neurotransmitter in the brain: Review of physiology and pathology
    • Meldrum BS. (2000) Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J. Nutr. 130:1007S-15S.
    • (2000) J. Nutr , vol.130
    • Meldrum, B.S.1
  • 38
    • 33847046311 scopus 로고    scopus 로고
    • The role of glutamate in central nervous system health and disease: A review
    • Platt SR. (2007) The role of glutamate in central nervous system health and disease: a review. Vet. J. 173:278-86.
    • (2007) Vet. J , vol.173 , pp. 278-286
    • Platt, S.R.1
  • 39
    • 0037361041 scopus 로고    scopus 로고
    • Group I metabotropic glutamate receptor activation produces prolonged epileptiform neuronal synchronization and alters evoked population responses in the hippocampus
    • Sayin U, Rutecki PA. (2003) Group I metabotropic glutamate receptor activation produces prolonged epileptiform neuronal synchronization and alters evoked population responses in the hippocampus. Epilepsy Res. 53:186-95.
    • (2003) Epilepsy Res , vol.53 , pp. 186-195
    • Sayin, U.1    Rutecki, P.A.2
  • 40
    • 0027983604 scopus 로고
    • The naming of voltage-gated calcium channels
    • Birnbaumer L et al. (1994) The naming of voltage-gated calcium channels. Neuron 13:505-6.
    • (1994) Neuron , vol.13 , pp. 505-506
    • Birnbaumer, L.1
  • 41
    • 0032400828 scopus 로고    scopus 로고
    • Stoichiometry of the glial glutamate transporter GLT-1 expressed inducibly in a Chinese hamster ovary cell line selected for low endogenous Na+-dependent glutamate uptake
    • Levy LM, Warr O, Attwell D. (1998) Stoichiometry of the glial glutamate transporter GLT-1 expressed inducibly in a Chinese hamster ovary cell line selected for low endogenous Na+-dependent glutamate uptake. J. Neurosci. 18:9620-8.
    • (1998) J. Neurosci , vol.18 , pp. 9620-9628
    • Levy, L.M.1    Warr, O.2    Attwell, D.3
  • 42
    • 0032506514 scopus 로고    scopus 로고
    • Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway
    • Yano S, Tokumitsu H, Soderling TR. (1998) Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway. Nature 396:584-7.
    • (1998) Nature , vol.396 , pp. 584-587
    • Yano, S.1    Tokumitsu, H.2    Soderling, T.R.3
  • 43
    • 0031706636 scopus 로고    scopus 로고
    • Factors affecting excitatory amino acid release following severe human head injury
    • Bullock R et al. (1998) Factors affecting excitatory amino acid release following severe human head injury. J. Neurosurg. 89:507-18.
    • (1998) J. Neurosurg , vol.89 , pp. 507-518
    • Bullock, R.1
  • 45
    • 33644644376 scopus 로고    scopus 로고
    • Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury
    • Yi JH, Hazell AS. (2006) Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury. Neurochem Int 48:394-403.
    • (2006) Neurochem Int , vol.48 , pp. 394-403
    • Yi, J.H.1    Hazell, A.S.2
  • 46
    • 0025809541 scopus 로고
    • Ischemic neuronal damage after acute subdural hematoma in the rat: Effects of pretreatment with a glutamate antagonist
    • Chen MH, Bullock R, Graham DI, Miller JD, McCulloch J. (1991) Ischemic neuronal damage after acute subdural hematoma in the rat: effects of pretreatment with a glutamate antagonist. J. Neurosurg. 74:944-50.
    • (1991) J. Neurosurg , vol.74 , pp. 944-950
    • Chen, M.H.1    Bullock, R.2    Graham, D.I.3    Miller, J.D.4    McCulloch, J.5
  • 48
    • 0034064252 scopus 로고    scopus 로고
    • CP-101,606, an NR2B subunit selective NMDA receptor antagonist, inhibits NMDA and injury induced c-fos expression and cortical spreading depression in rodents
    • Menniti FS, Pagnozzi MJ, Butler P, Chenard BL, Jaw-Tsai SS, Frost White W. (2000) CP-101,606, an NR2B subunit selective NMDA receptor antagonist, inhibits NMDA and injury induced c-fos expression and cortical spreading depression in rodents. Neuropharmacology 39:1147-55.
    • (2000) Neuropharmacology , vol.39 , pp. 1147-1155
    • Menniti, F.S.1    Pagnozzi, M.J.2    Butler, P.3    Chenard, B.L.4    Jaw-Tsai, S.S.5    Frost White, W.6
  • 49
    • 0033388098 scopus 로고    scopus 로고
    • Failure of the competitive N-methyl-D-aspartate antagonist Selfotel (CGS 19755) in the treatment of severe head injury: Results of two phase III clinical trials. The Selfotel Investigators
    • Morris GF, Bullock R, Marshall SB, Marmarou A, Maas A, Marshall LF. (1999) Failure of the competitive N-methyl-D-aspartate antagonist Selfotel (CGS 19755) in the treatment of severe head injury: results of two phase III clinical trials. The Selfotel Investigators. J. Neurosurg. 91:737-43.
    • (1999) J. Neurosurg , vol.91 , pp. 737-743
    • Morris, G.F.1    Bullock, R.2    Marshall, S.B.3    Marmarou, A.4    Maas, A.5    Marshall, L.F.6
  • 50
    • 0029100602 scopus 로고
    • (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy- 4-phenylpiperidino)-1-propanol: A potent new neuroprotectant which blocks N-methyl-D-aspartate responses
    • Chenard BL et al. (1995) (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy- 4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. J. Med. Chem. 38:3138-45.
    • (1995) J. Med. Chem , vol.38 , pp. 3138-3145
    • Chenard, B.L.1
  • 51
    • 0033392424 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study of the safety, tolerability and pharmacokinetics of CP-101,606 in patients with a mild or moderate traumatic brain injury
    • Merchant RE et al. (1999) A double-blind, placebo-controlled study of the safety, tolerability and pharmacokinetics of CP-101,606 in patients with a mild or moderate traumatic brain injury. Ann. N. Y. Acad. Sci. 890:42-50.
    • (1999) Ann. N. Y. Acad. Sci , vol.890 , pp. 42-50
    • Merchant, R.E.1
  • 52
    • 31044453436 scopus 로고    scopus 로고
    • The effect of the selective NMDA receptor antagonist traxoprodil in the treatment of traumatic brain injury
    • Yurkewicz L, Weaver J, Bullock MR, Marshall LF. (2005) The effect of the selective NMDA receptor antagonist traxoprodil in the treatment of traumatic brain injury. J. Neurotrauma 22:1428-43.
    • (2005) J. Neurotrauma , vol.22 , pp. 1428-1443
    • Yurkewicz, L.1    Weaver, J.2    Bullock, M.R.3    Marshall, L.F.4
  • 53
    • 0036260647 scopus 로고    scopus 로고
    • Clinical trials in head injury
    • Narayan RK et al. (2002) Clinical trials in head injury. J. Neurotrauma 19:503-557.
    • (2002) J. Neurotrauma , vol.19 , pp. 503-557
    • Narayan, R.K.1
  • 54
    • 0033385353 scopus 로고    scopus 로고
    • Magnesium in disease: A review with special emphasis on the serum ionized magnesium
    • Sanders GT, Huijgen HJ, Sanders R. (1999) Magnesium in disease: a review with special emphasis on the serum ionized magnesium. Clin. Chem. Lab. Med. 37:1011-33.
    • (1999) Clin. Chem. Lab. Med , vol.37 , pp. 1011-1033
    • Sanders, G.T.1    Huijgen, H.J.2    Sanders, R.3
  • 55
    • 0035109699 scopus 로고    scopus 로고
    • Hypomagnesemic disorders
    • viii
    • Dacey MJ. (2001) Hypomagnesemic disorders. Crit. Care Clin. 17:155-73, viii.
    • (2001) Crit. Care Clin , vol.17 , pp. 155-173
    • Dacey, M.J.1
  • 56
    • 12444304183 scopus 로고    scopus 로고
    • Monitoring of serum ionized magnesium in neurosurgical intensive care unit: Preliminary results
    • Kahraman S, Ozgurtas T, Kayali H, Atabey C, Kutluay T, Timurkaynak E. (2003) Monitoring of serum ionized magnesium in neurosurgical intensive care unit: preliminary results. Clin. Chim. Acta. 334:211-15.
    • (2003) Clin. Chim. Acta , vol.334 , pp. 211-215
    • Kahraman, S.1    Ozgurtas, T.2    Kayali, H.3    Atabey, C.4    Kutluay, T.5    Timurkaynak, E.6
  • 57
    • 0033932034 scopus 로고    scopus 로고
    • Hypomagnesemia and hypophosphatemia at admission in patients with severe head injury
    • Polderman KH, Bloemers FW, Peerdeman SM, Girbes AR. (2000) Hypomagnesemia and hypophosphatemia at admission in patients with severe head injury. Crit. Care Med. 28:2022-5.
    • (2000) Crit. Care Med , vol.28 , pp. 2022-2025
    • Polderman, K.H.1    Bloemers, F.W.2    Peerdeman, S.M.3    Girbes, A.R.4
  • 58
    • 0023869808 scopus 로고
    • Decline in intracellular free Mg2+ is associated with irreversible tissue injury after brain trauma
    • Vink R, McIntosh TK, Demediuk P, Weiner MW, Faden AI. (1988) Decline in intracellular free Mg2+ is associated with irreversible tissue injury after brain trauma. J. Biol. Chem. 263:757-61.
    • (1988) J. Biol. Chem , vol.263 , pp. 757-761
    • Vink, R.1    McIntosh, T.K.2    Demediuk, P.3    Weiner, M.W.4    Faden, A.I.5
  • 59
    • 0023769955 scopus 로고
    • Magnesium deficiency exacerbates and pretreatment improves outcome following traumatic brain injury in rats: 31P magnetic resonance spectroscopy and behavioral studies
    • McIntosh TK, Faden AI, Yamakami I, Vink R. (1988) Magnesium deficiency exacerbates and pretreatment improves outcome following traumatic brain injury in rats: 31P magnetic resonance spectroscopy and behavioral studies. J. Neurotrauma 5:17-31.
    • (1988) J. Neurotrauma , vol.5 , pp. 17-31
    • McIntosh, T.K.1    Faden, A.I.2    Yamakami, I.3    Vink, R.4
  • 60
    • 0035110917 scopus 로고    scopus 로고
    • Acute cytoskeletal alterations and cell death induced by experimental brain injury are attenuated by magnesium treatment and exacerbated by magnesium deficiency
    • Saatman KE, Bareyre FM, Grady MS, McIntosh TK. (2001) Acute cytoskeletal alterations and cell death induced by experimental brain injury are attenuated by magnesium treatment and exacerbated by magnesium deficiency. J. Neuropathol. Exp. Neurol. 60:183-94.
    • (2001) J. Neuropathol. Exp. Neurol , vol.60 , pp. 183-194
    • Saatman, K.E.1    Bareyre, F.M.2    Grady, M.S.3    McIntosh, T.K.4
  • 63
    • 33845309465 scopus 로고    scopus 로고
    • Magnesium sulfate for neuroprotection after traumatic brain injury: A randomised controlled trial
    • Temkin NR et al. (2007) Magnesium sulfate for neuroprotection after traumatic brain injury: a randomised controlled trial. Lancet Neurol. 6:29-38.
    • (2007) Lancet Neurol , vol.6 , pp. 29-38
    • Temkin, N.R.1
  • 64
    • 1842636595 scopus 로고    scopus 로고
    • Delayed Activation, rather than inhibition, of glutamate NMDA receptors improves neurological outcome after closed head injury in mice
    • Biegon A, Fry PA, Paden CMA, Tsenter J, Shohami E. (2004) Delayed Activation, rather than inhibition, of glutamate NMDA receptors improves neurological outcome after closed head injury in mice. Proc. Natl. Acad. Sci. U. S. A. 101 5117-22.
    • (2004) Proc. Natl. Acad. Sci. U. S. A , vol.101 , pp. 5117-5122
    • Biegon, A.1    Fry, P.A.2    Paden, C.M.A.3    Tsenter, J.4    Shohami, E.5
  • 65
    • 34347374299 scopus 로고    scopus 로고
    • D-cycloserine improves functional recovery and reinstates long-term potentiation (LTP) in a mouse model of closed head injury
    • Yaka R et al. (2007) D-cycloserine improves functional recovery and reinstates long-term potentiation (LTP) in a mouse model of closed head injury. FASEB J. 21:2033-41.
    • (2007) FASEB J , vol.21 , pp. 2033-2041
    • Yaka, R.1
  • 66
    • 0031922630 scopus 로고    scopus 로고
    • Cannabinoid receptors and their endogenous agonist, anandamide
    • Axelrod J, Felder CC. (1998) Cannabinoid receptors and their endogenous agonist, anandamide. Neurochem. Res. 23:575-81.
    • (1998) Neurochem. Res , vol.23 , pp. 575-581
    • Axelrod, J.1    Felder, C.C.2
  • 69
    • 0032802188 scopus 로고    scopus 로고
    • Pharmacology of cannabinoid receptor ligands
    • Pertwee RG. (1999) Pharmacology of cannabinoid receptor ligands. Curr. Med. Chem. 6:635-64.
    • (1999) Curr. Med. Chem , vol.6 , pp. 635-664
    • Pertwee, R.G.1
  • 70
    • 0027078685 scopus 로고
    • Isolation and structure of a brain constituent that binds to the cannabinoid receptor
    • Devane WA et al. (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258:1946-9.
    • (1992) Science , vol.258 , pp. 1946-1949
    • Devane, W.A.1
  • 71
    • 0029012014 scopus 로고
    • Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
    • Mechoulam R et al. (1995) Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem. Pharmacol. 50:83-90.
    • (1995) Biochem. Pharmacol , vol.50 , pp. 83-90
    • Mechoulam, R.1
  • 72
    • 0035957425 scopus 로고    scopus 로고
    • 2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor
    • Hanus L et al. (2001) 2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor. Proc. Natl. Acad. Sci. U. S. A. 98:3662-5.
    • (2001) Proc. Natl. Acad. Sci. U. S. A , vol.98 , pp. 3662-3665
    • Hanus, L.1
  • 73
    • 0033661740 scopus 로고    scopus 로고
    • Pathways and mechanisms of N-acylethanolamine biosynthesis: Can anandamide be generated selectively?
    • Schmid HH. (2000) Pathways and mechanisms of N-acylethanolamine biosynthesis: can anandamide be generated selectively? Chem. Phys. Lipids 108:71-87.
    • (2000) Chem. Phys. Lipids , vol.108 , pp. 71-87
    • Schmid, H.H.1
  • 74
    • 0035452256 scopus 로고    scopus 로고
    • Fatty acid amide hydrolase: Biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide
    • Fowler CJ, Jonsson KO, Tiger G. (2001) Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide. Biochem. Pharmacol. 62:517-526.
    • (2001) Biochem. Pharmacol , vol.62 , pp. 517-526
    • Fowler, C.J.1    Jonsson, K.O.2    Tiger, G.3
  • 76
    • 33847657051 scopus 로고    scopus 로고
    • Immune control by endocannabinoids - new mechanisms of neuroprotection?
    • Ullrich O, Merker K, Timm J, Tauber S. (2007) Immune control by endocannabinoids - new mechanisms of neuroprotection? J. Neuroimmunol. 184:127-35.
    • (2007) J. Neuroimmunol , vol.184 , pp. 127-135
    • Ullrich, O.1    Merker, K.2    Timm, J.3    Tauber, S.4
  • 77
    • 0024316874 scopus 로고
    • Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker
    • Feigenbaum JJ et al. (1989) Nonpsychotropic cannabinoid acts as a functional N-methyl-D-aspartate receptor blocker. Proc. Natl. Acad. Sci. U. S. A. 86:9584-7.
    • (1989) Proc. Natl. Acad. Sci. U. S. A , vol.86 , pp. 9584-9587
    • Feigenbaum, J.J.1
  • 78
    • 0023791260 scopus 로고
    • Enantiomeric cannabinoids: Stereospecificity of psychotropic activity
    • Mechoulam R et al. (1988) Enantiomeric cannabinoids: stereospecificity of psychotropic activity. Experientia 44:762-4.
    • (1988) Experientia , vol.44 , pp. 762-764
    • Mechoulam, R.1
  • 79
    • 0029165097 scopus 로고
    • Neuroprotective and antioxidant activities of HU-211, a novel NMDA receptor antagonist
    • Eshhar N, Striem S, Kohen R, Tirosh O, Biegon A. (1995) Neuroprotective and antioxidant activities of HU-211, a novel NMDA receptor antagonist. Eur. J. Pharmacol. 283:19-29.
    • (1995) Eur. J. Pharmacol , vol.283 , pp. 19-29
    • Eshhar, N.1    Striem, S.2    Kohen, R.3    Tirosh, O.4    Biegon, A.5
  • 80
    • 0030730585 scopus 로고    scopus 로고
    • Protection against septic shock and suppression of tumor necrosis factor alpha and nitric oxide production by dexanabinol (HU-211), a nonpsychotropic cannabinoid
    • Gallily R et al. (1997) Protection against septic shock and suppression of tumor necrosis factor alpha and nitric oxide production by dexanabinol (HU-211), a nonpsychotropic cannabinoid. J. Pharmacol. Exp. Ther. 283:918-24.
    • (1997) J. Pharmacol. Exp. Ther , vol.283 , pp. 918-924
    • Gallily, R.1
  • 81
    • 0031047431 scopus 로고    scopus 로고
    • Cytokine production in the brain following closed head injury: Dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant
    • Shohami E, Gallily R, Mechoulam R, Bass R, Ben-Hur T. (1997) Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant. J. Neuroimmunol. 72:169-77.
    • (1997) J. Neuroimmunol , vol.72 , pp. 169-177
    • Shohami, E.1    Gallily, R.2    Mechoulam, R.3    Bass, R.4    Ben-Hur, T.5
  • 82
    • 0035149749 scopus 로고    scopus 로고
    • Reactive oxygen radicals in signaling and damage in the ischemic brain
    • Chan PH. (2001) Reactive oxygen radicals in signaling and damage in the ischemic brain. J. Cereb. Blood Flow Metab. 21:2-14.
    • (2001) J. Cereb. Blood Flow Metab , vol.21 , pp. 2-14
    • Chan, P.H.1
  • 84
    • 0030827712 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of escalating i.v. doses of dexanabinol (HU-211), a neuroprotectant agent, in normal volunteers
    • Brewster ME et al. (1997) Clinical pharmacokinetics of escalating i.v. doses of dexanabinol (HU-211), a neuroprotectant agent, in normal volunteers. Int. J. Clin. Pharmacol. Ther. 35:361-5.
    • (1997) Int. J. Clin. Pharmacol. Ther , vol.35 , pp. 361-365
    • Brewster, M.E.1
  • 85
    • 0036192049 scopus 로고    scopus 로고
    • Dexanabinol (HU-211) in the treatment of severe closed head injury: A randomized, placebo-controlled, phase II clinical trial
    • Knoller N et al. (2002) Dexanabinol (HU-211) in the treatment of severe closed head injury: a randomized, placebo-controlled, phase II clinical trial. Crit. Care Med. 30:548-54.
    • (2002) Crit. Care Med , vol.30 , pp. 548-554
    • Knoller, N.1
  • 86
    • 29044436727 scopus 로고    scopus 로고
    • Efficacy and safety of dexanabinol in severe traumatic brain injury: Results of a phase III randomised, placebo-controlled, clinical trial
    • Maas AI et al. (2006) Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial. Lancet Neurol. 5:38-45.
    • (2006) Lancet Neurol , vol.5 , pp. 38-45
    • Maas, A.I.1
  • 89
    • 21744451343 scopus 로고    scopus 로고
    • Use of methylphenidate in traumatic brain injury
    • Siddall OM. (2005) Use of methylphenidate in traumatic brain injury. Ann. Pharmacother. 39:1309-13.
    • (2005) Ann. Pharmacother , vol.39 , pp. 1309-1313
    • Siddall, O.M.1
  • 90
    • 1642544030 scopus 로고    scopus 로고
    • Methylphenidate and MK-801, an N-methyl-d-aspartate receptor antagonist: Shared biological properties
    • Husson I, Mesples B, Medja F, Leroux P, Kosofsky B, Gressens P. (2004) Methylphenidate and MK-801, an N-methyl-d-aspartate receptor antagonist: shared biological properties. Neuroscience 125:163-70.
    • (2004) Neuroscience , vol.125 , pp. 163-170
    • Husson, I.1    Mesples, B.2    Medja, F.3    Leroux, P.4    Kosofsky, B.5    Gressens, P.6
  • 91
    • 1642569129 scopus 로고    scopus 로고
    • Effect of methylphenidate on vital signs and adverse effects in adults with traumatic brain injury
    • quiz 138-41, 167
    • Alban JP, Hopson MM, Ly V, Whyte J. (2004) Effect of methylphenidate on vital signs and adverse effects in adults with traumatic brain injury. Am. J. Phys. Med. Rehabil. 83:131-7; quiz 138-41, 167.
    • (2004) Am. J. Phys. Med. Rehabil , vol.83 , pp. 131-137
    • Alban, J.P.1    Hopson, M.M.2    Ly, V.3    Whyte, J.4
  • 92
    • 0038693343 scopus 로고    scopus 로고
    • Effects of methylphenidate on heart rate and blood pressure among inpatients with acquired brain injury
    • Burke DT et al. (2003) Effects of methylphenidate on heart rate and blood pressure among inpatients with acquired brain injury. Am. J. Phys Med. Rehabil. 82:493-7.
    • (2003) Am. J. Phys Med. Rehabil , vol.82 , pp. 493-497
    • Burke, D.T.1
  • 93
    • 33746933503 scopus 로고    scopus 로고
    • Effect of methylphenidate on ICU and hospital length of stay in patients with severe and moderate traumatic brain injury
    • Moein H, Khalili HA, Keramatian K. (2006) Effect of methylphenidate on ICU and hospital length of stay in patients with severe and moderate traumatic brain injury. Clin. Neurol. Neurosurg. 108:539-42.
    • (2006) Clin. Neurol. Neurosurg , vol.108 , pp. 539-542
    • Moein, H.1    Khalili, H.A.2    Keramatian, K.3
  • 94
    • 0036329446 scopus 로고    scopus 로고
    • Cyclosporin A improves brain tissue oxygen consumption and learning/memory performance after lateral fluid percussion injury in rats
    • Alessandri B, Rice AC, Levasseur J, DeFord M, Hamm RJ, Bullock MR. (2002) Cyclosporin A improves brain tissue oxygen consumption and learning/memory performance after lateral fluid percussion injury in rats. J. Neurotrauma 19:829-41.
    • (2002) J. Neurotrauma , vol.19 , pp. 829-841
    • Alessandri, B.1    Rice, A.C.2    Levasseur, J.3    DeFord, M.4    Hamm, R.J.5    Bullock, M.R.6
  • 95
    • 0345379310 scopus 로고    scopus 로고
    • Postinjury cyclosporin A administration limits axonal damage and disconnection in traumatic brain injury
    • Buki A, Okonkwo DO, Povlishock JT. (1999) Postinjury cyclosporin A administration limits axonal damage and disconnection in traumatic brain injury. J. Neurotrauma 16:511-21.
    • (1999) J. Neurotrauma , vol.16 , pp. 511-521
    • Buki, A.1    Okonkwo, D.O.2    Povlishock, J.T.3
  • 96
    • 0033525008 scopus 로고    scopus 로고
    • Cyclosporin A limits calcium-induced axonal damage following traumatic brain injury
    • Okonkwo DO, Buki A, Siman R, Povlishock JT. (1999) Cyclosporin A limits calcium-induced axonal damage following traumatic brain injury. Neuroreport 10:353-8.
    • (1999) Neuroreport , vol.10 , pp. 353-358
    • Okonkwo, D.O.1    Buki, A.2    Siman, R.3    Povlishock, J.T.4
  • 97
    • 0033509493 scopus 로고    scopus 로고
    • An intrathecal bolus of cyclosporin A before injury preserves mitochondrial integrity and attenuates axonal disruption in traumatic brain injury
    • Okonkwo DO, Povlishock JT. (1999) An intrathecal bolus of cyclosporin A before injury preserves mitochondrial integrity and attenuates axonal disruption in traumatic brain injury. J. Cereb. Blood Flow Metab. 19:443-451.
    • (1999) J. Cereb. Blood Flow Metab , vol.19 , pp. 443-451
    • Okonkwo, D.O.1    Povlishock, J.T.2
  • 98
    • 12244281831 scopus 로고    scopus 로고
    • Mitochondrial permeability transition in CNS trauma: Cause or effect of neuronal cell death?
    • Sullivan PG, Rabchevsky AG, Waldmeier PC, Springer JE. (2005) Mitochondrial permeability transition in CNS trauma: cause or effect of neuronal cell death? J. Neurosci. Res. 79:231-239.
    • (2005) J. Neurosci. Res , vol.79 , pp. 231-239
    • Sullivan, P.G.1    Rabchevsky, A.G.2    Waldmeier, P.C.3    Springer, J.E.4
  • 99
    • 0034057187 scopus 로고    scopus 로고
    • Continuous infusion of cyclosporin A postinjury significantly ameliorates cortical damage following traumatic brain injury
    • Sullivan PG, Thompson M, Scheff SW. (2000) Continuous infusion of cyclosporin A postinjury significantly ameliorates cortical damage following traumatic brain injury. Exp. Neurol. 161:631-7.
    • (2000) Exp. Neurol , vol.161 , pp. 631-637
    • Sullivan, P.G.1    Thompson, M.2    Scheff, S.W.3
  • 100
    • 0032736595 scopus 로고    scopus 로고
    • Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury
    • Sullivan PG, Thompson MB, Scheff SW. (1999) Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury. Exp. Neurol. 160:226-34.
    • (1999) Exp. Neurol , vol.160 , pp. 226-234
    • Sullivan, P.G.1    Thompson, M.B.2    Scheff, S.W.3
  • 101
    • 0023921505 scopus 로고
    • Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs
    • Kronbach T, Fischer V, Meyer UA. (1988) Cyclosporine metabolism in human liver: identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs. Clin. Pharmacol. Ther. 43:630-5.
    • (1988) Clin. Pharmacol. Ther , vol.43 , pp. 630-635
    • Kronbach, T.1    Fischer, V.2    Meyer, U.A.3
  • 103
    • 0034853437 scopus 로고    scopus 로고
    • Nimodipine attenuates lipid peroxidation during the acute phase of head trauma in rats
    • Ercan M, Inci S, Kilinc K, Palaoglu S, Aypar U. (2001) Nimodipine attenuates lipid peroxidation during the acute phase of head trauma in rats. Neurosurg. Rev. 24:127-30.
    • (2001) Neurosurg. Rev , vol.24 , pp. 127-130
    • Ercan, M.1    Inci, S.2    Kilinc, K.3    Palaoglu, S.4    Aypar, U.5
  • 104
    • 0027526550 scopus 로고
    • Regional changes in interstitial K+ and Ca2+ levels following cortical compression contusion trauma in rats
    • Nilsson P, Hillered L, Olsson Y, Sheardown MJ, Hansen AJ. (1993) Regional changes in interstitial K+ and Ca2+ levels following cortical compression contusion trauma in rats. J. Cereb. Blood Flow Metab. 13:183-92.
    • (1993) J. Cereb. Blood Flow Metab , vol.13 , pp. 183-192
    • Nilsson, P.1    Hillered, L.2    Olsson, Y.3    Sheardown, M.J.4    Hansen, A.J.5
  • 105
    • 0024349953 scopus 로고
    • Accumulation of calcium in the brain following head trauma
    • Shapira Y, Yadid G, Cotev S, Shohami E. (1989) Accumulation of calcium in the brain following head trauma. Neurol Res. 11:169-72.
    • (1989) Neurol Res , vol.11 , pp. 169-172
    • Shapira, Y.1    Yadid, G.2    Cotev, S.3    Shohami, E.4
  • 106
    • 0028356736 scopus 로고
    • A multicenter trial of the efficacy of nimodipine on outcome after severe head injury
    • The European Study Group on Nimodipine in Severe Head Injury
    • The European Study Group on Nimodipine in Severe Head Injury (1994) A multicenter trial of the efficacy of nimodipine on outcome after severe head injury. J. Neurosurg. 80:797-804.
    • (1994) J. Neurosurg , vol.80 , pp. 797-804
  • 107
    • 0025863565 scopus 로고
    • A trial of the effect of nimodipine on outcome after head injury
    • Bailey I et al. (1991) A trial of the effect of nimodipine on outcome after head injury. Acta Neurochir. (Wien) 110:97-105.
    • (1991) Acta Neurochir. (Wien) , vol.110 , pp. 97-105
    • Bailey, I.1
  • 108
    • 0029969691 scopus 로고    scopus 로고
    • Nimodipine in traumatic subarachnoid haemorrhage: A re-analysis of the HIT I and HIT II trials
    • Murray GD, Teasdale GM, Schmitz H. (1996) Nimodipine in traumatic subarachnoid haemorrhage: a re-analysis of the HIT I and HIT II trials. Acta Neurochir. (Wien) 138:1163-7.
    • (1996) Acta Neurochir. (Wien) , vol.138 , pp. 1163-1167
    • Murray, G.D.1    Teasdale, G.M.2    Schmitz, H.3
  • 109
    • 0026710102 scopus 로고
    • A randomized trial of nimodipine in severe head injury: HIT I. British/Finnish Co-operative Head Injury Trial Group
    • Teasdale G et al. (1992) A randomized trial of nimodipine in severe head injury: HIT I. British/Finnish Co-operative Head Injury Trial Group. J. Neurotrauma 9 Suppl 2:S545-50.
    • (1992) J. Neurotrauma , vol.9 , Issue.SUPPL. 2
    • Teasdale, G.1
  • 110
    • 0025616473 scopus 로고
    • The effect of nimodipine on outcome after head injury: A prospective randomised control trial. The British/Finnish Co-operative Head Injury Trial Group
    • Teasdale G et al. (1990) The effect of nimodipine on outcome after head injury: a prospective randomised control trial. The British/Finnish Co-operative Head Injury Trial Group. Acta Neurochir. Suppl. (Wien) 51:315-6.
    • (1990) Acta Neurochir. Suppl. (Wien) , vol.51 , pp. 315-316
    • Teasdale, G.1
  • 112
    • 0036788652 scopus 로고    scopus 로고
    • Molecular mechanisms in the pathogenesis of traumatic brain injury
    • Ray SK, Dixon CE, Banik NL. (2002) Molecular mechanisms in the pathogenesis of traumatic brain injury. Histol. Histopathol. 17:1137-52.
    • (2002) Histol. Histopathol , vol.17 , pp. 1137-1152
    • Ray, S.K.1    Dixon, C.E.2    Banik, N.L.3
  • 113
    • 0026544583 scopus 로고
    • Bradykinin and neuronal injury
    • Francel PC. (1992) Bradykinin and neuronal injury. J. Neurotrauma 9 Suppl 1:S27-45.
    • (1992) J. Neurotrauma , vol.9 , Issue.SUPPL. 1
    • Francel, P.C.1
  • 115
    • 0023177040 scopus 로고
    • Inhibition of bradykinin- and kallikrein-induced cerebral arteriolar dilation by a specific bradykinin antagonist
    • Ellis EF, Heizer ML, Hambrecht GS, Holt SA, Stewart JM, Vavrek RJ. (1987) Inhibition of bradykinin- and kallikrein-induced cerebral arteriolar dilation by a specific bradykinin antagonist. Stroke 18:792-5.
    • (1987) Stroke , vol.18 , pp. 792-795
    • Ellis, E.F.1    Heizer, M.L.2    Hambrecht, G.S.3    Holt, S.A.4    Stewart, J.M.5    Vavrek, R.J.6
  • 116
    • 0026556434 scopus 로고
    • Bioregulation of kinins: Kallikreins, kininogens, and kininases
    • Bhoola KD, Figueroa CD, Worthy K. (1992) Bioregulation of kinins: kallikreins, kininogens, and kininases. Pharmacol. Rev. 44:1-80.
    • (1992) Pharmacol. Rev , vol.44 , pp. 1-80
    • Bhoola, K.D.1    Figueroa, C.D.2    Worthy, K.3
  • 117
    • 0036674858 scopus 로고    scopus 로고
    • LF 16-0687 Ms, a bradykinin B2 receptor antagonist, reduces brain edema and improves long-term neurological function recovery after closed head trauma in rats
    • Kaplanski J et al. (2002) LF 16-0687 Ms, a bradykinin B2 receptor antagonist, reduces brain edema and improves long-term neurological function recovery after closed head trauma in rats. J. Neurotrauma 19:953-64.
    • (2002) J. Neurotrauma , vol.19 , pp. 953-964
    • Kaplanski, J.1
  • 118
    • 0032747821 scopus 로고    scopus 로고
    • Effect of LF 16-0687MS, a new nonpeptide bradykinin B2 receptor antagonist, in a rat model of closed head trauma
    • Pruneau D, Chorny I, Benkovitz V, Artru A, Roitblat L, Shapira Y. (1999) Effect of LF 16-0687MS, a new nonpeptide bradykinin B2 receptor antagonist, in a rat model of closed head trauma. J. Neurotrauma 16:1057-65.
    • (1999) J. Neurotrauma , vol.16 , pp. 1057-1065
    • Pruneau, D.1    Chorny, I.2    Benkovitz, V.3    Artru, A.4    Roitblat, L.5    Shapira, Y.6
  • 119
    • 0031716315 scopus 로고    scopus 로고
    • Traumatic brain contusions: A clinical role for the kinin antagonist CP-0127
    • discussion 802-3
    • Narotam PK et al. (1998) Traumatic brain contusions: a clinical role for the kinin antagonist CP-0127. Acta Neurochir. (Wien) 140:793-802; discussion 802-3.
    • (1998) Acta Neurochir. (Wien) , vol.140 , pp. 793-802
    • Narotam, P.K.1
  • 120
    • 0033034999 scopus 로고    scopus 로고
    • Effects of the bradykinin antagonist Bradycor (deltibant, CP-1027) in severe traumatic brain injury: Results of a multi-center, randomized, placebo-controlled trial. American Brain Injury Consortium Study Group
    • Marmarou A et al. (1999) Effects of the bradykinin antagonist Bradycor (deltibant, CP-1027) in severe traumatic brain injury: results of a multi-center, randomized, placebo-controlled trial. American Brain Injury Consortium Study Group. J. Neurotrauma 16:431-44.
    • (1999) J. Neurotrauma , vol.16 , pp. 431-444
    • Marmarou, A.1
  • 121
    • 0032748935 scopus 로고    scopus 로고
    • Pharmacological profile of LF 16-0687, a new potent non-peptide bradykinin B2 receptor antagonist
    • Pruneau D et al. (1999) Pharmacological profile of LF 16-0687, a new potent non-peptide bradykinin B2 receptor antagonist. Immunopharmacology 43:187-94.
    • (1999) Immunopharmacology , vol.43 , pp. 187-194
    • Pruneau, D.1
  • 122
    • 0141790068 scopus 로고    scopus 로고
    • Detrimental role of bradykinin B2 receptor in a murine model of diffuse brain injury
    • Hellal O et al. (2003) Detrimental role of bradykinin B2 receptor in a murine model of diffuse brain injury. J. Neurotrauma. 20:841-51.
    • (2003) J. Neurotrauma , vol.20 , pp. 841-851
    • Hellal, O.1
  • 123
    • 31044440134 scopus 로고    scopus 로고
    • A single dose, three-arm, placebo-controlled, phase I study of the bradykinin B2 receptor antagonist Anatibant (LF16-0687Ms) in patients with severe traumatic brain injury
    • Marmarou A et al. (2005) A single dose, three-arm, placebo-controlled, phase I study of the bradykinin B2 receptor antagonist Anatibant (LF16-0687Ms) in patients with severe traumatic brain injury. J. Neurotrauma 22:1444-55.
    • (2005) J. Neurotrauma , vol.22 , pp. 1444-1455
    • Marmarou, A.1
  • 124
    • 34547118091 scopus 로고    scopus 로고
    • Neurological recovery-promoting, anti-inflammatory, and anti-oxidative effects afforded by fenofibrate, a PPAR alpha agonist, in traumatic brain injury
    • Chen XR, Besson VC, Palmier B, Garcia Y, Plotkine M, Marchand-Leroux C. (2007) Neurological recovery-promoting, anti-inflammatory, and anti-oxidative effects afforded by fenofibrate, a PPAR alpha agonist, in traumatic brain injury. J. Neurotrauma 24:1119-31.
    • (2007) J. Neurotrauma , vol.24 , pp. 1119-1131
    • Chen, X.R.1    Besson, V.C.2    Palmier, B.3    Garcia, Y.4    Plotkine, M.5    Marchand-Leroux, C.6
  • 125
    • 43949146665 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: "key" regulators of neuroinflammation after traumatic brain injury
    • Stahel PF, Smith WR, Bruchis J, Rabb CH. (2008) Peroxisome proliferator-activated receptors: "key" regulators of neuroinflammation after traumatic brain injury. PPAR Res. 2008:538141.
    • (2008) PPAR Res , vol.2008 , pp. 538141
    • Stahel, P.F.1    Smith, W.R.2    Bruchis, J.3    Rabb, C.H.4
  • 126
    • 0036318206 scopus 로고    scopus 로고
    • Vaccinia virus complement control protein enhances functional recovery after traumatic brain injury
    • Hicks RR, Keeling KL, Yang MY, Smith SA, Simons AM, Kotwal GJ. (2002) Vaccinia virus complement control protein enhances functional recovery after traumatic brain injury. J. Neurotrauma 19:705-14.
    • (2002) J. Neurotrauma , vol.19 , pp. 705-714
    • Hicks, R.R.1    Keeling, K.L.2    Yang, M.Y.3    Smith, S.A.4    Simons, A.M.5    Kotwal, G.J.6
  • 127
    • 85052610430 scopus 로고    scopus 로고
    • Complement inhibition attenuates brain edema and neurological deficits induced by thrombin
    • Gong Y, Xi GH, Keep RF, Hoff JT, Hua Y. (2005) Complement inhibition attenuates brain edema and neurological deficits induced by thrombin. Acta Neurochir. Suppl. 95:389-92.
    • (2005) Acta Neurochir. Suppl , vol.95 , pp. 389-392
    • Gong, Y.1    Xi, G.H.2    Keep, R.F.3    Hoff, J.T.4    Hua, Y.5
  • 128
    • 33746930853 scopus 로고    scopus 로고
    • Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury
    • Leinhase I et al. (2006) Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury. Exp. Neurol. 199:454-64.
    • (2006) Exp. Neurol , vol.199 , pp. 454-464
    • Leinhase, I.1
  • 129
    • 34248676285 scopus 로고    scopus 로고
    • Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: A randomized placebo-controlled study in mice
    • Leinhase I et al. (2007) Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice. J. Neuroinflammation 4:13.
    • (2007) J. Neuroinflammation , vol.4 , pp. 13
    • Leinhase, I.1


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