Progesterone and the spinal cord: Good friends in bad times

NeuroImmunoModulation

Volumn 17, Issue 3, 2010, Pages 146-149

  Labombarda, Florencia ^a   González Deniselle, María Claudia ^a   De Nicola, Alejandro Federico ^a   González, Susana Laura ^a  

^a Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

Brain derived neurotrophic factor; Oligodendrocytes; Progesterone; Remyelination; Spinal cord injury

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM); BRAIN DERIVED NEUROTROPHIC FACTOR; BROXURIDINE; CHOLINE ACETYLTRANSFERASE; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN 2; NEUROMODULIN; NEUROTROPHIN; OIL; PROGESTERONE; SODIUM;

CELL FUNCTION; CELL MEMBRANE POTENTIAL; CONFERENCE PAPER; DRUG MECHANISM; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MUSCLE CONTRACTION; MYELINATION; NERVE CELL EXCITABILITY; NERVE DEGENERATION; NERVE FIBER REGENERATION; NEUROMUSCULAR SYNAPSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SPINAL CORD ATROPHY; SPINAL CORD INJURY; TARGET ORGAN; TIME SERIES ANALYSIS; UPREGULATION;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; HUMANS; MYELIN SHEATH; NERVE DEGENERATION; NERVE REGENERATION; NEUROPROTECTIVE AGENTS; PROGESTERONE; SPINAL CORD; SPINAL CORD INJURIES;

EID: 76949109199     PISSN: 10217401     EISSN: None     Source Type: Journal    
DOI: 10.1159/000258709     Document Type: Conference Paper

References (10)

1. Bareyre FM, Schwab ME: Inflammation, degeneration and regeneration in the injured spinal cord: insights from DNA microarrays. Trends Neurosci 2003; 26: 555-563.
2. Nacimiento W, Sappok T, Brook GA, Tóth L, Schoen SW, Noth J, Kreutzberg GW: Structural changes of anterior horn neurons and their synaptic input caudal to low thoracic spinal cord hemisection in the adult rat: a light and electron microscopic study. Acta Neuropathol 1995; 90: 552-564.
3. Labombarda F, González SL, González- Deniselle MC, Guennoun R, Schumacher M, De Nicola AF: Cellular basis for progesterone neuroprotection in the injured spinal cord. J of Neurotrauma 2002; 19: 343-355. (Pubitemid 34246121)
4. González SL, Labombarda F, Gonzalez Deniselle MC, Mougel A, Guennoun R, Schumacher M, De Nicola AF: Progesterone neuroprotection in spinal cord trauma involves up-regulation of brain-derived neurotrophic factor in motoneurones. J Steroid Biochem Mol Biol 2005; 94: 143-149.
5. González SL, López Costa JJ, Labombarda MF, Gonzalez Deniselle MC, Guennoun R, Schumacher M, De Nicola AF: Progesterone effects on neuronal ultrastructure and expression of microtubule-associated protein 2 (MAP2) in rats with acute spinal cord injury. Cell Mol Neurobiol 2009; 29: 27-39.
6. De Nicola AF, Labombarda F, González Deniselle MC, González SL, Garay L, Meyer M, Gargiulo G, Guennoun R, Schumacher M: Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration. Front Neuroendocrinol 2009; 30: 173-187.
7. Jodhka PK, Kaur P, Underwood W, Lydon JP, Singh M: The differences in neuroprotective efficacy of progesterone and medroxyprogesterone acetate correlate with their effects on brain-derived neurotrophic factor expression. Endocrinology 2009; 150: 3162-3168.
8. Labombarda MF, Gonzalez SL, Lima A, Roig P, Guennoun R, Schumacher M, De Nicola AF: Effects of progesterone on oligodendrocyte progenitors, oligodendrocyte transcription factors, and myelin proteins following spinal cord injury. Glia 2009; 57: 884-897.
9. Labombarda F, González SL, González Deniselle MC, Vinson GP, Schumacher M, De Nicola AF, Guennoun R: Effects of injury and progesterone treatment on progesterone receptor and progesterone binding protein 25-DX expression in the rat spinal cord. J Neurochem 2003; 87: 902-913.
10. Labombarda F, Pianos A, Liere P, Eychenne B, González S, Cambourg A, De Nicola AF, Schumacher M, Guennoun R: Injury elicited increase in spinal cord neurosteroid content analyzed by gas chromatography mass spectrometry. Endocrinology 2006; 147: 1847-1859.