Is there a link between proprotein convertase PC7 activity and human lipid homeostasis?

FEBS Open Bio

Volumn 4, Issue , 2014, Pages 741-745

  Guillemot, Johann ^a   Essalmani, Rachid ^a   Hamelin, Josée ^a   Seidah, Nabil G ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Apolipoprotein F; HDL LDL; Proprotein convertase PC7; Sortilin; Transferrin receptor 1; Triglycerides

Indexed keywords

APOLIPOPROTEIN; APOLIPOPROTEIN F; CD71 ANTIGEN; GLUCOSE; HIGH DENSITY LIPOPROTEIN; INSULIN; LOW DENSITY LIPOPROTEIN; MESSENGER RNA; PROPROTEIN CONVERTASE PC7; PROSORTILIN; SERINE PROTEINASE; SORTILIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; GENE MUTATION; GENETIC ASSOCIATION; HEK293 CELL LINE; HUMAN; HUMAN CELL; LIPID HOMEOSTASIS; LIPOPROTEIN BLOOD LEVEL; MALE; MOUSE; NONHUMAN; TRIACYLGLYCEROL BLOOD LEVEL; WILD TYPE;

EID: 84907095233     PISSN: 22115463     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fob.2014.08.004     Document Type: Article

References (27)

1. Seidah N.G., Prat A. The proprotein convertases are potential targets in the treatment of dyslipidemia. J. Mol. Med. 2007, 85:685-696.
2. Seidah N.G., Sadr M.S., Chretien M., Mbikay M. The multifaceted proprotein convertases: their unique, redundant, complementary and opposite functions. J. Biol. Chem. 2013, 288:21473-21481.
3. Seidah N.G., Chretien M. Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Res. 1999, 848:45-62.
4. Turpeinen H., Kukkurainen S., Pulkkinen K., Kauppila T., Ojala K., Hytonen V.P., Pesu M. Identification of proprotein convertase substrates using genome-wide expression correlation analysis. BMC Genomics 2011, 12:618.
5. Seidah N.G., Prat A. The biology and therapeutic targeting of the proprotein convertases. Nat. Rev. Drug Discov. 2012, 11:367-383.
6. Seidah N.G., Hamelin J., Mamarbachi M., Dong W., Tardos H., Mbikay M., Chretien M., Day R. CDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases. Proc. Natl. Acad. Sci. U.S.A. 1996, 93:3388-3393.
7. Bhattacharjya S., Xu P., Zhong M., Chretien M., Seidah N.G., Ni F. Inhibitory activity and structural characterization of a C-terminal peptide fragment derived from the prosegment of the proprotein convertase PC7. Biochemistry 2000, 39:2868-2877.
8. Zhong M., Munzer J.S., Basak A., Benjannet S., Mowla S.J., Decroly E., Chretien M., Seidah N.G. The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity. J. Biol. Chem. 1999, 274:33913-33920.
9. Rousselet E., Benjannet S., Hamelin J., Canuel M., Seidah N.G. The proprotein convertase PC7: unique zymogen activation and trafficking pathways. J. Biol. Chem. 2011, 286:2728-2738.
10. Henrich S., Lindberg I., Bode W., Than M.E. Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity. J. Mol. Biol. 2005, 345:211-227.
11. Seidah N.G., Chretien M. Eukaryotic protein processing: endoproteolysis of precursor proteins. Curr. Opin. Biotechnol. 1997, 8:602-607.
12. Oexle K., Ried J.S., Hicks A.A., Tanaka T., Hayward C., Bruegel M., Gogele M., Lichtner P., Muller-Myhsok B., Doring A., et al. Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels. Hum. Mol. Genet. 2011, 20:1042-1047.
13. Guillemot J., Canuel M., Essalmani R., Prat A., Seidah N.G. Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and Furin activates Hepcidin. Hepatology 2013, 57:2514-2524.
14. Wetsel W.C., Rodriguiz R.M., Guillemot J., Rousselet E., Essalmani R., Kim I.H., Bryant J.C., Marcinkiewicz J., Desjardins R., Day R., et al. Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:17362-17367.
15. McPherson R., Pertsemlidis A., Kavaslar N., Stewart A., Roberts R., Cox D.R., Hinds D.A., Pennacchio L.A., Tybjaerg-Hansen A., Folsom A.R., et al. A common allele on chromosome 9 associated with coronary heart disease. Science 2007, 316:1488-1491.
16. Chasman D.I., Pare G., Mora S., Hopewell J.C., Peloso G., Clarke R., Cupples L.A., Hamsten A., Kathiresan S., Malarstig A., et al. Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. PLoS Genet. 2009, 5:e1000730.
17. Peloso G.M., Auer P.L., Bis J.C., Voorman A., Morrison A.C., Stitziel N.O., Brody J.A., Khetarpal S.A., Crosby J.R., Fornage M., et al. Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. Am. J. Hum. Genet. 2014, 94:223-232.
18. Awan Z., Denis M., Bailey D., Giaid A., Prat A., Goltzman D., Seidah N.G., Genest J. The LDLR deficient mouse as a model for aortic calcification and quantification by micro-computed tomography. Atherosclerosis 2011, 219:455-462.
19. Fantus D., Awan Z., Seidah N.G., Genest J. Aortic calcification: novel insights from familial hypercholesterolemia and potential role for the low-density lipoprotein receptor. Atherosclerosis 2013, 226:9-15.
20. Cohen J., Pertsemlidis A., Kotowski I.K., Graham R., Garcia C.K., Hobbs H.H. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat. Genet. 2005, 37:161-165.
21. Seidah N.G., Awan Z., Chretien M., Mbikay M. PCSK9: a key modulator of cardiovascular health. Circ. Res. 2014, 114:1022-1036.
22. Lagor W.R., Brown R.J., Toh S.A., Millar J.S., Fuki I.V., Llera-Moya M., Yuen T., Rothblat G., Billheimer J.T., Rader D.J. Overexpression of apolipoprotein F reduces HDL cholesterol levels in vivo. Arterioscler. Thromb. Vasc. Biol. 2009, 29:40-46.
23. Koster A., Chao Y.B., Mosior M., Ford A., Gonzalez-DeWhitt P.A., Hale J.E., Li D., Qiu Y., Fraser C.C., Yang D.D., et al. Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism. Endocrinology 2005, 146:4943-4950.
24. Strong A., Ding Q., Edmondson A.C., Millar J.S., Sachs K.V., Li X., Kumaravel A., Wang M.Y., Ai D., Guo L., et al. Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism. J. Clin. Invest. 2012, 122:2807-2816.
25. Essalmani R., Susan-Resiga D., Chamberland A., Asselin M.-C., Canuel M., Constam D., Creemers J.W., Day R., Gauthier D., Prat A., et al. Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes. J. Biol. Chem. 2013, 288:26410-26418.
26. Coresh J., Kwiterovich P.O., Smith H.H., Bachorik P.S. Association of plasma triglyceride concentration and LDL particle diameter, density, and chemical composition with premature coronary artery disease in men and women. J. Lipid Res. 1993, 34:1687-1697.
27. Hoogeveen R.C., Gaubatz J.W., Sun W., Dodge R.C., Crosby J.R., Jiang J., Couper D., Virani S.S., Kathiresan S., Boerwinkle E., et al. Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease: the Atherosclerosis Risk In Communities (ARIC) study. Arterioscler. Thromb. Vasc. Biol. 2014, 34:1069-1077.