Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 43, 2013, Pages 17362-17367

  Wetsel, William C ^a   Rodriguiz, Ramona M ^a   Guillemot, Johann ^b   Rousselet, Estelle ^b   Essalmani, Rachid ^b   Kim, Il Hwan ^a   Bryant, Jesse C ^a   Marcinkiewicz, Jadwiga ^b   Desjardins, Roxane ^c   Day, Robert ^c   Constam, Daniel B ^d   Prat, Annik ^b   Seidah, Nabil G ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^c UNIVERSITÉ DE SHERBROOKE   (Canada)

^d EPFL   (Switzerland)

Author keywords

BDNF processing; Brain phenotypes; Fear conditioning; Gene knockout; PC7 substrates

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; FURIN; MESSENGER RNA; PROPROTEIN CONVERTASE 7; SERINE PROTEINASE; SORTILIN; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; EMOTIONALITY; EPISODIC MEMORY; FEAR; GENOTYPE; HIPPOCAMPUS; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; IN VITRO STUDY; IN VIVO STUDY; LEARNING DISORDER; LIVER CELL; MEMORY DISORDER; MOTIVATION; MOTOR PERFORMANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOCIAL INTERACTION; SPATIAL MEMORY; WESTERN BLOTTING;

BDNF PROCESSING; BRAIN PHENOTYPES; FEAR CONDITIONING; GENE KNOCKOUT; PC7 SUBSTRATES;

AMYGDALA; ANIMALS; BLOTTING, WESTERN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; COS CELLS; FEMALE; FLAVANONES; GENE EXPRESSION; HEK293 CELLS; HEPATOCYTES; HIPPOCAMPUS; HUMANS; IN SITU HYBRIDIZATION; MALE; MAZE LEARNING; MEMORY; MICE; MICE, KNOCKOUT; PROTEIN PRECURSORS; RNA, MESSENGER; SUBTILISINS;

EID: 84886441051     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1314698110     Document Type: Article

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