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Volumn 226, Issue 1, 2013, Pages 9-15

Aortic calcification: Novel insights from familial hypercholesterolemia and potential role for the low-density lipoprotein receptor

Author keywords

Animal models; Arterial calcification; Atherosclerosis; Familial hypercholesterolemia; Low density lipoprotein receptor; Osteoblasts

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MEMBRANE PROTEIN; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; UNCLASSIFIED DRUG;

EID: 84871399547     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2012.08.026     Document Type: Review
Times cited : (28)

References (58)
  • 1
    • 33847014811 scopus 로고    scopus 로고
    • Aortic valve calcification: determinants and progression in the population
    • Messika-Zeitoun D., Bielak L.F., Peyser P.A., et al. Aortic valve calcification: determinants and progression in the population. Arterioscler Thromb Vasc Biol 2007, 27(3):642-648.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , Issue.3 , pp. 642-648
    • Messika-Zeitoun, D.1    Bielak, L.F.2    Peyser, P.A.3
  • 2
    • 0004270125 scopus 로고    scopus 로고
    • Williams and Wilkins, Philadelphia, Lippincott
    • Kaplan N.M. Clinical hypertension 2002, Williams and Wilkins, Philadelphia, Lippincott, p. 4. 8th ed.
    • (2002) Clinical hypertension , pp. 4
    • Kaplan, N.M.1
  • 3
    • 23744457172 scopus 로고    scopus 로고
    • Morphological and clinical findings in 247 surgically excised native aortic valves
    • Butany J., Collins M.J., Demellawy D.E., et al. Morphological and clinical findings in 247 surgically excised native aortic valves. Can J Cardiol 2005, 21:747-755.
    • (2005) Can J Cardiol , vol.21 , pp. 747-755
    • Butany, J.1    Collins, M.J.2    Demellawy, D.E.3
  • 4
    • 33748453667 scopus 로고    scopus 로고
    • Burden of valvular heart diseases: a population-based study
    • Nkomo V.T., Gardin J.M., Skelton T.N., et al. Burden of valvular heart diseases: a population-based study. Lancet 2006, 368:1005-1011.
    • (2006) Lancet , vol.368 , pp. 1005-1011
    • Nkomo, V.T.1    Gardin, J.M.2    Skelton, T.N.3
  • 5
    • 64749086542 scopus 로고    scopus 로고
    • Aortic valve calcification: basic science to clinical practice
    • Akat K., Borggrefe M., Kaden J.J. Aortic valve calcification: basic science to clinical practice. Heart 2009, 95:616-623.
    • (2009) Heart , vol.95 , pp. 616-623
    • Akat, K.1    Borggrefe, M.2    Kaden, J.J.3
  • 6
    • 0031051128 scopus 로고    scopus 로고
    • Clinical factors associated with calcific aortic valve disease: cardiovascular health study
    • Stewart B.F., Siscovick D., Lind B.K., et al. Clinical factors associated with calcific aortic valve disease: cardiovascular health study. J Am Coll Cardiol 1997, 29:630-634.
    • (1997) J Am Coll Cardiol , vol.29 , pp. 630-634
    • Stewart, B.F.1    Siscovick, D.2    Lind, B.K.3
  • 7
    • 20344364674 scopus 로고    scopus 로고
    • A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis
    • Cowell S.J., Newby D.E., Prescott R.J., et al. A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis. N Engl J Med 2005, 352:2389-2397.
    • (2005) N Engl J Med , vol.352 , pp. 2389-2397
    • Cowell, S.J.1    Newby, D.E.2    Prescott, R.J.3
  • 8
    • 9644276844 scopus 로고    scopus 로고
    • Vascular calcification mechanisms
    • Giachelli C.M. Vascular calcification mechanisms. JASN 2004, 2959-2964.
    • (2004) JASN , pp. 2959-2964
    • Giachelli, C.M.1
  • 9
    • 79953688238 scopus 로고    scopus 로고
    • Systematic review of guidelines on imaging of asymptomatic coronary artery disease
    • [Review]
    • Ferket B.S., Genders T.S., Colkesen E.B., et al. Systematic review of guidelines on imaging of asymptomatic coronary artery disease. J Am Coll Cardiol 2011, 57(15):1591-1600. [Review].
    • (2011) J Am Coll Cardiol , vol.57 , Issue.15 , pp. 1591-1600
    • Ferket, B.S.1    Genders, T.S.2    Colkesen, E.B.3
  • 10
    • 67649678424 scopus 로고    scopus 로고
    • Vascular calcification: the killer of patients with chronic kidney disease
    • Mizobuchi M., Towler D., Slatopolsky E. Vascular calcification: the killer of patients with chronic kidney disease. JASN 2009, 1453-1464.
    • (2009) JASN , pp. 1453-1464
    • Mizobuchi, M.1    Towler, D.2    Slatopolsky, E.3
  • 11
    • 0031663520 scopus 로고    scopus 로고
    • Cutaneous necrosis from calcific uremic arteriolopathy
    • Coates T., Kirkland G.S., Dymock R.B., et al. Cutaneous necrosis from calcific uremic arteriolopathy. Am J Kidney Dis 1998, 32:384-391.
    • (1998) Am J Kidney Dis , vol.32 , pp. 384-391
    • Coates, T.1    Kirkland, G.S.2    Dymock, R.B.3
  • 12
    • 42249103629 scopus 로고    scopus 로고
    • Vascular calcification in homozygote familial hypercholesterolemia
    • Awan Z., Alrasadi K., Francis G.A., et al. Vascular calcification in homozygote familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 2008, 28:777-785.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 777-785
    • Awan, Z.1    Alrasadi, K.2    Francis, G.A.3
  • 13
    • 57149095250 scopus 로고    scopus 로고
    • Aortic calcification in familial hypercholesterolemia: potential role of the low-density lipoprotein receptor gene
    • Alrasadi K., Alwaili K., Awan Z., Valenti D., Couture P., Genest J. Aortic calcification in familial hypercholesterolemia: potential role of the low-density lipoprotein receptor gene. Heart J 2009, 157:171-176.
    • (2009) Heart J , vol.157 , pp. 171-176
    • Alrasadi, K.1    Alwaili, K.2    Awan, Z.3    Valenti, D.4    Couture, P.5    Genest, J.6
  • 14
    • 77149122729 scopus 로고    scopus 로고
    • Inflammation and the osteogenic regulation of vascular calcification: a review and perspective
    • Shao J.S., Cheng S.L., Sadhu J., Towler D.A. Inflammation and the osteogenic regulation of vascular calcification: a review and perspective. Hypertension 2010, 55:579-592.
    • (2010) Hypertension , vol.55 , pp. 579-592
    • Shao, J.S.1    Cheng, S.L.2    Sadhu, J.3    Towler, D.A.4
  • 15
    • 77956058459 scopus 로고    scopus 로고
    • Regulatory mechanisms in vascular calcification
    • Sage A.P., Tintut Y., Demer L.L. Regulatory mechanisms in vascular calcification. Nat Rev Cardiol 2010, 7:528-536.
    • (2010) Nat Rev Cardiol , vol.7 , pp. 528-536
    • Sage, A.P.1    Tintut, Y.2    Demer, L.L.3
  • 16
    • 33750904801 scopus 로고    scopus 로고
    • Vascular calcification: pathobiological mechanisms and clinical implications
    • Johnson R.C., Leopold J.A., Loscalzo J. Vascular calcification: pathobiological mechanisms and clinical implications. Circ Res 2006, 99:1044-1059.
    • (2006) Circ Res , vol.99 , pp. 1044-1059
    • Johnson, R.C.1    Leopold, J.A.2    Loscalzo, J.3
  • 17
    • 0021858001 scopus 로고
    • Induced regeneration of calvaria by bone morphogenetic protein (BMP) in dogs
    • Sato K., Urist M.R. Induced regeneration of calvaria by bone morphogenetic protein (BMP) in dogs. Clin Orthop Relat Res 1985, 197:301-311.
    • (1985) Clin Orthop Relat Res , vol.197 , pp. 301-311
    • Sato, K.1    Urist, M.R.2
  • 18
    • 33846498515 scopus 로고    scopus 로고
    • Bone marrow-derived osteoblast progenitor cells in circulating blood contribute to ectopic bone formation in mice
    • Otsuru S., Tamai K., Yamazaki T., Yoshikawa H., Kaneda Y. Bone marrow-derived osteoblast progenitor cells in circulating blood contribute to ectopic bone formation in mice. Biochem Biophysical Res Commun 2007, 354:453-458.
    • (2007) Biochem Biophysical Res Commun , vol.354 , pp. 453-458
    • Otsuru, S.1    Tamai, K.2    Yamazaki, T.3    Yoshikawa, H.4    Kaneda, Y.5
  • 21
    • 33847199795 scopus 로고    scopus 로고
    • Wnt signaling and human diseases: what are the therapeutic implications?
    • Luo J., Chen J., Deng Z.L., et al. Wnt signaling and human diseases: what are the therapeutic implications?. Lab Invest 2007, 87:97-103.
    • (2007) Lab Invest , vol.87 , pp. 97-103
    • Luo, J.1    Chen, J.2    Deng, Z.L.3
  • 22
    • 73549103784 scopus 로고    scopus 로고
    • Mechanisms of aortic valve calcification: the LDL density radius theory: a translation from cell signaling to physiology
    • Rajamannan N.M. Mechanisms of aortic valve calcification: the LDL density radius theory: a translation from cell signaling to physiology. Am J Physiol Heart Circ Physiol 2010, 298:5-15.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298 , pp. 5-15
    • Rajamannan, N.M.1
  • 24
    • 82955247920 scopus 로고    scopus 로고
    • The LDLR deficient mouse as a model for aortic calcification and quantification by micro-computed tomography
    • Awan Z., Denis M., Bailey D., et al. The LDLR deficient mouse as a model for aortic calcification and quantification by micro-computed tomography. Atherosclerosis 2011, 219:455-462.
    • (2011) Atherosclerosis , vol.219 , pp. 455-462
    • Awan, Z.1    Denis, M.2    Bailey, D.3
  • 25
    • 0032079445 scopus 로고    scopus 로고
    • Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
    • Bucay N., Sarosi I., Dunstan C.R., et al. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 1998, 12:1260-1268.
    • (1998) Genes Dev , vol.12 , pp. 1260-1268
    • Bucay, N.1    Sarosi, I.2    Dunstan, C.R.3
  • 26
    • 80053342747 scopus 로고    scopus 로고
    • Cell-specific effects of TNF-α and IL-1β on alkaline phosphatase: implication for syndesmophyte formation and vascular calcification
    • Lencel P., Delplace S., Pilet P., et al. Cell-specific effects of TNF-α and IL-1β on alkaline phosphatase: implication for syndesmophyte formation and vascular calcification. Lab Invest 2011, 91:1434-1442.
    • (2011) Lab Invest , vol.91 , pp. 1434-1442
    • Lencel, P.1    Delplace, S.2    Pilet, P.3
  • 27
    • 84864102071 scopus 로고    scopus 로고
    • The notch pathway attenuates interleukin 1β (IL1β)-mediated induction of adenylyl cyclase 8 (AC8) expression during vascular smooth muscle cell (VSMC) trans-differentiation
    • Keuylian Z., De Baaij J.H., Glorian M., et al. The notch pathway attenuates interleukin 1β (IL1β)-mediated induction of adenylyl cyclase 8 (AC8) expression during vascular smooth muscle cell (VSMC) trans-differentiation. J Biol Chem 2012; May 21.
    • (2012) J Biol Chem
    • Keuylian, Z.1    De Baaij, J.H.2    Glorian, M.3
  • 28
    • 84859531526 scopus 로고    scopus 로고
    • Interleukin-1β modulates smooth muscle cell phenotype to a distinct inflammatory state relative to PDGF-DD via NF-κB-dependent mechanisms
    • Alexander M.R., Murgai M., Moehle C.W., Owens G.K. Interleukin-1β modulates smooth muscle cell phenotype to a distinct inflammatory state relative to PDGF-DD via NF-κB-dependent mechanisms. Physiol Genomics 2012, 44:417-429.
    • (2012) Physiol Genomics , vol.44 , pp. 417-429
    • Alexander, M.R.1    Murgai, M.2    Moehle, C.W.3    Owens, G.K.4
  • 29
    • 0030947025 scopus 로고    scopus 로고
    • Spontaneous calcification of arteries and cartilage in mice lacking matrix gla protein
    • Luo G., Ducy P., McKee M.D., et al. Spontaneous calcification of arteries and cartilage in mice lacking matrix gla protein. Nature 1997, 386:78-81.
    • (1997) Nature , vol.386 , pp. 78-81
    • Luo, G.1    Ducy, P.2    McKee, M.D.3
  • 30
    • 70349256058 scopus 로고    scopus 로고
    • Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix gla protein
    • Yao Y., Watson A.D., Ji S., Bostrom K.I. Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix gla protein. Circ Res 2009, 105:575-584.
    • (2009) Circ Res , vol.105 , pp. 575-584
    • Yao, Y.1    Watson, A.D.2    Ji, S.3    Bostrom, K.I.4
  • 31
    • 0037426081 scopus 로고    scopus 로고
    • Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross sectional study
    • Ketteler M., Bongartz P., Westenfeld R., et al. Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross sectional study. Lancet 2003, 361:827-833.
    • (2003) Lancet , vol.361 , pp. 827-833
    • Ketteler, M.1    Bongartz, P.2    Westenfeld, R.3
  • 32
    • 0022549920 scopus 로고
    • A receptor-mediated pathway for cholesterol homeostasis
    • Brown M.S., Goldstein J.L. A receptor-mediated pathway for cholesterol homeostasis. Science 1986, 232:34-47.
    • (1986) Science , vol.232 , pp. 34-47
    • Brown, M.S.1    Goldstein, J.L.2
  • 34
    • 0035776760 scopus 로고    scopus 로고
    • Human genetics: lessons from Quebec populations
    • Scriver C.R. Human genetics: lessons from Quebec populations. Annu Rev Genomics Hum Genet 2001, 2:69-101.
    • (2001) Annu Rev Genomics Hum Genet , vol.2 , pp. 69-101
    • Scriver, C.R.1
  • 35
    • 33749025102 scopus 로고    scopus 로고
    • Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease risk
    • Humphries S.E., Whittall R.A., Hubbart C.S., et al. Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease risk. J Med Genet 2006, 43:943-949.
    • (2006) J Med Genet , vol.43 , pp. 943-949
    • Humphries, S.E.1    Whittall, R.A.2    Hubbart, C.S.3
  • 36
    • 34648860539 scopus 로고    scopus 로고
    • Genetic defects causing familial hypercholesterolaemia: identification of deletions and duplications in the LDL-receptor gene and summary of all mutations found in patients attending the Hammersmith hospital lipid clinic
    • Tosi I., Toledo-Leiva P., Neuwirth C., Naoumova R.P., Soutar A.K. Genetic defects causing familial hypercholesterolaemia: identification of deletions and duplications in the LDL-receptor gene and summary of all mutations found in patients attending the Hammersmith hospital lipid clinic. Atherosclerosis 2007, 194:102-111.
    • (2007) Atherosclerosis , vol.194 , pp. 102-111
    • Tosi, I.1    Toledo-Leiva, P.2    Neuwirth, C.3    Naoumova, R.P.4    Soutar, A.K.5
  • 37
    • 0022345240 scopus 로고
    • Improved survival of patients with homozygous familial hypercholesterolaemia treated with plasma exchange
    • Thompson G.R., Miller J.P., Breslow J.L. Improved survival of patients with homozygous familial hypercholesterolaemia treated with plasma exchange. BMJ (Clin Res Ed) 1985, 291:1671-1673.
    • (1985) BMJ (Clin Res Ed) , vol.291 , pp. 1671-1673
    • Thompson, G.R.1    Miller, J.P.2    Breslow, J.L.3
  • 38
    • 4043093508 scopus 로고    scopus 로고
    • Current management of severe homozygous hypercholesterolaemias
    • [Review]
    • Naoumova R.P., Thompson G.R., Soutar A.K. Current management of severe homozygous hypercholesterolaemias. Curr Opin Lipidol 2004, 15:413-422. [Review].
    • (2004) Curr Opin Lipidol , vol.15 , pp. 413-422
    • Naoumova, R.P.1    Thompson, G.R.2    Soutar, A.K.3
  • 39
    • 33748987891 scopus 로고    scopus 로고
    • A systematic review of LDL apheresis in the treatment of cardiovascular disease
    • Thompsen J., Thompson P.D. A systematic review of LDL apheresis in the treatment of cardiovascular disease. Atherosclerosis 2006, 189:31-38.
    • (2006) Atherosclerosis , vol.189 , pp. 31-38
    • Thompsen, J.1    Thompson, P.D.2
  • 40
    • 38549136555 scopus 로고    scopus 로고
    • Surgical strategies for severe calcification of the aorta (porcelain aorta) in two patients with homozygous familial hypercholesterolemia
    • Grenon S.M., Lachapelle K., Marcil M., Omeroglu A., Genest J., de Varennes B. Surgical strategies for severe calcification of the aorta (porcelain aorta) in two patients with homozygous familial hypercholesterolemia. Can J Cardiol 2007, 23:1159-1161.
    • (2007) Can J Cardiol , vol.23 , pp. 1159-1161
    • Grenon, S.M.1    Lachapelle, K.2    Marcil, M.3    Omeroglu, A.4    Genest, J.5    de Varennes, B.6
  • 41
    • 29244464311 scopus 로고    scopus 로고
    • Surgery for calcific aortic root stenosis in homozygous familial hypercholesterolemia
    • Saito S., Usui A., Akita T., Ueda Y. Surgery for calcific aortic root stenosis in homozygous familial hypercholesterolemia. Eur J Cardiothorac Surg 2006, 29:114-116.
    • (2006) Eur J Cardiothorac Surg , vol.29 , pp. 114-116
    • Saito, S.1    Usui, A.2    Akita, T.3    Ueda, Y.4
  • 42
    • 0034255620 scopus 로고    scopus 로고
    • Aortic valve replacement for the calcified ascending aorta in homozygous familial hypercholesterolemia
    • Yasuda T., Kawasuji M., Sakakibara N., Watanabe Y. Aortic valve replacement for the calcified ascending aorta in homozygous familial hypercholesterolemia. Eur J Cardiothorac Surg 2000, 18:249-250.
    • (2000) Eur J Cardiothorac Surg , vol.18 , pp. 249-250
    • Yasuda, T.1    Kawasuji, M.2    Sakakibara, N.3    Watanabe, Y.4
  • 43
    • 82155197192 scopus 로고    scopus 로고
    • Lipid lowering on progression of mild to moderate aortic stenosis: meta-analysis of the randomized placebo-controlled clinical trials on 2344 patients
    • Teo K.K., Corsi D.J., Tam J.W., Dumesnil J.G., Chan K.L. Lipid lowering on progression of mild to moderate aortic stenosis: meta-analysis of the randomized placebo-controlled clinical trials on 2344 patients. Can J Cardiol 2011, 27(6):800-808.
    • (2011) Can J Cardiol , vol.27 , Issue.6 , pp. 800-808
    • Teo, K.K.1    Corsi, D.J.2    Tam, J.W.3    Dumesnil, J.G.4    Chan, K.L.5
  • 44
  • 46
    • 33646853310 scopus 로고    scopus 로고
    • Possible role of LRP1, a CCN2 receptor, in chondrocytes
    • Kawata K., Eguchi T., Kubota S., et al. Possible role of LRP1, a CCN2 receptor, in chondrocytes. Biochem Biophys Res Commun 2006, 345(2):552-559.
    • (2006) Biochem Biophys Res Commun , vol.345 , Issue.2 , pp. 552-559
    • Kawata, K.1    Eguchi, T.2    Kubota, S.3
  • 47
    • 0032446373 scopus 로고    scopus 로고
    • A new low-density lipoprotein receptor related protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E
    • Kim D.H., Inagaki Y., Suzuki T., et al. A new low-density lipoprotein receptor related protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E. J Biochem 1998, 124:1072-1076.
    • (1998) J Biochem , vol.124 , pp. 1072-1076
    • Kim, D.H.1    Inagaki, Y.2    Suzuki, T.3
  • 48
    • 0037422571 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion
    • Fujinoa T.H., Asabab M.J., Kang Y., et al. Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. PNAS 2003, 100:229-234.
    • (2003) PNAS , vol.100 , pp. 229-234
    • Fujinoa, T.H.1    Asabab, M.J.2    Kang, Y.3
  • 49
    • 33847656105 scopus 로고    scopus 로고
    • LRP6 mutation in a family with early coronary disease and metabolic risk factors
    • Mani A., Radhakrishnan J., Wang H., et al. LRP6 mutation in a family with early coronary disease and metabolic risk factors. Science 2007, 315:1278-1282.
    • (2007) Science , vol.315 , pp. 1278-1282
    • Mani, A.1    Radhakrishnan, J.2    Wang, H.3
  • 50
    • 84862908198 scopus 로고    scopus 로고
    • LRP6 protein regulates low density lipoprotein (LDL) receptor-mediated LDL uptake
    • Ye Z.J., Go G.W., Singh R., Liu W., Keramati A.R., Mani A. LRP6 protein regulates low density lipoprotein (LDL) receptor-mediated LDL uptake. J Biol Chem 2012, 287(2):1335-1344.
    • (2012) J Biol Chem , vol.287 , Issue.2 , pp. 1335-1344
    • Ye, Z.J.1    Go, G.W.2    Singh, R.3    Liu, W.4    Keramati, A.R.5    Mani, A.6
  • 51
    • 52449087975 scopus 로고    scopus 로고
    • Uptake of postprandial lipoproteins into bone in vivo: impact on osteoblast function
    • Niemeier A., Niedzielska D., Secer R., et al. Uptake of postprandial lipoproteins into bone in vivo: impact on osteoblast function. Bone 2008, 43:230-237.
    • (2008) Bone , vol.43 , pp. 230-237
    • Niemeier, A.1    Niedzielska, D.2    Secer, R.3
  • 52
    • 1842863965 scopus 로고    scopus 로고
    • Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo
    • Tintut Y., Morony S., Demer L.L. Hyperlipidemia promotes osteoclastic potential of bone marrow cells ex vivo. Arter Thromb Vasc Biol 2004, 24:e6-10.
    • (2004) Arter Thromb Vasc Biol , vol.24
    • Tintut, Y.1    Morony, S.2    Demer, L.L.3
  • 53
    • 0030929793 scopus 로고    scopus 로고
    • Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation
    • Parhami F., Morrow A.D., Balucan J., et al. Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. Arter Thromb Vasc Biol 1997, 17:680-687.
    • (1997) Arter Thromb Vasc Biol , vol.17 , pp. 680-687
    • Parhami, F.1    Morrow, A.D.2    Balucan, J.3
  • 54
    • 77957734152 scopus 로고    scopus 로고
    • Calcium homeostasis and skeletal integrity in individuals with familial hypercholesterolemia and aortic calcification
    • Awan Z., Alwaili K., Alshahrani A., Langsetmo L., Goltzman D., Genest J. Calcium homeostasis and skeletal integrity in individuals with familial hypercholesterolemia and aortic calcification. Clin Chem 2010, 56:1599-1607.
    • (2010) Clin Chem , vol.56 , pp. 1599-1607
    • Awan, Z.1    Alwaili, K.2    Alshahrani, A.3    Langsetmo, L.4    Goltzman, D.5    Genest, J.6
  • 55
    • 0034968385 scopus 로고    scopus 로고
    • Arterial calcification: a review of mechanisms, animal models, and the prospects for therapy
    • Wallin R., Wajih N., Greenwood G.T., Sane D.C. Arterial calcification: a review of mechanisms, animal models, and the prospects for therapy. Med Res Rev 2001, 21(4):274-301.
    • (2001) Med Res Rev , vol.21 , Issue.4 , pp. 274-301
    • Wallin, R.1    Wajih, N.2    Greenwood, G.T.3    Sane, D.C.4
  • 56
    • 80053644777 scopus 로고    scopus 로고
    • Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: rationale and design of the canakinumab anti-inflammatory thrombosis outcomes study (CANTOS)
    • Ridker P.M., Thuren T., Zalewski A., Libby P. Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: rationale and design of the canakinumab anti-inflammatory thrombosis outcomes study (CANTOS). Am Heart J 2011, 162(4):597-605.
    • (2011) Am Heart J , vol.162 , Issue.4 , pp. 597-605
    • Ridker, P.M.1    Thuren, T.2    Zalewski, A.3    Libby, P.4
  • 57
    • 0029964683 scopus 로고    scopus 로고
    • Relation of cholesterol-year score to severity of calcific atherosclerosis and tissue deposition in homozygous familial hypercholesterolemia
    • Schmidt H.H., Hill S., Makariou E.V., Feuerstein I.M., Dugi K.A., Hoeg J.M. Relation of cholesterol-year score to severity of calcific atherosclerosis and tissue deposition in homozygous familial hypercholesterolemia. Am J Cardiol 1996, 77:575-580.
    • (1996) Am J Cardiol , vol.77 , pp. 575-580
    • Schmidt, H.H.1    Hill, S.2    Makariou, E.V.3    Feuerstein, I.M.4    Dugi, K.A.5    Hoeg, J.M.6
  • 58
    • 77953535507 scopus 로고    scopus 로고
    • Does statin therapy affect the progression of atherosclerosis measured by a coronary calcium score?
    • Gill E.A. Does statin therapy affect the progression of atherosclerosis measured by a coronary calcium score?. Curr Atheroscler Rep 2010, 12(2):83-87.
    • (2010) Curr Atheroscler Rep , vol.12 , Issue.2 , pp. 83-87
    • Gill, E.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.