The LDLR deficient mouse as a model for aortic calcification and quantification by micro-computed tomography

Atherosclerosis

Volumn 219, Issue 2, 2011, Pages 455-462

  Awan, Zuhier ^a,c   Denis, Maxime ^a   Bailey, Dana ^c   Giaid, Adel ^c   Prat, Annik ^a   Goltzman, David ^b   Seidah, Nabil G ^a   Genest, Jacques ^c  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

Aortic calcification and micro computed tomography; Familial hypercholesterolemia; LDLR; PCSK9

Indexed keywords

CHOLESTEROL; GLUCOSE; LOW DENSITY LIPOPROTEIN RECEPTOR; TRIACYLGLYCEROL; WNT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CALCIFICATION; AORTA DISEASE; ARTERY CALCIFICATION; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FAMILIAL HYPERCHOLESTEROLEMIA; GLUCOSE BLOOD LEVEL; HISTOLOGY; IMMUNOHISTOCHEMISTRY; LIVER WEIGHT; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

AGE FACTORS; AGING; ANIMALS; AORTIC DISEASES; AORTOGRAPHY; BIOLOGICAL MARKERS; CHOLESTEROL; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-5; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PARAFFIN EMBEDDING; RECEPTORS, LDL; SERINE ENDOPEPTIDASES; SEVERITY OF ILLNESS INDEX; STAINING AND LABELING; VASCULAR CALCIFICATION; WNT PROTEINS; X-RAY MICROTOMOGRAPHY;

EID: 82955247920     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2011.08.035     Document Type: Article

References (30)

1. Grenon S.M., Lachapelle K., Marcil M., Omeroglu A., Genest J., de Varennes B. Surgical strategies for severe calcification of the aorta (porcelain aorta) in two patients with homozygous familial hypercholesterolemia. Can J Cardiol 2007, 23(December (14)):1159-1161. [PubMed PMID: 18060104].
2. Awan Z., Alrasadi K., Francis G.A., et al. Vascular calcifications in homozygote familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 2008, 28(April (4)):777-785. [Epub 2008, Jan 31. PubMed PMID: 18239150].
3. Alrasadi K., Alwaili K., Awan Z., Valenti D., Couture P., Genest J. Aortic calcifications in familial hypercholesterolemia: potential role of the low-density lipoprotein receptor gene. Am Heart J 2009, 157(January (1)):170-176. [PubMed PMID: 19081415].
4. McEniery C.M., McDonnell B.J., So A., et al. Aortic calcification is associated with aortic stiffness and isolated systolic hypertension in healthy individuals. Hypertension 2009, 53(March (3)):524-531. [PubMed PMID: 19171791].
5. Houslay E.S., Cowell S.J., Prescott R.J., et al. Progressive coronary calcification despite intensive lipid-lowering treatment: a randomised controlled trial. Heart 2006, 92(September (9_):1207-1212. [Epub 2006, Jan 31. PubMed PMID: 16449511; PubMed Central PMCID: PMC1861190].
6. Bazan H.A., Pradhan S., Mojibian H., Kyriakides T., Dardik A. Increased aortic arch calcification in patients older than 75 years: implications for carotid artery stenting in elderly patients. J Vasc Surg 2007, 46(November (5)):841-845. [PubMed PMID: 17980267].
7. Iribarren C., Sidney S., Sternfeld B., Browner W.S. Calcification of the aortic arch: risk factors and association with coronary heart disease, stroke, and peripheral vascular disease. JAMA 2000, 283(June (21)):2810-2815. [PubMed PMID: 10838649].
8. Wilson P.W., Kauppila L.I., O'Donnell C.J., et al. Abdominal aortic calcific deposits are an important predictor of vascular morbidity and mortality. Circulation 2001, 103(March (11)):1529-1534. [PubMed PMID: 11257080].
9. Oliver T.B., Lammie G.A., Wright A.R., et al. Atherosclerotic plaque at the carotid bifurcation: CT angiographic appearance with histopathologic correlation. AJNR Am J Neuroradiol 1999, 20(May (5)):897-901. [PubMed PMID: 10369363].
10. Gaitini D., Soudack M. Diagnosing carotid stenosis by Doppler sonography: state of the art. J Ultrasound Med 2005, 24(August (8)):1127-1136. [Review. PubMed PMID: 16040828].
11. Awan Z., Alwaili K., Alshahrani A., Langsetmo L., Goltzman D., Genest J. Calcium homeostasis and skeletal integrity in individuals with familial hypercholesterolemia and aortic calcification. Clin Chem 2010, 56(October (10)):1599-1607. [Epub 2010, Aug 11. PubMed PMID: 20702785].
12. Hoshino H., Kushida K., Takahashi M., Ohishi T., Sugiyama E., Inoue T. The influence of aortic calcification on spinal bone mineral density in vitro. Calcif Tissue Int 1996, 59(July (1)):21-23. [PubMed PMID: 8661979].
13. Lokoski S.G., Lagace T.A., Cohen J.C., Horton J.D., Hobbs H.H. Genetic and metabolic determinants of plasma PCSK9 levels. J Clin Endocrinol Metab 2009, 94(July (7)):2537-2543. [Epub 2009, Apr 7. PubMed PMID: 19351729; PubMed Central PMCID: PMC2708952].
14. Cunningham D., Danley D.E., Geoghegan K.F., et al. Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia. Nat Struct Mol Biol 2007, 14(May (5)):413-419. [Epub 2007, Apr 15. PubMed PMID: 17435765].
15. Maxwell K.N., Fisher E.A., Breslow J.L. Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment. Proc Natl Acad Sci U S A 2005, 102(February (6)):2069-2074. [Epub 2005, Jan 27. PubMed PMID: 15677715; PubMed Central PMCID: PMC546019].
16. Abifadel M., Rabès J.P., Devillers M., et al. Mutations and polymorphisms in the proprotein convertase subtilisin kexin 9 (PCSK9) gene in cholesterol metabolism and disease. Hum Mutat 2009, 30(April (4)):520-529. [Review. PubMed PMID: 19191301].
17. Zaid A., Roubtsova A., Essalmani R., et al. Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration. Hepatology 2008, 48(August (2)):646-654. [PubMed PMID: 18666258].
18. Baglione J., Smith J.D. Quantitative assay for mouse atherosclerosis in the aortic root. Methods Mol Med 2006, 129:83-95. [PubMed PMID: 17085806].
19. Iijima K., Hashimoto H., Hashimoto M., et al. Aortic arch calcification detectable on chest X-ray is a strong independent predictor of cardiovascular events beyond traditional risk factors. Atherosclerosis 2010, 210(May (1)):137-144. [Epub 2009, Nov 17. PubMed PMID: 20006335].
20. Ngai Y.F., Quong W.L., Glier M.B., et al. Ldlr-/- mice display decreased susceptibility to Western-type diet-induced obesity due to increased thermogenesis. Endocrinology 2010, 151(November (11)):5226-5236. [Epub 2010, Sep 29. PubMed PMID: 20881250].
21. Ishibashi S., Brown M.S., Goldstein J.L., Gerard R.D., Hammer R.E., Herz J. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 1993, 92(August (2)):883-893. [PubMed PMID: 8349823; PubMed Central PMCID: PMC294927].
22. Sage A.P., Tintut Y., Demer L.L. Regulatory mechanisms in vascular calcification. Nat Rev Cardiol 2010, 7(September (9)):528-536. [Epub 2010, Jul 27. Review. PubMed PMID: 20664518; PubMed Central PMCID: PMC3014092].
23. Shao J.S., Cheng S.L., Sadhu J., Towler D.A. Inflammation and the osteogenic regulation of vascular calcification: a review and perspective. Hypertension 2010, 55(March (3)):579-592. [Epub 2010, Jan 25. Review. PubMed PMID: 20101002; PubMed Central PMCID: PMC2853014].
24. Giachelli C.M. Vascular calcification mechanisms. J Am Soc Nephrol 2004, 15(December (12)):2959-2964. [Review. PubMed PMID: 15579497].
25. Weissen-Plenz G., Nitschke Y., Rutsch F. Mechanisms of arterial calcification: spotlight on the inhibitors. Adv Clin Chem 2008, 46:263-293. [Review. PubMed PMID: 19004192].
26. Touyz R.M., Montezano A.C. Vascular smooth muscle cells sense calcium: a new paradigm in vascular calcification. Cardiovasc Res 2009, 81(February (2)):237-239. [Epub 2008, Dec 16. PubMed PMID: 19088081].
27. Shao J.S., Cai J., Towler D.A. Molecular mechanisms of vascular calcification: lessons learned from the aorta. Arterioscler Thromb Vasc Biol 2006, 26(July (7)):1423-1430. [Epub 2006, Apr 6. Review. PubMed PMID: 16601233].
28. Moe S.M., Chen N.X. Pathophysiology of vascular calcification in chronic kidney disease. Circ Res 2004, 95(September (6)):560-567. [Review. PubMed PMID: 15375022].
29. Rutsch F., Böyer P., Nitschke Y., et al. Hypophosphatemia, hyperphosphaturia, and bisphosphonate treatment are associated with survival beyond infancy in generalized arterial calcification of infancy. Circ Cardiovasc Genet 2008, 1(December (2)):133-140. [PubMed PMID: 20016754; PubMed Central PMCID: PMC2794045].
30. Speer M.Y., McKee M.D., Guldberg R.E., et al. Inactivation of the osteopontin gene enhances vascular calcification of matrix Gla protein-deficient mice: evidence for osteopontin as an inducible inhibitor of vascular calcification in vivo. J Exp Med 2002, 196(October (8)):1047-1055. [PubMed PMID: 12391016; PubMed Central PMCID: PMC2194039].