Critical role of STAT3 in melanoma metastasis through anoikis resistance

Oncotarget

Volumn 5, Issue 16, 2014, Pages 7051-7064

  Fofaria, Neel M ^a   Srivastava, Sanjay K ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Anoikis resistance; Melanoma; Metastasis; STAT3

Indexed keywords

INTERLEUKIN 6; JANUS KINASE; STAT3 PROTEIN; ALPHA-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMIDE; PIPERIDONE DERIVATIVE; PIPLARTINE; STAT3 PROTEIN, HUMAN; TYRPHOSTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANOIKIS; ARTICLE; BASEMENT MEMBRANE; CANCER CELL; CELL DEATH; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MELANOMA; METASTASIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; TUMOR MODEL; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; DEFICIENCY; DRUG EFFECTS; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SCID MOUSE; SIGNAL TRANSDUCTION; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; ANOIKIS; CELL LINE, TUMOR; GENE KNOCKDOWN TECHNIQUES; HETEROGRAFTS; HUMANS; MALE; MELANOMA; MICE; MICE, SCID; PHOSPHORYLATION; PIPERIDONES; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANSFECTION; TYRPHOSTINS;

EID: 84907086036     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2251     Document Type: Article

References (52)

1. Gilmore AP. Anoikis. Cell Death Differ. 2005; 12 Suppl 2:1473-1477.
2. Grossmann J. Molecular mechanisms of "detachment-induced apoptosis-Anoikis". Apoptosis. 2002; 7(3):247-260.
3. Frisch SM and Screaton RA. Anoikis mechanisms. Curr Opin Cell Biol. 2001; 13(5):555-562.
4. Simpson CD, Anyiwe K and Schimmer AD. Anoikis resistance and tumor metastasis. Cancer Lett. 2008; 272(2):177-185.
5. Coates JM, Galante JM and Bold RJ. Cancer therapy beyond apoptosis: autophagy and anoikis as mechanisms of cell death. J Surg Res. 2010; 164(2):301-308.
6. Ihle JN. STATs: signal transducers and activators of transcription. Cell. 1996; 84(3):331-334.
7. Darnell JE, Jr. STATs and gene regulation. Science. 1997; 277(5332):1630-1635.
8. Horvath CM and Darnell JE. The state of the STATs: recent developments in the study of signal transduction to the nucleus. Curr Opin Cell Biol. 1997; 9(2):233-239.
9. Duncan SA, Zhong Z, Wen Z and Darnell JE, Jr. STAT signaling is active during early mammalian development. Dev Dyn. 1997; 208(2):190-198.
10. Bromberg JF, Wrzeszczynska MH, Devgan G, Zhao Y, Pestell RG, Albanese C and Darnell JE, Jr. Stat3 as an oncogene. Cell. 1999; 98(3):295-303.
11. Brivanlou AH and Darnell JE, Jr. Signal transduction and the control of gene expression. Science. 2002; 295(5556):813-818.
12. Benekli M, Baer MR, Baumann H and Wetzler M. Signal transducer and activator of transcription proteins in leukemias. Blood. 2003; 101(8):2940-2954.
13. Germain D and Frank DA. Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy. Clin Cancer Res. 2007; 13(19):5665-5669.
14. Huang M, Page C, Reynolds RK and Lin J. Constitutive activation of stat 3 oncogene product in human ovarian carcinoma cells. Gynecol Oncol. 2000; 79(1):67-73.
15. Bowman T, Garcia R, Turkson J and Jove R. STATs in oncogenesis. Oncogene. 2000; 19(21):2474-2488.
16. Coffer PJ, Koenderman L and de Groot RP. The role of STATs in myeloid differentiation and leukemia. Oncogene. 2000; 19(21):2511-2522.
17. Song JI and Grandis JR. STAT signaling in head and neck cancer. Oncogene. 2000; 19(21):2489-2495.
18. Niu G, Bowman T, Huang M, Shivers S, Reintgen D, Daud A, Chang A, Kraker A, Jove R and Yu H. Roles of activated Src and Stat3 signaling in melanoma tumor cell growth. Oncogene. 2002; 21(46):7001-7010.
19. Levy DE and Darnell JE, Jr. Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol. 2002; 3(9):651-662.
20. Darnell JE, Jr. Transcription factors as targets for cancer therapy. Nat Rev Cancer. 2002; 2(10):740-749.
21. Darnell JE. Validating Stat3 in cancer therapy. Nat Med. 2005; 11(6):595-596.
22. Epling-Burnette PK, Liu JH, Catlett-Falcone R, Turkson J, Oshiro M, Kothapalli R, Li Y, Wang JM, Yang-Yen HF, Karras J, Jove R and Loughran TP, Jr. Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J Clin Invest. 2001; 107(3):351-362.
23. Gritsko T, Williams A, Turkson J, Kaneko S, Bowman T, Huang M, Nam S, Eweis I, Diaz N, Sullivan D, Yoder S, Enkemann S, Eschrich S, Lee JH, Beam CA, Cheng J, et al. Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. Clin Cancer Res. 2006; 12(1):11-19.
24. Balch CM, Buzaid AC, Soong SJ, Atkins MB, Cascinelli N, Coit DG, Fleming ID, Gershenwald JE, Houghton A, Jr., Kirkwood JM, McMasters KM, Mihm MF, Morton DL, Reintgen DS, Ross MI, Sober A, et al. Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol. 2001; 19(16):3635-3648.
25. Lui P, Cashin R, Machado M, Hemels M, Corey-Lisle PK and Einarson TR. Treatments for metastatic melanoma: synthesis of evidence from randomized trials. Cancer Treat Rev. 2007; 33(8):665-680.
26. Boisvert-Adamo K and Aplin AE. B-RAF and PI-3 kinase signaling protect melanoma cells from anoikis. Oncogene. 2006; 25(35):4848-4856.
27. Boisvert-Adamo K and Aplin AE. Mutant B-RAF mediates resistance to anoikis via Bad and Bim. Oncogene. 2008; 27(23):3301-3312.
28. Sahu RP and Srivastava SK. The role of STAT3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate. J Natl Cancer Inst. 2009; 101(3):176-193.
29. Lahav R, Heffner G and Patterson PH. An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo. Proc Natl Acad Sci U S A. 1999; 96(20):11496-11500.
30. Isoldi MC, Scarparo AC, Schumacher RI and Castrucci AM. Psoralen activity and binding sites in melanotic and amelanotic human melanoma cells. Pigment Cell Res. 1999; 12(6):367-375.
31. Lillehammer T, Tveito S, Engesaeter BO, Fodstad O, Maelandsmo GM and Engebraaten O. Melanoma-specific expression in first-generation adenoviral vectors in vitro and in vivo - use of the human tyrosinase promoter with human enhancers. Cancer Gene Ther. 2005; 12(11):864-872.
32. Wolf M, Bauder-Wust U, Mohammed A, Schonsiegel F, Mier W, Haberkorn U and Eisenhut M. Alkylating benzamides with melanoma cytotoxicity. Melanoma Res. 2004; 14(5):353-360.
33. Vad NM, Yount G and Moridani MY. Biochemical mechanism of acetylsalicylic acid (Aspirin) selective toxicity toward melanoma cell lines. Melanoma Res. 2008; 18(6):386-399.
34. Niles RM, McFarland M, Weimer MB, Redkar A, Fu YM and Meadows GG. Resveratrol is a potent inducer of apoptosis in human melanoma cells. Cancer Lett. 2003; 190(2):157-163.
35. Aoyama A and Chen WT. A 170-kDa membrane-bound protease is associated with the expression of invasiveness by human malignant melanoma cells. Proc Natl Acad Sci U S A. 1990; 87(21):8296-8300.
36. Cheng HL, Su SJ, Huang LW, Hsieh BS, Hu YC, Hung TC and Chang KL. Arecoline induces HA22T/VGH hepatoma cells to undergo anoikis - involvement of STAT3 and RhoA activation. Mol Cancer. 2010; 9:126.
37. Du XL, Yang H, Liu SG, Luo ML, Hao JJ, Zhang Y, Lin DC, Xu X, Cai Y, Zhan QM and Wang MR. Calreticulin promotes cell motility and enhances resistance to anoikis through STAT3-CTTN-Akt pathway in esophageal squamous cell carcinoma. Oncogene. 2009; 28(42):3714-3722.
38. Neiva KG, Zhang Z, Miyazawa M, Warner KA, Karl E and Nor JE. Cross talk initiated by endothelial cells enhances migration and inhibits anoikis of squamous cell carcinoma cells through STAT3/Akt/ERK signaling. Neoplasia. 2009; 11(6):583-593.
39. Gazit A, Osherov N, Posner I, Yaish P, Poradosu E, Gilon C and Levitzki A. Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. Journal of medicinal chemistry. 1991; 34(6):1896-1907.
40. Samanta AK, Lin H, Sun T, Kantarjian H and Arlinghaus RB. Janus kinase 2: a critical target in chronic myelogenous leukemia. Cancer research. 2006; 66(13):6468-6472.
41. Packer L, Pavey S, Parker A, Stark M, Johansson P, Clarke B, Pollock P, Ringner M and Hayward N. Osteopontin is a downstream effector of the PI3-kinase pathway in melanomas that is inversely correlated with functional PTEN. Carcinogenesis. 2006; 27(9):1778-1786.
42. Pavey S, Johansson P, Packer L, Taylor J, Stark M, Pollock PM, Walker GJ, Boyle GM, Harper U, Cozzi SJ, Hansen K, Yudt L, Schmidt C, Hersey P, Ellem KA, O'Rourke MG, et al. Microarray expression profiling in melanoma reveals a BRAF mutation signature. Oncogene. 2004; 23(23):4060-4067.
43. Pramanik KC, Kudugunti SK, Fofaria NM, Moridani MY and Srivastava SK. Caffeic acid phenethyl ester suppresses melanoma tumor growth by inhibiting PI3K/AKT/XIAP pathway. Carcinogenesis. 2013; 34(9):2061-2070.
44. Kandala PK and Srivastava SK. Diindolylmethane-mediated Gli1 protein suppression induces anoikis in ovarian cancer cells in vitro and blocks tumor formation ability in vivo. J Biol Chem. 2012; 287(34):28745-28754.
45. Gupta P and Srivastava SK. Inhibition of Integrin-HER2 signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppression. Oncotarget. 2014; 5(7):1812-28.
46. Gupta P, Adkins C, Lockman P and Srivastava SK. Metastasis of Breast Tumor Cells to Brain Is Suppressed by Phenethyl Isothiocyanate in a Novel Metastasis Model. PLoS One. 2013; 8(6):e67278.
47. Boreddy SR and Srivastava SK. Deguelin suppresses pancreatic tumor growth and metastasis by inhibiting epithelial-to-mesenchymal transition in an orthotopic model. Oncogene. 2012 32(34):3980-91.
48. Boreddy SR, Sahu RP and Srivastava SK. Benzyl isothiocyanate suppresses pancreatic tumor angiogenesis and invasion by inhibiting HIF-alpha/VEGF/Rho-GTPases: pivotal role of STAT3. PLoS One. 2011; 6(10):e25799.
49. Pramanik KC and Srivastava SK. Apoptosis signal-regulating kinase 1-thioredoxin complex dissociation by capsaicin causes pancreatic tumor growth suppression by inducing apoptosis. Antioxid Redox Signal. 2012; 17(10):1417-1432.
50. Gupta P and Srivastava SK. Antitumor activity of phenethyl isothiocyanate in HER2-positive breast cancer models. BMC Med. 2012; 10:80.
51. Kandala PK and Srivastava SK. Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3). BMC Med. 2012; 10:9.
52. Pramanik KC, Fofaria NM, Gupta P and Srivastava SK. CBP-Mediated FOXO-1 Acetylation Inhibits Pancreatic Tumor Growth by Targeting SirT. Mol Cancer Ther. 2014; 13(3):687-698.