Caffeic acid phenethyl ester suppresses melanoma tumor growth by inhibiting PI3K/AKT/XIAP pathway

Carcinogenesis

Volumn 34, Issue 9, 2013, Pages 2061-2070

  Pramanik, Kartick C ^a   Kudugunti, Shashi K ^a   Fofaria, Neel M ^a   Moridani, Majid Y ^a   Srivastava, Sanjay K ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ACETYLCYSTEINE; CAFFEIC ACID PHENETHYL ESTER; CASPASE 3; MAMMALIAN TARGET OF RAPAMYCIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SURVIVIN; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; TUMOR XENOGRAFT;

ANIMALS; APOPTOSIS; CAFFEIC ACIDS; GENE EXPRESSION REGULATION, NEOPLASTIC; HETEROGRAFTS; HUMANS; MELANOMA; MICE; ONCOGENE PROTEIN V-AKT; PHENYLETHYL ALCOHOL; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 84887004037     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt154     Document Type: Article

References (38)

1. Kudugunti, S.K. et al. (2011) Efficacy of caffeic acid phenethyl ester (CAPE) in skin B16-F0 melanoma tumor bearing C57BL/6 mice. Invest. New Drugs, 29, 52-62.
2. Cartee, T.V. et al. (2011) Melanoma reporting to central cancer registries by US dermatologists: an analysis of the persistent knowledge and practice gap. J. Am. Acad. Dermatol., 65(5 suppl. 1), S124-S132.
3. Kudugunti, S.K. et al. (2010) Biochemical mechanism of caffeic acid phenylethyl ester (CAPE) selective toxicity towards melanoma cell lines. Chem. Biol. Interact., 188, 1-14.
4. Doan, P.S. (2008) Primary cutaneous malignant melanoma. Aviat. Space. Environ. Med., 79, 919-921.
5. Watson, M. et al. (2011) Melanoma surveillance in the United States: overview of methods. J. Am. Acad. Dermatol., 65(5 suppl. 1), S6-16.
6. Whiteman, D. et al. (1999) The pathogenesis of melanoma induced by ultraviolet radiation. N. Engl. J. Med., 341, 766-767.
7. Bataille, V. et al. (2008) Melanoma-Part 1: epidemiology, risk factors, and prevention. BMJ, 337, a2249.
8. Lin, H.P. et al. (2012) Caffeic acid phenethyl ester causes p21 induction, Akt signaling reduction, and growth inhibition in PC-3 human prostate cancer cells. PLoS One, 7, e31286.
9. Dan, H.C. et al. (2004) Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). J. Biol. Chem., 279, 5405-5412.
10. Carter, B.Z. et al. (2003) Regulation and targeting of antiapoptotic XIAP in acute myeloid leukemia. Leukemia, 17, 2081-2089.
11. Vidwans, S.J. et al. (2011) A melanoma molecular disease model. PLoS One, 6, e18257.
12. Yang, C. et al. (2005) Caffeic acid phenethyl ester (CAPE) prevents transformation of human cells by arsenite (As) and suppresses growth of As-transformed cells. Toxicology, 213, 81-96.
13. Jung, W.K. et al. (2008) Caffeic acid phenethyl ester protects mice from lethal endotoxin shock and inhibits lipopolysaccharide-induced cyclooxygenase- 2 and inducible nitric oxide synthase expression in RAW 264.7 macrophages via the p38/ERK and NF-kappaB pathways. Int. J. Biochem. Cell Biol., 40, 2572-2582.
14. Demestre, M. et al. (2009) CAPE (caffeic acid phenethyl ester)-based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice. Phytother. Res., 23, 226-230.
15. Bhimani, R.S. et al. (1993) Inhibition of oxidative stress in HeLa cells by chemopreventive agents. Cancer Res., 53, 4528-4533.
16. Bhimani, R.S. et al. (1995) Human promyelocytic leukemia cells (HL-60): a new model to study the effects of chemopreventive agents on H2O2 production. Cancer Detect. Prev., 19, 292-298.
17. Su, Z.Z. et al. (1991) Suppression of adenovirus type 5 E1A-mediated transformation and expression of the transformed phenotype by caffeic acid phenethyl ester (CAPE). Mol. Carcinog., 4, 231-242.
18. Grunberger, D. et al. (1988) Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis. Experientia, 44, 230-232.
19. Watabe, M. et al. (2004) Caffeic acid phenethyl ester induces apoptosis by inhibition of NFkappaB and activation of Fas in human breast cancer MCF-7 cells. J. Biol. Chem., 279, 6017-6026.
20. McEleny, K. et al. (2004) Caffeic acid phenethyl ester-induced PC-3 cell apoptosis is caspase-dependent and mediated through the loss of inhibitors of apoptosis proteins. BJU Int., 94, 402-406.
21. Wang, L.C. et al. (2010) Caffeic acid phenethyl ester inhibits nuclear factorkappaB and protein kinase B signalling pathways and induces caspase-3 expression in primary human CD4+ T cells. Clin. Exp. Immunol., 160, 223-232.
22. Chen, Y.J. et al. (2001) Effect of caffeic acid phenethyl ester, an antioxidant from propolis, on inducing apoptosis in human leukemic HL-60 cells. J. Agric. Food Chem., 49, 5615-5619.
23. He, Y.J. et al. (2006) Inhibitory effect of caffeic acid phenethyl ester on the growth of SW480 colorectal tumor cells involves beta-catenin associated signaling pathway down-regulation. World J. Gastroenterol., 12, 4981-4985.
24. Kuo, H.C. et al. (2006) Inhibitory effect of caffeic acid phenethyl ester on the growth of C6 glioma cells in vitro and in vivo. Cancer Lett., 234, 199-208.
25. Frenkel, K. et al. (1993) Inhibition of tumor promoter-mediated processes in mouse skin and bovine lens by caffeic acid phenethyl ester. Cancer Res., 53, 1255-1261.
26. Huang, M.T. et al. (1996) Inhibitory effects of caffeic acid phenethyl ester (CAPE) on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in mouse skin and the synthesis of DNA, RNA and protein in HeLa cells. Carcinogenesis, 17, 761-765.
27. Pramanik, K.C. et al. (2012) Apoptosis signal-regulating kinase 1-thioredoxin complex dissociation by capsaicin causes pancreatic tumor growth suppression by inducing apoptosis. Antioxid. Redox Signal., 17, 1417-1432.
28. Boreddy, S.R. et al. (2011) Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway. Clin. Cancer Res., 17, 1784-1795.
29. Pramanik, K.C. et al. (2011) Role of mitochondrial electron transport chain complexes in capsaicin mediated oxidative stress leading to apoptosis in pancreatic cancer cells. PLoS One, 6, e20151.
30. Sahu, R.P. et al. (2009) The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate. J. Natl Cancer Inst., 101, 176-193.
31. Russell, J.C. et al. (2008) Nuclear translocation of X-linked inhibitor of apoptosis (XIAP) determines cell fate after hypoxia ischemia in neonatal brain. J. Neurochem., 106, 1357-1370.
32. Nowak, D. et al. (2004) Upon drug-induced apoptosis in lymphoma cells X-linked inhibitor of apoptosis (XIAP) translocates from the cytosol to the nucleus. Leuk. Lymphoma, 45, 1429-1436.
33. Schlieman, M.G. et al. (2003) Incidence, mechanism and prognostic value of activated AKT in pancreas cancer. Br. J. Cancer, 89, 2110-2115.
34. Chuu, C.P. et al. (2012) Caffeic acid phenethyl ester suppresses the proliferation of human prostate cancer cells through inhibition of p70S6K and Akt signaling networks. Cancer Prev. Res. (Phila), 5, 788-797.
35. Deveraux, Q.L. et al. (1997) X-linked IAP is a direct inhibitor of cell-death proteases. Nature, 388, 300-304.
36. Deveraux, Q.L. et al. (1998) IAPs block apoptotic events induced by caspase- 8 and cytochrome c by direct inhibition of distinct caspases. EMBO J., 17, 2215-2223.
37. Datta, R. et al. (2000) XIAP regulates DNA damage-induced apoptosis downstream of caspase-9 cleavage. J. Biol. Chem., 275, 31733-31738.
38. Sasaki, H. et al. (2000) Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells. Cancer Res., 60, 5659-5666.