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Volumn 124, Issue 9, 2014, Pages 3767-3780

Hedgehog signaling regulates FOXA2 in esophageal embryogenesis and Barrett's metaplasia

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; HEPATOCYTE NUCLEAR FACTOR 3BETA; MUCIN 2; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR SOX9; AGR2 PROTEIN, MOUSE; FOXA2 PROTEIN, MOUSE; GLI PROTEIN, MOUSE; KRUPPEL LIKE FACTOR; MUC2 PROTEIN, MOUSE; MUCOPROTEIN; SOX9 PROTEIN, MOUSE;

EID: 84907014877     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI66603     Document Type: Article
Times cited : (78)

References (65)
  • 1
    • 0036517883 scopus 로고    scopus 로고
    • How cells change their phenotype
    • Tosh D, Slack JM. How cells change their phenotype. Nat Rev Mol Cell Biol. 2002;3(3):187-194.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , Issue.3 , pp. 187-194
    • Tosh, D.1    Slack, J.M.2
  • 2
    • 0037215539 scopus 로고    scopus 로고
    • Is intestinal metaplasia of the stomach reversible?
    • Walker MM. Is intestinal metaplasia of the stomach reversible? Gut. 2003;52(1):1-4.
    • (2003) Gut , vol.52 , Issue.1 , pp. 1-4
    • Walker, M.M.1
  • 3
    • 72849170034 scopus 로고
    • Changes in bronchial epithelium in relation to cigarette smoking and in relation to lung cancer
    • Auerbach O, Stout AP, Hammond EC, Garfinkel L. Changes in bronchial epithelium in relation to cigarette smoking and in relation to lung cancer. N Engl J Med. 1961;265:253-267.
    • (1961) N Engl J Med , vol.265 , pp. 253-267
    • Auerbach, O.1    Stout, A.P.2    Hammond, E.C.3    Garfinkel, L.4
  • 4
    • 84881458405 scopus 로고    scopus 로고
    • Barrett esophagus and risk of esophageal cancer: A clinical review
    • Spechler SJ. Barrett esophagus and risk of esophageal cancer: a clinical review. JAMA. 2013;310(6):627-636.
    • (2013) JAMA , vol.310 , Issue.6 , pp. 627-636
    • Spechler, S.J.1
  • 5
    • 9244221172 scopus 로고    scopus 로고
    • Tissue repair and stem cell renewal in carcinogenesis
    • Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature. 2004;432(7015):324-331.
    • (2004) Nature , vol.432 , Issue.7015 , pp. 324-331
    • Beachy, P.A.1    Karhadkar, S.S.2    Berman, D.M.3
  • 6
    • 70350534843 scopus 로고    scopus 로고
    • Hedgehog target genes: Mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation
    • Katoh Y, Katoh M. Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. Curr Mol Med. 2009;9(7):873-886.
    • (2009) Curr Mol Med , vol.9 , Issue.7 , pp. 873-886
    • Katoh, Y.1    Katoh, M.2
  • 7
    • 0036234316 scopus 로고    scopus 로고
    • The burden of selected digestive diseases in the United States
    • Sandler RS, et al. The burden of selected digestive diseases in the United States. Gastroenterology. 2002;122(5):1500-1511.
    • (2002) Gastroenterology , vol.122 , Issue.5 , pp. 1500-1511
    • Sandler, R.S.1
  • 8
    • 77953307285 scopus 로고    scopus 로고
    • Esophageal adenocarcinoma incidence: Are we reaching the peak?
    • Pohl H, Sirovich B, Welch HG. Esophageal adenocarcinoma incidence: are we reaching the peak? Cancer Epidemiol Biomarkers Prev. 2010;19(6):1468-1470.
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , Issue.6 , pp. 1468-1470
    • Pohl, H.1    Sirovich, B.2    Welch, H.G.3
  • 10
    • 0033594485 scopus 로고    scopus 로고
    • P63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
    • Yang A, et al. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature. 1999;398(6729):714-718.
    • (1999) Nature , vol.398 , Issue.6729 , pp. 714-718
    • Yang, A.1
  • 11
    • 2942677539 scopus 로고    scopus 로고
    • Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium
    • Daniely Y, et al. Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium. Am J Physiol Cell Physiol. 2004;287(1):C171-C181.
    • (2004) Am J Physiol Cell Physiol , vol.287 , Issue.1 , pp. C171-C181
    • Daniely, Y.1
  • 12
    • 70350641014 scopus 로고    scopus 로고
    • SOX2 is an amplified lineagesurvival oncogene in lung and esophageal squamous cell carcinomas
    • Bass AJ, et al. SOX2 is an amplified lineagesurvival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet. 2009;41(11):1238-1242.
    • (2009) Nat Genet , vol.41 , Issue.11 , pp. 1238-1242
    • Bass, A.J.1
  • 13
    • 70449105187 scopus 로고    scopus 로고
    • SOX2 is highly expressed in squamous cell carcinomas of the gastrointestinal tract
    • Long KB, Hornick JL. SOX2 is highly expressed in squamous cell carcinomas of the gastrointestinal tract. Hum Pathol. 2009;40(12):1768-1773.
    • (2009) Hum Pathol , vol.40 , Issue.12 , pp. 1768-1773
    • Long, K.B.1    Hornick, J.L.2
  • 14
    • 60549115231 scopus 로고    scopus 로고
    • Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1
    • Chan CW, et al. Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1. Proc Natl Acad Sci U S A. 2009;106(6):1936-1941.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.6 , pp. 1936-1941
    • Chan, C.W.1
  • 15
    • 19644370204 scopus 로고    scopus 로고
    • CDX1 is an important molecular mediator of Barrett's metaplasia
    • Wong NA, et al. CDX1 is an important molecular mediator of Barrett's metaplasia. Proc Natl Acad Sci U S A. 2005;102(21):7565-7570.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.21 , pp. 7565-7570
    • Wong, N.A.1
  • 16
    • 77953556073 scopus 로고    scopus 로고
    • Acid and bile salt-induced CDX2 expression differs in esophageal squamous cells from patients with and without Barrett's esophagus
    • Huo X, et al. Acid and bile salt-induced CDX2 expression differs in esophageal squamous cells from patients with and without Barrett's esophagus. Gastroenterology. 2010;139(1):194-203.
    • (2010) Gastroenterology , vol.139 , Issue.1 , pp. 194-203
    • Huo, X.1
  • 17
    • 64549114508 scopus 로고    scopus 로고
    • Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2
    • Gao N, White P, Kaestner KH. Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2. Dev Cell. 2009;16(4):588-599.
    • (2009) Dev Cell , vol.16 , Issue.4 , pp. 588-599
    • Gao, N.1    White, P.2    Kaestner, K.H.3
  • 18
    • 3142669010 scopus 로고    scopus 로고
    • SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes
    • Blache P, et al. SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. J Cell Biol. 2004;166(1):37-47.
    • (2004) J Cell Biol , vol.166 , Issue.1 , pp. 37-47
    • Blache, P.1
  • 19
    • 77951684109 scopus 로고    scopus 로고
    • Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia
    • Wang DH, et al. Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia. Gastroenterology. 2010;138(5):1810-1822.
    • (2010) Gastroenterology , vol.138 , Issue.5 , pp. 1810-1822
    • Wang, D.H.1
  • 20
    • 0035824487 scopus 로고    scopus 로고
    • Requirement of Math1 for secretory cell lineage commitment in the mouse intestine
    • Yang Q, Bermingham NA, Finegold MJ, Zoghbi HY. Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science. 2001;294(5549):2155-2158.
    • (2001) Science , vol.294 , Issue.5549 , pp. 2155-2158
    • Yang, Q.1    Bermingham, N.A.2    Finegold, M.J.3    Zoghbi, H.Y.4
  • 21
    • 0035185632 scopus 로고    scopus 로고
    • Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders
    • Glickman JN, Yang A, Shahsafaei A, McKeon F, Odze RD. Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders. Hum Pathol. 2001;32(11):1157-1165.
    • (2001) Hum Pathol , vol.32 , Issue.11 , pp. 1157-1165
    • Glickman, J.N.1    Yang, A.2    Shahsafaei, A.3    McKeon, F.4    Odze, R.D.5
  • 22
    • 40949151584 scopus 로고    scopus 로고
    • Multilayered epithelium in a rat model and human Barrett's esophagus: Similar expression patterns of transcription factors and differentiation markers
    • Chen X, et al. Multilayered epithelium in a rat model and human Barrett's esophagus: similar expression patterns of transcription factors and differentiation markers. BMC Gastroenterol. 2008;8:1.
    • (2008) BMC Gastroenterol , vol.8 , pp. 1
    • Chen, X.1
  • 23
    • 0037288305 scopus 로고    scopus 로고
    • Aberrant expression of CDX2 in Barrett's epithelium and inflammatory esophageal mucosa
    • Eda A, et al. Aberrant expression of CDX2 in Barrett's epithelium and inflammatory esophageal mucosa. J Gastroenterol. 2003;38(1):14-22.
    • (2003) J Gastroenterol , vol.38 , Issue.1 , pp. 14-22
    • Eda, A.1
  • 25
    • 67649538054 scopus 로고    scopus 로고
    • Intestinal differentiation in metaplastic, nongoblet columnar epithelium in the esophagus
    • Hahn HP, et al. Intestinal differentiation in metaplastic, nongoblet columnar epithelium in the esophagus. Am J Surg Pathol. 2009;33(7):1006-1015.
    • (2009) Am J Surg Pathol , vol.33 , Issue.7 , pp. 1006-1015
    • Hahn, H.P.1
  • 26
    • 79952305740 scopus 로고    scopus 로고
    • American Gastroenterological Association technical review on the management of Barrett's esophagus
    • Spechler SJ, Sharma P, Souza RF, Inadomi JM, Shaheen NJ. American Gastroenterological Association technical review on the management of Barrett's esophagus. Gastroenterology. 2011;140(3):e18-e52.
    • (2011) Gastroenterology , vol.140 , Issue.3 , pp. e18-e52
    • Spechler, S.J.1    Sharma, P.2    Souza, R.F.3    Inadomi, J.M.4    Shaheen, N.J.5
  • 27
    • 0030891148 scopus 로고    scopus 로고
    • A binding site for Gli proteins is essential for HNF- 3β floor plate enhancer activity in transgenics and can respond to Shh in vitro
    • Sasaki H, Hui C, Nakafuku M, Kondoh H. A binding site for Gli proteins is essential for HNF- 3β floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development. 1997;124(7):1313-1322.
    • (1997) Development , vol.124 , Issue.7 , pp. 1313-1322
    • Sasaki, H.1    Hui, C.2    Nakafuku, M.3    Kondoh, H.4
  • 28
    • 0031594949 scopus 로고    scopus 로고
    • The transcription factor HNF3β is required in visceral endoderm for normal primitive streak morphogenesis
    • Dufort D, Schwartz L, Harpal K, Rossant J. The transcription factor HNF3β is required in visceral endoderm for normal primitive streak morphogenesis. Development. 1998;125(16):3015-3025.
    • (1998) Development , vol.125 , Issue.16 , pp. 3015-3025
    • Dufort, D.1    Schwartz, L.2    Harpal, K.3    Rossant, J.4
  • 29
    • 0028169992 scopus 로고
    • HNF-3β is essential for node and notochord formation in mouse development
    • Ang SL, Rossant J. HNF-3β is essential for node and notochord formation in mouse development. Cell. 1994;78(4):561-574.
    • (1994) Cell , vol.78 , Issue.4 , pp. 561-574
    • Ang, S.L.1    Rossant, J.2
  • 30
    • 3042773498 scopus 로고    scopus 로고
    • The Barrett's antigen anterior gradient-2 silences the p53 transcriptional response to DNA damage
    • Pohler E, et al. The Barrett's antigen anterior gradient-2 silences the p53 transcriptional response to DNA damage. Mol Cell Proteomics. 2004;3(6):534-547.
    • (2004) Mol Cell Proteomics , vol.3 , Issue.6 , pp. 534-547
    • Pohler, E.1
  • 31
    • 70349652391 scopus 로고    scopus 로고
    • Differential gene expression in normal esophagus and Barrett's esophagus
    • Wang J, et al. Differential gene expression in normal esophagus and Barrett's esophagus. J Gastroenterol. 2009;44(9):897-911.
    • (2009) J Gastroenterol , vol.44 , Issue.9 , pp. 897-911
    • Wang, J.1
  • 32
    • 33748117784 scopus 로고    scopus 로고
    • Gene expression profiling reveals stromal genes expressed in common between Barrett's esophagus and adenocarcinoma
    • Hao Y, Triadafilopoulos G, Sahbaie P, Young HS, Omary MB, Lowe AW. Gene expression profiling reveals stromal genes expressed in common between Barrett's esophagus and adenocarcinoma. Gastroenterology. 2006;131(3):925-933.
    • (2006) Gastroenterology , vol.131 , Issue.3 , pp. 925-933
    • Hao, Y.1    Triadafilopoulos, G.2    Sahbaie, P.3    Young, H.S.4    Omary, M.B.5    Lowe, A.W.6
  • 34
    • 23244440980 scopus 로고    scopus 로고
    • Conversion of columnar to stratified squamous epithelium in the developing mouse oesophagus
    • Yu WY, Slack JM, Tosh D. Conversion of columnar to stratified squamous epithelium in the developing mouse oesophagus. Dev Biol. 2005;284(1):157-170.
    • (2005) Dev Biol , vol.284 , Issue.1 , pp. 157-170
    • Yu, W.Y.1    Slack, J.M.2    Tosh, D.3
  • 35
    • 41249090141 scopus 로고    scopus 로고
    • Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells
    • van der Sluis M, et al. Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells. Biochem Biophys Res Commun. 2008;369(4):1108-1113.
    • (2008) Biochem Biophys Res Commun , vol.369 , Issue.4 , pp. 1108-1113
    • Van Der Sluis, M.1
  • 36
    • 70949092295 scopus 로고    scopus 로고
    • Foxa1 and Foxa2 control the differentiation of goblet and enteroendocrine L- and D-cells in mice
    • Ye DZ, Kaestner KH. Foxa1 and Foxa2 control the differentiation of goblet and enteroendocrine L- and D-cells in mice. Gastroenterology. 2009;137(6):2052-2062.
    • (2009) Gastroenterology , vol.137 , Issue.6 , pp. 2052-2062
    • Ye, D.Z.1    Kaestner, K.H.2
  • 37
    • 10244257711 scopus 로고    scopus 로고
    • Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues
    • Besnard V, Wert SE, Hull WM, Whitsett JA. Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues. Gene Expr Patterns. 2004;5(2):193-208.
    • (2004) Gene Expr Patterns , vol.5 , Issue.2 , pp. 193-208
    • Besnard, V.1    Wert, S.E.2    Hull, W.M.3    Whitsett, J.A.4
  • 38
    • 0031711075 scopus 로고    scopus 로고
    • Sonic hedgehog is essential to foregut development
    • Litingtung Y, Lei L, Westphal H, Chiang C. Sonic hedgehog is essential to foregut development. Nat Genet. 1998;20(1):58-61.
    • (1998) Nat Genet , vol.20 , Issue.1 , pp. 58-61
    • Litingtung, Y.1    Lei, L.2    Westphal, H.3    Chiang, C.4
  • 39
    • 0031683165 scopus 로고    scopus 로고
    • Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus
    • Motoyama J, Liu J, Mo R, Ding Q, Post M, Hui CC. Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Genet. 1998;20(1):54-57.
    • (1998) Nat Genet , vol.20 , Issue.1 , pp. 54-57
    • Motoyama, J.1    Liu, J.2    Mo, R.3    Ding, Q.4    Post, M.5    Hui, C.C.6
  • 41
    • 30344475256 scopus 로고    scopus 로고
    • Homozygous inactivation of Sox9 causes complete XY sex reversal in mice
    • Barrionuevo F, et al. Homozygous inactivation of Sox9 causes complete XY sex reversal in mice. Biol Reprod. 2006;74(1):195-201.
    • (2006) Biol Reprod , vol.74 , Issue.1 , pp. 195-201
    • Barrionuevo, F.1
  • 42
    • 4644328190 scopus 로고    scopus 로고
    • Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities
    • Harfe BD, Scherz PJ, Nissim S, Tian H, McMahon AP, Tabin CJ. Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell. 2004;118(4):517-528.
    • (2004) Cell , vol.118 , Issue.4 , pp. 517-528
    • Harfe, B.D.1    Scherz, P.J.2    Nissim, S.3    Tian, H.4    McMahon, A.P.5    Tabin, C.J.6
  • 43
    • 0036830491 scopus 로고    scopus 로고
    • The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6
    • Akiyama H, Chaboissier MC, Martin JF, Schedl A, de Crombrugghe B. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 2002;16(21):2813-2828.
    • (2002) Genes Dev , vol.16 , Issue.21 , pp. 2813-2828
    • Akiyama, H.1    Chaboissier, M.C.2    Martin, J.F.3    Schedl, A.4    De Crombrugghe, B.5
  • 44
    • 0029777408 scopus 로고    scopus 로고
    • Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
    • Chiang C, et al. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature. 1996;383(6599):407-413.
    • (1996) Nature , vol.383 , Issue.6599 , pp. 407-413
    • Chiang, C.1
  • 45
    • 17144407948 scopus 로고    scopus 로고
    • Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis
    • Wan H, et al. Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis. J Biol Chem. 2005;280(14):13809-13816.
    • (2005) J Biol Chem , vol.280 , Issue.14 , pp. 13809-13816
    • Wan, H.1
  • 46
    • 34249668293 scopus 로고    scopus 로고
    • Characterization of telomerase-immortalized, non-neoplastic, human Barrett's cell line (BAR-T)
    • Jaiswal KR, et al. Characterization of telomerase-immortalized, non-neoplastic, human Barrett's cell line (BAR-T). Dis Esophagus. 2007;20(3):256-264.
    • (2007) Dis Esophagus , vol.20 , Issue.3 , pp. 256-264
    • Jaiswal, K.R.1
  • 47
    • 44349187242 scopus 로고    scopus 로고
    • Repeated exposure to acid and bile selectively induces colonic phenotype expression in a heterogeneous Barrett's epithelial cell line
    • Bajpai M, Liu J, Geng X, Souza RF, Amenta PS, Das KM. Repeated exposure to acid and bile selectively induces colonic phenotype expression in a heterogeneous Barrett's epithelial cell line. Lab Invest. 2008;88(6):643-651.
    • (2008) Lab Invest , vol.88 , Issue.6 , pp. 643-651
    • Bajpai, M.1    Liu, J.2    Geng, X.3    Souza, R.F.4    Amenta, P.S.5    Das, K.M.6
  • 48
    • 0034738979 scopus 로고    scopus 로고
    • Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
    • Taipale J, et al. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature. 2000;406(6799):1005-1009.
    • (2000) Nature , vol.406 , Issue.6799 , pp. 1005-1009
    • Taipale, J.1
  • 49
    • 66349091311 scopus 로고    scopus 로고
    • The protein disulfide isomerase AGR2 is essential for production of intestinal mucus
    • Park SW, et al. The protein disulfide isomerase AGR2 is essential for production of intestinal mucus. Proc Natl Acad Sci U S A. 2009;106(17):6950-6955.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.17 , pp. 6950-6955
    • Park, S.W.1
  • 50
    • 74749103667 scopus 로고    scopus 로고
    • Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice
    • Zhao F, et al. Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice. Dev Biol. 2010;338(2):270-279.
    • (2010) Dev Biol , vol.338 , Issue.2 , pp. 270-279
    • Zhao, F.1
  • 51
    • 23644434605 scopus 로고    scopus 로고
    • Characterization of a novel Foxa (hepatocyte nuclear factor-3) site in the glucagon promoter that is conserved between rodents and humans
    • Sharma SK, et al. Characterization of a novel Foxa (hepatocyte nuclear factor-3) site in the glucagon promoter that is conserved between rodents and humans. Biochem J. 2005;389(pt 3):831-841.
    • (2005) Biochem J , vol.389 , pp. 831-841
    • Sharma, S.K.1
  • 52
    • 80053444296 scopus 로고    scopus 로고
    • Study of FoxA pioneer factor at silent genes reveals Rfx-repressed enhancer at Cdx2 and a potential indicator of esophageal adenocarcinoma development
    • Watts JA, et al. Study of FoxA pioneer factor at silent genes reveals Rfx-repressed enhancer at Cdx2 and a potential indicator of esophageal adenocarcinoma development. PLoS Genet. 2011;7(9):e1002277.
    • (2011) PLoS Genet , vol.7 , Issue.9 , pp. e1002277
    • Watts, J.A.1
  • 53
    • 79959631111 scopus 로고    scopus 로고
    • Residual embryonic cells as precursors of a Barrett's-like metaplasia
    • Wang X, et al. Residual embryonic cells as precursors of a Barrett's-like metaplasia. Cell. 2011;145(7):1023-1035.
    • (2011) Cell , vol.145 , Issue.7 , pp. 1023-1035
    • Wang, X.1
  • 54
    • 84862909168 scopus 로고    scopus 로고
    • Bile acid and inflammation activate gastric cardia stem cells in a mouse model of barrett-like metaplasia
    • Quante M, et al. Bile acid and inflammation activate gastric cardia stem cells in a mouse model of barrett-like metaplasia. Cancer Cell. 2012;21(1):36-51.
    • (2012) Cancer Cell , vol.21 , Issue.1 , pp. 36-51
    • Quante, M.1
  • 55
    • 13844275941 scopus 로고    scopus 로고
    • Transdifferentiation, metaplasia and tissue regeneration
    • Shen CN, Burke ZD, Tosh D. Transdifferentiation, metaplasia and tissue regeneration. Organogenesis. 2004;1(2):36-44.
    • (2004) Organogenesis , vol.1 , Issue.2 , pp. 36-44
    • Shen, C.N.1    Burke, Z.D.2    Tosh, D.3
  • 56
    • 53449083667 scopus 로고    scopus 로고
    • Differences in activity and phosphorylation of MAPK enzymes in esophageal squamous cells of GERD patients with and without Barrett's esophagus
    • Zhang HY, et al. Differences in activity and phosphorylation of MAPK enzymes in esophageal squamous cells of GERD patients with and without Barrett's esophagus. Am J Physiol Gastrointest Liver Physiol. 2008;295(3):G470-G478.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.295 , Issue.3 , pp. G470-G478
    • Zhang, H.Y.1
  • 57
    • 16744369176 scopus 로고    scopus 로고
    • Differences in ERK activation in squamous mucosa in patients who have gastroesophageal reflux disease with and without Barrett's esophagus
    • Souza RF, et al. Differences in ERK activation in squamous mucosa in patients who have gastroesophageal reflux disease with and without Barrett's esophagus. Am J Gastroenterol. 2005;100(3):551-559.
    • (2005) Am J Gastroenterol , vol.100 , Issue.3 , pp. 551-559
    • Souza, R.F.1
  • 58
    • 77649199102 scopus 로고    scopus 로고
    • Conversion of metaplastic Barrett's epithelium into post-mitotic goblet cells by gamma-secretase inhibition
    • Menke V, et al. Conversion of metaplastic Barrett's epithelium into post-mitotic goblet cells by gamma-secretase inhibition. Dis Model Mech. 2010;3(1-2):104-110.
    • (2010) Dis Model Mech , vol.3 , Issue.1-2 , pp. 104-110
    • Menke, V.1
  • 59
    • 34447530782 scopus 로고    scopus 로고
    • Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm
    • Que J, et al. Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development. 2007;134(13):2521-2531.
    • (2007) Development , vol.134 , Issue.13 , pp. 2521-2531
    • Que, J.1
  • 60
    • 78650191905 scopus 로고    scopus 로고
    • BMP signaling in the development of the mouse esophagus and forestomach
    • Rodriguez P, Da Silva S, Oxburgh L, Wang F, Hogan BL, Que J. BMP signaling in the development of the mouse esophagus and forestomach. Development. 2010;137(24):4171-4176.
    • (2010) Development , vol.137 , Issue.24 , pp. 4171-4176
    • Rodriguez, P.1    Da Silva, S.2    Oxburgh, L.3    Wang, F.4    Hogan, B.L.5    Que, J.6
  • 61
    • 84861618608 scopus 로고    scopus 로고
    • Notch signaling pathway and Cdx2 expression in the development of Barrett's esophagus
    • Tamagawa Y, et al. Notch signaling pathway and Cdx2 expression in the development of Barrett's esophagus. Lab Invest. 2012;92(6):896-909.
    • (2012) Lab Invest , vol.92 , Issue.6 , pp. 896-909
    • Tamagawa, Y.1
  • 62
    • 0032923739 scopus 로고    scopus 로고
    • Generalized lacZ expression with the ROSA26 Cre reporter strain
    • Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet. 1999;21(1):70-71.
    • (1999) Nat Genet , vol.21 , Issue.1 , pp. 70-71
    • Soriano, P.1
  • 63
    • 41149154521 scopus 로고    scopus 로고
    • Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma
    • Briggs KJ, et al. Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma. Genes Dev. 2008;22(6):770-785.
    • (2008) Genes Dev , vol.22 , Issue.6 , pp. 770-785
    • Briggs, K.J.1
  • 64
    • 0034923013 scopus 로고    scopus 로고
    • On differential variability of expression ratios: Improving statistical inference about gene expression changes from microarray data
    • Newton MA, Kendziorski CM, Richmond CS, Blattner FR, Tsui KW. On differential variability of expression ratios: improving statistical inference about gene expression changes from microarray data. J Comput Biol. 2001;8(1):37-52.
    • (2001) J Comput Biol , vol.8 , Issue.1 , pp. 37-52
    • Newton, M.A.1    Kendziorski, C.M.2    Richmond, C.S.3    Blattner, F.R.4    Tsui, K.W.5
  • 65
    • 1642306592 scopus 로고    scopus 로고
    • Parametric empirical Bayes methods for microarrays
    • Parmigiani G, Garrett ES, Irizarry R, Zeger SL, eds. New York, New York, USA: Springer Verlag
    • Newton MA, Kendziorski CM. Parametric empirical Bayes methods for microarrays. In: Parmigiani G, Garrett ES, Irizarry R, Zeger SL, eds. The Analysis Of Gene Expression Data: Methods And Software. New York, New York, USA: Springer Verlag; 2003:254-271.
    • (2003) The Analysis of Gene Expression Data: Methods and Software , pp. 254-271
    • Newton, M.A.1    Kendziorski, C.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.