Study of foxA pioneer factor at silent genes reveals Rfx-repressed enhancer at Cdx2 and a potential indicator of esophageal adenocarcinoma development

PLoS Genetics

Volumn 7, Issue 9, 2011, Pages

  Watts, Jason A ^a,b   Zhang, Chaolin ^c   Klein Szanto, Andres J ^b   Kormish, Jay D ^b   Fu, Jian ^b   Zhang, Michael Q ^d,e   Zaret, Kenneth S ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b FOX CHASE CANCER CENTER   (United States)

^c Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^d UNIVERSITY OF TEXAS AT DALLAS   (United States)

^e TSINGHUA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; NUCLEAR HORMONE RECEPTOR TYPE 2; REPRESSOR PROTEIN; RFX PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR FOXA; UNCLASSIFIED DRUG; CDX2 PROTEIN, MOUSE; DNA BINDING PROTEIN; FOXA1 PROTEIN, MOUSE; FOXA2 PROTEIN, MOUSE; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; HEPATOCYTE NUCLEAR FACTOR 3BETA; HOMEODOMAIN PROTEIN; REGULATORY FACTOR X TRANSCRIPTION FACTORS;

ANIMAL TISSUE; ARTICLE; BARRETT ESOPHAGUS; CARCINOGENESIS; CDX2 GENE; CONTROLLED STUDY; ENHANCER REGION; ESOPHAGEAL ADENOCARCINOMA; ESOPHAGUS MUCOSA; GENE; GENE EXPRESSION; GENE REPRESSION; GENE SILENCING; GENETIC REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALIGNANT TRANSFORMATION; METAPLASIA; MOUSE; NONHUMAN; PROMOTER REGION; TRANSCRIPTION INITIATION; ADENOCARCINOMA; ANIMAL; BINDING SITE; CELL TRANSFORMATION; ESOPHAGUS TUMOR; GENE EXPRESSION REGULATION; GENETICS; GENOME; LIVER; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PATHOLOGY;

ADENOCARCINOMA; ANIMALS; BARRETT ESOPHAGUS; BASE SEQUENCE; BINDING SITES; CELL TRANSFORMATION, NEOPLASTIC; DNA-BINDING PROTEINS; ENHANCER ELEMENTS, GENETIC; ESOPHAGEAL NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENOME; HEPATOCYTE NUCLEAR FACTOR 3-ALPHA; HEPATOCYTE NUCLEAR FACTOR 3-BETA; HOMEODOMAIN PROTEINS; HUMANS; LIVER; MICE; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 80053444296     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002277     Document Type: Article

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