Expression of p53-related protein p63 in the gastrointestinal tract and in esophageal metaplastic and neoplastic disorders

Human Pathology

Volumn 32, Issue 11, 2001, Pages 1157-1165

  Glickman, Jonathan N ^a   Yang, Annie ^a   Shahsafaei, Aliakbar ^a   McKeon, Frank ^a   Odze, Robert D ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Barrett esophagus; Intestinal metaplasia; P63; Squamous cell carcinoma

Indexed keywords

CYTOKERATIN; DNA BINDING PROTEIN; KI 67 ANTIGEN; MESSENGER RNA; PROTEIN P53; PROTEIN P63;

ADENOCARCINOMA; ARTICLE; BARRETT ESOPHAGUS; COLUMNAR EPITHELIUM; CONTROLLED STUDY; DYSPLASIA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; INTESTINE METAPLASIA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SQUAMOUS CELL CARCINOMA; SQUAMOUS EPITHELIUM; STOMACH;

EID: 0035185632     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1053/hupa.2001.28951     Document Type: Article

References (47)

1. P53 mutations in human cancers
2. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors
3. Tumor spectrum analysis in p53-mutant mice
4. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
5. The spectrum of mutations at the p53 locus. Evidence for tissue-specific mutagenesis, selection of mutant alleles, and a "gain of function" phenotype
6. Cell cycle control and cancer
7. p53: Puzzle and paradigm
8. A model for p53-induced apoptosis
9. Monoallelically expressed gene related to p53 at lp36, a region frequently deleted in neuroblastoma and other human cancers
10. P73 is a human p53-related protein that can induce apoptosis
11. p63, a p53 homolog at 3q27-29. Encodes multiple products with transactivating, death-inducing, and dominant-negative activities
12. p63 is a p53 homolog required for limb and epidermal morphogenesis
13. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development
14. The diagnosis and management of Barrett's esophagus
15. Molecular evolution of the metaplasia-dysplasia-adenocarcinoma sequence in the esophagus
16. Detection by scanning electron microscopy of a distinctive esophageal surface epithelium at the junction of squamous and Barrett's epithelium
17. Morphological characterization of the squamocolumnar junction of the esophagus in patients with and without Barrett's epithelium
18. Distribution of cytokeratin markers in Barret's specialized columnar epithelium
19. Significance of acid-mucin-positive nongoblet columnar cells in the distal esophagus and gastroesophageal junction
20. Characterization of a distinctive multilayered epithelium associated with Barrett's esophagus
21. Role of p53 gene mutations in human esophageal carcinogenesis: Results from immunohistochemical and mutation analyses of carcinomas and nearby noncancerous lesions
22. Histologic precursors of squamous esophageal cancer
23. The catalog of human cytokeratins: Patterns of expression in normal epithelia, tumors and cultured cells
24. Keratin expression in cervical cancer
25. Immunohistochemical staining patterns of keratins in normal oesophageal epithelium and carcinoma of the esophagus
26. Expression of cytokeratin mRNAs in normal human esophageal epithelium
27. Basal-cell keratins in cervical reserve cells and a comparison of their expression in cervical intraepithelial neoplasia
28. Reproducible and highly sensitive detection of the broad spectrum epithelial marker keratin 19 in routine cancer diagnosis
29. Expression of simple type cytokeratins in stratified epithelia as detected by immunolocalization and hybridization in situ
30. p53 protein accumulation and gene mutations in multifocal esophageal precancerous lesions from symptom free subjects in a high incidence area for esophageal carcinoma in Henan, China
31. Role of p53 gene mutations in human esophageal carcinogenesis: Results from immunohistochemical and mutation analyses of carcinomas and nearby noncancerous lesions
32. A Multifocal accumulation of p53 protein in esophageal carcinoma: Evidence for field cancerization
33. p63 identifies keratinocyte stem cells
34. Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome
35. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
36. Mutational analysis of the p63/p73/p51/p40/CUSP/KET gene in human cancer cell liens using intronic primers
37. Cloning and functional analysis of human p51, which structurally and functionally resembles p53
38. Mutation and expression of the p51 gene in human lung cancer
39. Prospective evaluation of multilayered epithelium in Barrett's esophagus
40. The lower esophagus lined by columnar epithelium: Its association with hiatal hernia, ulcer stricture, and tumor
41. Barrett-esophagus following total gastrectomy
42. Experimental columnar metaplasia in the canine oesophagus
43. Mechanisms of columnar metaplasia and squamous regeneration in experimental Barrett's esophagus
44. Barrett's esophagus: Congenital or acquired? An experimental study of esophageal mucosal regeneration in the dog
45. Mechanisms of columnar metaplasia and squamous regeneration in experimental Barrett's esophagus
46. Stratified mucin-producing intraepithelial lesions of the cervix: Adenosquamous or columnar cell neoplasia?
47. Expression of the p53 homologue p63 in early cervical neoplasia