The Barrett's antigen anterior gradient-2 silences the p53 transcriptional response to DNA damage

Molecular and Cellular Proteomics

Volumn 3, Issue 6, 2004, Pages 534-547

  Pohler, Elizabeth ^a   Craig, Ashley L ^a   Cotton, James ^a   Lawrie, Laura ^b   Dillon, John F ^a   Ross, Pete ^a   Kernohan, Neil ^a   Hupp, Ted R ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTIGEN ANTERIOR GRADIENT 2; HISTIDINE; POLYPEPTIDE; PROTEIN P53; PROTEIN SERINE KINASE; SERINE; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; BARRETT ESOPHAGUS; CARBOXY TERMINAL SEQUENCE; CELL CYCLE; CELL DAMAGE; CELL SURVIVAL; COLONY FORMATION; CONTROLLED STUDY; DNA DAMAGE; ESOPHAGUS MUCOSA; GENE ACTIVITY; GENE DELETION; GENE FUNCTION; GENE MUTATION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC CODE; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; ONCOGENE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEOMICS; REGULATORY MECHANISM; SQUAMOUS EPITHELIUM; TRANSACTIVATION; TUMOR SUPPRESSOR GENE; ULTRAVIOLET RADIATION; UPREGULATION;

AMINO ACID SEQUENCE; BARRETT ESOPHAGUS; CELL CYCLE; CELL SURVIVAL; COLONY-FORMING UNITS ASSAY; DNA DAMAGE; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; EPITHELIAL CELLS; GENE SILENCING; HUMANS; INTESTINAL NEOPLASMS; MASS SPECTROMETRY; METAPLASIA; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS; XENOPUS PROTEINS;

EID: 3042773498     PISSN: 15359476     EISSN: None     Source Type: Journal    
DOI: 10.1074/mcp.M300089-MCP200     Document Type: Article

References (43)

1. Arends, J. W. (2000) Molecular interactions in the Vogelstein model of colorectal carcinoma. J. Pathol. 190, 412-416
2. Nowak, M. A., Komarova, N. L., Sengupta, A., Jallepalli, P. V., Shih le, M., Vogelstein, B., and Lengauer, C. (2002) The role of chromosomal instability in tumor initiation. Proc. Natl. Acad. Sci. U. S. A. 99, 16226-16231
3. Feinberg, A. P., Cui, H., and Ohlsson, R. (2002) DNA methylation and genomic imprinting: Insights from cancer into epigenetic mechanisms. Semin. Cancer Biol. 12, 389-398
4. Yan, H., Dobbie, Z., Gruber, S. B., Markowitz, S., Romans, K., Giardiello, F. M., Kinzler, K. W., and Vogelstein, B. (2002) Small changes in expression affect predisposition to tumorigenesis. Nat. Genet. 30, 25-26
5. Reid, B. J., Blount, P. L., and Rabinovitch, P. S. (2003) Biomarkers in Barrett's esophagus. Gastrointest. Endosc. Clin. N. Am. 13, 369-397
6. Reid, B. J. (2001) p53 and neoplastic progression in Barrett's esophagus. Am. J. Gastroenterol. 96, 1321-1323
7. Casson, A. G., Tammemagi, M., Eskandarian, S., Redston, M., McLaughlin, J., and Ozcelik, H. (1998) p53 alterations in oesophageal cancer: Association with clinicopathological features, risk factors, and survival. Mol. Pathol. 51, 71-79
8. Walch, A. K., Zitzelsberger, H. F., Bink, K., Hutzler, P., Bruch, J., Braselmann, H., Aubele, M. M., Mueller, J., Stein, H., Siewert, J. R., Hofler, H., and Werner, M. (2000) Molecular genetic changes in metastatic primary Barrett's adenocarcinoma and related lymph node metastases: Comparison with nonmetastatic Barrett's adenocarcinoma. Mod. Pathol. 13, 814-824
9. Mueller, J., Werner, M., and Siewert, J. R. (2000) Malignant progression in Barrett's esophagus: Pathology and molecular biology. Recent Results Cancer Res. 155, 29-41
10. Moreto, M. (2003) Diagnosis of esophagogastric tumors. Endoscopy 35, 36-42
11. Jenkins, G. J., Doak, S. H., Parry, J. M., D'Souza, F. R., Griffiths, A. P., and Baxter, J. N. (2002) Genetic pathways involved in the progression of Barrett's metaplasia to adenocarcinoma. Br. J. Surg. 89, 824-837
12. Casson, A. G., Mukhopadhyay, T., Cleary, K. R., Ro, J. Y., Levin, B., and Roth, J. A. (1991) p53 gene mutations in Barrett's epithelium and esophageal cancer. Cancer Res. 51, 4495-4499
13. Campomenosi, P., Conio, M., Bogliolo, M., Urbini, S., Assereto, P., Aprile, A., Monti, P., Aste, H., Lapertosa, G., Inga, A., Abbondandolo, A., and Fronza, G. (1996) p53 is frequently mutated in Barrett's metaplasia of the intestinal type. Cancer Epidemiol. Biomarkers Prev. 5, 559-565
14. Prevo, L. J., Sanchez, C. A., Galipeau, P. C., and Reid, B. J. (1999) p53-mutant clones and field effects in Barrett's esophagus. Cancer Res. 59, 4784-4787
15. Fitzgerald, R. C. (2003) Significance of acid exposure in Barrett's esophagus. Am. J. Gastroenterol. 98, 699-700
16. Fitzgerald, R. C., Abdalla, S., Onwuegbusi, B. A., Sirieix, P., Saeed, I. T., Burnham, W. R., and Farthing, M. J. (2002) Inflammatory gradient in Barrett's oesophagus: Implications for disease complications. Gut 51, 316-322
17. Achison, M., and Hupp, T. R. (2003) Hypoxia attenuates the p53 response to cellular damage. Oncogene 22, 3431-3440
18. Nitta, M., Okamura, H., Aizawa, S., and Yamaizumi, M. (1997) Heat shock induces transient p53-dependent cell cycle arrest at G1/S. Oncogene 15, 561-568
19. Williams, A. C., Collard, T. J., and Paraskeva, C. (1999) An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: Implications for clonal selection during colorectal carcinogenesis. Oncogene 18, 3199-3204
20. Hopwood, D., Moitra, S., Vojtesek, B., Johnston, D. A., Dillon, J. F., and Hupp, T. R. (1997) Biochemical analysis of the stress protein response in human oesophageal epithelium. Gut 41, 156-163
21. Yagui-Beltran, A., Craig, A. L., Lawrie, L., Thompson, D., Pospisilova, S., Johnston, D., Kernohan, N., Hopwood, D., Dillon, J. F., and Hupp, T. R. (2001) The human oesophageal squamous epithelium exhibits a novel type of heat shock protein response. Eur. J. Biochem. 268, 5343-5355
22. Loffler, B. M., and Kunze, H. (1989) Refinement of the Coomassie brilliant blue G assay for quantitative protein determination. Anal. Biochem. 177, 100-102
23. Votyakova, T. V., Wallace, H. M., Dunbar, B., and Wilson, S. B. (1999) The covalent attachment of polyamines to proteins in plant mitochondria. Eur. J. Biochem. 260, 250-257
24. Blaydes, J. P., Craig, A. L., Wallace, M., Ball, H. M., Traynor, N. J., Gibbs, N. K., and Hupp, T. R. (2000) Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways. Oncogene 19, 3829-3839
25. Craig, A. L., Blaydes, J. P., Burch, L. R., Thompson, A. M., and Hupp, T. R. (1999) Dephosphorylation of p53 at Ser2O after cellular exposure to low levels of non-ionizing radiation. Oncogene 18, 6305-6312
26. Dornan, D., Shimizu, H., Burch, L., Smith, A. J., and Hupp, T. R. (2003) The proline repeat domain of p53 binds directly to the transcriptional coactivator p3OO and allosterically controls DNA-dependent acetylation of p53. Mol. Cell. Biol. 23, 8846-8861
27. Hermeking, H., Lengauer, C., Polyak, K., He, T. C., Zhang, L., Thiagalingam, S., Kinzler, K. W., and Vogelstein, B. (1997) 14-3-3σ is a p53-regulated inhibitor of G2/M progression. Mol. Cell 1, 3-11
28. Gao, C., Zou, Z., Xu, L., Moul, J., Seth, P., and Srivastava, S. (2000) p53-dependent induction of heat shock protein 27 (HSP27) expression. Int. J. Cancer 88, 191-194
29. Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., and Vogelstein, B. (1997) A model for p53-Induced apoptosis. Nature 389, 300-305
30. Aberger, F., Weidinger, G., Grunz, H., and Richter, K. (1998) Anterior specification of embryonic ectoderm: The role of the Xenopus cement gland-specific gene XAG-2. Mech. Dev. 72, 115-130
31. Thompson, D. A., and Weigel, R. J. (1998) hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines. Biochem. Biophys. Res. Commun. 251, 111-116
32. Fletcher, G. C., Patel, S., Tyson, K., Adam, P. J., Schenker, M., Loader, J. A., Daviet, L., Legrain, P., Parekh, R., Harris, A. L., and Terrett, J. A. (2003) hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. Br. J. Cancer 88, 579-585
33. Adam, P. J., Boyd, R., Tyson, K. L., Fletcher, G. C., Stamps, A., Hudson, L., Poyser, H. R., Redpath, N., Griffiths, M., Steers, G., Harris, A. L., Patel, S., Berry, J., Loader, J. A., Townsend, R. R., Daviet, L., Legrain, P., Parekh, R., and Terrett, J. A. (2003) Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer. J. Biol. Chem. 278, 6482-6489
34. Dittmer, D., Pati, S., Zambetti, G., Chu, S., Teresky, A. K., Moore, M., Finlay, C., and Levine, A. J. (1993) Gain of function mutations in p53. Nat. Genet. 4, 42-46
35. Blaydes, J. P., and Hupp, T. R. (1998) DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site. Oncogene 17, 1045-1052
36. Tibbetts, R. S., Brumbaugh, K. M., Williams, J. M., Sarkaria, J. N., Cliby, W. A., Shieh, S. Y., Taya, Y., Prives, C., and Abraham, R. T. (1999) A role for ATR in the DNA damage-induced phosphorylation of p53. Genes Dev. 13, 152-157
37. Banin, S., Moyal, L., Shieh, S., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., and Ziv, Y. (1998) Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281, 1674-1677
38. Raskind, W. H., Norwood, T., Levine, D. S., Haggitt, R. C., Rabinovitch, P. S., and Reid, B. J. (1992) Persistent clonal areas and clonal expansion in Barrett's esophagus. Cancer Res. 52, 2946-2950
39. Galipeau, P. C., Cowan, D. S., Sanchez, C. A., Barrett, M. T., Emond, M. J., Levine, D. S., Rabinovitch, P. S., and Reid, B. J. (1996) 17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus. Proc. Natl. Acad. Sci. U. S. A. 93, 7081-7084
40. Barrett, M. T., Pritchard, D., Palanca-Wessels, C., Anderson, J., Reid, B. J., and Rabinovitch, P. S. (2003) Molecular phenotype of spontaneously arising 4N (G2-tetraploid) intermediates of neoplastic progression in Barrett's esophagus. Cancer Res. 63, 4211-4217
41. Nakano, K., Balint, E., Ashcroft, M., and Vousden, K. H. (2000) A ribonucleotide reductase gene is a transcriptional target of p53 and p73. Oncogene 19, 4283-4289
42. Liepinsh, E., Baryshev, M., Sharipo, A., Ingelman-Sundberg, M., Otting, G., and Mkrtchian, S. (2001) Thioredoxin fold as homodimerization module in the putative chaperone ERp29: NMR structures of the domains and experimental model of the 51 kDa dimer. Structure 9, 457-471
43. Sargsyan, E., Baryshev, M., Szekely, L., Sharipo, A., and Mkrtchian, S. (2002) Identification of ERp29, an endoplasmic reticulum lumenal protein, as a new member of the thyroglobulin folding complex. J. Biol. Chem. 277, 17009-17015