Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis

Journal of Clinical Investigation

Volumn 124, Issue 9, 2014, Pages 3793-3806

  De Jong, Petrus R ^a,b   Takahashi, Naoki ^a,c   Harris, Alexandra R ^a   Lee, Jihyung ^a   Bertin, Samuel ^a   Jeffries, James ^a   Jung, Michael ^a   Duong, Jen ^a   Triano, Amy I ^a   Lee, Jongdae ^a   Niv, Yaron ^d   Herdman, David S ^a   Taniguchi, Koji ^a,e   Kim, Chang Whan ^a,f   Dong, Hui ^a   Eckmann, Lars ^a   Stanford, Stephanie M ^g   Bottini, Nunzio ^g   Corr, Maripat ^a   Raz, Eyal ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^d TEL AVIV UNIVERSITY   (Israel)

^e KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f The Catholic University of Korea   (South Korea)

^g LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; CALCIUM ION; CALPAIN; CAPSAICIN; CELECOXIB; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; GEFITINIB; PROTEIN TYROSINE PHOSPHATASE 1B; VANILLOID RECEPTOR 1; CALCIUM; CALCIUM CHANNEL; PTPN1 PROTEIN, HUMAN; TRPV1 PROTEIN, HUMAN; VANILLOID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; COLON CARCINOGENESIS; COLORECTAL ADENOMA; CONTROLLED STUDY; FEEDBACK SYSTEM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE CARCINOGENESIS; INTESTINE EPITHELIUM CELL; INTESTINE TUMOR; LOW DRUG DOSE; MEDIATOR; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; SINGLE DRUG DOSE; TUMOR CELL LINE; TUMOR GROWTH; TUMOR XENOGRAFT; ANIMAL; ANTAGONISTS AND INHIBITORS; ENZYME ACTIVATION; INTESTINAL NEOPLASMS; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM; CALCIUM CHANNELS; CALPAIN; CELL PROLIFERATION; CYCLOOXYGENASE 2 INHIBITORS; ENZYME ACTIVATION; HUMANS; INTESTINAL NEOPLASMS; MICE; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TRPV CATION CHANNELS;

EID: 84907007750     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI72340     Document Type: Article

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