A novel functional site in the PB2 subunit of influenza a virus essential for acetyl-CoA interaction, RNA polymerase activity, and viral replication

Journal of Biological Chemistry

Volumn 289, Issue 36, 2014, Pages 24980-24994

  Hatakeyama, Dai ^a   Shoji, Masaki ^a   Yamayoshi, Seiya ^b   Hirota, Takenori ^a   Nagae, Monami ^a   Yanagisawa, Shin ^a   Nakano, Masahiro ^b,d   Ohmi, Naho ^a   Noda, Takeshi ^b,d   Kawaoka, Yoshihiro ^b,c,e   Kuzuhara, Takashi ^a  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^b University of Tokyo   (Japan)

^c THE UNIVERSITY OF TOKYO   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; RECOMBINANT PROTEINS; TRANSCRIPTION; VIRUSES;

ARGININE RESIDUE; BINDING ABILITIES; ENDONUCLEASE ACTIVITIES; HISTONE ACETYLTRANSFERASES; INFLUENZA A VIRUS; RNA-DEPENDENT RNA POLYMERASE; VIRAL REPLICATION; VIRAL TRANSCRIPTION;

RNA;

7 METHYLGUANOSINE TRIPHOSPHATE; ACETYL COENZYME A; ANACARDIC ACID; ANTIVIRUS AGENT; CURCUMIN; EPIGALLOCATECHIN GALLATE; GARCINOL; GUANOSINE TRIPHOSPHATE; HISTONE ACETYLTRANSFERASE; PB2 PROTEIN; PLUMBAGIN; RIBAVIRIN; RNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS PROTEIN; ACYLTRANSFERASE; CAPPED RNA; PB2 PROTEIN, INFLUENZAVIRUS A; PROTEIN BINDING; RNA DIRECTED RNA POLYMERASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; ENZYME ACTIVITY; GROWTH INHIBITION; IN VITRO STUDY; INFLUENZA VIRUS A; NONHUMAN; NUCLEOTIDE BINDING SITE; NUCLEOTIDE SEQUENCE; PROTEIN ACETYLATION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN TERTIARY STRUCTURE; RNA SYNTHESIS; VIROGENESIS; VIRUS REPLICATION; VIRUS TITRATION; ANIMAL; BINDING SITE; CHEMISTRY; DOG; ENZYMOLOGY; EUKARYOTIC CELL; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; INFLUENZA VIRUS A H3N2; MDCK CELL LINE; METABOLISM; MOLECULAR DOCKING; MOLECULAR GENETICS; MUTATION; PROKARYOTIC CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; TUMOR CELL LINE;

ACETYL COENZYME A; ACETYLTRANSFERASES; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL LINE, TUMOR; DOGS; EUKARYOTIC CELLS; HUMANS; INFLUENZA A VIRUS, H3N2 SUBTYPE; MADIN DARBY CANINE KIDNEY CELLS; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; MUTATION; PROKARYOTIC CELLS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA CAPS; RNA REPLICASE; SEQUENCE HOMOLOGY, AMINO ACID; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 84906963029     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.559708     Document Type: Article

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