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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 18, 2014, Pages 4486-4489

Substrate derived peptidic α-ketoamides as inhibitors of the malarial protease PfSUB1

(6) Kher, Samir S a Penzo, Maria b Fulle, Simone c Finn, Paul W c Blackman, Michael J b Jirgensons, Aigars a

a LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (Latvia)

b NATIONAL INSTITUTE FOR MEDICAL RESEARCH (United Kingdom)

c INHIBOX LTD (United Kingdom)

Author keywords

Malaria; Peptides; PfSUB1; Serine protease; Ketoamide

Indexed keywords

AMIDE; AMINO ACID; ASPARTIC ACID; PEPTIDIC ALPHA KETOAMIDE; PLASMODIUM FALCIPARUM SUBTILISIN LIKE SERINE PROTEASE 1; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; PEPTIDE; PROTOZOAL PROTEIN; SUBTILISIN; SUBTILISIN-LIKE PROTEASE 1, PLASMODIUM FALCIPARUM;

ARTICLE; CHEMICAL INTERACTION; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; MALARIA; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM; MOLECULAR DOCKING; SYNTHESIS;

AMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; PEPTIDES; PROTOZOAN PROTEINS; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBTILISINS;

EID: 84906962389 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.07.086 Document Type: Article

Times cited : (25)

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