Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 16, 2012, Pages 5317-5321

  Gemma, Sandra ^a,b   Giovani, Simone ^a,b   Brindisi, Margherita ^a,b   Tripaldi, Pierangela ^a,b   Brogi, Simone ^a,b   Savini, Luisa ^a,b   Fiorini, Isabella ^a,b   Novellino, Ettore ^a,c   Butini, Stefania ^a,b   Campiani, Giuseppe ^a,b   Penzo, Maria ^d   Blackman, Michael J ^d  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Egress; Hydrazones; Malaria; PfSUB1; Serine protease inhibitors

Indexed keywords

ERYTHROCYTE MEMBRANE PROTEIN 1; HYDRAZONE DERIVATIVE; QUINOLYLHYDRAZONE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; DRUG POTENCY; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTIMALARIALS; HYDRAZONES; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; QUINOLINES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBTILISINS;

PLASMODIUM FALCIPARUM;

EID: 84864413500     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.06.023     Document Type: Article

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