Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 23, 2013, Pages 6317-6320

  Prior, Allan M ^a   Kim, Yunjeong ^a   Weerasekara, Sahani ^a   Moroze, Meghan ^a   Alliston, Kevin R ^b   Uy, Roxanne Adeline Z ^b   Groutas, William C ^b   Chang, Kyeong Ok ^a   Hua, Duy H ^a  

^a KANSAS STATE UNIVERSITY   (United States)

^b WICHITA STATE UNIVERSITY   (United States)

Author keywords

Coronavirus 229E; Human rhinovirus; Norovirus; Severe acute respiratory syndrome coronavirus; Viral 3C and 3C like protease inhibitors

Indexed keywords

ALDEHYDE; AMIDE; ANTIVIRUS AGENT; BISULFITE; CHYMOTRYPSIN A; CYSTEINE PROTEINASE INHIBITOR; LEUKOCYTE ELASTASE; PHOSPHONIC ACID DERIVATIVE; THROMBIN; TRYPSIN;

ANTIVIRAL ACTIVITY; ARTICLE; CELL ASSAY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; HUMAN RHINOVIRUS; IC 50; NONHUMAN; NOROVIRUS; SARS CORONAVIRUS; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS STRAIN;

CORONAVIRUS; HUMAN RHINOVIRUS SP.; NOROVIRUS; NORWALK VIRUS; SARS CORONAVIRUS;

CORONAVIRUS 229E; HUMAN RHINOVIRUS; NOROVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS; VIRAL 3C AND 3C-LIKE PROTEASE INHIBITORS;

ANTIVIRAL AGENTS; CYSTEINE ENDOPEPTIDASES; DRUG DESIGN; GLUTAMINE; HUMANS; MODELS, MOLECULAR; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84886949349     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.09.070     Document Type: Article

References (23)

1. V.R. Racaniello D.M. Knipe, P.M. Howley, Field's Virology Vol. 1 2007 Lippincott, Williams and Wilkins Philadelphia 795 838
2. K. Green D.M. Knipe, P.M. Howley, Field's Virology Vol. 1 2007 Lippincott, Williams and Wilkins Philadelphia 949 980
3. M. Lai, S. Perlman, and L. Anderson D.M. Knipe, P.M. Howley, Field's Virology Vol. 1 2007 Lippincott, Williams and Wilkins Philadelphia 1305 1336
4. P.C. McMinn Curr. Opin. Virol. 2 2010 199
5. R.B. Turner, and R.B. Couch D.M. Knipe, P.M. Howley, Field's Virology Vol. 1 2007 Lippincott, Williams and Wilkins Philadelphia 895 909
6. S.K. Lal Molecular Biology of the SARS-Coronavirus 2010 Springer Berlin, Heidelberg
7. H.L. Koo, N. Ajami, R.L. Atmar, and H.L. DuPont Discov. Med. 10 2010 61
8. S. Drosten, S. Gunther, W. Preiser, S. van der Werf, H.R. Brodt, S. Becker, H. Rabenau, M. Panning, L. Kolesnikova, R.A. Fouchier, A. Berger, A.M. Burguiere, J. Cinatl, M. Eickmann, N. Escriou, K. Grywna, S. Kramme, J.C. Manuguerra, S. Muller, V. Rickerts, M. Sturmer, S. Vieth, H.D. Klenk, A.D. Osterhaus, H. Schmitz, and H.W. Doerr N. Eng. J. Med. 348 2003 1967
9. T.G. Ksiazek, D. Erdman, C.S. Goldsmith, S.R. Zaki, T. Peret, S. Emery, S. Tong, C. Urbani, J.A. Comer, W. Lim, P.E. Rollin, S.F. Dowell, A.E. Ling, C.D. Humphrey, W.J. Shieh, J. Guarner, C.D. Paddock, P. Rota, B. Fields, J. DeRisi, J.Y. Yang, N. Cox, J.M. Hughes, J.W. LeDuc, W.J. Bellini, and L.J. Anderson N. Eng. J. Med. 348 2003 1953
10. M. Pallansch, and R. Roos D.M. Knipe, P.M. Howley, Field's Virology Vol. 1 2007 Lippincott, Williams and Wilkins Philadelphia 839 894
11. A.M. De Palma, I. Vliegen, E. De Clercq, and J. Neyts Med. Res. Rev. 2008 1
12. Y. Kim, S. Lovell, K.-C. Tiew, S.R. Mandadapu, K.R. Alliston, K. Battaile, W.C. Groutas, and K.-O. Chang J. Virol. 86 2012 11754
13. S.R. Mandadapu, P.M. Weerawarna, M.R. Gunnam, K.R. Alliston, G.H. Lushington, Y. Kim, K.-O. Chang, and W.C. Groutas Bioorg. Med. Chem. Lett. 22 2012 4820
14. S.R. Mandadapu, M.R. Gunnam, K.-C. Tiew, R.A.Z. Uy, A.M. Prior, K.R. Alliston, D.H. Hua, Y. Kim, K.-O. Chang, and W.C. Groutas Bioorg. Med. Chem. Lett. 23 2013 62
15. Q. Tian, N.K. Nayyar, S. Babu, L. Chen, J. Tao, S. Lee, A. Tibbetts, T. Moran, J. Liou, M. Guo, and T.P. Kennedy Tetetrahedron Lett. 42 2001 6807 and references cited therein
16. S.E. Webber, K. Okano, T.L. Little, S.H. Reich, Y. Xin, S.A. Fuhrman, D.A. Matthews, R.A. Love, T.F. Hendrickson, A.K. Pattick, J.W. Meador III, R.A. Ferre, E.L. Brown, C.E. Ford, S.L. Binford, and S.T. Worland J. Med. Chem. 41 1998 2786
17. S. Kono, P. Thanigaimalai, T. Yamamoto, K. Nakada, R. Kakiuchi, K. Takayama, Y. Yamazaki, F. Yakushiji, K. Akaji, Y. Kiso, Y. Kawasaki, S.-E. Chen, E. Freire, and Y. Hayashi Bioorg. Med. Chem. 21 2013 412 and references cited therein
18. C.-J. Kuo, J.-J. Shie, J.-M. Fang, G.-R. Yen, J.T.-A. Hus, H.-G. Liu, S.-N. Tseng, S.-C. Chang, C.-Y. Lee, S.-R. Shih, and P.-H. Liang Bioorg. Med. Chem. 16 2008 7388 and references cited therein
19. J.M. Chalker, C.S.C. Wood, and B.G. Davis J. Am. Chem. Soc. 131 2009 16346
20. A. Tarcsay, K. Nyiri, and G.M. Keseru J. Med. Chem. 55 2012 1252
21. D.V. Patel, K. Riellygauvin, and D.E. Ryono Tetrahedron Lett. 31 1990 5587
22. K.-O. Chang, D. Takahashi, O. Prakash, and Y. Kim Virology 423 2011 125
23. K.-O. Chang, S.V. Sosnovtsev, G. Belliot, and K.Y. Green Virology 353 2006 463