Novel CADD-based peptidyl vinyl ester derivatives as potential proteasome inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 6, 2008, Pages 2198-2202

  Mou, Ke ^a   Xu, Bo ^a   Ma, Chao ^a   Yang, Xiaoming ^a   Zou, Xiaomin ^a   Lü, Yang ^a   Xu, Ping ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

Binding mode; Bioactivity; CADD; Peptidomimetic; Peptidyl vinyl ester derivatives; Proteasome inhibitor; Synthesis

Indexed keywords

PEPTIDYL VINYL ESTER DERIVATIVE; PROTEASOME; PROTEASOME INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; CELL STRAIN HL 60; COMPUTER AIDED DESIGN; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; FLUORESCENCE; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; STRUCTURE ACTIVITY RELATION;

ANIMALS; CATTLE; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; ESTERS; FLUORESCENCE; HUMANS; NEOPLASMS; PEPTIDE FRAGMENTS; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; VINYL COMPOUNDS;

EID: 40749103758     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.12.077     Document Type: Article

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