Biomolecular evidence of anti-inflammatory effects by Clematis mandshurica Ruprecht root extract in rodent cells

Journal of Ethnopharmacology

Volumn 155, Issue 2, 2014, Pages 1141-1155

  Lee, Chul Won ^a   Park, Sang Mi ^b   Kim, Youn Sook ^c   Jegal, Kyung Hwan ^b   Lee, Jong Rok ^b   Cho, Il Je ^b   Ku, Sae Kwang ^b   Lee, Ji Yeon ^a   Ahn, Yong Tae ^a   Son, Yonghae ^a   A Ju, Seong ^d   Kim, Sang Chan ^b   An, Won G ^a  

^a Pusan National University   (South Korea)

^b Daegu Haany University   (South Korea)

^c Pusan National University School of Medicine   (South Korea)

^d University of Ulsan College of Medicine   (South Korea)

Author keywords

Anti inflammation; Clematis mandshurica Ruprecht; Histological examination; Mitogen activated protein kinases; Nuclear factor kappa B; Rat paw edema

Indexed keywords

ANTIINFLAMMATORY AGENT; CLEMATIS MANDSHURICA EXTRACT; CYCLOOXYGENASE 2; DEXAMETHASONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PLANT EXTRACT; PROSTAGLANDIN E2; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AUTACOID; CARRAGEENAN; CYTOKINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; CLEMATIS; CLEMATIS MANDSHURICA RUPRECHT; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MAST CELL; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PAW EDEMA; PLANT ROOT; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKINFOLD THICKNESS; ANIMAL; CELL LINE; CHEMISTRY; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; EDEMA; INFLAMMATION; ISOLATION AND PURIFICATION; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

CLEMATIS; RATTUS; RODENTIA;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; CELL LINE; CLEMATIS; CYTOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; INFLAMMATION; INFLAMMATION MEDIATORS; MACROPHAGES; MALE; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84906935719     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.06.048     Document Type: Article

References (61)

1. B.B. Aggarwal Nuclear factor-κB: The enemy within Cancer cell 6 2004 203 208
2. W.P. Arend The balance between IL-1 and IL-1Ra in disease Cytokine & Growth Factor Reviews 13 2002 323 340
3. T. Armbrust, D. Batusic, B. Ringe, and G. Ramadori Mast cells distribution in human liver disease and experimental rat liver fibrosis. Indications for mast cell participation in development of liver fibrosis Journal of Hepatology 26 1997 1042 1054
4. H. Beloeil, Z. Ababneh, R. Chung, D. Zurakowski, R.V. Mulkern, and C.B. Berde Effects of bupivacaine and tetrodotoxin on carrageenan-induced hind paw inflammation in rats (Part 1): hyperalgesia, edema, and systemic cytokines Anesthesiology 105 2006 128 138
5. A. Borthakur, S. Bhattacharyya, P.K. Dudeja, and J.K. Tobacman Carrageenan induces interleukin-8 production through distinct Bcl10 pathway in normal human colonic epithelial cells American Journal of Physiology. Gastrointestinal and Liver Physiology 292 2007 829 838
6. Cha, J.Y.;Jung, J.Y.;Jung, J.Y.;Lee, J.R.;Cho, I.J.;Ku, S.K.;Byun, S.H.;Ahn, Y.T.;Lee, C.W.;Kim, S.C.;An, W.G.;2013. Inhibitory effects of traditional herbal formula Pyungwi-san on inflammatory response in vitro and in vivo. Evidence-Based Complementary and Alternative Medicine, 630198-1- 630198-19, 10.1155/2013/630198
7. E.D. Chan, and D.W.H. Riches IFN-γ+LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38mapk in a mouse macrophage cell line American Journal of Physiology-Cell Physiology 280 2001 C441 C450
8. P. Chanez, J.Y. Lacoste, B. Guillot, J. Giron, G. Barnéon, I. Enander, P. Godard, F.B. Michel, and J. Bousquet Mast cells' contribution to the fibrosing alveolitis of the scleroderma lung The American Review of Respiratory Disease 147 1993 1497 1502
9. R. Chawla, S. Kumar, and A. Sharma The genus Clematis (Ranunculaceae): chemical and pharmacological perspectives Journal of Ethnopharmacology 143 2012 116 150
10. S. Chell, A. Kadi, A.C. Williams, and C. Paraskeva Mediators of PGE2 synthesis and signaling downstream of COX-2 represent potential targets for the prevention/treatment of colorectal cancer Biochimica et Biophysica Acta 1766 2006 104 119
11. Chinese Pharmacopeia Committee Chinese Pharmacopoeia 2010 Chemical and Industry Press Beijing, China
12. M.S. Choi, S.H. Lee, H.S. Cho, Y. Kim, Y.P. Yun, H.Y. Jung, J.K. Jung, B.C. Lee, H.B. Pyo, and J.T. Hong Inhibitory effect of obovatol on nitric oxide production and activation of NF-κB/MAP kinases in lipopolysaccharide- treated RAW 264.7 cells European Journal of Pharmacology 556 2007 181 189
13. L. Corsi, M. Zavatti, E. Geminiani, P. Zanoli, and M. Baraldi Anti-inflammatory activity of the non-peptidyl low molecular weight radical scavenger IAC in carrageenan-induced oedema in rats The Journal of Pharmacy and Pharmacology 63 2011 417 422
14. J. Dawson, A.D. Sedgwick, J.C. Edwards, and P. Lees A comparative study of the cellular, exudative and histological responses to carrageenan, dextran and zymosan in the mouse International Journal of Tissue Reactions 13 1991 171 185
15. A.V. Delgado, A.T. McManus, and J.P. Chambers Production of tumor necrosis factor-alpha, interleukin 1-beta, interleukin 2, and interleukin 6 by rat leukocyte subpopulations after exposure to substance P Neuropeptides 37 2003 355 361
16. Q. Fu, K. Zan, M. Zhao, S. Zhou, S. Shi, Y. Jiang, and P. Tu Triterpene saponins from Clematis chinensis and their potential anti-inflammatory activity Journal of Natural Products 73 2010 1234 1239
17. D.A. Gamache, J.T. Povlishock, and E.F. Ellis Carrageenan-induced brain inflammation. Characterization of the model Journal of Neurosurgery 65 1986 679 685
18. G.M. Gauvreau, J.M. Lee, R.M. Watson, A.M. Irani, L.B. Schwartz, and P.M. O'Byrne Increased numbers of both airway basophils and mast cells in sputum after allergen inhalation challenge of atopic asthmatics American Journal of Respiratory and Critical Care Medicine 161 2000 1473 1478
19. S. Ghosh, and M. Ksarin Missing pieces in the NF-κB puzzle Cell 109 2002 S81 S96
20. M. Guha, and N. Mackman LPS induction of gene expression in human monocytes Cellular Signalling 13 2001 85 94
21. M. Gupta, U.K. Mazumder, P. Gomathi, and V.T. Selvan Anti-inflammatory evaluation of leaves of Plumeria acuminate BioMed Central Complementary and Alternative Medicine 6 2006 36 10.1186/1472-6882-6-36
22. T.J. Guzik, R. Korbut, and T. Adamek-Guzik Nitric oxide and superoxide in inflammation and immune regulation Journal of Physiology and Pharmacology 54 2003 469 487
23. T.P. Hamsa, and G. Kuttan Evaluation of the anti-inflammatory and anti-tumor effect of Ipomoea obscura (L) and its mode of action through the inhibition of pro-inflammatory cytokines, nitric oxide and COX-2 Inflammation 34 2011 171 183
24. R.L.C. Handy, and P.K. Moore A comparison of the effects of L-NAME, 7-NI and L-NIL on carrageenan-induced hindpaw oedema and NOS activity British Journal of Pharmacology 123 1998 1119 1126
25. D.C. Hao, X.J. Gu, P.G. Xiao, and Y. Peng Chemical and biological research of Clematis medicinal resources Chinese Science Bulletin 58 2013 1120 1129
26. Y.X. He, L. Li, K. Zhang, and Z.R. Liu Cytotoxic triterpene saponins from Clematis mandshurica Journal of Asian Natural Products Research 13 2011 1104 1109
27. S.T. Holgate The role of mast cells and basophils in inflammation Clinical and Experimental Allergy 30 2000 28 32
28. K.C. Huang The Pharmacology of Chinese Herbs 1999 CRC press USA
29. S.S. Huang, C.S. Chiu, T.H. Lin, M.M. Lee, C.Y. Lee, S.J. Chang, W.C. Hou, G.J. Huang, and J.S. Deng Antioxidant and anti-inflammatory activities of aqueous extract of Centipeda minima Journal of Ethnopharmacololgy 147 2013 395 405
30. D. Impellizzeri, E. Esposito, E. Mazzon, I. Paterniti, R.D. Paola, P. Bramanti, and S. Cuzzocrea Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation Biochemistry and Pharmacology 81 2011 636 648
31. Y. Ishida, T. Kondo, A. Kimura, K. Matsushima, and N. Mukaida Absence of IL-1 receptor antagonist impaired wound healing along with aberrant NF-κB activation and a reciprocal suppression of TGF-β signal pathway The Journal of Immunology 176 2006 5598 5606
32. H. Jijon, B. Allard, and C. Jobin NF-κB inducing kinase activates NF-κB transcriptional activity independently of IκB kinase γ through a p38 MAPK-dependent RelA phosphorylation pathway Cellular Signalling 16 2004 1023 1032
33. T. Lawrence, D.A. Willoughby, and D.W. Gilroy Anti-inflammatory lipid mediators and insights into the resolution of inflammation Nature Reviews Immunology 2 2002 787 795
34. A.K. Lee, S.H. Sung, Y.C. Kim, and S.G. Kim Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaB alpha phosphorylation, C/EBP and AP-1 activation British Journal of Pharmacology 139 2003 11 20
35. Lee, C.W.;Kim, S.C.;Kwak, T.W.;Lee, J.R.;Jo, M.J.;Ahn, Y.T.;Kim, J.M.;An, W.G.;2012. Anti-inflammatory effects of Bangpungtongsung-san, a traditional herbal prescription. Evidence-Based Complementary and Alternative Medicine, 892943-1-892943-12, 10.1155/2012/892943.
36. J. Liu, W. Zhang, L. Zhou, X. Wang, and Q. Lian Anti-inflammatory effect and mechanism of osthole in rats Journal of Chinese Medicinal Materials 28 2005 1002 1006
37. A. Mantovani, P. Allavena, A. Sica, and F. Balkwill Cancer-related inflammation Nature 454 2008 436 444
38. K. Matsushima, and J.J. Oppenheim Interleukin 8 and MCAF: novel inflammatory cytokines inducible by IL 1 and TNF Cytokine 1 1989 2 13
39. S. Mazzari, R. Canella, L. Petrelli, G. Marcolongo, and A. Leon N-(2-hydroxyethyl) hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation European Journal of Pharmacology 300 1996 227 236
40. Y. Mimaki, A. Yokosuka, M. Hamanaka, C. Sakuma, T. Yamori, and Y. Sashida Triterpene saponins from the roots of Clematis chinensis Journal of Natural Products 67 2004 1511 1516
41. M.M. Mohy El-Din, A.M. Senbel, A.A. Bistawroos, A. El-Mallah, N.A. Nour El-Din, A.A. Bekhit, and H.A. Abd El Razik A novel COX-2 inhibitor pyrazole derivative proven effective as an anti-inflammatory and analgesic drug Basic & Clinical Pharmacology & Toxicology 108 2011 263 273
42. L.J. Old Tumor necrosis factor (TNF) Science 230 1985 630 632
43. C.M. Olson, M.N. Hedrick, H. Izadi, T.C. Bates, E.R. Olivera, and J. Anguita P38 mitogen-activated protein kinase controls NF-κB transcriptional activation and tumor necrosis factor alpha production through Rel A phosphorylation mediated by mitogen- and stress-activated protein kinase 1 in response to Borrelia burgdorferi antigens Infection and Immunity 75 2007 270 277
44. E.K. Park, M.H. Ryu, Y.H. Kim, Y.A. Lee, S.H. Lee, D.H. Woo, S.J. Hong, J.S. Han, M.C. Yoo, and H.I. Yang Anti-inflammatory effects of an ethanolic extract from Clematis mandshurica Rupr. Journal of Ethnopharmacology 108 2006 142 147
45. C.V. Rao, A.R. Verma, P.K. Gupta, and M. Vijayakumar Anti-inflammatory and anti-nociceptive activities of Fumaria indica whole plant extract in experimental animals Acta Pharmaceutica 57 2007 491 498
46. S. Shi, D. Jiang, C. Dong, and P. Tu Triterpene saponins from Clematis mandshurica Journal of Natural Products 69 2006 1591 1595
47. Y.M. Sin, A.D. Sedgwick, E.P. Chea, and D.A. Willoughby Mast cells in newly formed lining tissue during acute inflammation: a six day air pouch model in the mouse Annals of the Rheumatic Diseases 45 1986 873 877
48. K.H. Sohn, M.J. Jo, W.J. Cho, J.R. Lee, I.J. Cho, S.C. Kim, Y.W. Kim, and S.Y. Jee Bojesodok-eum, a herbal prescription, ameliorates acute inflammation in association with the inhibition of NF-κB-mediated nitric oxide and pro-inflammatory cytokine production Evidence Based Complementary and Alternative Medicine 2012 2012 57370
49. G.J. Southan, and C. Szabó Selective pharmacological inhibition of distinct nitric oxide synthase isoforms Biochemistry and Pharmacology 51 1996 383 394
50. C. Szabó Alterations in nitric oxide production in various forms of circulatory shock New Horizons 3 1995 2 32
51. The Korea Food and Drug Administration, 2014. The Korean Herbal Pharmacopoeia, Notification 2014-2074.
52. H. Wang, J. Gao, J. Kou, D. Zhu, and B. Yu Anti-inflammatory activities of triterpenoid saponins from Polygala japonica Phytomedicine 15 2008 321 326
53. J.P. Wang, Y.M. Zhou, Y.J. Ye, X.M. Shang, Y.L. Cai, C.M. Xiong, Y.X. Wu, and H.X. Xu Topical anti-inflammatory and analgesic activity of kirenol isolated from Siegesbeckia orientalis Journal of Ethnopharmacology 137 2011 1089 1094
54. K. Watanabe, T. Kawamori, S. Nakatsugi, and K. Wakabayashi COX-2 and iNOS, good targets for chemoprevention of colon cancer BioFactors 12 2000 129 133
55. B.J. Whittle, C. Varga, A. Berko, K. Horvath, A. Posa, J.P. Riley, K.A. Lundeen, A.M. Fourie, and P.J. Dunford Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase British Journal of Pharmacology 153 2008 983 991
56. W. Wu, X. Xu, Y. Dai, and L. Xia Therapeutic effect of the saponin fraction from clematis chinensis osbeck roots on osteoarthritis induced by monosodium iodoacetate through protecting articular cartilage Phytotherapy Research 24 2010 538 546
57. Z.Y. Xiao, W.X. Zhou, Y.X. Zhang, J.P. Cheng, J.F. He, R.F. Yang, and L.H. Yun Inhibitory effect of linomide on lipopolysaccharide-induced pro-inflammatory cytokine tumor necrosis factor-alpha production in RAW 264.7 macrophages through suppression of NF-κB, p38, and JNK activation Immunology Letters 114 2007 81 85
58. J.H. Yang, S.C. Kim, B.Y. Shin, S.H. Jin, M.J. Jo, K.H. Jegal, Y.W. Kim, J.R. Lee, S.K. Ku, I.J. Cho, and S.H. Ki O-methylated flavonol isorhamnetin prevents acute inflammation through blocking of NF-κB activation Food and Chemical Toxicology 59 2013 362 372
59. E. Yesilada, and E. Kupeli Clematis vitalba L. Aerial part exhibits potent anti-inflammatory, antinociceptive and antipyretic effects Journal of Ethnopharmacology 110 2007 504 515
60. A. Yoshimura Signal transduction of inflammatory cytokines and tumor development Cancer Science 97 2006 439 447
61. Y. Zhou, Y. Guan, J. Shi, X. Zhang, L. Yao, and L. Liu Development and validation of a chromatographic method for determining Clematichinenoside AR and related impurities Chemistry Central Journal 6 2012 150