-
1
-
-
84877605189
-
A randomized, open-label, phase III study of lapatinib in combination with weekly paclitaxel versus weekly paclitaxel alone in the second-line treatment of HER2 amplified advanced gastric cancer (AGC) in Asian population: Tytan study
-
Bang Y (2012) A randomized, open-label, phase III study of lapatinib in combination with weekly paclitaxel versus weekly paclitaxel alone in the second-line treatment of HER2 amplified advanced gastric cancer (AGC) in Asian population: Tytan study. J Clin Oncol 30(34):11
-
(2012)
J Clin Oncol
, vol.30
, Issue.34
, pp. 11
-
-
Bang, Y.1
-
2
-
-
77956262693
-
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): A phase 3, open-label, randomised controlled trial
-
Bang YJ, Van Cutsem E et al (2010) Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 376 (9742):687–697
-
(2010)
Lancet
, vol.376
, Issue.9742
, pp. 687-697
-
-
Bang, Y.J.1
Van Cutsem, E.2
-
3
-
-
84857236823
-
Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): A randomised, open-label, multicentre, phase 3 trial
-
Baselga J, Bradbury I et al (2012) Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial. Lancet 379(9816):633–640
-
(2012)
Lancet
, vol.379
, Issue.9816
, pp. 633-640
-
-
Baselga, J.1
Bradbury, I.2
-
4
-
-
20844437246
-
Phase I pharmacokinetic studies evaluating single and multiple doses of oral GW572016, a dual EGFR-ErbB2 inhibitor, in healthy subjects
-
Bence AK, Anderson EB et al (2005) Phase I pharmacokinetic studies evaluating single and multiple doses of oral GW572016, a dual EGFR-ErbB2 inhibitor, in healthy subjects. Invest New Drugs 23(1):39–49
-
(2005)
Invest New Drugs
, vol.23
, Issue.1
, pp. 39-49
-
-
Bence, A.K.1
Erson, E.B.2
-
5
-
-
4544284509
-
A phase II, open-label, multicenter study of GW572016 in patients with trastuzumab-refractory metastatic breast cancer
-
Blackwell K, Kaplan E et al (2004) A phase II, open-label, multicenter study of GW572016 in patients with trastuzumab-refractory metastatic breast cancer. J Clin Oncol 22(3006)
-
(2004)
J Clin Oncol
, vol.22
, Issue.3006
-
-
Blackwell, K.1
Kaplan, E.2
-
6
-
-
77949884661
-
Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer
-
Blackwell KL, Burstein HJ et al (2010) Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer. J Clin Oncol 28(7):1124–1130
-
(2010)
J Clin Oncol
, vol.28
, Issue.7
, pp. 1124-1130
-
-
Blackwell, K.L.1
Burstein, H.J.2
-
8
-
-
2942592008
-
Dual kinase inhibition in the treatment of breast cancer: Initial experience with the EGFR/ErbB-2 inhibitor lapatinib
-
Burris HA 3rd (2004) Dual kinase inhibition in the treatment of breast cancer: initial experience with the EGFR/ErbB-2 inhibitor lapatinib. Oncologist 9(Suppl 3):10–15
-
(2004)
Oncologist
, vol.9
, pp. 10-15
-
-
Burris, H.A.1
-
9
-
-
23944476155
-
Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas
-
Burris HA 3rd, Hurwitz HI et al (2005) Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas. J Clin Oncol 23(23):5305–5313
-
(2005)
J Clin Oncol
, vol.23
, Issue.23
, pp. 5305-5313
-
-
Burris, H.A.1
Hurwitz, H.I.2
-
10
-
-
56549113680
-
A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: Updated efficacy and biomarker analyses
-
Cameron D, Casey M et al (2008) A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses. Breast Cancer Res Treat 112(3):533–543
-
(2008)
Breast Cancer Res Treat
, vol.112
, Issue.3
, pp. 533-543
-
-
Cameron, D.1
Casey, M.2
-
11
-
-
77957771125
-
Lapatinib plus capecitabine in women with HER-2-positive advanced breast cancer: Final survival analysis of a phase III randomized trial
-
Cameron D, Casey M et al (2010) Lapatinib plus capecitabine in women with HER-2-positive advanced breast cancer: final survival analysis of a phase III randomized trial. Oncologist 15(9):924–934
-
(2010)
Oncologist
, vol.15
, Issue.9
, pp. 924-934
-
-
Cameron, D.1
Casey, M.2
-
12
-
-
84883401358
-
Prognostic role of human epidermal growth factor receptor in gastric cancer: A systematic review and meta-analysis
-
Chen C, Yang JM et al (2013) Prognostic role of human epidermal growth factor receptor in gastric cancer: a systematic review and meta-analysis. Arch Med Res 44(5):380–389
-
(2013)
Arch Med Res
, vol.44
, Issue.5
, pp. 380-389
-
-
Chen, C.1
Yang, J.M.2
-
13
-
-
34548497892
-
Phase I and pharmacokinetic study of lapatinib in combination with capecitabine in patients with advanced solid malignancies
-
Chu QS, Schwartz G et al (2007) Phase I and pharmacokinetic study of lapatinib in combination with capecitabine in patients with advanced solid malignancies. J Clin Oncol 25(24): 3753–3758
-
(2007)
J Clin Oncol
, vol.25
, Issue.24
, pp. 3753-3758
-
-
Chu, Q.S.1
Schwartz, G.2
-
14
-
-
51549101729
-
A phase I and pharmacokinetic study of lapatinib in combination with letrozole in patients with advanced cancer
-
Chu QS, Cianfrocca ME et al (2008) A phase I and pharmacokinetic study of lapatinib in combination with letrozole in patients with advanced cancer. Clin Cancer Res 14(14): 4484–4490
-
(2008)
Clin Cancer Res
, vol.14
, Issue.14
, pp. 4484-4490
-
-
Chu, Q.S.1
Cianfrocca, M.E.2
-
15
-
-
33745828702
-
EGF-ERBB signalling: Towards the systems level
-
Citri A, Yarden Y (2006) EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol 7(7):505–516
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, Issue.7
, pp. 505-516
-
-
Citri, A.1
Yarden, Y.2
-
16
-
-
4344691784
-
Incidence of cerebral metastases in patients treated with trastuzumab for metastatic breast cancer
-
Clayton AJ, Danson S et al (2004) Incidence of cerebral metastases in patients treated with trastuzumab for metastatic breast cancer. Br J Cancer 91(4):639–643
-
(2004)
Br J Cancer
, vol.91
, Issue.4
, pp. 639-643
-
-
Clayton, A.J.1
Danson, S.2
-
17
-
-
0036287040
-
The EGF/ErbB receptor family and apoptosis
-
Danielsen AJ, Maihle NJ (2002) The EGF/ErbB receptor family and apoptosis. Growth Factors 20(1):1–15
-
(2002)
Growth Factors
, vol.20
, Issue.1
, pp. 1-15
-
-
Danielsen, A.J.1
Maihle, N.J.2
-
18
-
-
57149096463
-
Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer
-
Di Leo A, Gomez HL et al (2008) Phase III, double-blind, randomized study comparing lapatinib plus paclitaxel with placebo plus paclitaxel as first-line treatment for metastatic breast cancer. J Clin Oncol 26(34):5544–5552
-
(2008)
J Clin Oncol
, vol.26
, Issue.34
, pp. 5544-5552
-
-
Di Leo, A.1
Gomez, H.L.2
-
19
-
-
84879491743
-
An open-label safety study of lapatinib plus trastuzumab plus paclitaxel in first-line HER2-positive metastatic breast cancer
-
Esteva FJ, Franco SX et al (2013) An open-label safety study of lapatinib plus trastuzumab plus paclitaxel in first-line HER2-positive metastatic breast cancer. Oncologist 18(6):661–666
-
(2013)
Oncologist
, vol.18
, Issue.6
, pp. 661-666
-
-
Esteva, F.J.1
Franco, S.X.2
-
20
-
-
40449112910
-
Letrozole versus letrozole plus Lapatinib (GW572016) in hormone-sensitive, HER2-negative operable breast cancer: A double-blind, randomized, phase II study with biomarker evaluation (EGF109077-LAP107692/LETLOB)
-
Frassoldati A, Guarneri V et al (2008) Letrozole versus letrozole plus Lapatinib (GW572016) in hormone-sensitive, HER2-negative operable breast cancer: a double-blind, randomized, phase II study with biomarker evaluation (EGF109077-LAP107692/LETLOB). Clin Breast Cancer 8(1):97–100
-
(2008)
Clin Breast Cancer
, vol.8
, Issue.1
, pp. 97-100
-
-
Frassoldati, A.1
Guarneri, V.2
-
21
-
-
84866536687
-
Open-label phase III randomized controlled trial comparing taxane-based chemotherapy (Tax) with lapatinib (L) or trastuzumab (T) as first-line therapy for women with HER2+ metastatic breast cancer: Interim analysis (IA) of NCIC CTG MA.31/GSK EGF 108919
-
(ASCO Annual Meeting Abstracts) (LBA671)
-
Gelmon KA, Boyle F et al. (2012) Open-label phase III randomized controlled trial comparing taxane-based chemotherapy (Tax) with lapatinib (L) or trastuzumab (T) as first-line therapy for women with HER2+ metastatic breast cancer: interim analysis (IA) of NCIC CTG MA.31/GSK EGF 108919. J Clin Oncol 30: 812. (ASCO Annual Meeting Abstracts) (LBA671)
-
(2012)
J Clin Oncol
, vol.30
, Issue.812
-
-
Gelmon, K.A.1
Boyle, F.2
-
22
-
-
33845886440
-
Lapatinib plus capecitabine for HER2-positive advanced breast cancer
-
Geyer CE, Forster J et al (2006) Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 355(26):2733–2743
-
(2006)
N Engl J Med
, vol.355
, Issue.26
, pp. 2733-2743
-
-
Geyer, C.E.1
Forster, J.2
-
25
-
-
46449113024
-
Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer
-
Gomez HL, Doval DC et al (2008) Efficacy and safety of lapatinib as first-line therapy for ErbB2-amplified locally advanced or metastatic breast cancer. J Clin Oncol 26(18):2999–3005
-
(2008)
J Clin Oncol
, vol.26
, Issue.18
, pp. 2999-3005
-
-
Gomez, H.L.1
Doval, D.C.2
-
26
-
-
84871712684
-
Adjuvant lapatinib for women with early-stage HER2-positive breast cancer: A randomised, controlled, phase 3 trial
-
Goss PE, Smith IE et al (2012) Adjuvant lapatinib for women with early-stage HER2-positive breast cancer: a randomised, controlled, phase 3 trial. Lancet Oncol 14(1):88–96
-
(2012)
Lancet Oncol
, vol.14
, Issue.1
, pp. 88-96
-
-
Goss, P.E.1
Smith, I.E.2
-
27
-
-
0030944455
-
ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling
-
Graus-Porta D, Beerli RR et al (1997) ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO J 16(7):1647–1655
-
(1997)
EMBO J
, vol.16
, Issue.7
, pp. 1647-1655
-
-
Graus-Porta, D.1
Beerli, R.R.2
-
28
-
-
49449112267
-
Effect of lapatinib on the outgrowth of metastatic breast cancer cells to the brain
-
Gril B, Palmieri D et al (2008) Effect of lapatinib on the outgrowth of metastatic breast cancer cells to the brain. J Natl Cancer Inst 100(15):1092–1103
-
(2008)
J Natl Cancer Inst
, vol.100
, Issue.15
, pp. 1092-1103
-
-
Gril, B.1
Palmieri, D.2
-
29
-
-
84880452171
-
Randomized trial of lapatinib versus placebo added to paclitaxel in the treatment of human epidermal growth factor receptor 2-overexpressing metastatic breast cancer
-
Guan Z, Xu B et al (2013) Randomized trial of lapatinib versus placebo added to paclitaxel in the treatment of human epidermal growth factor receptor 2-overexpressing metastatic breast cancer. J Clin Oncol 31(16):1947–1953
-
(2013)
J Clin Oncol
, vol.31
, Issue.16
, pp. 1947-1953
-
-
Guan, Z.1
Xu, B.2
-
30
-
-
84864018421
-
Preoperative chemotherapy plus trastuzumab, lapatinib, or both in human epidermal growth factor receptor 2-positive operable breast cancer: Results of the randomized phase II CHER-LOB study
-
Guarneri V, Frassoldati A et al (2012) Preoperative chemotherapy plus trastuzumab, lapatinib, or both in human epidermal growth factor receptor 2-positive operable breast cancer: results of the randomized phase II CHER-LOB study. J Clin Onco l30(16):1989–1995
-
(2012)
J Clin Onco
, vol.130
, Issue.16
, pp. 1989-1995
-
-
Guarneri, V.1
Frassoldati, A.2
-
31
-
-
84882418636
-
Lapatinib in combination with capecitabine plus oxaliplatin (CapeOx) in HER2-positive advanced or metastatic gastric, esophageal, or gastroesophageal adenocarcinoma (AC): The TRIO-013/LOGiC Trial
-
abstract-LBA4001 [ASCO Annual Meeting Proceedings (Post-Meeting Edition)]
-
Hecht J R, Y J Bang et al (2013) Lapatinib in combination with capecitabine plus oxaliplatin (CapeOx) in HER2-positive advanced or metastatic gastric, esophageal, or gastroesophageal adenocarcinoma (AC): The TRIO-013/LOGiC Trial. J Clin Oncol 31(18):abstract-LBA4001 [ASCO Annual Meeting Proceedings (Post-Meeting Edition)]
-
(2013)
J Clin Oncol
, vol.31
, Issue.18
-
-
Hecht, J.R.1
Bang, Y.J.2
-
32
-
-
84883556549
-
Prognostic value of epidermal growth factor receptor in patients with gastric cancer: A meta-analysis
-
Hong L, Han Y et al (2013) Prognostic value of epidermal growth factor receptor in patients with gastric cancer: a meta-analysis. Gene 529(1):69–72
-
(2013)
Gene
, vol.529
, Issue.1
, pp. 69-72
-
-
Hong, L.1
Han, Y.2
-
33
-
-
84870406909
-
Update on HER1-3 in advanced non-small-cell lung cancer
-
Horn L, Lovly C (2012) Update on HER1-3 in advanced non-small-cell lung cancer. J Thorac Oncol 7(16):S369–S371
-
(2012)
J Thorac Oncol
, vol.7
, Issue.16
-
-
Horn, L.1
Lovly, C.2
-
34
-
-
38649093257
-
S0413: A phase II SWOG study of GW572016 (lapatinib) as first line therapy in patients with advanced or metastatic gastric cancer
-
(ASCO Annual Meeting Proceedings (Post-Meeting Edition))
-
Iqbal S, Goldman B et al. (2007). S0413: a phase II SWOG study of GW572016 (lapatinib) as first line therapy in patients with advanced or metastatic gastric cancer. J Clin Oncol 25(18):4621 (ASCO Annual Meeting Proceedings (Post-Meeting Edition))
-
(2007)
J Clin Oncol
, vol.25
, Issue.18
, pp. 4621
-
-
Iqbal, S.1
Goldman, B.2
-
35
-
-
73149115341
-
Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer
-
Johnston S, Pippen J Jr et al (2009) Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J Clin Oncol 27(33):5538–5546
-
(2009)
J Clin Oncol
, vol.27
, Issue.33
, pp. 5538-5546
-
-
Johnston, S.1
Pippen, J.2
-
36
-
-
55949117201
-
The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines
-
Kim JW, Kim HP et al (2008) The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines. Cancer Lett 272(2):296–306
-
(2008)
Cancer Lett
, vol.272
, Issue.2
, pp. 296-306
-
-
Kim, J.W.1
Kim, H.P.2
-
37
-
-
0033992633
-
Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors
-
Klapper LN, Kirschbaum MH et al (2000) Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors. Adv Cancer Res 77:25–79
-
(2000)
Adv Cancer Res
, vol.77
, pp. 25-79
-
-
Klapper, L.N.1
Kirschbaum, M.H.2
-
38
-
-
84884775038
-
Afatinib, Erlotinib and Gefitinib in the first-line therapy of EGFR mutation-positive lung adenocarcinoma: A review
-
Kohler J, Schuler M (2013) Afatinib, Erlotinib and Gefitinib in the first-line therapy of EGFR mutation-positive lung adenocarcinoma: a review. Onkologie 36(9):510–518
-
(2013)
Onkologie
, vol.36
, Issue.9
, pp. 510-518
-
-
Kohler, J.1
Schuler, M.2
-
39
-
-
32944461545
-
Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells
-
Konecny GE, Pegram MD et al (2006) Activity of the dual kinase inhibitor lapatinib (GW572016) against HER-2-overexpressing and trastuzumab-treated breast cancer cells. Cancer Res 66(3):1630–1639
-
(2006)
Cancer Res
, vol.66
, Issue.3
, pp. 1630-1639
-
-
Konecny, G.E.1
Pegram, M.D.2
-
40
-
-
4544341724
-
New targets for therapy in breast cancer: Small molecule tyrosine kinase inhibitors
-
Lin NU, Winer EP (2004) New targets for therapy in breast cancer: small molecule tyrosine kinase inhibitors. Breast Cancer Res 6(5):204–210
-
(2004)
Breast Cancer Res
, vol.6
, Issue.5
, pp. 204-210
-
-
Lin, N.U.1
Winer, E.P.2
-
41
-
-
42949112556
-
Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer
-
Lin NU, Carey LA et al (2008) Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol 26(12): 1993–1999
-
(2008)
J Clin Oncol
, vol.26
, Issue.12
, pp. 1993-1999
-
-
Lin, N.U.1
Carey, L.A.2
-
42
-
-
63149110733
-
Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer
-
Lin NU, Dieras V et al (2009) Multicenter phase II study of lapatinib in patients with brain metastases from HER2-positive breast cancer. Clin Cancer Res 15(4):1452–1459
-
(2009)
Clin Cancer Res
, vol.15
, Issue.4
, pp. 1452-1459
-
-
Lin, N.U.1
Dieras, V.2
-
43
-
-
82955163167
-
Randomized phase II study of lapatinib plus capecitabine or lapatinib plus topotecan for patients with HER2-positive breast cancer brain metastases
-
Lin NU, Eierman W et al (2011) Randomized phase II study of lapatinib plus capecitabine or lapatinib plus topotecan for patients with HER2-positive breast cancer brain metastases. J Neurooncol 105(3):613–620
-
(2011)
J Neurooncol
, vol.105
, Issue.3
, pp. 613-620
-
-
Lin, N.U.1
Eierman, W.2
-
44
-
-
51549083821
-
Lapatinib: A dual inhibitor of human epidermal growth factor receptor tyrosine kinases
-
Medina PJ, Goodin S (2008) Lapatinib: a dual inhibitor of human epidermal growth factor receptor tyrosine kinases. Clin Ther 30(8):1426–1447
-
(2008)
Clin Ther
, vol.30
, Issue.8
, pp. 1426-1447
-
-
Medina, P.J.1
Goodin, S.2
-
45
-
-
0041629450
-
Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
-
Mendelsohn J, Baselga J (2003) Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J Clin Oncol 21(14):2787–2799
-
(2003)
J Clin Oncol
, vol.21
, Issue.14
, pp. 2787-2799
-
-
Mendelsohn, J.1
Baselga, J.2
-
46
-
-
34548222618
-
Lapatinib-associated toxicity and practical management recommendations
-
Moy B, Goss PE (2007) Lapatinib-associated toxicity and practical management recommendations. Oncologist 12(7):756–765
-
(2007)
Oncologist
, vol.12
, Issue.7
, pp. 756-765
-
-
Moy, B.1
Goss, P.E.2
-
47
-
-
55649100253
-
Molecularly targeted therapy in breast cancer: The new generation
-
Nahleh ZA (2008) Molecularly targeted therapy in breast cancer: the new generation. Recent Patents Anticancer Drug Discov 3(2):100–104
-
(2008)
Recent Patents Anticancer Drug Discov
, vol.3
, Issue.2
, pp. 100-104
-
-
Nahleh, Z.A.1
-
48
-
-
0037285971
-
Growth factor receptors in breast cancer: Potential for therapeutic intervention
-
Nahta R, Hortobagyi GN et al (2003) Growth factor receptors in breast cancer: potential for therapeutic intervention. Oncologist 8(1):5–17
-
(2003)
Oncologist
, vol.8
, Issue.1
, pp. 5-17
-
-
Nahta, R.1
Hortobagyi, G.N.2
-
49
-
-
33144481305
-
Lapatinib: A novel dual tyrosine kinase inhibitor with activity in solid tumors
-
Nelson MH, Dolder CR (2006) Lapatinib: a novel dual tyrosine kinase inhibitor with activity in solid tumors. Ann Pharmacother 40(2):261–269
-
(2006)
Ann Pharmacother
, vol.40
, Issue.2
, pp. 261-269
-
-
Nelson, M.H.1
Dolder, C.R.2
-
50
-
-
0034613381
-
Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation
-
Okano J, Gaslightwala I et al (2000) Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation. J Biol Chem 275(40):30934–30942
-
(2000)
J Biol Chem
, vol.275
, Issue.40
, pp. 30934-30942
-
-
Okano, J.1
Gaslightwala, I.2
-
51
-
-
0034600849
-
The ErbB signaling network: Receptor heterodimerization in development and cancer
-
Olayioye MA, Neve RM et al (2000) The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J 19(13):3159–3167
-
(2000)
EMBO J
, vol.19
, Issue.13
, pp. 3159-3167
-
-
Olayioye, M.A.1
Neve, R.M.2
-
52
-
-
44949253343
-
Cardiac safety of lapatinib: Pooled analysis of 3689 patients enrolled in clinical trials
-
Perez EA, Koehler M et al (2008) Cardiac safety of lapatinib: pooled analysis of 3689 patients enrolled in clinical trials. Mayo Clin Proc 83(6):679–686
-
(2008)
Mayo Clin Proc
, vol.83
, Issue.6
, pp. 679-686
-
-
Perez, E.A.1
Koehler, M.2
-
53
-
-
26844503270
-
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
-
Piccart-Gebhart MJ, Procter M et al (2005) Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 353(16):1659–1672
-
(2005)
N Engl J Med
, vol.353
, Issue.16
, pp. 1659-1672
-
-
Piccart-Gebhart, M.J.1
Procter, M.2
-
54
-
-
0034992521
-
The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification
-
Prenzel N, Fischer OM et al (2001) The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification. Endocr Relat Cancer 8(1):11–31
-
(2001)
Endocr Relat Cancer
, vol.8
, Issue.1
, pp. 11-31
-
-
Prenzel, N.1
Fischer, O.M.2
-
55
-
-
36849078567
-
The value meal: Effect of food on lapatinib bioavailability
-
Rahman A, Pazdur R et al (2007) The value meal: effect of food on lapatinib bioavailability. J Clin Oncol 25(33):5333–5335
-
(2007)
J Clin Oncol
, vol.25
, Issue.33
, pp. 5333-5335
-
-
Rahman, A.1
Pazdur, R.2
-
56
-
-
84859463502
-
Efficacy and tolerability of lapatinib in the management of breast cancer
-
Rana P, Sridhar SS (2012) Efficacy and tolerability of lapatinib in the management of breast cancer. Breast Cancer (Auckl) 6:67–77
-
(2012)
Breast Cancer (Auckl)
, vol.6
, pp. 67-77
-
-
Rana, P.1
Sridhar, S.S.2
-
57
-
-
54049137661
-
Targeted therapies in head and neck cancer: Past, present and future
-
Rapidis AD, Vermorken JB et al (2008) Targeted therapies in head and neck cancer: past, present and future. Rev Recent Clin Trials 3(3):156–166
-
(2008)
Rev Recent Clin Trials
, vol.3
, Issue.3
, pp. 156-166
-
-
Rapidis, A.D.1
Vermorken, J.B.2
-
58
-
-
34548178015
-
The value meal: How to save $1,700 per month or more on lapatinib
-
Ratain MJ, Cohen EE (2007) The value meal: how to save $1,700 per month or more on lapatinib. J Clin Oncol 25(23):3397–3398
-
(2007)
J Clin Oncol
, vol.25
, Issue.23
, pp. 3397-3398
-
-
Ratain, M.J.1
Cohen, E.E.2
-
59
-
-
37849037481
-
Cetuximab, its clinical use and future perspectives
-
Rivera F, Vega-Villegas ME et al (2008) Cetuximab, its clinical use and future perspectives. Anticancer Drugs 19(2):99–113
-
(2008)
Anticancer Drugs
, vol.19
, Issue.2
, pp. 99-113
-
-
Rivera, F.1
Vega-Villegas, M.E.2
-
60
-
-
84866541367
-
Evaluation of lapatinib as a component of neoadjuvant therapy for HER2+ operable breast cancer: NSABP protocol B-41
-
(ASCO Annual Meeting Abstract LBA506)
-
Robidoux A, Tang G et al (2012) Evaluation of lapatinib as a component of neoadjuvant therapy for HER2+ operable breast cancer: NSABP protocol B-41. J Clin Oncol 30:812 (ASCO Annual Meeting Abstract LBA506)
-
(2012)
J Clin Oncol
, vol.812
, pp. 30
-
-
Robidoux, A.1
Tang, G.2
-
61
-
-
26844536978
-
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
-
Romond EH, Perez EA et al (2005) Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 353(16):1673–1684
-
(2005)
N Engl J Med
, vol.353
, Issue.16
, pp. 1673-1684
-
-
Romond, E.H.1
Perez, E.A.2
-
62
-
-
60149109196
-
Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity
-
Scaltriti M, Verma C et al (2009) Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity. Oncogene 28(6):803–814
-
(2009)
Oncogene
, vol.28
, Issue.6
, pp. 803-814
-
-
Scaltriti, M.1
Verma, C.2
-
63
-
-
10944253706
-
Effects of food on the clinical pharmacokinetics of anticancer agents: Underlying mechanisms and implications for oral chemotherapy
-
Singh BN, Malhotra BK (2004) Effects of food on the clinical pharmacokinetics of anticancer agents: underlying mechanisms and implications for oral chemotherapy. Clin Pharmacokinet 43(15):1127–1156
-
(2004)
Clin Pharmacokinet
, vol.43
, Issue.15
, pp. 1127-1156
-
-
Singh, B.N.1
Malhotra, B.K.2
-
64
-
-
0037334935
-
Ready to partner
-
Sliwkowski MX (2003) Ready to partner. Nat Struct Biol 10(3):158–159
-
(2003)
Nat Struct Biol
, vol.10
, Issue.3
, pp. 158-159
-
-
Sliwkowski, M.X.1
-
65
-
-
0034254775
-
Herceptin (Trastuzamab) in advanced breast cancer
-
Stebbing J, Copson E et al (2000) Herceptin (trastuzamab) in advanced breast cancer. Cancer Treat Rev 26(4):287–290
-
(2000)
Cancer Treat Rev
, vol.26
, Issue.4
, pp. 287-290
-
-
Stebbing, J.1
Copson, E.2
-
66
-
-
0034468132
-
Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases
-
Stern DF (2000) Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases. Breast Cancer Res 2(3):176–183
-
(2000)
Breast Cancer Res
, vol.2
, Issue.3
, pp. 176-183
-
-
Stern, D.F.1
-
68
-
-
61449558807
-
Jumping higher: Is it still possible? The ALTTO trial challenge
-
Tomasello G, de Azambuja E et al (2008) Jumping higher: is it still possible? The ALTTO trial challenge. Expert Rev Anticancer Ther 8(12):1883–1890
-
(2008)
Expert Rev Anticancer Ther
, vol.8
, Issue.12
, pp. 1883-1890
-
-
Tomasello, G.1
De Azambuja, E.2
-
69
-
-
84856444501
-
Lapatinib versus trastuzumab in combination with neoadjuvant anthracycline-taxane-based chemotherapy (GeparQuinto, GBG 44): A randomised phase 3 trial
-
Untch M, Loibl S et al (2012) Lapatinib versus trastuzumab in combination with neoadjuvant anthracycline-taxane-based chemotherapy (GeparQuinto, GBG 44): a randomised phase 3 trial. Lancet Oncol 13(2):135–144
-
(2012)
Lancet Oncol
, vol.13
, Issue.2
, pp. 135-144
-
-
Untch, M.1
Loibl, S.2
-
70
-
-
77649162889
-
Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo
-
Wainberg ZA, Anghel A et al (2010) Lapatinib, a dual EGFR and HER2 kinase inhibitor, selectively inhibits HER2-amplified human gastric cancer cells and is synergistic with trastuzumab in vitro and in vivo. Clin Cancer Res 16(5):1509–1519
-
(2010)
Clin Cancer Res
, vol.16
, Issue.5
, pp. 1509-1519
-
-
Wainberg, Z.A.1
Anghel, A.2
-
71
-
-
0038575385
-
Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer
-
Witton CJ, Reeves JR et al (2003) Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer. J Pathol 200(3):290–297
-
(2003)
J Pathol
, vol.200
, Issue.3
, pp. 290-297
-
-
Witton, C.J.1
Reeves, J.R.2
-
72
-
-
4644289313
-
A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): Relationships among protein conformation, inhibitor offrate, and receptor activity in tumor cells
-
Wood ER, Truesdale AT et al (2004) A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor offrate, and receptor activity in tumor cells. Cancer Res 64(18):6652–6659
-
(2004)
Cancer Res
, vol.64
, Issue.18
, pp. 6652-6659
-
-
Wood, E.R.1
Truesdale, A.T.2
-
73
-
-
1242273590
-
Truncated ErbB2 receptor (P95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016
-
Xia W, Liu LH et al (2004) Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016. Oncogene 23(3):646–653
-
(2004)
Oncogene
, vol.23
, Issue.3
, pp. 646-653
-
-
Xia, W.1
Liu, L.H.2
-
74
-
-
30544450275
-
Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells
-
Xia W, Gerard CM et al (2005) Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene 24(41):6213–6221
-
(2005)
Oncogene
, vol.24
, Issue.41
, pp. 6213-6221
-
-
Xia, W.1
Gerard, C.M.2
-
75
-
-
0035256698
-
Untangling the ErbB signalling network
-
Yarden Y, Sliwkowski MX (2001) Untangling the ErbB signalling network. Nat Rev Mol Cell Biol 2(2):127–137
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, Issue.2
, pp. 127-137
-
-
Yarden, Y.1
Sliwkowski, M.X.2
|