-
1
-
-
53149091690
-
Lung cancer occurrence in never-smokers: An analysis of 13 cohorts and 22 cancer registry studies
-
Thun MJ, Hannan LM, Adams-Campbell LL, et al.: Lung cancer occurrence in never-smokers: an analysis of 13 cohorts and 22 cancer registry studies. PLoS Med 2008;5:e185.
-
(2008)
PLoS Med
, vol.5
-
-
Thun, M.J.1
Hannan, L.M.2
Adams-Campbell, L.L.3
-
4
-
-
0037103424
-
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
-
Demetri GD, von Mehren M, Blanke CD, et al.: Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med 2002;347:472-480.
-
(2002)
N Engl J Med
, vol.347
, pp. 472-480
-
-
Demetri, G.D.1
Von Mehren, M.2
Blanke, C.D.3
-
5
-
-
10744233716
-
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
-
O'Brien SG, Guilhot F, Larson RA, et al.: Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2003;348:994-1004.
-
(2003)
N Engl J Med
, vol.348
, pp. 994-1004
-
-
O'Brien, S.G.1
Guilhot, F.2
Larson, R.A.3
-
6
-
-
38749114995
-
Oncogenes and cancer
-
Croce CM: Oncogenes and cancer. N Engl J Med 2008;358:502-511.
-
(2008)
N Engl J Med
, vol.358
, pp. 502-511
-
-
Croce, C.M.1
-
7
-
-
0037025173
-
Cancer. Addiction to oncogenes-The Achilles heal of cancer
-
Weinstein IB: Cancer. Addiction to oncogenes-the Achilles heal of cancer. Science 2002;297:63-64.
-
(2002)
Science
, vol.297
, pp. 63-64
-
-
Weinstein, I.B.1
-
8
-
-
84916265276
-
Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal
-
Cohen S: Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal. J Biol Chem 1962; 237:1555-1562.
-
(1962)
J Biol Chem
, vol.237
, pp. 1555-1562
-
-
Cohen, S.1
-
9
-
-
40849147041
-
EGFR antagonists in cancer treatment
-
Ciardiello F, Tortora G: EGFR antagonists in cancer treatment. N Engl J Med 2008;358:1160-1174.
-
(2008)
N Engl J Med
, vol.358
, pp. 1160-1174
-
-
Ciardiello, F.1
Tortora, G.2
-
10
-
-
0037115674
-
Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma
-
Ang KK, Berkey BA, Tu X, et al.: Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Res 2002;62: 7350-7356.
-
(2002)
Cancer Res
, vol.62
, pp. 7350-7356
-
-
Ang, K.K.1
Berkey, B.A.2
Tu, X.3
-
11
-
-
1242270605
-
Epidermal growth factor receptor and tumor response to radiation: In vivo preclinical studies
-
Milas L, Fan Z, Andratschke NH, Ang KK: Epidermal growth factor receptor and tumor response to radiation: in vivo preclinical studies. Int J Radiat Oncol Biol Phys 2004;58:966-971.
-
(2004)
Int J Radiat Oncol Biol Phys
, vol.58
, pp. 966-971
-
-
Milas, L.1
Fan, Z.2
Andratschke, N.H.3
Ang, K.K.4
-
12
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al.: Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005;353:123-132.
-
(2005)
N Engl J Med
, vol.353
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues Pereira, J.2
Ciuleanu, T.3
-
13
-
-
27544503230
-
Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
-
Thatcher N, Chang A, Parikh P, et al.: Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 2005;366:1527-1537.
-
(2005)
Lancet
, vol.366
, pp. 1527-1537
-
-
Thatcher, N.1
Chang, A.2
Parikh, P.3
-
14
-
-
84862819699
-
Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): A phase 2 trial
-
Yang JC, Shih JY, Su WC, et al.: Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial. Lancet Oncol 2012;13:539-548.
-
(2012)
Lancet Oncol
, vol.13
, pp. 539-548
-
-
Yang, J.C.1
Shih, J.Y.2
Su, W.C.3
-
15
-
-
84866434919
-
Genomic landscape of non-small cell lung cancer in smokers and never-smokers
-
Govindan R, Ding L, Griffith M, et al.: Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell 2012;150:1121-1134.
-
(2012)
Cell
, vol.150
, pp. 1121-1134
-
-
Govindan, R.1
Ding, L.2
Griffith, M.3
-
16
-
-
0142119289
-
Epidermal growth factor receptor in non-small-cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis
-
Hirsch FR, Varella-Garcia M, Bunn PA Jr, et al.: Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis. J Clin Oncol 2003;21:3798-3807.
-
(2003)
J Clin Oncol
, vol.21
, pp. 3798-3807
-
-
Hirsch, F.R.1
Varella-Garcia, M.2
Bunn Jr., P.A.3
-
17
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Janne PA, Lee JC, et al.: EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004;304:1497-1500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
-
18
-
-
24744461722
-
EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients
-
Tang X, Shigematsu H, Bekele BN, et al.: EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients. Cancer Res 2005;65:7568-7572.
-
(2005)
Cancer Res
, vol.65
, pp. 7568-7572
-
-
Tang, X.1
Shigematsu, H.2
Bekele, B.N.3
-
19
-
-
77349124901
-
EGFR mutations and the terminal respiratory unit
-
Yatabe Y: EGFR mutations and the terminal respiratory unit. Cancer Metastasis Rev 2010;29:23-36.
-
(2010)
Cancer Metastasis Rev
, vol.29
, pp. 23-36
-
-
Yatabe, Y.1
-
20
-
-
79955905942
-
Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: A novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma
-
Centeno I, Blay P, Santamaria I, et al.: Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: a novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma. BMC Cancer 2011;11:172.
-
(2011)
BMC Cancer
, vol.11
, pp. 172
-
-
Centeno, I.1
Blay, P.2
Santamaria, I.3
-
21
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, et al.: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004;350:2129-2139.
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
-
22
-
-
73449096114
-
Frequency of and variables associated with the EGFR mutation and its subtypes
-
Tanaka T, Matsuoka M, Sutani A, et al.: Frequency of and variables associated with the EGFR mutation and its subtypes. Int J Cancer 2010;126:651-655.
-
(2010)
Int J Cancer
, vol.126
, pp. 651-655
-
-
Tanaka, T.1
Matsuoka, M.2
Sutani, A.3
-
23
-
-
20044364940
-
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
-
Shigematsu H, Lin L, Takahashi T, et al.: Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 2005;97:339-346.
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 339-346
-
-
Shigematsu, H.1
Lin, L.2
Takahashi, T.3
-
24
-
-
80055074897
-
Histopathologic characteristics of lung adenocarcinomas with epidermal growth factor receptor mutations in the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society lung adenocarcinoma classification
-
Shim HS, Lee da H, Park EJ, Kim SH: Histopathologic characteristics of lung adenocarcinomas with epidermal growth factor receptor mutations in the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society lung adenocarcinoma classification. Arch Pathol Lab Med 2011;135:1329-1334.
-
(2011)
Arch Pathol Lab Med
, vol.135
, pp. 1329-1334
-
-
Shim, H.S.1
Lee Da, H.2
Park, E.J.3
Kim, S.H.4
-
25
-
-
84863273943
-
Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability
-
Thu KL, Vucic EA, Chari R, et al.: Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability. PLoS One 2012;7:e33003.
-
(2012)
PLoS One
, vol.7
-
-
Thu, K.L.1
Vucic, E.A.2
Chari, R.3
-
26
-
-
75749131958
-
EGFR mutations are associated with prognosis but not with the response to front-line chemotherapy in the Chinese patients with advanced non-small cell lung cancer
-
Wu M, Zhao J, Song SW, et al.: EGFR mutations are associated with prognosis but not with the response to front-line chemotherapy in the Chinese patients with advanced non-small cell lung cancer. Lung Cancer 2010;67:343-347.
-
(2010)
Lung Cancer
, vol.67
, pp. 343-347
-
-
Wu, M.1
Zhao, J.2
Song, S.W.3
-
27
-
-
78651082546
-
Prognostic and predictive value of epidermal growth factor receptor tyrosine kinase domain mutation status and gene copy number for adjuvant chemotherapy in non-small cell lung cancer
-
Tsao MS, Sakurada A, Ding K, et al.: Prognostic and predictive value of epidermal growth factor receptor tyrosine kinase domain mutation status and gene copy number for adjuvant chemotherapy in non-small cell lung cancer. J Thorac Oncol 2011; 6:139-147.
-
(2011)
J Thorac Oncol
, vol.6
, pp. 139-147
-
-
Tsao, M.S.1
Sakurada, A.2
Ding, K.3
-
28
-
-
24944497744
-
Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
-
Eberhard DA, Johnson BE, Amler LC, et al.: Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 2005;23:5900-5909.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5900-5909
-
-
Eberhard, D.A.1
Johnson, B.E.2
Amler, L.C.3
-
29
-
-
33745964591
-
Epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer: Impact of primary or secondary mutations
-
Sakurada A, Shepherd FA, Tsao MS: Epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer: impact of primary or secondary mutations. Clin Lung Cancer 2006;7(suppl 4):S138-S144.
-
(2006)
Clin Lung Cancer
, vol.7
, Issue.SUPPL. 4
-
-
Sakurada, A.1
Shepherd, F.A.2
Tsao, M.S.3
-
30
-
-
33748066632
-
Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib
-
Carey KD, Garton AJ, Romero MS, et al.: Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib. Cancer Res 2006;66: 8163-8171.
-
(2006)
Cancer Res
, vol.66
, pp. 8163-8171
-
-
Carey, K.D.1
Garton, A.J.2
Romero, M.S.3
-
31
-
-
34249810645
-
KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-smallcell lung cancer
-
Massarelli E, Varella-Garcia M, Tang X, et al.: KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-smallcell lung cancer. Clin Cancer Res 2007;13:2890-2896.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2890-2896
-
-
Massarelli, E.1
Varella-Garcia, M.2
Tang, X.3
-
32
-
-
78751574026
-
Do changes in cigarette design influence the rise in adenocarcinoma of the lung?
-
Burns DM, Anderson CM, Gray N: Do changes in cigarette design influence the rise in adenocarcinoma of the lung? Cancer Causes Control 2011; 22:13-22.
-
(2011)
Cancer Causes Control
, vol.22
, pp. 13-22
-
-
Burns, D.M.1
Anderson, C.M.2
Gray, N.3
-
33
-
-
33750700477
-
Erlotinib for frontline treatment of advanced non-small cell lung cancer: A phase II study
-
Giaccone G, Gallegos Ruiz M, Le Chevalier T, et al.: Erlotinib for frontline treatment of advanced non-small cell lung cancer: a phase II study. Clin Cancer Res 2006;12:6049-6055.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 6049-6055
-
-
Giaccone, G.1
Gallegos Ruiz, M.2
Le Chevalier, T.3
-
34
-
-
33745897107
-
Gefitinib monotherapy in chemotherapy-naive patients with inoperable stage III/IV non-small-cell lung cancer
-
Reck M, Buchholz E, Romer KS, et al.: Gefitinib monotherapy in chemotherapy-naive patients with inoperable stage III/IV non-small-cell lung cancer. Clin Lung Cancer 2006;7:406-411.
-
(2006)
Clin Lung Cancer
, vol.7
, pp. 406-411
-
-
Reck, M.1
Buchholz, E.2
Romer, K.S.3
-
35
-
-
65649085659
-
A phase II study of erlotinib as initial treatment for patients with stage IIIB-IV nonsmall cell lung cancer
-
Akerley W, Boucher KM, Bentz JS, Arbogast K, Walters T: A phase II study of erlotinib as initial treatment for patients with stage IIIB-IV nonsmall cell lung cancer. J Thorac Oncol 2009;4:214-219.
-
(2009)
J Thorac Oncol
, vol.4
, pp. 214-219
-
-
Akerley, W.1
Boucher, K.M.2
Bentz, J.S.3
Arbogast, K.4
Walters, T.5
-
36
-
-
33947504732
-
Phase II clinical trial of chemotherapy-naive patients > or = 70 years of age treated with erlotinib for advanced non-small-cell lung cancer
-
Jackman DM, Yeap BY, Lindeman NI, et al.: Phase II clinical trial of chemotherapy-naive patients > or = 70 years of age treated with erlotinib for advanced non-small-cell lung cancer. J Clin Oncol 2007;25:760-766.
-
(2007)
J Clin Oncol
, vol.25
, pp. 760-766
-
-
Jackman, D.M.1
Yeap, B.Y.2
Lindeman, N.I.3
-
37
-
-
58149132477
-
Southwest Oncology Group phase II trial (S0341) of erlotinib (OSI-774) in patients with advanced nonsmall cell lung cancer and a performance status of 2
-
Hesketh PJ, Chansky K, Wozniak AJ, et al.: Southwest Oncology Group phase II trial (S0341) of erlotinib (OSI-774) in patients with advanced nonsmall cell lung cancer and a performance status of 2. J Thorac Oncol 2008;3:1026-1031.
-
(2008)
J Thorac Oncol
, vol.3
, pp. 1026-1031
-
-
Hesketh, P.J.1
Chansky, K.2
Wozniak, A.J.3
-
38
-
-
52049096854
-
Gefitinib versus vinorelbine in chemotherapy-naive elderly patients with advanced non-small-cell lung cancer (INVITE): A randomized, phase II study
-
Crino L, Cappuzzo F, Zatloukal P, et al.: Gefitinib versus vinorelbine in chemotherapy-naive elderly patients with advanced non-small-cell lung cancer (INVITE): a randomized, phase II study. J Clin Oncol 2008;26:4253-4260.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4253-4260
-
-
Crino, L.1
Cappuzzo, F.2
Zatloukal, P.3
-
39
-
-
39749087795
-
Randomized phase II trial of erlotinib or standard chemotherapy in patients with advanced nonsmall-cell lung cancer and a performance status of 2
-
Lilenbaum R, Axelrod R, Thomas S, et al.: Randomized phase II trial of erlotinib or standard chemotherapy in patients with advanced nonsmall-cell lung cancer and a performance status of 2. J Clin Oncol 2008;26:863-869.
-
(2008)
J Clin Oncol
, vol.26
, pp. 863-869
-
-
Lilenbaum, R.1
Axelrod, R.2
Thomas, S.3
-
40
-
-
84868192444
-
First-line erlotinib in patients with advanced non-small-cell lung cancer unsuitable for chemotherapy (TOPICAL): A double-blind, placebo-controlled, phase 3 trial
-
Lee SM, Khan I, Upadhyay S, et al.: First-line erlotinib in patients with advanced non-small-cell lung cancer unsuitable for chemotherapy (TOPICAL): a double-blind, placebo-controlled, phase 3 trial. Lancet Oncol 2012;13:1161-1170.
-
(2012)
Lancet Oncol
, vol.13
, pp. 1161-1170
-
-
Lee, S.M.1
Khan, I.2
Upadhyay, S.3
-
41
-
-
77956805350
-
Randomized phase II trial of gefitinib or gemcitabine or docetaxel chemotherapy in patients with advanced non-small-cell lung cancer and a performance status of 2 or 3 (IFCT-0301 study)
-
Morere JF, Brechot JM, Westeel V, et al.: Randomized phase II trial of gefitinib or gemcitabine or docetaxel chemotherapy in patients with advanced non-small-cell lung cancer and a performance status of 2 or 3 (IFCT-0301 study). Lung Cancer 2010;70:301-307.
-
(2010)
Lung Cancer
, vol.70
, pp. 301-307
-
-
Morere, J.F.1
Brechot, J.M.2
Westeel, V.3
-
42
-
-
65549154268
-
Randomized phase II study of gefitinib compared with placebo in chemotherapy-naive patients with advanced non-small-cell lung cancer and poor performance status
-
Goss G, Ferry D, Wierzbicki R, et al.: Randomized phase II study of gefitinib compared with placebo in chemotherapy-naive patients with advanced non-small-cell lung cancer and poor performance status. J Clin Oncol 2009;27:2253-2260.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2253-2260
-
-
Goss, G.1
Ferry, D.2
Wierzbicki, R.3
-
43
-
-
45749120442
-
Specific EGFR mutations predict treatment outcome of stage IIIB/IV patients with chemotherapy-naive nonsmall-cell lung cancer receiving first-line gefitinib monotherapy
-
Yang CH, Yu CJ, Shih JY, et al.: Specific EGFR mutations predict treatment outcome of stage IIIB/IV patients with chemotherapy-naive nonsmall-cell lung cancer receiving first-line gefitinib monotherapy. J Clin Oncol 2008;26:2745-2753.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2745-2753
-
-
Yang, C.H.1
Yu, C.J.2
Shih, J.Y.3
-
44
-
-
33644845421
-
First-line single agent treatment with gefitinib in patients with advanced non-small-cell lung cancer: A phase II study
-
Niho S, Kubota K, Goto K, et al.: First-line single agent treatment with gefitinib in patients with advanced non-small-cell lung cancer: a phase II study. J Clin Oncol 2006;24:64-69.
-
(2006)
J Clin Oncol
, vol.24
, pp. 64-69
-
-
Niho, S.1
Kubota, K.2
Goto, K.3
-
45
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok TS, Wu YL, Thongprasert S, et al.: Gefitinib or carboplatin- paclitaxel in pulmonary adenocarcinoma. N Engl J Med 2009;361:947-957.
-
(2009)
N Engl J Med
, vol.361
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
-
46
-
-
58949088423
-
A phase II trial of gefitinib monotherapy in chemotherapynaive patients of 75 years or older with advanced non-small cell lung cancer
-
Ebi N, Semba H, Tokunaga SJ, et al.: A phase II trial of gefitinib monotherapy in chemotherapynaive patients of 75 years or older with advanced non-small cell lung cancer. J Thorac Oncol 2008; 3:1166-1171.
-
(2008)
J Thorac Oncol
, vol.3
, pp. 1166-1171
-
-
Ebi, N.1
Semba, H.2
Tokunaga, S.J.3
-
47
-
-
79960889662
-
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive nonsmall-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
-
Zhou C, Wu YL, Chen G, et al.: Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive nonsmall-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol 2011;12:735-742.
-
(2011)
Lancet Oncol
, vol.12
, pp. 735-742
-
-
Zhou, C.1
Wu, Y.L.2
Chen, G.3
-
48
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
Maemondo M, Inoue A, Kobayashi K, et al.: Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 2010; 362:2380-2388.
-
(2010)
N Engl J Med
, vol.362
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
-
49
-
-
84857502654
-
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer ( EURTAC): A multicentre, open-label, randomised phase 3 trial
-
Rosell R, Carcereny E, Gervais R, et al.: Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer ( EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 2012;13:239-246.
-
(2012)
Lancet Oncol
, vol.13
, pp. 239-246
-
-
Rosell, R.1
Carcereny, E.2
Gervais, R.3
-
50
-
-
75249087060
-
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
-
Mitsudomi T, Morita S, Yatabe Y, et al.: Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol 2010;11:121-128.
-
(2010)
Lancet Oncol
, vol.11
, pp. 121-128
-
-
Mitsudomi, T.1
Morita, S.2
Yatabe, Y.3
-
51
-
-
74949117339
-
Somatic EGFR mutation and gene copy gain as predictive biomarkers for response to tyrosine kinase inhibitors in non-small cell lung cancer
-
Dahabreh IJ, Linardou H, Siannis F, et al.: Somatic EGFR mutation and gene copy gain as predictive biomarkers for response to tyrosine kinase inhibitors in non-small cell lung cancer. Clin Cancer Res 2010;16:291-303.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 291-303
-
-
Dahabreh, I.J.1
Linardou, H.2
Siannis, F.3
-
52
-
-
84857414572
-
Efficacy of EGFR tyrosine kinase inhibitors in patients with EGFR-mutated non-small-cell lung cancer: A meta-analysis of 13 randomized trials
-
Petrelli F, Borgonovo K, Cabiddu M, Barni S: Efficacy of EGFR tyrosine kinase inhibitors in patients with EGFR-mutated non-small-cell lung cancer: a meta-analysis of 13 randomized trials. Clin Lung Cancer 2012;13:107-114.
-
(2012)
Clin Lung Cancer
, vol.13
, pp. 107-114
-
-
Petrelli, F.1
Borgonovo, K.2
Cabiddu, M.3
Barni, S.4
-
53
-
-
69349088824
-
Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomes in prezviously untreated non-small cell lung cancer patients: Results of an online tumor registry of clinical trials
-
Jackman DM, Miller VA, Cioffredi LA, et al.: Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomes in prezviously untreated non-small cell lung cancer patients: results of an online tumor registry of clinical trials. Clin Cancer Res 2009;15:5267-5273.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5267-5273
-
-
Jackman, D.M.1
Miller, V.A.2
Cioffredi, L.A.3
-
54
-
-
79960702788
-
Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced nonsmall-cell lung cancer in Asia (IPASS)
-
Fukuoka M, Wu YL, Thongprasert S, et al.: Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced nonsmall-cell lung cancer in Asia (IPASS). J Clin Oncol 2011;29:2866-2874.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2866-2874
-
-
Fukuoka, M.1
Wu, Y.L.2
Thongprasert, S.3
-
55
-
-
84884736973
-
Phase III study of afatinib or cisplatin plus pemetrexed in patiens with metastatic lung adenocarinoma with EGFR mutations
-
DOI: 10,1200/JCO.2012.44,2806
-
Sequist LV, Yang JC, Yamamoto N, et al.: Phase III study of afatinib or cisplatin plus pemetrexed in patiens with metastatic lung adenocarinoma with EGFR mutations. J Clin Oncol 2013 DOI: 10,1200/JCO.2012.44,2806.
-
(2013)
J Clin Oncol
-
-
Sequist, L.V.1
Yang, J.C.2
Yamamoto, N.3
-
56
-
-
84884605223
-
Symptom control and quality of life in LUX-Lung 3: A phase III strudy of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations
-
DOI: 10,1200/JCO.2012.46,1764
-
Yang JC, Hirsh V, Schuler M, et al.: Symptom control and quality of life in LUX-Lung 3: a phase III strudy of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations. J Clin Oncol 2013 DOI: 10,1200/JCO.2012.46,1764.
-
(2013)
J Clin Oncol
-
-
Yang, J.C.1
Hirsh, V.2
Schuler, M.3
-
57
-
-
54049153188
-
First-or second-line therapy with gefitinib produces equal survival in non-small cell lung cancer
-
Wu JY, Yu CJ, Yang CH, et al.: First-or second-line therapy with gefitinib produces equal survival in non-small cell lung cancer. Am J Respir Crit Care Med 2008;178:847-853.
-
(2008)
Am J Respir Crit Care Med
, vol.178
, pp. 847-853
-
-
Wu, J.Y.1
Yu, C.J.2
Yang, C.H.3
-
58
-
-
84860479704
-
Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804): A multicentre, double-blind randomised phase 3 trial
-
Zhang L, Ma S, Song X, et al.: Gefitinib versus placebo as maintenance therapy in patients with locally advanced or metastatic non-small-cell lung cancer (INFORM; C-TONG 0804): a multicentre, double-blind randomised phase 3 trial. Lancet Oncol 2012;13:466-475.
-
(2012)
Lancet Oncol
, vol.13
, pp. 466-475
-
-
Zhang, L.1
Ma, S.2
Song, X.3
-
59
-
-
77953541527
-
Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: A multicentre, randomised, placebo-controlled phase 3 study
-
Cappuzzo F, Ciuleanu T, Stelmakh L, et al.: Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study. Lancet Oncol 2010;11:521-529.
-
(2010)
Lancet Oncol
, vol.11
, pp. 521-529
-
-
Cappuzzo, F.1
Ciuleanu, T.2
Stelmakh, L.3
-
60
-
-
84862880250
-
Quality of life with gefitinib in patients with EGFR-mutated non-small cell lung cancer: Quality of life analysis of North East Japan Study Group 002 Trial
-
Oizumi S, Kobayashi K, Inoue A, et al.: Quality of life with gefitinib in patients with EGFR-mutated non-small cell lung cancer: quality of life analysis of North East Japan Study Group 002 Trial. Oncologist 2012;17:863-870.
-
(2012)
Oncologist
, vol.17
, pp. 863-870
-
-
Oizumi, S.1
Kobayashi, K.2
Inoue, A.3
-
61
-
-
80155135291
-
Gefitinib as first-line treatment in elderly epidermal growth factor receptor-mutated patients with advanced lung adenocarcinoma: Results of a Nagano Lung Cancer Research Group study
-
Asami K, Koizumi T, Hirai K, et al.: Gefitinib as first-line treatment in elderly epidermal growth factor receptor-mutated patients with advanced lung adenocarcinoma: results of a Nagano Lung Cancer Research Group study. Clin Lung Cancer 2011;12:387-392.
-
(2011)
Clin Lung Cancer
, vol.12
, pp. 387-392
-
-
Asami, K.1
Koizumi, T.2
Hirai, K.3
-
62
-
-
49249136311
-
An international, multicenter, randomized phase III study of first-line erlotinib followed by second-line cisplatin/gemcitabine versus first-line cisplatin/gemcitabine followed by second-line erlotinib in advanced non-small-cell lung cancer: Treatment rationale and protocol dynamics of the TORCH trial
-
Gridelli C, Butts C, Ciardiello F, et al.: An international, multicenter, randomized phase III study of first-line erlotinib followed by second-line cisplatin/gemcitabine versus first-line cisplatin/gemcitabine followed by second-line erlotinib in advanced non-small-cell lung cancer: treatment rationale and protocol dynamics of the TORCH trial. Clin Lung Cancer 2008;9:235-238.
-
(2008)
Clin Lung Cancer
, vol.9
, pp. 235-238
-
-
Gridelli, C.1
Butts, C.2
Ciardiello, F.3
-
63
-
-
84861973944
-
Innovations: Randomized phase II trial of erlotinib (E)/bevacizumab (B) compared with cisplatin (P)/gemcitabine (G) plus B in first-line treatment of advanced nonsquamous (NS) non-small cell lung cancer (NSCLC)
-
abstr 7504
-
Thomas M, Reuss A, Fischer JR, et al.: Innovations: Randomized phase II trial of erlotinib (E)/bevacizumab (B) compared with cisplatin (P)/gemcitabine (G) plus B in first-line treatment of advanced nonsquamous (NS) non-small cell lung cancer (NSCLC). J Clin Oncol 2011;29(suppl);abstr 7504.
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Thomas, M.1
Reuss, A.2
Fischer, J.R.3
-
64
-
-
1542503746
-
Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial-INTACT 1
-
Giaccone G, Herbst RS, Manegold C, et al.: Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 1. J Clin Oncol 2004; 22:777-784.
-
(2004)
J Clin Oncol
, vol.22
, pp. 777-784
-
-
Giaccone, G.1
Herbst, R.S.2
Manegold, C.3
-
65
-
-
1542713370
-
Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial-INTACT 2
-
Herbst RS, Giaccone G, Schiller JH, et al.: Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 2. J Clin Oncol 2004;22:785-794.
-
(2004)
J Clin Oncol
, vol.22
, pp. 785-794
-
-
Herbst, R.S.1
Giaccone, G.2
Schiller, J.H.3
-
66
-
-
84863892117
-
Randomized phase II trial of erlotinib alone or with carboplatin and paclitaxel in patients who were never or light former smokers with advanced lung adenocarcinoma: CALGB 30406 trial
-
Janne PA, Wang X, Socinski MA, et al.: Randomized phase II trial of erlotinib alone or with carboplatin and paclitaxel in patients who were never or light former smokers with advanced lung adenocarcinoma: CALGB 30406 trial. J Clin Oncol 2012;30:2063-2069.
-
(2012)
J Clin Oncol
, vol.30
, pp. 2063-2069
-
-
Janne, P.A.1
Wang, X.2
Socinski, M.A.3
-
67
-
-
80052437758
-
New strategies in overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer
-
Oxnard GR, Arcila ME, Chmielecki J, et al.: New strategies in overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer. Clin Cancer Res 2011; 17:5530-5537.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 5530-5537
-
-
Oxnard, G.R.1
Arcila, M.E.2
Chmielecki, J.3
-
68
-
-
40049099220
-
The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
-
Yun CH, Mengwasser KE, Toms AV, et al.: The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc Natl Acad Sci USA 2008;105:2070-2075.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 2070-2075
-
-
Yun, C.H.1
Mengwasser, K.E.2
Toms, A.V.3
-
69
-
-
84863011443
-
Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with nonsmall-cell lung cancer
-
Su KY, Chen HY, Li KC, et al.: Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with nonsmall-cell lung cancer. J Clin Oncol 2012;30:433-440.
-
(2012)
J Clin Oncol
, vol.30
, pp. 433-440
-
-
Su, K.Y.1
Chen, H.Y.2
Li, K.C.3
-
70
-
-
84877100240
-
Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFRmutant lung cancers
-
Yu HA, Arcila ME, Rekhtman N, et al.: Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFRmutant lung cancers. Clin Cancer Res 2013;19: 2240-2247.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 2240-2247
-
-
Yu, H.A.1
Arcila, M.E.2
Rekhtman, N.3
-
71
-
-
77953799106
-
Cancer-associated fibroblasts derived from EGFR-TKIresistant tumors reverse EGFR pathway inhibition by EGFR-TKIs
-
Mink SR, Vashistha S, Zhang W, et al.: Cancer-associated fibroblasts derived from EGFR-TKIresistant tumors reverse EGFR pathway inhibition by EGFR-TKIs. Mol Cancer Res 2010;8:809-820.
-
(2010)
Mol Cancer Res
, vol.8
, pp. 809-820
-
-
Mink, S.R.1
Vashistha, S.2
Zhang, W.3
-
72
-
-
84867760241
-
HER2 amplification: A potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation
-
Takezawa K, Pirazzoli V, Arcila ME, et al.: HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation. Cancer Discov 2012;2:922-933.
-
(2012)
Cancer Discov
, vol.2
, pp. 922-933
-
-
Takezawa, K.1
Pirazzoli, V.2
Arcila, M.E.3
-
73
-
-
20144386787
-
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas
-
Shigematsu H, Takahashi T, Nomura M, et al.: Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. Cancer Res 2005;65:1642-1646.
-
(2005)
Cancer Res
, vol.65
, pp. 1642-1646
-
-
Shigematsu, H.1
Takahashi, T.2
Nomura, M.3
-
74
-
-
17644403128
-
Association of HER-2 overexpression with prognosis in nonsmall cell lung carcinoma: A metaanalysis
-
Nakamura H, Kawasaki N, Taguchi M, Kabasawa K: Association of HER-2 overexpression with prognosis in nonsmall cell lung carcinoma: a metaanalysis. Cancer 2005;103:1865-1873.
-
(2005)
Cancer
, vol.103
, pp. 1865-1873
-
-
Nakamura, H.1
Kawasaki, N.2
Taguchi, M.3
Kabasawa, K.4
-
75
-
-
33846552656
-
Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
-
Sergina NV, Rausch M, Wang D, et al.: Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature 2007; 445:437-441.
-
(2007)
Nature
, vol.445
, pp. 437-441
-
-
Sergina, N.V.1
Rausch, M.2
Wang, D.3
-
76
-
-
58149333768
-
Acquired resistance to epidermal growth factor receptor kinase inhibitors associated with a novel T854A mutation in a patient with EGFR-mutant lung adenocarcinoma
-
Bean J, Riely GJ, Balak M, et al.: Acquired resistance to epidermal growth factor receptor kinase inhibitors associated with a novel T854A mutation in a patient with EGFR-mutant lung adenocarcinoma. Clin Cancer Res 2008;14:7519-7525.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7519-7525
-
-
Bean, J.1
Riely, G.J.2
Balak, M.3
-
77
-
-
49149118719
-
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
-
Li D, Ambrogio L, Shimamura T, et al.: BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene 2008;27:4702-4711.
-
(2008)
Oncogene
, vol.27
, pp. 4702-4711
-
-
Li, D.1
Ambrogio, L.2
Shimamura, T.3
-
78
-
-
84862785051
-
Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): A phase 2b/3 randomised trial
-
Miller VA, Hirsh V, Cadranel J, et al.: Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial. Lancet Oncol 2012;13:528-538.
-
(2012)
Lancet Oncol
, vol.13
, pp. 528-538
-
-
Miller, V.A.1
Hirsh, V.2
Cadranel, J.3
-
79
-
-
84859795661
-
Phase i study of continuous afatinib (BIBW 2992) in patients with advanced non-small cell lung cancer after prior chemotherapy/erlotinib/gefitinib (LUXLung 4)
-
Murakami H, Tamura T, Takahashi T, et al.: Phase I study of continuous afatinib (BIBW 2992) in patients with advanced non-small cell lung cancer after prior chemotherapy/erlotinib/gefitinib (LUXLung 4). Cancer Chemother Pharmacol 2012;69: 891-899.
-
(2012)
Cancer Chemother Pharmacol
, vol.69
, pp. 891-899
-
-
Murakami, H.1
Tamura, T.2
Takahashi, T.3
-
80
-
-
49049089802
-
Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapynaive patients with advanced-stage non-small-cell lung cancer
-
Scagliotti GV, Parikh P, von Pawel J, et al.: Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapynaive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2008;26:3543-3551.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3543-3551
-
-
Scagliotti, G.V.1
Parikh, P.2
Von Pawel, J.3
-
81
-
-
49049112495
-
First-line chemotherapy for nonsmall-cell lung cancer: Is there a superior regimen based on histology?
-
Einhorn LH: First-line chemotherapy for nonsmall-cell lung cancer: is there a superior regimen based on histology? J Clin Oncol 2008;26:3485-3486.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3485-3486
-
-
Einhorn, L.H.1
-
82
-
-
33845671340
-
Mortality within 30 days of chemotherapy: A clinical governance benchmarking issue for oncology patients
-
O'Brien ME, Borthwick A, Rigg A, et al.: Mortality within 30 days of chemotherapy: a clinical governance benchmarking issue for oncology patients. Br J Cancer 2006;95:1632-1636.
-
(2006)
Br J Cancer
, vol.95
, pp. 1632-1636
-
-
O'Brien, M.E.1
Borthwick, A.2
Rigg, A.3
-
83
-
-
84867843511
-
Fatal asymmetric interstitial lung disease after erlotinib for lung cancer
-
Ren S, Li Y, Li W, et al.: Fatal asymmetric interstitial lung disease after erlotinib for lung cancer. Respiration 2012;84:431-435.
-
(2012)
Respiration
, vol.84
, pp. 431-435
-
-
Ren, S.1
Li, Y.2
Li, W.3
-
84
-
-
84876682148
-
Acute fatal liver toxicity under erlotinib
-
Schacher-Kaufmann S, Pless M: Acute fatal liver toxicity under erlotinib. Case Rep Oncol 2010;3: 182-188.
-
(2010)
Case Rep Oncol
, vol.3
, pp. 182-188
-
-
Schacher-Kaufmann, S.1
Pless, M.2
-
85
-
-
84866144502
-
Relationship between skin rash and outcome in non-small-cell lung cancer patients treated with anti-EGFR tyrosine kinase inhibitors: A literature-based meta-analysis of 24 trials
-
Petrelli F, Borgonovo K, Cabiddu M, Lonati V, Barni S: Relationship between skin rash and outcome in non-small-cell lung cancer patients treated with anti-EGFR tyrosine kinase inhibitors: a literature-based meta-analysis of 24 trials. Lung Cancer 2012;78:8-15.
-
(2012)
Lung Cancer
, vol.78
, pp. 8-15
-
-
Petrelli, F.1
Borgonovo, K.2
Cabiddu, M.3
Lonati, V.4
Barni, S.5
-
86
-
-
20844448897
-
HER1/EGFR inhibitor-associated rash: Future directions for management and investigation outcomes from the HER1/EGFR inhibitor rash management forum
-
Perez-Soler R, Delord JP, Halpern A, et al.: HER1/EGFR inhibitor-associated rash: future directions for management and investigation outcomes from the HER1/EGFR inhibitor rash management forum. Oncologist 2005;10:345-356.
-
(2005)
Oncologist
, vol.10
, pp. 345-356
-
-
Perez-Soler, R.1
Delord, J.P.2
Halpern, A.3
-
87
-
-
79959295780
-
Managing treatment-related adverse events associated with EGFR tyrosine kinase inhibitors in advanced non-small-cell lung cancer
-
Hirsh V: Managing treatment-related adverse events associated with EGFR tyrosine kinase inhibitors in advanced non-small-cell lung cancer. Curr Oncol 2011;18:126-138.
-
(2011)
Curr Oncol
, vol.18
, pp. 126-138
-
-
Hirsh, V.1
-
88
-
-
4544368057
-
Understanding and managing chemotherapy-induced diarrhea
-
discussion 38-41, 45-36
-
Saltz LB: Understanding and managing chemotherapy-induced diarrhea. J Support Oncol 2003;1: 35-46; discussion 38-41, 45-36.
-
(2003)
J Support Oncol
, vol.1
, pp. 35-46
-
-
Saltz, L.B.1
-
89
-
-
51649105187
-
Prevention and management of chemotherapy-induced diarrhea in patients with colorectal cancer: A consensus statement by the Canadian Working Group on Chemotherapy-Induced Diarrhea
-
Maroun JA, Anthony LB, Blais N, et al.: Prevention and management of chemotherapy-induced diarrhea in patients with colorectal cancer: a consensus statement by the Canadian Working Group on Chemotherapy-Induced Diarrhea. Curr Oncol 2007;14:13-20.
-
(2007)
Curr Oncol
, vol.14
, pp. 13-20
-
-
Maroun, J.A.1
Anthony, L.B.2
Blais, N.3
-
90
-
-
77049124105
-
Interstitial lung disease in gefitinib-treated Japanese patients with non-small cell lung cancer-A retrospective analysis: JMTO LC03-02
-
Nakagawa M, Nishimura T, Teramukai S, et al.: Interstitial lung disease in gefitinib-treated Japanese patients with non-small cell lung cancer-a retrospective analysis: JMTO LC03-02. BMC Res Notes 2009;2:157.
-
(2009)
BMC Res Notes
, vol.2
, pp. 157
-
-
Nakagawa, M.1
Nishimura, T.2
Teramukai, S.3
-
91
-
-
34249695579
-
Interstitial lung disease associated with epidermal growth factor receptor tyrosine kinase inhibitor therapy in non-small-cell lung carcinoma
-
Yoneda KY, Hardin KA, Gandara DR, Shelton DK: Interstitial lung disease associated with epidermal growth factor receptor tyrosine kinase inhibitor therapy in non-small-cell lung carcinoma. Clin Lung Cancer 2006;8(suppl 1):S31-S35.
-
(2006)
Clin Lung Cancer
, vol.8
, Issue.SUPPL. 1
-
-
Yoneda, K.Y.1
Hardin, K.A.2
Gandara, D.R.3
Shelton, D.K.4
-
92
-
-
77958011527
-
Efficacy and safety of PF299804 versus erlotinib (E): A global, randomized phase II trial in patients (pts) with advanced non-small cell lung cancer (NSCLC) after failure of chemotherapy (CT)
-
abstr LBA7523
-
Boyer MJ, Blackhall FH, Park K, et al.: Efficacy and safety of PF299804 versus erlotinib (E): a global, randomized phase II trial in patients (pts) with advanced non-small cell lung cancer (NSCLC) after failure of chemotherapy (CT). J Clin Oncol 2010;28(suppl 18s):abstr LBA7523.
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL. 18S
-
-
Boyer, M.J.1
Blackhall, F.H.2
Park, K.3
-
93
-
-
84866756012
-
Overall survival (OS) results from OPTIMAL (CTONG0802), a phase III trial of erlotinib (E) versus carboplatin plus gemcitabine (GC) as first-line treatment for Chinese patients with EGFR mutation-positive advanced non-small cell lung cancer (NSCLC)
-
abstr 7520
-
Zhou C, Wu Y, Liu X, et al.: Overall survival (OS) results from OPTIMAL (CTONG0802), a phase III trial of erlotinib (E) versus carboplatin plus gemcitabine (GC) as first-line treatment for Chinese patients with EGFR mutation-positive advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2012;30(suppl):abstr 7520.
-
(2012)
J Clin Oncol
, vol.30
, Issue.SUPPL.
-
-
Zhou, C.1
Wu, Y.2
Liu, X.3
-
94
-
-
84879347777
-
Diarrhea associated with afatinib: An oral ErbB family blocker
-
Yang JC, Reguart N, Barinoff J, et al.: Diarrhea associated with afatinib: an oral ErbB family blocker. Expert Rev Anticancer Ther 2013;13:729-736.
-
(2013)
Expert Rev Anticancer Ther
, vol.13
, pp. 729-736
-
-
Yang, J.C.1
Reguart, N.2
Barinoff, J.3
-
95
-
-
84879347673
-
Dermatologic adverse events associated with afatinib: An oral ErbB family blocker
-
Lacouture ME, Schadendorf D, Chu CY, et al.: Dermatologic adverse events associated with afatinib: an oral ErbB family blocker. Expert Rev Anticancer Ther 2013;13:721-728.
-
(2013)
Expert Rev Anticancer Ther
, vol.13
, pp. 721-728
-
-
Lacouture, M.E.1
Schadendorf, D.2
Chu, C.Y.3
-
96
-
-
77953725855
-
Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia
-
Kantarjian H, Shah NP, Hochhaus A, et al.: Dasatinib versus imatinib in newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med 2010;362:2260-2270.
-
(2010)
N Engl J Med
, vol.362
, pp. 2260-2270
-
-
Kantarjian, H.1
Shah, N.P.2
Hochhaus, A.3
-
97
-
-
72949092456
-
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
-
Zhou W, Ercan D, Chen L, et al.: Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature 2009;462:1070-1074.
-
(2009)
Nature
, vol.462
, pp. 1070-1074
-
-
Zhou, W.1
Ercan, D.2
Chen, L.3
-
98
-
-
80052511675
-
Final efficacy results from OAM4558g, a randomized phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC
-
abstr 7505
-
Spigel DR, Ervin TJ, Ramlau R, et al.: Final efficacy results from OAM4558g, a randomized phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC. J Clin Oncol 2011;29(suppl):abstr 7505.
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Spigel, D.R.1
Ervin, T.J.2
Ramlau, R.3
-
99
-
-
80052441453
-
Activity and tolerability of afatinib (BIBW 2992) and cetuximab in NSCLC patients with acquired resistance to erlotinib or gefitinib
-
abstr 7525
-
Janjigian YY, Groen HJM, Horn L, et al.: Activity and tolerability of afatinib (BIBW 2992) and cetuximab in NSCLC patients with acquired resistance to erlotinib or gefitinib. J Clin Oncol 2011;29(suppl):abstr 7525.
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Janjigian, Y.Y.1
Hjm, G.2
Horn, L.3
-
100
-
-
70349464846
-
Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway
-
Nguyen KS, Kobayashi S, Costa DB: Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway. Clin Lung Cancer 2009;10: 281-289.
-
(2009)
Clin Lung Cancer
, vol.10
, pp. 281-289
-
-
Nguyen, K.S.1
Kobayashi, S.2
Costa, D.B.3
-
101
-
-
84872591018
-
Resistance to irreversible EGFR tyrosine kinase inhibitors through a multistep mechanism involving the IGF1R pathway
-
Cortot AB, Repellin CE, Shimamura T, et al.: Resistance to irreversible EGFR tyrosine kinase inhibitors through a multistep mechanism involving the IGF1R pathway. Cancer Res 2013;73:834-843.
-
(2013)
Cancer Res
, vol.73
, pp. 834-843
-
-
Cortot, A.B.1
Repellin, C.E.2
Shimamura, T.3
-
102
-
-
33646381931
-
Gefitinib therapy in advanced bronchioloalveolar carcinoma: Southwest Oncology Group Study S0126
-
West HL, Franklin WA, McCoy J, et al.: Gefitinib therapy in advanced bronchioloalveolar carcinoma: Southwest Oncology Group Study S0126. J Clin Oncol 2006;24:1807-1813.
-
(2006)
J Clin Oncol
, vol.24
, pp. 1807-1813
-
-
West, H.L.1
Franklin, W.A.2
McCoy, J.3
-
103
-
-
69549103046
-
IFCT-0401 trial: A phase II study of gefitinib administered as first-line treatment in advanced adenocarcinoma with bronchioloalveolar carcinoma subtype
-
Cadranel J, Quoix E, Baudrin L, et al.: IFCT-0401 trial: a phase II study of gefitinib administered as first-line treatment in advanced adenocarcinoma with bronchioloalveolar carcinoma subtype. J Thorac Oncol 2009;4:1126-1135.
-
(2009)
J Thorac Oncol
, vol.4
, pp. 1126-1135
-
-
Cadranel, J.1
Quoix, E.2
Baudrin, L.3
-
104
-
-
17144385106
-
Gefitinib as a first-line therapy of advanced or metastatic adenocarcinoma of the lung in never-smokers
-
Lee DH, Han JY, Lee HG, et al.: Gefitinib as a first-line therapy of advanced or metastatic adenocarcinoma of the lung in never-smokers. Clin Cancer Res 2005;11:3032-3037.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3032-3037
-
-
Lee, D.H.1
Han, J.Y.2
Lee, H.G.3
-
105
-
-
76649134591
-
Phase II trial of erlotinib in chemotherapy-naive women with advanced pulmonary adenocarcinoma
-
abstr 8065
-
Jackman DM, Cioffredi L, Lindeman NI: Phase II trial of erlotinib in chemotherapy-naive women with advanced pulmonary adenocarcinoma. J Clin Oncol 2009;27(suppl 15S):abstr 8065.
-
(2009)
J Clin Oncol
, vol.27
, Issue.SUPPL. 15S
-
-
Jackman, D.M.1
Cioffredi, L.2
Lindeman, N.I.3
-
106
-
-
84861976809
-
First-SIGNAL: First-line single-agent Iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung
-
Han JY, Park K, Kim SW, et al.: First-SIGNAL: first-line single-agent Iressa versus gemcitabine and cisplatin trial in never-smokers with adenocarcinoma of the lung. J Clin Oncol 2012;30:1122-1128.
-
(2012)
J Clin Oncol
, vol.30
, pp. 1122-1128
-
-
Han, J.Y.1
Park, K.2
Kim, S.W.3
-
107
-
-
33750205340
-
A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations
-
Asahina H, Yamazaki K, Kinoshita I, et al.: A phase II trial of gefitinib as first-line therapy for advanced non-small cell lung cancer with epidermal growth factor receptor mutations. Br J Cancer 2006;95:998-1004.
-
(2006)
Br J Cancer
, vol.95
, pp. 998-1004
-
-
Asahina, H.1
Yamazaki, K.2
Kinoshita, I.3
-
108
-
-
33746789922
-
Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations
-
Inoue A, Suzuki T, Fukuhara T, et al.: Prospective phase II study of gefitinib for chemotherapy-naive patients with advanced non-small-cell lung cancer with epidermal growth factor receptor gene mutations. J Clin Oncol 2006;24:3340-3346.
-
(2006)
J Clin Oncol
, vol.24
, pp. 3340-3346
-
-
Inoue, A.1
Suzuki, T.2
Fukuhara, T.3
-
109
-
-
45149084723
-
First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations
-
Sequist LV, Martins RG, Spigel D, et al.: First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. J Clin Oncol 2008;26:2442-2449.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2442-2449
-
-
Sequist, L.V.1
Martins, R.G.2
Spigel, D.3
-
110
-
-
69949186250
-
Screening for epidermal growth factor receptor mutations in lung cancer
-
Rosell R, Moran T, Queralt C, et al.: Screening for epidermal growth factor receptor mutations in lung cancer. N Engl J Med 2009;361:958-967.
-
(2009)
N Engl J Med
, vol.361
, pp. 958-967
-
-
Rosell, R.1
Moran, T.2
Queralt, C.3
-
111
-
-
63049132774
-
First-line gefitinib for patients with advanced non-smallcell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy
-
Inoue A, Kobayashi K, Usui K, et al.: First-line gefitinib for patients with advanced non-smallcell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy. J Clin Oncol 2009;27:1394-1400.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1394-1400
-
-
Inoue, A.1
Kobayashi, K.2
Usui, K.3
|