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Volumn 11, Issue 7, 2014, Pages 672-680

Fluoxetine improves behavioral performance by suppressing the production of soluble β-amyloid in APP/PS1 mice

Author keywords

Alzheimer's disease (AD); Amyloid precursor protein (APP); Behavior; Fluoxetine; Soluble A

Indexed keywords

AMYLOID BETA PROTEIN; FLUOXETINE; MICROTUBULE ASSOCIATED PROTEIN 2; SYNAPTOPHYSIN; AMYLOID PRECURSOR PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; MTAP2 PROTEIN, MOUSE; NOOTROPIC AGENT; SYP PROTEIN, MOUSE;

EID: 84906912513     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/1567205011666140812114715     Document Type: Article
Times cited : (52)

References (46)
  • 1
    • 77955281765 scopus 로고    scopus 로고
    • Activated astroglia during chronic inflammation in Alzheimer's disease-Do they neglect their neurosupportive roles?
    • Fuller S, Steele M, Munch G. Activated astroglia during chronic inflammation in Alzheimer's disease-Do they neglect their neurosupportive roles? Mutat Res-Fund Mol M 690(1-2): 40-49 (2010).
    • (2010) Mutat Res-Fund Mol M , vol.690 , Issue.1-2 , pp. 40-49
    • Fuller, S.1    Steele, M.2    Munch, G.3
  • 3
    • 49849085127 scopus 로고    scopus 로고
    • Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation
    • Choi SH, Veeraraghavalu K, Lazarov O, Marler S, Ransohoff RM, Ramirez JM, et al. Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation. Neuron 59(4): 568-80 (2008).
    • (2008) Neuron , vol.59 , Issue.4 , pp. 568-580
    • Choi, S.H.1    Veeraraghavalu, K.2    Lazarov, O.3    Marler, S.4    Ransohoff, R.M.5    Ramirez, J.M.6
  • 4
    • 34547760490 scopus 로고    scopus 로고
    • Treatment of Alzheimer's disease across the spectrum of severity
    • Shah S, Reichman WE. Treatment of Alzheimer's disease across the spectrum of severity. Clin Interv Aging 1(2): 131-42 (2006).
    • (2006) Clin Interv Aging , vol.1 , Issue.2 , pp. 131-142
    • Shah, S.1    Reichman, W.E.2
  • 5
    • 41049111771 scopus 로고    scopus 로고
    • Effectiveness of cholinesterase inhibitors and memantine for treating dementia: Evidence review for a clinical practice guideline
    • Raina P, Santaguida P, Ismaila A, Patterson C, Cowan D, Levine M, et al. Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. Ann Intern Med 148(5): 379-97 (2008).
    • (2008) Ann Intern Med , vol.148 , Issue.5 , pp. 379-397
    • Raina, P.1    Santaguida, P.2    Ismaila, A.3    Patterson, C.4    Cowan, D.5    Levine, M.6
  • 6
    • 0034904017 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled study of fluoxetine in depressed patients with Alzheimer's disease
    • Petracca GM, Chemerinski E, Starkstein SE. A double-blind, placebo-controlled study of fluoxetine in depressed patients with Alzheimer's disease. Int Psychogeriatr 13(2): 233-40 (2001).
    • (2001) Int Psychogeriatr , vol.13 , Issue.2 , pp. 233-240
    • Petracca, G.M.1    Chemerinski, E.2    Starkstein, S.E.3
  • 7
    • 0242288869 scopus 로고    scopus 로고
    • Fluoxetine in Alzheimer's disease with severe obsessive compulsive symptoms and a low density of serotonin transporter sites
    • Marksteiner J, Walch T, Bodner T, Gurka P, Donnemiller E. Fluoxetine in Alzheimer's disease with severe obsessive compulsive symptoms and a low density of serotonin transporter sites. Pharmacopsychiatry 36(5): 207-9 (2003).
    • (2003) Pharmacopsychiatry , vol.36 , Issue.5 , pp. 207-209
    • Marksteiner, J.1    Walch, T.2    Bodner, T.3    Gurka, P.4    Donnemiller, E.5
  • 9
    • 77955923792 scopus 로고    scopus 로고
    • Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans
    • Keowkase R, Aboukhatwa M, Luo Y. Fluoxetine protects against amyloid-beta toxicity, in part via daf-16 mediated cell signaling pathway, in Caenorhabditis elegans. Neuropharmacology 59(4-5): 358-65 (2010).
    • (2010) Neuropharmacology , vol.59 , Issue.4-5 , pp. 358-365
    • Keowkase, R.1    Aboukhatwa, M.2    Luo, Y.3
  • 10
    • 33750116129 scopus 로고    scopus 로고
    • Treatment of non cognitive symptoms of Alzheimer's disease
    • Grau-Veciana JM. [Treatment of non cognitive symptoms of Alzheimer's disease]. Revista de neurologia 42(8): 482-8 (2006).
    • (2006) Revista De Neurologia , vol.42 , Issue.8 , pp. 482-488
    • Grau-Veciana, J.M.1
  • 11
    • 0031786078 scopus 로고    scopus 로고
    • Depression and Alzheimer's disease
    • Tune LE. Depression and Alzheimer's disease. Depression and anxiety 8(1): 91-5 (1998).
    • (1998) Depression and Anxiety , vol.8 , Issue.1 , pp. 91-95
    • Tune, L.E.1
  • 12
    • 34548699679 scopus 로고    scopus 로고
    • Does serotonin augmentation have any effect on cognition and activities of daily living in Alzheimer's dementia? A double-blind, placebo-controlled clinical trial
    • Mowla A, Mosavinasab M, Haghshenas H, Borhani Haghighi A. Does serotonin augmentation have any effect on cognition and activities of daily living in Alzheimer's dementia? A double-blind, placebo-controlled clinical trial. J Clin Psychopharmacol 27(5): 484-7 (2007).
    • (2007) J Clin Psychopharmacol , vol.27 , Issue.5 , pp. 484-487
    • Mowla, A.1    Mosavinasab, M.2    Haghshenas, H.3    Borhani, H.A.4
  • 13
    • 75149138979 scopus 로고    scopus 로고
    • Efficacy of SSRIs on cognition of Alzheimer's disease patients treated with cholinesterase inhibitors
    • Rozzini L, Chilovi BV, Conti M, Bertoletti E, Zanetti M, Trabucchi M, et al. Efficacy of SSRIs on cognition of Alzheimer's disease patients treated with cholinesterase inhibitors. Int Psychogeriatr 22(1): 114-9 (2010).
    • (2010) Int Psychogeriatr , vol.22 , Issue.1 , pp. 114-119
    • Rozzini, L.1    Chilovi, B.V.2    Conti, M.3    Bertoletti, E.4    Zanetti, M.5    Trabucchi, M.6
  • 14
    • 84896764452 scopus 로고    scopus 로고
    • Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease
    • Born HA, Kim JY, Savjani RR, Das P, Dabaghian YA, Guo QX, et al. Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease. J Neurosci 34(11): 3826-40 (2014).
    • (2014) J Neurosci , vol.34 , Issue.11 , pp. 3826-3840
    • Born, H.A.1    Kim, J.Y.2    Savjani, R.R.3    Das, P.4    Dabaghian, Y.A.5    Guo, Q.X.6
  • 15
    • 84859422726 scopus 로고    scopus 로고
    • Preclinical antiepileptic actions of selective serotonin reuptake inhibitors--implications for clinical trial design
    • Igelstrom KM. Preclinical antiepileptic actions of selective serotonin reuptake inhibitors--implications for clinical trial design. Epilepsia 53(4): 596-605 (2012).
    • (2012) Epilepsia , vol.53 , Issue.4 , pp. 596-605
    • Igelstrom, K.M.1
  • 16
    • 49449113629 scopus 로고    scopus 로고
    • Depression after status epilepticus: Behavioural and biochemical deficits and effects of fluoxetine
    • Mazarati A, Siddarth P, Baldwin RA, Shin D, Caplan R, Sankar R. Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine. Brain: J Neurol 131(Pt 8): 2071-83 (2008).
    • (2008) Brain: J Neurol , vol.131 , Issue.Pt 8 , pp. 2071-2083
    • Mazarati, A.1    Siddarth, P.2    Baldwin, R.A.3    Shin, D.4    Caplan, R.5    Sankar, R.6
  • 18
    • 84868089366 scopus 로고    scopus 로고
    • Fluoxetine induces vasodilatation of cerebral arterioles by co-modulating NO/muscarinic signalling
    • Ofek K, Schoknecht K, Melamed-Book N, Heinemann U, Friedman A, Soreq H. Fluoxetine induces vasodilatation of cerebral arterioles by co-modulating NO/muscarinic signalling. J Cell Mol Med 16(11): 2736-44 (2012).
    • (2012) J Cell Mol Med , vol.16 , Issue.11 , pp. 2736-2744
    • Ofek, K.1    Schoknecht, K.2    Melamed-Book, N.3    Heinemann, U.4    Friedman, A.5    Soreq, H.6
  • 19
    • 3042524560 scopus 로고    scopus 로고
    • The effects of fluoxetine on cognitive functions in animal model of Alzheimer's disease
    • Ivkovic M, Damjanovic A, Jasovic-Gasic M, Paunovic VR. The effects of fluoxetine on cognitive functions in animal model of Alzheimer's disease. Psychiatria Danubina 16(1-2): 15-20 (2004).
    • (2004) Psychiatria Danubina , vol.16 , Issue.1-2 , pp. 15-20
    • Ivkovic, M.1    Damjanovic, A.2    Jasovic-Gasic, M.3    Paunovic, V.R.4
  • 20
    • 77249109792 scopus 로고    scopus 로고
    • Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer's disease
    • Toledo EM, Inestrosa NC. Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer's disease. Molecular Psychiatry 15(3): 272-85+28 (2010).
    • (2010) Molecular Psychiatry , vol.15 , Issue.3
    • Toledo, E.M.1    Inestrosa, N.C.2
  • 21
    • 9644252796 scopus 로고    scopus 로고
    • Longitudinal observation on CSF Abeta42 levels in young to middle-aged amyloid precursor protein/presenilin-1 doubly transgenic mice
    • Liu L, Herukka SK, Minkeviciene R, van Groen T, Tanila H. Longitudinal observation on CSF Abeta42 levels in young to middle-aged amyloid precursor protein/presenilin-1 doubly transgenic mice. Neurobiol Dis 17(3): 516-23 (2004).
    • (2004) Neurobiol Dis , vol.17 , Issue.3 , pp. 516-523
    • Liu, L.1    Herukka, S.K.2    Minkeviciene, R.3    van Groen, T.4    Tanila, H.5
  • 22
    • 45549101680 scopus 로고    scopus 로고
    • Quetiapine facilitates oligodendrocyte development and prevents mice from myelin breakdown and behavioral changes
    • Xiao L, Xu H, Zhang Y, Wei Z, He J, Jiang W, et al. Quetiapine facilitates oligodendrocyte development and prevents mice from myelin breakdown and behavioral changes. Molecular Psychiatry 13(7): 697-708 (2008).
    • (2008) Molecular Psychiatry , vol.13 , Issue.7 , pp. 697-708
    • Xiao, L.1    Xu, H.2    Zhang, Y.3    Wei, Z.4    He, J.5    Jiang, W.6
  • 23
    • 67349203223 scopus 로고    scopus 로고
    • Beneficial effects of quetiapine in a transgenic mouse model of Alzheimer's disease
    • He J, Luo H, Yan B, Yu Y, Wang H, Wei Z, et al. Beneficial effects of quetiapine in a transgenic mouse model of Alzheimer's disease. Neurobiol Aging 30(8): 1205-16 (2009).
    • (2009) Neurobiol Aging , vol.30 , Issue.8 , pp. 1205-1216
    • He, J.1    Luo, H.2    Yan, B.3    Yu, Y.4    Wang, H.5    Wei, Z.6
  • 24
    • 84890128743 scopus 로고    scopus 로고
    • Effects of neural stem cells on synaptic proteins and memory in a mouse model of Alzheimer's disease
    • Zhang W, Wang GM, Wang PJ, Zhang Q, Sha SH. Effects of neural stem cells on synaptic proteins and memory in a mouse model of Alzheimer's disease. J Neurosci Res 92(2): 185-94 (2014).
    • (2014) J Neurosci Res , vol.92 , Issue.2 , pp. 185-194
    • Zhang, W.1    Wang, G.M.2    Wang, P.J.3    Zhang, Q.4    Sha, S.H.5
  • 25
    • 72449208698 scopus 로고    scopus 로고
    • Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway
    • Canas PM, Porciuncula LO, Cunha GM, Silva CG, Machado NJ, Oliveira JM, et al. Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway. J Neurosci 29(47): 14741-51 (2009).
    • (2009) J Neurosci , vol.29 , Issue.47 , pp. 14741-14751
    • Canas, P.M.1    Porciuncula, L.O.2    Cunha, G.M.3    Silva, C.G.4    Machado, N.J.5    Oliveira, J.M.6
  • 26
    • 67249087641 scopus 로고    scopus 로고
    • Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake
    • Li S, Hong S, Shepardson NE, Walsh DM, Shankar GM, Selkoe D. Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron 62(6): 788-801 (2009).
    • (2009) Neuron , vol.62 , Issue.6 , pp. 788-801
    • Li, S.1    Hong, S.2    Shepardson, N.E.3    Walsh, D.M.4    Shankar, G.M.5    Selkoe, D.6
  • 27
    • 49149124343 scopus 로고    scopus 로고
    • Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
    • Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, et al. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 14(8): 837-42 (2008).
    • (2008) Nat Med , vol.14 , Issue.8 , pp. 837-842
    • Shankar, G.M.1    Li, S.2    Mehta, T.H.3    Garcia-Munoz, A.4    Shepardson, N.E.5    Smith, I.6
  • 28
    • 84881496428 scopus 로고    scopus 로고
    • Activity- Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway
    • Das U, Scott DA, Ganguly A, Koo EH, Tang Y, Roy S. Activity- Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway. Neuron 79(3): 447-60 (2013).
    • (2013) Neuron , vol.79 , Issue.3 , pp. 447-460
    • Das, U.1    Scott, D.A.2    Ganguly, A.3    Koo, E.H.4    Tang, Y.5    Roy, S.6
  • 29
    • 54949130109 scopus 로고    scopus 로고
    • Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease
    • Sanchez-Mejia RO, Newman JW, Toh S, Yu GQ, Zhou Y, Halabisky B, et al. Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease. Nat Neurosci 11(11): 1311-8 (2008).
    • (2008) Nat Neurosci , vol.11 , Issue.11 , pp. 1311-1318
    • Sanchez-Mejia, R.O.1    Newman, J.W.2    Toh, S.3    Yu, G.Q.4    Zhou, Y.5    Halabisky, B.6
  • 30
    • 77955046461 scopus 로고    scopus 로고
    • SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10
    • Donmez G, Wang D, Cohen DE, Guarente L. SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell 142(2): 320-32 (2010).
    • (2010) Cell , vol.142 , Issue.2 , pp. 320-332
    • Donmez, G.1    Wang, D.2    Cohen, D.E.3    Guarente, L.4
  • 31
    • 0028295848 scopus 로고
    • Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein
    • Suzuki T, Oishi M, Marshak DR, Czernik AJ, Nairn AC, Greengard P. Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein. The EMBO J 13(5): 1114-22 (1994).
    • (1994) The EMBO J , vol.13 , Issue.5 , pp. 1114-1122
    • Suzuki, T.1    Oishi, M.2    Marshak, D.R.3    Czernik, A.J.4    Nairn, A.C.5    Greengard, P.6
  • 32
    • 20944448555 scopus 로고    scopus 로고
    • Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial
    • Gilman S, Koller M, Black RS, Jenkins L, Griffith SG, Fox NC, et al. Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial. Neurology 64(9): 1553-62 (2005).
    • (2005) Neurology , vol.64 , Issue.9 , pp. 1553-1562
    • Gilman, S.1    Koller, M.2    Black, R.S.3    Jenkins, L.4    Griffith, S.G.5    Fox, N.C.6
  • 33
    • 26444606932 scopus 로고    scopus 로고
    • Immunotherapy for Alzheimer disease: The promise and the problem
    • Rosenberg RN. Immunotherapy for Alzheimer disease: the promise and the problem. Arch Neurol 62(10): 1506-7 (2005).
    • (2005) Arch Neurol , vol.62 , Issue.10 , pp. 1506-1507
    • Rosenberg, R.N.1
  • 34
    • 13444293174 scopus 로고    scopus 로고
    • Defining molecular targets to prevent Alzheimer disease
    • Selkoe DJ. Defining molecular targets to prevent Alzheimer disease. Arch Neurol 62(2): 192-5 (2005).
    • (2005) Arch Neurol , vol.62 , Issue.2 , pp. 192-195
    • Selkoe, D.J.1
  • 35
    • 2542427690 scopus 로고    scopus 로고
    • Oligomers on the brain: The emerging role of soluble protein aggregates in neurodegeneration
    • Walsh DM, Selkoe DJ. Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration. Protein Pept Lett 11(3): 213-28 (2004).
    • (2004) Protein Pept Lett , vol.11 , Issue.3 , pp. 213-228
    • Walsh, D.M.1    Selkoe, D.J.2
  • 36
    • 0031914718 scopus 로고    scopus 로고
    • Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes
    • Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nature Med 4(1): 97-100 (1998).
    • (1998) Nature Med , vol.4 , Issue.1 , pp. 97-100
    • Holcomb, L.1    Gordon, M.N.2    McGowan, E.3    Yu, X.4    Benkovic, S.5    Jantzen, P.6
  • 37
    • 79955749452 scopus 로고    scopus 로고
    • The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease
    • McClean PL, Parthsarathy V, Faivre E, Holscher C. The Diabetes Drug Liraglutide Prevents Degenerative Processes in a Mouse Model of Alzheimer's Disease. J Neurosci 31(17): 6587-94 (2011).
    • (2011) J Neurosci , vol.31 , Issue.17 , pp. 6587-6594
    • McClean, P.L.1    Parthsarathy, V.2    Faivre, E.3    Holscher, C.4
  • 38
    • 33846222301 scopus 로고    scopus 로고
    • Does fluoxetine have any effect on the cognition of patients with mild cognitive impairment? A double-blind, placebo-controlled, clinical trial
    • Mowla A, Mosavinasab M, Pani A. Does fluoxetine have any effect on the cognition of patients with mild cognitive impairment? A double-blind, placebo-controlled, clinical trial. J Clin Psychopharmacol 27(1): 67-70 (2007).
    • (2007) J Clin Psychopharmacol , vol.27 , Issue.1 , pp. 67-70
    • Mowla, A.1    Mosavinasab, M.2    Pani, A.3
  • 39
    • 34147157711 scopus 로고    scopus 로고
    • Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden
    • Malm TM, Iivonen H, Goldsteins G, Keksa-Goldsteine V, Ahtoniemi T, Kanninen K, et al. Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden. J Neurosci 27(14): 3712-21 (2007).
    • (2007) J Neurosci , vol.27 , Issue.14 , pp. 3712-3721
    • Malm, T.M.1    Iivonen, H.2    Goldsteins, G.3    Keksa-Goldsteine, V.4    Ahtoniemi, T.5    Kanninen, K.6
  • 41
    • 84871397626 scopus 로고    scopus 로고
    • Cholinergic degeneration is associated with increased plaque deposition and cognitive impairment in APPswe/PS1dE9 mice
    • Laursen B, Mork A, Plath N, Kristiansen U, Bastlund JF. Cholinergic degeneration is associated with increased plaque deposition and cognitive impairment in APPswe/PS1dE9 mice. Behavioural Brain Res 240: 146-52 (2013).
    • (2013) Behavioural Brain Res , vol.240 , pp. 146-152
    • Laursen, B.1    Mork, A.2    Plath, N.3    Kristiansen, U.4    Bastlund, J.F.5
  • 42
    • 37549022563 scopus 로고    scopus 로고
    • Changes in readthrough acetylcholinesterase expression modulate amyloid-beta pathology
    • Berson A, Knobloch M, Hanan M, Diamant S, Sharoni M, Schuppli D, et al. Changes in readthrough acetylcholinesterase expression modulate amyloid-beta pathology. Brain 131: 109-19 (2008).
    • (2008) Brain , vol.131 , pp. 109-119
    • Berson, A.1    Knobloch, M.2    Hanan, M.3    Diamant, S.4    Sharoni, M.5    Schuppli, D.6
  • 43
    • 84864795907 scopus 로고    scopus 로고
    • Cholinergic-associated loss of hnRNP-A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice
    • Berson A, Barbash S, Shaltiel G, Goll Y, Hanin G, Greenberg DS, et al. Cholinergic-associated loss of hnRNP-A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice. Embo Mol Med 4(8): 730-42 (2012).
    • (2012) Embo Mol Med , vol.4 , Issue.8 , pp. 730-742
    • Berson, A.1    Barbash, S.2    Shaltiel, G.3    Goll, Y.4    Hanin, G.5    Greenberg, D.S.6
  • 44
    • 0031949925 scopus 로고    scopus 로고
    • The cholinergic hypothesis of neuropsychiatric symptoms in Alzheimer's disease
    • Cummings JL, Back C. The cholinergic hypothesis of neuropsychiatric symptoms in Alzheimer's disease. Am J Geriatr Psychiatry 6(2 Suppl 1): S64-78 (1998).
    • (1998) Am J Geriatr Psychiatry , vol.6 , Issue.SUPPL. 1
    • Cummings, J.L.1    Back, C.2
  • 45
    • 84874506923 scopus 로고    scopus 로고
    • Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior
    • Mineur YS, Obayemi A, Wigestrand MB, Fote GM, Calarco CA, Li AM, et al. Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior. Proc Natl Acad Sci U S A 110(9): 3573-78 (2013).
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.9 , pp. 3573-3578
    • Mineur, Y.S.1    Obayemi, A.2    Wigestrand, M.B.3    Fote, G.M.4    Calarco, C.A.5    Li, A.M.6


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