Determination of Neotame by High-Performance Capillary Electrophoresis Using ß-cyclodextrin as a Chiral Selector

Analytical Letters

Volumn 47, Issue 17, 2014, Pages 2795-2812

  Bathinapatla, Ayyappa ^a   Kanchi, Suvardhan ^a   Singh, Parvesh ^b   Sabela, Myalowenkosi I ^a   Bisetty, Krishna ^a  

^a DURBAN UNIVERSITY OF TECHNOLOGY   (South Africa)

^b UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

Diastereomers; Electrokinetic chromatography (EKC); Food samples; Heptakis 2,3,6 tri o methylbetacyclodextrin; Molecular docking; Neotame

Indexed keywords

EID: 84906860708     PISSN: 00032719     EISSN: 1532236X     Source Type: Journal    
DOI: 10.1080/00032719.2014.924008     Document Type: Article

References (37)

1. Alghamdi, A. H., A. F. Alghamdi, and A. A. Alwarthan. 2005. Determination of content levels of some food additives in beverages consumed in Riyadh city. J. King Saud Univ. 18: 99 - 109.
2. Banerjee, A., E. Mikhailova, S. Cheley, L. Q. Gu, M. Montoya, Y. Nagaoka, E. Gouaux., and H. Bayley. 2010. Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores. Proc. Natl. Acad. Sci. USA. 107: 8165 - 8170.
3. Berset, J. D., and N. Ochsenbein. 2012. Stability considerations of aspartame in the direct analysis of artificial sweeteners in water samples using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Chemosphere. 88: 563 - 569.
4. Buchgraber, M., and A. Wasik. 2009. Determination of nine intense sweeteners in foodstuffs by high-performance liquid chromatography and evaporative light-scattering detection: Interlaboratory study. J. Assoc. Off. Anal. Chem. Int. 92: 208 - 222.
5. Chankvetadze, B., and G. Blaschke. 2001. Enantio separations in capillary electromigration techniques: Recent developments and future trends. J. Chromatogr. A. 906: 309 - 363.
6. Fisher, R. S. 1989. Aspartame, neurotoxicity and seizures: A review. J. Epilepsy. 2(2): 55 - 64.
7. Gan, Z., H. Sun, R. Wang, and B. Feng. 2013. A novel solid-phase extraction for the concentration of sweeteners in water and analysis by ion-pair liquid chromatography-triple quadrupole mass spectrometry. J. Chromatogr. A. 1274: 87 - 96.
8. Giuffrida, A., R. Caruso, M. Messina, G. Maccarrone, A. Contino, A. Cifuentes, and V. Cucinotta. 2012. Chiral separation of amino acids derivatized with fluorescein isothiocyanate by single isomer derivatives 3-monodeoxy-3-monoamino-β- and γ-cyclodextrins: The effect of the cavity size. J. Chromatogr. A. 1269: 360 - 365.
9. Hassan, Y. A. E. 2001. High-performance liquid chromatographic enantioseparation of drugs containing multiple chiral centers on polysaccharide-type chiral stationary phases. J. Chromatogr. A. 906: 185 - 193.
10. He, Y. C., S. Fang, and X. J. Xu. 2013. Simultanious determination of acesulfame-K, aspartame and stevioside in sweetener blends by ultraviolet spectroscopy with variable selection by sipls algorithm. Maced. J. Chem. Chem. Eng. 31: 17-28.
11. Hu, F., L. Xu, F. Luan, H. Liu, and Y. Gao. 2013. Determination of neotame in non-alcoholic beverage by capillary zone electrophoresis. J. Sci. Food Agric. 93: 3334 - 3338.
12. Hui, L. C., L. S. Juan, A. Juan, and L. J. Zhong. 2009. Simultaneous determination of various kinds of synthetic sweeteners in foods by RPLC/MS/MS. Sci. Technol. Food Ind. 30: 319 - 320.
13. Ji, C., Y. Sun, X. Li, X. Chu, and Z. Chen. 2009. Simultaneous determination of artificial sweeteners in beverage by ultra-performance liquid chromatography. Chin. J. Chromatogr. 27: 111 - 113.
14. Jizhi, C., L. Jie, and L. Jinhua. 2009. Determination of neotame in food by high performance liquid chromatography. Guangdong Chem. Ind. 36: 176 - 188.
15. Lim, H. S., S. K. Park, K. I. S. Kwak, H. Kim, J. H. Sung, S. J. Jang, M. Y. Byun, and S. H. Kim. 2013. HPLC-MS/MS analysis of 9 artificial sweeteners in imported foods. Food Sci. Biotechnol. 22: 233 - 240.
16. Matsumoto, H., K. Hirata, N. Sakamaki, K. Hagino, and H. Ushiyama. 2008. Simultaneous determination of neotame, alitame and aspartame in foods by HPLC. Shokuhin Eiseigaku Zasshi 49: 31 - 36.
17. Mayhew, D. A., C. P. Comer, and W. W. Stargel. 2003. Food consumption and body weight changes with neotame, a new sweetener with intense taste: Differentiating effects of palatability from toxicity in dietary safety studies. Regul. Toxicol. Pharm. 38: 124 - 143.
18. Min, L. L., and P. J. Dong. 2008. Simultaneous determination of five sweeteners by reversed-phase high performance liquid chromatography. J. Instrum. Anal. 27: 549 - 552.
19. National Standard Method of China. 2009. Method for the determination of neotame in foods - high-performance liquid chromatography. GB 23378-2009.
20. Nofre, C., and J. M. Tinti. 2000. Neotame: Discovery, properties, utility. Food Chem. 69: 245 - 257.
21. Peter, A., E. Vekes, and D. W. Armstrong. 2002. Effects of temperature on retention of chiral compounds on a ristocetinA chiral stationary phase. J. Chromatogr. A 958: 89 - 107.
22. Prakash, I., I. Bishay, and S. Schroeder. 1999. Neotame: Synthesis, stereochemistry and sweetness. Synth. Commun. 29: 4461 - 4467.
23. Sabela, M. I., P. Singh, N. J. Gumede, K. Bisetty, and S. Sagrado. 2012. Evaluation of enantiomer resolution of (±)-catechin using electrokinetic chromatography and molecular docking. J. Sci. Res. Pharm. 1(2): 1 - 4.
24. Scientific opinion of the Panel on Food Additives, Flavorings, Processing Aids, and Materials in Contact with Food on a request from European Commission on neotame as a sweetener, and flavor enhancer. 2007. EFSAJ. 581: 1-3.
25. Scheurer, M., H. J. Brauch, and F. T. Lange. 2009. Analysis and occurrence of seven artificial sweeteners in German waste water and surface water and in soil aquifer treatment (SAT). Anal. Bioanal. Chem. 394: 1585 - 1594.
26. Tomasik, P. 2004. Chemical and functional properties of food saccharides. CRC Press LLC, 397 p.
27. United States Food and Drug Administration. 2013. Department of Health and Human Services, Code of Federal Regulations Title 21 (21CFR172.829) Vol. 3, Revised as of April, 2013.
28. Vianna-Soares, C. D., and J. L. S. Martins. 2002. Saccharin analysis in pharmaceutical and cosmetic preparations by derivative ultraviolet spectrophotometry. Braz. J. Pharm. Sci. 38: 471 - 478.
29. Wasik, A., J. McCourt, and M. Buchgraber. 2007. Simultaneous determination of nine intense sweeteners in foodstuffs by high performance liquid chromatography and evaporative light scattering detection-Development and single-laboratory validation. J. Chromatogr. A. 1157: 187 - 196.
30. Wu, G., D. H. Robertson, C. L. Brooks III, and M. Vieth. 2003. Detailed analysis of grid-based molecular docking: A case study of CDOCKER-A CHARMm-based MD docking algorithm. J. Comp. Chem. 24: 1549-1562.
31. Wu, S. J., H. X. Wang, and G. J. Tao. 2010. Ultra-high pressure liquid chromatography-mass spectrometry method for simultaneous determination of six micro-sweeteners in distilled spirit. J. Food Sci. Biotechnol. 29: 670 - 675.
32. Yang, D., and B. Chen. 2009. Simultaneous determination of non-nutritive sweeteners in foods by HPLC/ESI-MS. J. Agric. Food. Chem. 57: 3022 - 3027.
33. Yang, D., and B. Chen. 2010. Determination of neotame in beverages, cakes and preserved fruits by column-switching high-performance liquid chromatography. Food Addit. Contam. Part A 27: 1221 - 1225.
34. Zhao, Y. G., M. Q. Cai, X. H. Chen, S. D. Pan, S. S. Yao, and M. C. Jin. 2013. Analysis of nine food additives in wine by dispersive solid-phase extraction and reversed-phase high performance liquid chromatography. Food Res. Int. 52: 350 - 358.
35. Zhao, Y., X. Chen, X. Li, S. Yao, and M. Jin. 2011. Influences of ion-suppressors on retention behaviors of nine food additives in reversed-phase high performance liquid chromatographic separation. Chin. J. Chromatogr. 29: 988 - 994.
36. Zhao, Y. G., X. H. Chen, S. S. Yao, S. D. Pan, X. P. Li, and M. C. Jin. 2012. Analysis of nine food additives in red wine by ion-suppression reversed phase high-performance liquid chromatography using trifluoroaceticacid and ammonium acetate as ion-suppressors. Anal. Sci. 28: 967 - 971.
37. Zygler, A., A. Wasik, A. Kot-Wasik, and J. Namiésnik. 2011. Determination of nine high-intensity sweeteners in various foods by high-performance liquid chromatography with mass spectrometric detection. Anal. Bioanal. Chem. 400: 2159 - 2172.