SCM-198 inhibits microglial overactivation and attenuates Aβ1-40-induced cognitive impairments in rats via JNK and NF-k{cyrillic}B pathways

Journal of Neuroinflammation

Volumn 11, Issue 1, 2014, Pages

  Hong, Zhen Yi ^a   Shi, Xue Ru ^a   Zhu, Kai ^a   Wu, Ting Ting ^a   Zhu, Yi Zhun ^a,b  

^a FUDAN UNIVERSITY   (China)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Alzheimer's disease; Co culture; Lipopolysaccharide; Microglia; Morris water maze; Neuroinflammation; Primary neuron; SCM 198; Amyloid1 40

Indexed keywords

4 GUANIDINO N BUTYL SYRINGATE; ALKALOID DERIVATIVE; AMYLOID BETA PROTEIN[1-40]; DONEPEZIL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TAU PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; CYTOKINE; GALLIC ACID; LEONURINE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; NEUROPROTECTIVE AGENT; PEPTIDE FRAGMENT;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENTIATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROGLIA; NERVE CELL NECROSIS; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN CORTEX; CELL CULTURE; CELL SURVIVAL; CHEMICALLY INDUCED; COCULTURE; COGNITION DISORDERS; CYTOLOGY; DRUG EFFECTS; GENETICS; MAZE TEST; METABOLISM; NERVE CELL; NEWBORN; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

AMYLOID BETA-PEPTIDES; ANIMALS; ANIMALS, NEWBORN; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; COCULTURE TECHNIQUES; COGNITION DISORDERS; CYTOKINES; GALLIC ACID; L-LACTATE DEHYDROGENASE; MALE; MAP KINASE KINASE 4; MAZE LEARNING; MICROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; NF-KAPPA B; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 84906859422     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-014-0147-x     Document Type: Article

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