메뉴 건너뛰기




Volumn 65, Issue 4, 2014, Pages 469-476

Metabolic modulators of the exercise response: Doping control analysis of an agonist of the peroxisome proliferator-activated receptor δ (GW501516) and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR)

Author keywords

Adenosine monophosphate activated protein kinase; Anti doping; Peroxisome proliferator activated receptor; Peroxisome proliferator activated receptor coactivator 1 alpha; Physical performance; Sport

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE; AICA RIBONUCLEOTIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; RIBONUCLEOTIDE; THIAZOLE DERIVATIVE; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID;

EID: 84906853694     PISSN: 08675910     EISSN: 18991505     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (28)

References (69)
  • 1
    • 84906866669 scopus 로고    scopus 로고
    • http://ec.europa.eu/sport.
  • 2
    • 84906866670 scopus 로고    scopus 로고
    • http://www.who.int/dietphysicalactivity.
  • 3
    • 84906866671 scopus 로고    scopus 로고
    • http://www.cdc.gov.
  • 4
    • 34347214464 scopus 로고    scopus 로고
    • Impact of selected risk factors on expected lifetime without long-standing, limiting illness in Denmark
    • Bronnum-Hansen H, Juel K, Davidsen M, Sorensen J. Impact of selected risk factors on expected lifetime without long-standing, limiting illness in Denmark. Prev Med 2007; 45: 49-53.
    • (2007) Prev Med , vol.45 , pp. 49-53
    • Bronnum-Hansen, H.1    Juel, K.2    Davidsen, M.3    Sorensen, J.4
  • 5
    • 48449094498 scopus 로고    scopus 로고
    • AMPK and PPARd agonists are exercise mimetics
    • Narkar VA, Downes M, Yu RT, et al. AMPK and PPARd agonists are exercise mimetics. Cell 2008; 134: 405-415.
    • (2008) Cell , vol.134 , pp. 405-415
    • Narkar, V.A.1    Downes, M.2    Yu, R.T.3
  • 6
    • 84893146305 scopus 로고    scopus 로고
    • PPARd activation in human myotubes increases mitochondrial fatty acid oxidative capacity and reduces glucose utilization by a switch in substrate preference
    • Feng YZ, Nikolic N, Bakke SS, et al. PPARd activation in human myotubes increases mitochondrial fatty acid oxidative capacity and reduces glucose utilization by a switch in substrate preference. Arch Physiol Biochem 2014; 120: 12-21.
    • (2014) Arch Physiol Biochem , vol.120 , pp. 12-21
    • Feng, Y.Z.1    Nikolic, N.2    Bakke, S.S.3
  • 7
    • 84901366691 scopus 로고    scopus 로고
    • Use of metformin alone is not associated with survival outcomes of colorectal cancer cell but AMPK activator AICAR sensitizes anticancer effect of 5-fluorouracil through AMPK activation
    • Sui X, Xu Y, Yang J, et al. Use of metformin alone is not associated with survival outcomes of colorectal cancer cell but AMPK activator AICAR sensitizes anticancer effect of 5-fluorouracil through AMPK activation. PLoS One 2014; 9: e97781.
    • (2014) PLoS One , vol.9
    • Sui, X.1    Xu, Y.2    Yang, J.3
  • 9
    • 84877329207 scopus 로고    scopus 로고
    • PPARg signaling and metabolism: The good, the bad and the future
    • Ahmadian M, Suh JM, Hah N, et al. PPARg signaling and metabolism: the good, the bad and the future. Nat Med 2013; 19: 557-566.
    • (2013) Nat Med , vol.19 , pp. 557-566
    • Ahmadian, M.1    Suh, J.M.2    Hah, N.3
  • 11
    • 0036839889 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor alpha and gamma agonists upregulate human macrophage lipoprotein lipase expression
    • Li L, Beauchamp MC, Renier G. Peroxisome proliferatoractivated receptor alpha and gamma agonists upregulate human macrophage lipoprotein lipase expression. Atherosclerosis 2002; 165: 101-110.
    • (2002) Atherosclerosis , vol.165 , pp. 101-110
    • Li, L.1    Beauchamp, M.C.2    Renier, G.3
  • 12
    • 84888213779 scopus 로고    scopus 로고
    • Comparison of anti-inflammatory properties of peroxisome proliferatoractivated receptor gamma agonists rosiglitazone and troglitazone in prophylactic treatment of experimental colitis
    • Celinski K, Dworzanski T, Fornal R, et al. Comparison of anti-inflammatory properties of peroxisome proliferatoractivated receptor gamma agonists rosiglitazone and troglitazone in prophylactic treatment of experimental colitis. J Physiol Pharmacol 2013; 64: 587-595.
    • (2013) J Physiol Pharmacol , vol.64 , pp. 587-595
    • Celinski, K.1    Dworzanski, T.2    Fornal, R.3
  • 13
    • 0029609755 scopus 로고
    • PPAR: A mediator of peroxisome proliferator action
    • Green S. PPAR: a mediator of peroxisome proliferator action. Mutat Res 1995; 333: 101-109.
    • (1995) Mutat Res , vol.333 , pp. 101-109
    • Green, S.1
  • 14
    • 73449096390 scopus 로고    scopus 로고
    • Similar expression of oxidative genes after interval and continuous exercise
    • Wang L, Psilander N, Tonkonogi M, Ding S, Sahlin K. Similar expression of oxidative genes after interval and continuous exercise. Med Sci Sports Exerc 2009; 41: 2136-2144.
    • (2009) Med Sci Sports Exerc , vol.41 , pp. 2136-2144
    • Wang, L.1    Psilander, N.2    Tonkonogi, M.3    Ding, S.4    Sahlin, K.5
  • 15
    • 8844276054 scopus 로고    scopus 로고
    • Regulation of muscle fiber type and running endurance by PPARdelta
    • Wang YX, Zhang CL, Yu RT, et al. Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol 2004; 2: 1532-1539.
    • (2004) PLoS Biol , vol.2 , pp. 1532-1539
    • Wang, Y.X.1    Zhang, C.L.2    Yu, R.T.3
  • 16
    • 33947171948 scopus 로고    scopus 로고
    • Genetic model for the chronic activation of skeletal muscle AMP-activated protein kinase leads to glycogen accumulation
    • Barre L, Richardson C, Hirshman MF, et al. Genetic model for the chronic activation of skeletal muscle AMP-activated protein kinase leads to glycogen accumulation. Am J Physiol Endocrinol Metab J 2007; 292: E802-E811.
    • (2007) Am J Physiol Endocrinol Metab J , vol.292
    • Barre, L.1    Richardson, C.2    Hirshman, M.F.3
  • 17
    • 56549125328 scopus 로고    scopus 로고
    • Are "exercise pills" the answer to the growing problem of physical inactivity?
    • Warden SJ, Fuchs RK. Are "exercise pills" the answer to the growing problem of physical inactivity? Br J Sports Med 2008; 42: 862-863.
    • (2008) Br J Sports Med , vol.42 , pp. 862-863
    • Warden, S.J.1    Fuchs, R.K.2
  • 18
    • 65649085174 scopus 로고    scopus 로고
    • Exercise: It's the real thing!
    • Hawley JA, Holloszy JO. Exercise: it's the real thing! Nutr Rev 2009; 67: 172-178.
    • (2009) Nutr Rev , vol.67 , pp. 172-178
    • Hawley, J.A.1    Holloszy, J.O.2
  • 19
    • 54949149122 scopus 로고    scopus 로고
    • The exercise pill - too good to be true?
    • Goodyear LJ. The exercise pill - too good to be true? N Engl J Med 2008; 359: 1842-1844.
    • (2008) N Engl J Med , vol.359 , pp. 1842-1844
    • Goodyear, L.J.1
  • 20
    • 33644645013 scopus 로고    scopus 로고
    • PPARd: A dagger in the heart of the metabolic syndrome
    • Barish GD, Narkar VA, Evans RM. PPARd: a dagger in the heart of the metabolic syndrome. J Clin Invest 2006; 116: 590-597.
    • (2006) J Clin Invest , vol.116 , pp. 590-597
    • Barish, G.D.1    Narkar, V.A.2    Evans, R.M.3
  • 21
    • 77956859042 scopus 로고    scopus 로고
    • Endurance exercise mimetics in skeletal muscle
    • Matsakas A, Narkar VA. Endurance exercise mimetics in skeletal muscle. Curr Sports Med Rep 2010; 9: 227-232.
    • (2010) Curr Sports Med Rep , vol.9 , pp. 227-232
    • Matsakas, A.1    Narkar, V.A.2
  • 22
    • 0037067666 scopus 로고    scopus 로고
    • The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signalling pathways
    • Fryer LG, Parbu-Patel A, Carling D. The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signalling pathways. J Biol Chem 2002; 277: 25226-25232.
    • (2002) J Biol Chem , vol.277 , pp. 25226-25232
    • Fryer, L.G.1    Parbu-Patel, A.2    Carling, D.3
  • 23
    • 33644664433 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor PPARa activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: Comparison of activation of PPARa, PPARg, and their combination
    • Tsuchida A, Yamauchi T, Takekawa S, et al. Peroxisome proliferator-activated receptor PPARa activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARa, PPARg, and their combination. Diabetes 2005; 54: 3358-3370.
    • (2005) Diabetes , vol.54 , pp. 3358-3370
    • Tsuchida, A.1    Yamauchi, T.2    Takekawa, S.3
  • 24
    • 84906866672 scopus 로고    scopus 로고
    • http://www.sec.gov
  • 25
    • 0029994543 scopus 로고    scopus 로고
    • Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
    • Schoonjans K, Staels B, Auwerx J. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res 1996; 37: 907-925.
    • (1996) J Lipid Res , vol.37 , pp. 907-925
    • Schoonjans, K.1    Staels, B.2    Auwerx, J.3
  • 26
    • 0036307179 scopus 로고    scopus 로고
    • Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome
    • Buhl ES, Jessen N, Pold R, et al. Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome. Diabetes 2002; 51: 2199-2206.
    • (2002) Diabetes , vol.51 , pp. 2199-2206
    • Buhl, E.S.1    Jessen, N.2    Pold, R.3
  • 27
    • 0036788292 scopus 로고    scopus 로고
    • AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats
    • Iglesias MI, Ye JM, Frangioudakis G, et al. AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats. Diabetes 2002; 51: 2886-2894.
    • (2002) Diabetes , vol.51 , pp. 2886-2894
    • Iglesias, M.I.1    Ye, J.M.2    Frangioudakis, G.3
  • 28
    • 79955623949 scopus 로고    scopus 로고
    • AICAR inhibits cancer cell growth and triggers cell-type distinct effects on OXPHOS biogenesis, oxidative stress and Akt activation
    • Jose C, Hebert-Chatelain E, Bellance N, et al. AICAR inhibits cancer cell growth and triggers cell-type distinct effects on OXPHOS biogenesis, oxidative stress and Akt activation. Biochim Biophys Acta 2011; 1807: 707-718.
    • (2011) Biochim Biophys Acta , vol.1807 , pp. 707-718
    • Jose, C.1    Hebert-Chatelain, E.2    Bellance, N.3
  • 29
    • 84856694906 scopus 로고    scopus 로고
    • AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation
    • Lanner JT, Georgiou DK, Dagnino-Acosta A, et al. AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. Nat Med 2012; 18: 244-251.
    • (2012) Nat Med , vol.18 , pp. 244-251
    • Lanner, J.T.1    Georgiou, D.K.2    Dagnino-Acosta, A.3
  • 30
    • 84906881268 scopus 로고    scopus 로고
    • AICAR induces cell death in LKB1-deficient NSCLC
    • Liu F, Zhou W, Liu X, et al. AICAR induces cell death in LKB1-deficient NSCLC. Cancer Res 2013; 73 (Suppl. 8): 1975.
    • (2013) Cancer Res , vol.73 , Issue.SUPPL. 8 , pp. 1975
    • Liu, F.1    Zhou, W.2    Liu, X.3
  • 31
    • 20144386698 scopus 로고    scopus 로고
    • Long-term AICAR administration and exercise prevents diabetes in ZDF rats
    • Pold R, Jensen LS, Jessen N, et al. Long-term AICAR administration and exercise prevents diabetes in ZDF rats. Diabetes 2005; 54: 928-934.
    • (2005) Diabetes , vol.54 , pp. 928-934
    • Pold, R.1    Jensen, L.S.2    Jessen, N.3
  • 32
    • 84904015161 scopus 로고    scopus 로고
    • Uveal melanoma cells are inhibited by AICAR partially through activation of AMP-dependent kinase
    • Al-Moujahed A, Nicolaou F, Brodowska K, et al. Uveal melanoma cells are inhibited by AICAR partially through activation of AMP-dependent kinase. Invest Ophthalmol Vis Sci 2014; 55: 4175-4185.
    • (2014) Invest Ophthalmol Vis Sci , vol.55 , pp. 4175-4185
    • Al-Moujahed, A.1    Nicolaou, F.2    Brodowska, K.3
  • 33
    • 84896818078 scopus 로고    scopus 로고
    • Synergistic anti-tumor activity of acadesine (AICAR) in combination with the anti-CD20 monoclonal antibody rituximab in vivo and in vitro models of mantle cell lymphoma
    • Montraveta A, Xargay-Torrent S, Lopez-Guerra M, et al. Synergistic anti-tumor activity of acadesine (AICAR) in combination with the anti-CD20 monoclonal antibody rituximab in vivo and in vitro models of mantle cell lymphoma. Oncotarget 2014; 5: 726-739.
    • (2014) Oncotarget , vol.5 , pp. 726-739
    • Montraveta, A.1    Xargay-Torrent, S.2    Lopez-Guerra, M.3
  • 34
    • 85047279405 scopus 로고
    • The enzymatic synthesis of 5-amino-4-imidazolecarboxamide riboside triphosphate (ZTP)
    • Sabina RL, Holmes EW, Becker MA. The enzymatic synthesis of 5-amino-4-imidazolecarboxamide riboside triphosphate (ZTP). Science 1984; 223: 1193-1195.
    • (1984) Science , vol.223 , pp. 1193-1195
    • Sabina, R.L.1    Holmes, E.W.2    Becker, M.A.3
  • 35
    • 62849099045 scopus 로고    scopus 로고
    • AMPactivated protein kinase (AMPK) in the rock crab, cancer irroratus: An early indicator of temperature stress
    • Frederich MO, Rourke MR, Furey NB, Jost JA. AMPactivated protein kinase (AMPK) in the rock crab, cancer irroratus: an early indicator of temperature stress. J Exp Biol 2009; 212: 722-730.
    • (2009) J Exp Biol , vol.212 , pp. 722-730
    • Frederich, M.O.1    Rourke, M.R.2    Furey, N.B.3    Jost, J.A.4
  • 36
    • 20844451123 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Ancient energy review gauge provides clues to modern understanding of metabolism
    • Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy review gauge provides clues to modern understanding of metabolism. Cell Metab 2005; 1: 15-25.
    • (2005) Cell Metab , vol.1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 37
    • 33751011308 scopus 로고    scopus 로고
    • PGC-1alpha: A key regulator of energy metabolism
    • Liang H, Ward WF. PGC-1alpha: a key regulator of energy metabolism. Adv Physiol Educ 2006; 30: 145-151.
    • (2006) Adv Physiol Educ , vol.30 , pp. 145-151
    • Liang, H.1    Ward, W.F.2
  • 38
    • 40849092782 scopus 로고    scopus 로고
    • Adenosine 5'-monophosphateactivated protein kinase regulation of fatty acid oxidation in skeletal muscle
    • Osler ME, Zierath JR. Adenosine 5'-monophosphateactivated protein kinase regulation of fatty acid oxidation in skeletal muscle. Endocrinology 2008; 149: 935-941.
    • (2008) Endocrinology , vol.149 , pp. 935-941
    • Osler, M.E.1    Zierath, J.R.2
  • 39
    • 38949119767 scopus 로고    scopus 로고
    • Contrasting effects of exercise, AICAR, and increased fatty acid supply on in vivo and skeletal muscle glucose metabolism
    • Rantzau C, Christopher M, Alford FP. Contrasting effects of exercise, AICAR, and increased fatty acid supply on in vivo and skeletal muscle glucose metabolism. J Appl Physiol 2008: 104: 363-370.
    • (2008) J Appl Physiol , vol.104 , pp. 363-370
    • Rantzau, C.1    Christopher, M.2    Alford, F.P.3
  • 40
    • 84906866673 scopus 로고    scopus 로고
    • http://playtrue.wada-ama.org
  • 43
    • 1942470331 scopus 로고    scopus 로고
    • Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth
    • Gupta RA, Wang D, Katkuri S, Wang H, Dey SK, DuBois RN. Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nat Med 2004; 10: 245-247.
    • (2004) Nat Med , vol.10 , pp. 245-247
    • Gupta, R.A.1    Wang, D.2    Katkuri, S.3    Wang, H.4    Dey, S.K.5    Dubois, R.N.6
  • 44
    • 84906866662 scopus 로고    scopus 로고
    • http://www.clinicaltrials.gov
  • 45
    • 84865507796 scopus 로고    scopus 로고
    • Lipid effects of peroxisome proliferator-activated receptor-d agonist GW501516 in subjects with low high-density lipoprotein cholesterol: Characteristics of metabolic syndrome
    • Olson EJ, Pearce GL, Jones NP, Sprecher DL. Lipid effects of peroxisome proliferator-activated receptor-d agonist GW501516 in subjects with low high-density lipoprotein cholesterol: characteristics of metabolic syndrome. Arterioscler Thromb Vasc Biol 2012; 32: 2289-2294.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 2289-2294
    • Olson, E.J.1    Pearce, G.L.2    Jones, N.P.3    Sprecher, D.L.4
  • 46
    • 80053521381 scopus 로고    scopus 로고
    • Mechanism of action of a peroxisome proliferator-activated receptor (PPAR)-delta agonist on lipoprotein metabolism in dyslipidemic subjects with central obesity
    • Ooi EM, Watts GF, Sprecher DL, Chan DC, Barrett PH. Mechanism of action of a peroxisome proliferator-activated receptor (PPAR)-delta agonist on lipoprotein metabolism in dyslipidemic subjects with central obesity. J Clin Endocrinol Metab 2011; 96: E1568-E1576.
    • (2011) J Clin Endocrinol Metab , vol.96
    • Ooi, E.M.1    Watts, G.F.2    Sprecher, D.L.3    Chan, D.C.4    Barrett, P.H.5
  • 47
    • 39649101196 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men
    • Riserus U, Sprecher D, Johnson T, et al. Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men. Diabetes 2008; 57: 332-339.
    • (2008) Diabetes , vol.57 , pp. 332-339
    • Riserus, U.1    Sprecher, D.2    Johnson, T.3
  • 48
    • 33846443997 scopus 로고    scopus 로고
    • Triglyceride: Highdensity lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist
    • Sprecher DL, Massien C, Pearce G, et al. Triglyceride: highdensity lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist. Arterioscler Thromb Vasc Biol 2007; 27: 359-365.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 359-365
    • Sprecher, D.L.1    Massien, C.2    Pearce, G.3
  • 50
    • 84906866663 scopus 로고    scopus 로고
    • http://www.wada-ama.org
  • 51
    • 65749098867 scopus 로고    scopus 로고
    • Doping control analysis of emerging drugs in human plasma-identification of GW501516, S-107, JTV-519, and S-40503
    • Thevis M, Beuck S, Thomas A, et al. Doping control analysis of emerging drugs in human plasma-identification of GW501516, S-107, JTV-519, and S-40503. Rapid Commun Mass Spectrum 2009; 23: 1139-1146.
    • (2009) Rapid Commun Mass Spectrum , vol.23 , pp. 1139-1146
    • Thevis, M.1    Beuck, S.2    Thomas, A.3
  • 52
    • 70350433566 scopus 로고    scopus 로고
    • Police find range of drugs after trawling bins used by Tour de France cyclists
    • Benkimoun P. Police find range of drugs after trawling bins used by Tour de France cyclists. BMJ 2009; 339: b4201.
    • (2009) BMJ , vol.339
    • Benkimoun, P.1
  • 53
    • 84890124526 scopus 로고    scopus 로고
    • Quantification of AICAR-ribotide concentrations in red blood cells by means of LC-MS/MS
    • Thomas A, Vogel M, Piper T, et al. Quantification of AICAR-ribotide concentrations in red blood cells by means of LC-MS/MS. Anal Bioanal Chem 2013; 405: 9703-9709.
    • (2013) Anal Bioanal Chem , vol.405 , pp. 9703-9709
    • Thomas, A.1    Vogel, M.2    Piper, T.3
  • 55
    • 77951254123 scopus 로고    scopus 로고
    • Characterization of two major urinary metabolites of the PPARdelta-agonist GW1516 and implementation of the drug in routine doping controls
    • Thevis M, Moller I, Thomas A, et al. Characterization of two major urinary metabolites of the PPARdelta-agonist GW1516 and implementation of the drug in routine doping controls. Anal Bioanal Chem 2010; 396: 2479-2491.
    • (2010) Anal Bioanal Chem , vol.396 , pp. 2479-2491
    • Thevis, M.1    Moller, I.2    Thomas, A.3
  • 56
    • 84870550019 scopus 로고    scopus 로고
    • Synthesis, mass spectrometric characterization, and analysis of the PPARd agonist GW1516 and its major human metabolites: Targets in sports drug testing
    • Thevis M, Moller I, Beuck S, Schanzer W. Synthesis, mass spectrometric characterization, and analysis of the PPARd agonist GW1516 and its major human metabolites: targets in sports drug testing. Methods Mol Biol 2013; 952: 301-312.
    • (2013) Methods Mol Biol , vol.952 , pp. 301-312
    • Thevis, M.1    Moller, I.2    Beuck, S.3    Schanzer, W.4
  • 57
    • 84868199824 scopus 로고    scopus 로고
    • Detection of PPARd agonists GW1516 and GW0742 and their metabolites in human urine
    • doi: 10.1002/dta.1413
    • Sobolevsky T, Dikunets M, Sukhanova I, Virus E, Rodchenkov G. Detection of PPARd agonists GW1516 and GW0742 and their metabolites in human urine. Drug Test Anal 2012; doi: 10.1002/dta.1413.
    • (2012) Drug Test Anal
    • Sobolevsky, T.1    Dikunets, M.2    Sukhanova, I.3    Virus, E.4    Rodchenkov, G.5
  • 58
    • 84906866664 scopus 로고    scopus 로고
    • http://www.uci.ch/.
  • 59
    • 79960641097 scopus 로고    scopus 로고
    • Some new psychoactive substances: Precursor chemicals and synthesis-driven end-products
    • Collins M. Some new psychoactive substances: precursor chemicals and synthesis-driven end-products. Drug Test Anal 2011; 3: 404-416.
    • (2011) Drug Test Anal , vol.3 , pp. 404-416
    • Collins, M.1
  • 60
    • 84901601208 scopus 로고    scopus 로고
    • Detection of b- methylphenethylamine, a novel doping substance, by means of UPLC/MS/MS
    • Cholbinski P, Wicka M, Kowalczyk K, et al. Detection of b- methylphenethylamine, a novel doping substance, by means of UPLC/MS/MS. Anal Bioanal Chem 2014; 406: 3681-3688.
    • (2014) Anal Bioanal Chem , vol.406 , pp. 3681-3688
    • Cholbinski, P.1    Wicka, M.2    Kowalczyk, K.3
  • 61
    • 84886800419 scopus 로고    scopus 로고
    • Determination of selected biogenic amines in Acacia rigidula plant materials and dietary supplements using LCMS/ MS methods
    • Pawar RS, Grundel E, Fardin-Kia AR, Rader JI. Determination of selected biogenic amines in Acacia rigidula plant materials and dietary supplements using LCMS/ MS methods. J Pharm Biomed Anal 2014; 88: 457-466.
    • (2014) J Pharm Biomed Anal , vol.88 , pp. 457-466
    • Pawar, R.S.1    Grundel, E.2    Fardin-Kia, A.R.3    Rader, J.I.4
  • 62
  • 63
    • 80155148732 scopus 로고    scopus 로고
    • Ingestion of designer supplements produced positive doping cases unexpected by the athletes
    • Parr MK, Pokrywka A, Kwiatkowska D, Schanzer W. Ingestion of designer supplements produced positive doping cases unexpected by the athletes. Biol Sport 2011; 28: 153-157.
    • (2011) Biol Sport , vol.28 , pp. 153-157
    • Parr, M.K.1    Pokrywka, A.2    Kwiatkowska, D.3    Schanzer, W.4
  • 64
    • 79956187784 scopus 로고    scopus 로고
    • Trafficking of drug candidates relevant for sports drug testing: Detection of non-approved therapeutics categorized as anabolic and gene doping agents in products distributed via the Internet
    • Thevis M, Geyer H, Thomas A, Schanzer W. Trafficking of drug candidates relevant for sports drug testing: detection of non-approved therapeutics categorized as anabolic and gene doping agents in products distributed via the Internet. Drug Test Anal 2011; 3: 331-336.
    • (2011) Drug Test Anal , vol.3 , pp. 331-336
    • Thevis, M.1    Geyer, H.2    Thomas, A.3    Schanzer, W.4
  • 65
    • 84894907371 scopus 로고    scopus 로고
    • Bioactivity screening and mass spectrometric confirmation for the detection of PPARd agonists that increase type 1 muscle fibres
    • Bovee TF, Blokland M, Kersten S, et al. Bioactivity screening and mass spectrometric confirmation for the detection of PPARd agonists that increase type 1 muscle fibres. Anal Bioanal Chem 2014; 406: 705-713.
    • (2014) Anal Bioanal Chem , vol.406 , pp. 705-713
    • Bovee, T.F.1    Blokland, M.2    Kersten, S.3
  • 66
    • 77951221074 scopus 로고    scopus 로고
    • Quantification of urinary AICAR concentrations as a matter of doping control
    • Thomas A, Beuck S, Eichoff JC, et al. Quantification of urinary AICAR concentrations as a matter of doping control. Anal Bioanal Chem 2010; 396: 2899-2908.
    • (2010) Anal Bioanal Chem , vol.396 , pp. 2899-2908
    • Thomas, A.1    Beuck, S.2    Eichoff, J.C.3
  • 67
    • 47749087836 scopus 로고    scopus 로고
    • The application of carbon isotope ratio mass spectrometry to doping control
    • Cawley A, Flenker U. The application of carbon isotope ratio mass spectrometry to doping control. J Mass Spectrom 2008; 43: 854-864.
    • (2008) J Mass Spectrom , vol.43 , pp. 854-864
    • Cawley, A.1    Flenker, U.2
  • 68
    • 79960562136 scopus 로고    scopus 로고
    • Recent development in the use of isotope ratio mass spectrometry in sport drug testing
    • Piper T, Emery C, Saugy M. Recent development in the use of isotope ratio mass spectrometry in sport drug testing. Anal Bioanal Chem 2011; 401: 433-447.
    • (2011) Anal Bioanal Chem , vol.401 , pp. 433-447
    • Piper, T.1    Emery, C.2    Saugy, M.3
  • 69
    • 84899425876 scopus 로고    scopus 로고
    • Determination of 13C/12C ratios of endogenous urinary 5-aminoimidazole-4- carboxamide 1β-D-ribofuranoside (AICAR)
    • Piper T, Thomas A, Baume N, et al. Determination of 13C/12C ratios of endogenous urinary 5-aminoimidazole-4- carboxamide 1b-D-ribofuranoside (AICAR). Rapid Commun Mass Spectrom 2014; 28: 1194-1202.
    • (2014) Rapid Commun Mass Spectrom , vol.28 , pp. 1194-1202
    • Piper, T.1    Thomas, A.2    Baume, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.