Detection of β-methylphenethylamine, a novel doping substance, by means of UPLC/MS/MS Euroanalysis XVII

Analytical and Bioanalytical Chemistry

Volumn 406, Issue 15, 2014, Pages 3681-3688

  Chołbiński, Piotr ^a   Wicka, Mariola ^a   Kowalczyk, Katarzyna ^a,b   Jarek, Anna ^a   Kaliszewski, Paweł ^a   Pokrywka, Andrzej ^a   Bulska, Ewa ^b   Kwiatkowska, Dorota ^a  

^a Institute of Sport National Research Institute   (Poland)

^b UNIVERSITY OF WARSAW   (Poland)

Author keywords

Amphetamine isomer; Doping; Liquid chromatography; Mass spectrometry; Sport; Stimulant

Indexed keywords

DOPING (ADDITIVES); HIGH PRESSURE LIQUID CHROMATOGRAPHY; HYDROLYSIS; LABORATORIES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

CHROMATOGRAPHIC SEPARATIONS; COLLISION-INDUCED DISSOCIATION SPECTRA; DETECTION CAPABILITY; DEVELOPMENT AND APPLICATIONS; LIQUID-LIQUID EXTRACTION; SPORT; STIMULANT; WORLD ANTI-DOPING AGENCY;

ISOMERS;

AMPHETAMINE DERIVATIVE; CENTRAL STIMULANT AGENT; METHAMPHETAMINE; N-METHYLPHENETHYLAMINE;

ANALOGS AND DERIVATIVES; DOPING; FORENSIC TOXICOLOGY; HUMAN; HYDROLYSIS; LABORATORY DIAGNOSIS; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROCEDURES; SENSITIVITY AND SPECIFICITY; SUBSTANCE ABUSE; TANDEM MASS SPECTROMETRY; TEMPERATURE; URINE;

AMPHETAMINES; CENTRAL NERVOUS SYSTEM STIMULANTS; CHROMATOGRAPHY, LIQUID; DOPING IN SPORTS; FALSE NEGATIVE REACTIONS; FORENSIC TOXICOLOGY; HUMANS; HYDROLYSIS; LIMIT OF DETECTION; MASS SPECTROMETRY; METHAMPHETAMINE; SENSITIVITY AND SPECIFICITY; SUBSTANCE ABUSE DETECTION; TANDEM MASS SPECTROMETRY; TEMPERATURE;

EID: 84901601208     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-014-7728-5     Document Type: Article

References (27)

1. Deventer K, Roels K, Delbeke FT, Van Eenoo P (2011) Prevalence of legal and illegal stimulating agents in sports. Anal Bioanal Chem 401:421-432
2. Collins M (2011) Some new psychoactive substances: precursor chemicals and synthesis-driven end-products. Drug Test Anal 3:404-416
3. Carroll FI, Lewin AH, Mascarella SW, Seltzman HH, Reddy PA (2012) Designer drugs: a medicinal chemistry perspective. Ann N Y Acad Sci 1248:18-38
4. Parr MK, Pokrywka A, Kwiatkowska D, Schänzer W (2011) Ingestion of designer supplements produced positive doping cases unexpected by the athletes. Biol Sport 28:153-157
5. Thevis M, Geyer H, Thomas A, Schanzer W (2011) Trafficking of drug candidates relevant for sports drug testing: detection of non-approved therapeutics categorized as anabolic and gene doping agents in products distributed via the Internet. Drug Test Anal 3:331-336
6. Kohler M, Thomas A, Geyer H, Petrou M, Schanzer W, Thevis M (2010) Confiscated black market products and nutritional supplements with non-approved ingredients analyzed in the Cologne Doping Control Laboratory 2009. Drug Test Anal 2:533-537
7. World Anti-Doping Agency (2013) The 2013 prohibited list. http://www.wada-ama.org. Accessed Sep 2013
8. Pokrywka A, Kwiatkowska D, Kaliszewski P, Grucza R (2010) Some aspects concerning modifications of the List of Prohibited Substances and Methods in sport. Biol Sport 27:307-314
9. Perrenoud L, Saugy M, Saudan C (2009) Detection in urine of 4-methyl-2-hexaneamine, a doping agent. J Chromatogr B Analyt Technol Biomed Life Sci 877:3767-3770
10. Vonaparti A, Lyris E, Angelis YS, Panderi I, Koupparis M, Tsantili-Kakoulidou A, Peters RJ, Nielen MW, Georgakopoulos C (2010) Preventive doping control screening analysis of prohibited substances in human urine using rapid-resolution liquid chromatography/high-resolution time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 24:1595-1609
11. National Center for Biotechnology Information. PubChem Substance Database; CID=7753. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid= 7753. Accessed Sep 2013
12. Gauthier TD (2013) Evidence for the presence of 1,3-dimethylamylamine (1,3-DMAA) in geranium plant materials. Anal Chem Insights 8:29-40
13. Lisi A, Hasick N, Kazlauskas R, Goebel C (2011) Studies of methylhexaneamine in supplements and geranium oil. Drug Test Anal 3:873-876
14. Di Lorenzo C, Moro E, Dos Santos A, Uberti F, Restani P (2013) Could 1,3 dimethylamylamine (DMAA) in food supplements have a natural origin? Drug Test Anal 5:116-121
15. Austin KG, Travis J, Pace G, Lieberman HR (2013) Analysis of 1,3 dimethylamylamine concentrations in Geraniaceae, geranium oil and dietary supplements. Drug Test Anal. doi: 10.1002/dta.1491
16. Eliason MJ, Eichner A, Cancio A, Bestervelt L, Adams BD, Deuster PA (2012) Case reports: death of active duty soldiers following ingestion of dietary supplements containing 1,3-dimethylamylamine (DMAA). Mil Med 177:1455-1459
17. Mroczkowska H (2012) Style of thinking about doping among sportspersons: characterizing the attitudes of risk-takers and risk-avoiders. Biol Sport 29:151-155
18. Thevis M (2010) Mass spectrometry in sports drug testing: characterization of prohibited substances and doping control analytical assays. John Wiley & Sons, Inc, New Jersey, pp 279-280
19. World Anti-Doping Agency (2010) Technical document: identification criteria for qualitative assays incorporating column chromatography and mass spectrometry (TD2010IDCR). http://www.wada-ama.org. Accessed Sep 2013
20. World Anti-Doping Agency (2013) Technical document: minimum required performance levels for detection and identification of non-threshold substances (TD2013MRPL). http://www.wada-ama.org. Accessed Sep 2013
21. Matuszewski BK, Constanzer ML, Chavez-Eng CM (2003) Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal Chem 75:3019-3030
22. Marchi I, Viette V, Badoud F, Fathi M, Saugy M, Rudaz S, Veuthey JL (2010) Characterization and classification of matrix effects in biological samples analyses. J Chromatogr A 1217:4071-4078
23. World Anti-Doping Agency (2012) International standard for laboratories V7.0. http://www.wada-ama.org. Accessed Sep 2013
24. EURACHEM (1998) The fitness for purpose of analytical methods. http://www.eurachem.org. Accessed Sep 2013
25. Viswanathan CT, Bansal S, Booth B, DeStefano AJ, Rose MJ, Sailstad J, Shah VP, Skelly JP, Swann PG, Weiner R (2007) Quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays. Pharm Res 24:1962-1973
26. Musshoff F (2000) Illegal or legitimate use? Precursor compounds to amphetamine and methamphetamine. Drug Metab Rev 32:15-44
27. Carvalho M, Carmo H, Costa VM, Capela JP, Pontes H, Remiao F, Carvalho F, Bastos Mde L (2012) Toxicity of amphetamines: an update. Arch Toxicol 86:1167-1231