Doping control analysis of emerging drugs in human plasma-Identification of GW501516, S-107, JTV-519, and S-40503

Rapid Communications in Mass Spectrometry

Volumn 23, Issue 8, 2009, Pages 1139-1146

  Theyis, Mario ^a   Beuck, Simon ^a   Thomas, Andreas ^a   Kortner, Blrthe ^a   Kohler, Maxie ^a   Rodchenkov, Grlgory ^b   Schlnzer, Wilhelm ^a  

^a GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

^b Moscow Anti Doping Center   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

CONTROLLED DRUG DELIVERY; DIAGNOSIS; DISEASES; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; MASS SPECTROMETERS; MASS SPECTROMETRY;

ANDROGEN RECEPTORS; DIFFERENT CLASS; DOPING CONTROL; DOPING CONTROL ANALYSIS; HUMAN PLASMAS; MEDICAL CONDITIONS; METABOLIC SYNDROMES; PLASMA IDENTIFICATION; RYANODINE; STABILISER;

METABOLISM;

2,3,4,5 TETRAHYDRO 7 METHOXY 4 METHYL 1,4 BENZOTHIAZEPINE; 4 [3 (4 BENZYL 1 PIPERIDINYL)PROPIONYL] 2,3,4,5 TETRAHYDRO 7 METHOXY 1,4 BENZOTHIAZEPINE; ACETONITRILE; S 40503; SELECTIVE ANDROGEN RECEPTOR MODULATOR; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; ANDROGEN RECEPTOR; FK 506 BINDING PROTEIN; K201 COMPOUND; QUINOLINE DERIVATIVE; RYANODINE; S 107 COMPOUND; S-107 COMPOUND; TACROLIMUS BINDING PROTEIN 1B; THIAZEPINE DERIVATIVE; THIAZOLE DERIVATIVE;

ARTICLE; BLOOD SAMPLING; COLLISIONALLY ACTIVATED DISSOCIATION; CONCENTRATION (PARAMETER); DOPING; DOPING CONTROL; DRUG BLOOD LEVEL; DRUG CONTROL; DRUG IDENTIFICATION; ELECTROSPRAY MASS SPECTROMETRY; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MEASUREMENT ACCURACY; MEASUREMENT PRECISION; MULTIPLE REACTION MONITORING; TANDEM MASS SPECTROMETRY; TRIPLE QUADRUPOLE MASS SPECTROMETRY; BLOOD; CHEMICAL STRUCTURE; CHEMISTRY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHODOLOGY; MOLECULAR WEIGHT; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

CHROMATOGRAPHY, LIQUID; DOPING IN SPORTS; HUMANS; MASS SPECTROMETRY; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; QUINOLINES; RECEPTORS, ANDROGEN; REPRODUCIBILITY OF RESULTS; RYANODINE; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TACROLIMUS BINDING PROTEINS; TANDEM MASS SPECTROMETRY; THIAZEPINES; THIAZOLES;

EID: 65749098867     PISSN: 09514198     EISSN: 10970231     Source Type: Journal    
DOI: 10.1002/rcm.3987     Document Type: Article

References (45)

1. Narkar VA, Dowries M, Yu RT, Embler E, Wang YX, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, Kang H, Shaw RJ, Evans RM. Cell 2008; 134: 405.
2. Wang YX, Zhang CL, Yu RT, Cho HK, Nelson MC, Bayuga-Ocampo CR, Ham J, Kang H, Evans RM. PLoS Biol. 2004; 2: e294.
3. Bellinger AM, Mongillo M, Marks AR. J. Clin. Invest. 2008; 118: 445.
4. Bellinger AM, Reiken S, Dura M, Murphy PW, Deng SX, Landry DW, Nieman D, Lehnart SE, Samaru M, LaCampagne A, Marks AR. Proc. Natl. Acad. Sci. USA 2008; 105: 2198.
5. Mohler ML, Nair VA, Hwang DJ, Rakov IM, Patil R, Miller DD. Exp. Opin. Ther. Patents 2005; 15: 1565.
6. Cadilla R, Turnbull P. Curr. Top. Med. Chem. 2006; 6: 245.
7. Omwancha J, Brown TR, Curr. Opin. Investig. Drugs 2006; 7: 873.
8. Chen J, Kim J, Dalton JT. Mol. Interv. 2005; 5: 173.
9. Bhasin S, Calof OM, Storer TW, Lee ML, Mazer NA, Jasuja R, Montori VM, Gao W, Dalton JT. Nat. Clin. Pract. Endocrinol. I Metab. 2006; 2: 146.
10. Gao W, Reiser PJ, Coss CC, Phelps MA, Kearbev JD, Miller DD, Dalton JT. Endocrinology 2005; 146: 4887.
11. Gao W, Dalton JT. Drug Discov. Today 2007; 12: 241.
12. Thevis M, Schanzer W. J. Mass Spectrom. 2008; 43: 865.
13. Thevis M, Kohler M, Schänzer W. Drug Discov. Today 2008; 13: 59..
14. Hanada K, Furuya K, Yamamoto N, Nejishima H, Ichikawa K, Nakamura T, Mivakawa M, Amano S, Sumita Y, Oguro N. Biol. Pharm. Bull 2003; 26: 1563.
15. Wang YX, Lee CH, Tiep S, Yu RT, Ham J, Kang H, Evans RM, Cell 2003; 113: 159.
16. Kramer DK, Al-Khalili L, Guigas B, Leng Y, Garcia-Roves PM, Krook A. J. Biol. Chem. 2007; 282: 19313.
17. Luquet S, Lopez-Soriano J, Hoist D, Gaudel C, Jehl-Pietri C, Fredenrich A, Grimaldi PA. Biochimie 2004; 86: 833.
18. Brunmair B, Staniek K, Dorig J, Szocs Z, Stadlbauer K, Marian V, Gras F, Anderwald C, Nohl H, Waldhausl W, Furnsinn C. Diabetologia 2006; 49: 2713.
19. World Anti-Doping Agency. 2009; Available: hftp://www.wada-ama.org/ rtecontent/document/2009-Prohibited-List-ENG-Final-20-Sept-08.pdf (Accessed 2 January 2009).
20. Thevis M, Schänzer W. Organogenesis 2008; 4: 264.
21. Brillantes AB, Ondrias K, Scott A, Kobrrnsky E, Ondriasova E, Moschella MC, Jayaraman T, Landers M, Ehrlich BE, Marks AR. Cell 1994; 77: 513.
22. Ochi R, Gupte SA. Recent Patents Cardiovasc. Drug Discov. 2007; 2: 110.
23. Thevis M, Kamber M, Schänzer W. Rapid Commun. Mass Spectromnn. 2006; 20: 870.
24. Thevis M, Lohmann W, Schrader Y, Kohler M, Bornatsch W, Karst U, Schänzer W. Eur. J. Mass Spectrom. 2008; 14: 163.
25. Thevis M, Kohler M, Schlorer N, Kamber M, Kuhn A, Linscheid MW, Schänzer W. J. Mass Spectrom. 2008; 43: 639.
26. Thevis M, Kohler M, Schlörer N, Fusshöller G, Schänzer W. Eur. J. Mass Spectrom. 2008; 14: 153.
27. Thevis M, Kohler M, Thomas A, Maurer J, Schlörer N, Kamber M, Schanzer W. Anal, Bioanal. Chem. 2008; 391: 251.
28. Thevis M, Kohler M, Maurer J, Schlörer N, Kamber M, Schänzer W. Rapid Commun. Mass Spectrom. 2007; 21: 3477.
29. GTx, Inc., 2006. Available: http://www.salesandmarketingnetwork.com/news- release.php?ID=2015328 (Accessed 8 December 2006).
30. Thevis M, Kohler M, Thomas A, Schlörer N, Schänzer W. Rapid Commun. Mass Spectrom. 2008; 22: 2471.
31. Thevis M, Beuck S, Thomas A, Kohler M, Schlörer N, Vajiala I, Schänzer W. Drug Test. Anal. 2009; 1: 32.
32. Kaken. European Patent, 1 221 439 B1 2007.
33. International Conference on Harmonisation, 2004. Available: http://www.ich.org/LOB/media/MEDIA417.pdf (Accessed 28 January 2007).
34. Kromidas A. Validierung in der Analytik. Wiley-VCH: Weinheim, 1999.
35. Dams R, Huestis MA, Lambert WE, Murphy CM. J. Am. Soc. Mass Spectrom. 2003; 14: 1290.
36. Matuszewski BK, Constanzer ML, Chavez-Eng CM. Anal. Chem. 2003; 75: 3019.
37. Pelton P. Curr. Opin. Investig. Drugs 2006; 7: 360.
38. Wehrens XH, Lehnart SE, Reiken S, van der Nagel R, Morales R, Sun J, Cheng Z, Deng SX, de Windt LJ, Landry DW, Marks AR. Proc. Natl. Acad. Sci. USA 2005; 102: 9607.
39. Thevis M, Schanzer W. Mass Spectrom. Rev. 2007; 26: 79.
40. Thevis M, Schanzer W. Mini-Rev. Med. Client. 2007; 7: 533.
41. Levesque JF, Templeton E, Trimble L, Berthelette C, Chauret N. Anal. Chem. 2005; 77: 3164.
42. Botre F. Toxicol. In Vitro 2003; 17: 509.
43. Levesque E, Gaudreault M, Houle R, Chauret N. J, Chromatogr. B 2002; 780: 145.
44. Kuuranne T, Leinonen A, Schänzer W, Kamber M, Kostiainen R, Thevis M. Drug Metab. Dispos. 2008; 36: 571.
45. Kuuranne T, Pystvnen KH, Thevis M, Leinonen A, Schänzer W, Kostiainen R. Eur. J. Mass Spectrom. 2008; 14: 181.