Evolution from a natural flavones nucleus to obtain 2-(4-propoxyphenyl) quinoline derivatives as potent inhibitors of the S. aureus NorA efflux pump

Journal of Medicinal Chemistry

Volumn 54, Issue 16, 2011, Pages 5722-5736

  Sabatini, Stefano ^a   Gosetto, Francesca ^a   Manfroni, Giuseppe ^a   Tabarrini, Oriana ^a   Kaatz, Glenn W ^b   Patel, Diixa ^b   Cecchetti, Violetta ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 PIPERIDIN 1 YLETHYL) 2 (4 PROPOXYPHENYL)QUINOLIN 4(1H) ONE; 2 (4 PROPOXYPHENYL)QUINOLINE DERIVATIVE; 4 (2 PIPERIDIN 1 YLETHOXY) 2 (4 PROPOXYPHENYL)QUINOLINE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; CIPROFLOXACIN; ETHIDIUM BROMIDE; FLAVONE DERIVATIVE; N,N DIETHYL 2 [[2 (4 PROPOXYPHENYL)QUINOLIN 4 YL]OXY]ETHANAMINE; N,N DIETHYL 2 [[2 [4 (2 PIPERIDIN 1 YLETHOXY)PHENYL]QUINOLIN 4 YL]OXY]ETHANAMINE; PAROXETINE; PROTEIN NORA; QUINOLINE DERIVATIVE; RESERPINE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG POTENCY; DRUG POTENTIATION; DRUG SYNTHESIS; GENE OVEREXPRESSION; NONHUMAN; NORA GENE; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CIPROFLOXACIN; DRUG SYNERGISM; FLAVONES; HYDROXYQUINOLINES; MICROBIAL SENSITIVITY TESTS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION; SPECIES SPECIFICITY; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80051910934     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200370y     Document Type: Article

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